JP2005512564A5 - - Google Patents
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- JP2005512564A5 JP2005512564A5 JP2003554878A JP2003554878A JP2005512564A5 JP 2005512564 A5 JP2005512564 A5 JP 2005512564A5 JP 2003554878 A JP2003554878 A JP 2003554878A JP 2003554878 A JP2003554878 A JP 2003554878A JP 2005512564 A5 JP2005512564 A5 JP 2005512564A5
- Authority
- JP
- Japan
- Prior art keywords
- cell density
- infected
- culture
- microcarrier
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002028 Biomass Substances 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000004113 cell culture Methods 0.000 description 2
- 230000001464 adherent effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 238000011176 pooling Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/006,881 US6951752B2 (en) | 2001-12-10 | 2001-12-10 | Method for large scale production of virus antigen |
| PCT/EP2002/014011 WO2003054174A1 (en) | 2001-12-10 | 2002-12-10 | Method for large scale production of virus antigen |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009157882A Division JP5021000B2 (ja) | 2001-12-10 | 2009-07-02 | ウイルス抗原の大規模生成方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005512564A JP2005512564A (ja) | 2005-05-12 |
| JP2005512564A5 true JP2005512564A5 (enExample) | 2009-08-20 |
| JP4370511B2 JP4370511B2 (ja) | 2009-11-25 |
Family
ID=21723079
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003554878A Expired - Lifetime JP4370511B2 (ja) | 2001-12-10 | 2002-12-10 | ウイルス抗原の大規模生成方法 |
| JP2009157882A Expired - Lifetime JP5021000B2 (ja) | 2001-12-10 | 2009-07-02 | ウイルス抗原の大規模生成方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009157882A Expired - Lifetime JP5021000B2 (ja) | 2001-12-10 | 2009-07-02 | ウイルス抗原の大規模生成方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6951752B2 (enExample) |
| EP (3) | EP2330189B1 (enExample) |
| JP (2) | JP4370511B2 (enExample) |
| CN (2) | CN101100657B (enExample) |
| AT (1) | ATE447010T2 (enExample) |
| AU (1) | AU2002358662B2 (enExample) |
| CA (1) | CA2469644C (enExample) |
| DE (2) | DE60234211D1 (enExample) |
| DK (2) | DK2330189T3 (enExample) |
| ES (2) | ES2488818T3 (enExample) |
| FR (1) | FR10C0026I1 (enExample) |
| HU (1) | HU225791B1 (enExample) |
| MX (1) | MXPA04005644A (enExample) |
| NO (1) | NO20042910L (enExample) |
| PL (1) | PL208232B1 (enExample) |
| RU (1) | RU2314344C2 (enExample) |
| WO (1) | WO2003054174A1 (enExample) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7445924B2 (en) | 2000-11-23 | 2008-11-04 | Bavarian Nordic A/S | Modified Vaccinia Ankara virus variant and cultivation method |
| US6951752B2 (en) * | 2001-12-10 | 2005-10-04 | Bexter Healthcare S.A. | Method for large scale production of virus antigen |
| ATE302268T1 (de) * | 2001-12-20 | 2005-09-15 | Bavarian Nordic As | Methode zur gewinnung und reinigung von poxviren aus infizierten zellen |
| UA85543C2 (ru) | 2002-09-05 | 2009-02-10 | Бавариан Нордик А/С | Способ культивирования первичных клеток и амплификации вирусов в условиях безсывороточной среды, композиция и ее применение, и способ лечения или вакцинации животных |
| BR0317723A (pt) * | 2002-12-23 | 2005-11-22 | Bristol Myers Squibb Co | Processo de cultura de células de mamìfero para a produção de proteìna |
| US20050153419A1 (en) * | 2003-12-23 | 2005-07-14 | Schering Corporation | Methods for producing cell lines stable in serum-free medium suspension culture |
| ES2329607T3 (es) | 2004-02-23 | 2009-11-27 | Crucell Holland B.V. | Metodos de purificacion de virus. |
| WO2005103235A1 (ja) * | 2004-04-19 | 2005-11-03 | Denka Seiken Co., Ltd. | ウイルスの生産方法 |
| NZ551640A (en) * | 2004-05-20 | 2010-05-28 | Id Biomedical Corp | Process for the production of an influenza vaccine |
| CN101189326B (zh) * | 2004-12-23 | 2013-06-12 | 米迪缪尼有限公司 | 用于病毒增殖的非致瘤性mdck细胞系 |
| US7344839B2 (en) * | 2004-12-23 | 2008-03-18 | Aurx, Inc. | Virus preparations and methods |
| WO2007126810A2 (en) | 2006-03-31 | 2007-11-08 | Warf - Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
| EP2069480B1 (en) * | 2006-09-15 | 2014-03-19 | MedImmune, LLC | Mdck cell lines supporting viral growth to high titers and bioreactor process using the same |
| JP5084214B2 (ja) * | 2006-09-29 | 2012-11-28 | 一般財団法人日本ポリオ研究所 | Ｉｐｖワクチン |
| ES2521496T3 (es) * | 2007-05-04 | 2014-11-12 | Baxter International Inc. | Perfil de temperatura en dos etapas para la propagación de virus |
| WO2008156778A2 (en) | 2007-06-18 | 2008-12-24 | Tokiko Watanabe | Influenza m2 protein mutant viruses as live influenza attenuated vaccines |
| US20110014624A1 (en) * | 2008-03-12 | 2011-01-20 | Wyeth Llc | Methods For Identifying Cells Suitable For Large-Scale Production of Recombinant Proteins |
| MY172788A (en) | 2008-08-01 | 2019-12-12 | Gamma Vaccines Pty Ltd | Influenza vaccines |
| CN103952376A (zh) | 2008-09-24 | 2014-07-30 | 米迪缪尼有限公司 | 培养细胞、增殖和纯化病毒的方法 |
| JP5548207B2 (ja) | 2008-09-24 | 2014-07-16 | メディミューン，エルエルシー | ウイルスの精製方法 |
| DK2459709T3 (en) | 2009-07-31 | 2014-12-01 | Ge Healthcare Bio Sciences | HIGH-REPLACED YELLOW FEBER VIRUS TREASURY WITH INCREASED CELL STORAGE |
| WO2011056591A1 (en) | 2009-10-26 | 2011-05-12 | Warf - Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in vero cells |
| AU2010334723C1 (en) * | 2009-12-23 | 2015-05-28 | Sanofi Pasteur | Method for culturing adherent cells |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| BR112012026095A2 (pt) | 2010-04-14 | 2015-09-15 | Emd Millipore Corp | métodos de produção de estoques de vírus de alta pureza e altos títulos e métodos de uso dos mesmos. |
| WO2012048298A2 (en) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
| CN101979517B (zh) * | 2010-10-15 | 2011-12-28 | 普莱柯生物工程股份有限公司 | 一种利用生物反应器大规模生产流感病毒的方法 |
| US20140079732A1 (en) | 2011-01-27 | 2014-03-20 | Gamma Vaccines Pty Limited | Combination vaccines |
| JP2014527799A (ja) | 2011-08-26 | 2014-10-23 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | 変異型ｐｂ２遺伝子セグメントを有する弱毒化生ワクチンとしてのインフルエンザウイルス |
| CN102492659A (zh) * | 2011-11-14 | 2012-06-13 | 成都康华生物制品有限公司 | 一种疫苗生产用甲肝病毒的生产方法 |
| WO2015009743A1 (en) | 2013-07-15 | 2015-01-22 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs |
| CN103387958B (zh) * | 2013-08-16 | 2016-04-06 | 北京科兴中维生物技术有限公司 | 人胚肺成纤维细胞sv-7在病毒培养中的应用 |
| WO2015073918A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
| US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
| US10053671B2 (en) | 2014-06-20 | 2018-08-21 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| WO2016049421A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled feed |
| WO2016121768A1 (ja) | 2015-01-26 | 2016-08-04 | 宇部興産株式会社 | 物質の産生方法 |
| EP3406710A1 (en) | 2015-01-26 | 2018-11-28 | UBE Industries, Ltd. | Method, device and kit for mass cultivation of cells using polyimide porous membrane |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| US9890363B2 (en) | 2015-07-06 | 2018-02-13 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| WO2017143236A1 (en) | 2016-02-19 | 2017-08-24 | Yoshihiro Kawaoka | Improved influenza b virus replication for vaccine development |
| US11965175B2 (en) | 2016-05-25 | 2024-04-23 | Terumo Bct, Inc. | Cell expansion |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US20190264156A1 (en) | 2016-07-25 | 2019-08-29 | Ube Industries, Ltd. | Siphon type cultivation method |
| SG11201900674XA (en) | 2016-07-25 | 2019-02-27 | Ube Industries | Cell culture module |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| US11629332B2 (en) | 2017-03-31 | 2023-04-18 | Terumo Bct, Inc. | Cell expansion |
| US11197926B2 (en) | 2017-10-25 | 2021-12-14 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| US11612648B2 (en) * | 2018-01-18 | 2023-03-28 | Yisheng Biopharma (Singapore) Pte Ltd | Method for adapting influenza viruses to Vero cells |
| SG11202007503WA (en) | 2018-02-07 | 2020-09-29 | Bharat Biotech Int Ltd | A process for enterovirus purification and inactivation and vaccine compositions obtained thereof |
| JP7783047B2 (ja) | 2018-08-07 | 2025-12-09 | ウィスコンシン アルムニ リサーチ ファンデイション | 組換えの生物学的に封じ込められたフィロウイルスワクチン |
| JP7655849B2 (ja) | 2018-08-20 | 2025-04-02 | ウィスコンシン アルムニ リサーチ ファンデイション | ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター |
| JP2022527235A (ja) | 2019-01-23 | 2022-06-01 | 義裕 河岡 | インフルエンザウイルスにおける付加的遺伝子に遺伝的安定性を付与する突然変異 |
| WO2020153619A1 (ko) * | 2019-01-25 | 2020-07-30 | 바이로큐어 주식회사 | Bhk-21 세포를 이용한 바이러스 생산방법 |
| KR102228267B1 (ko) * | 2019-01-25 | 2021-03-17 | 바이로큐어 주식회사 | Bhk-21 세포를 이용한 바이러스 생산방법 |
| EP3921413A1 (en) | 2019-02-08 | 2021-12-15 | Wisconsin Alumni Research Foundation (WARF) | Humanized cell line |
| JP7548916B2 (ja) * | 2019-02-15 | 2024-09-10 | オロジー バイオサーヴィシズ、インク． | ウイルスの製造方法 |
| US11390649B2 (en) | 2019-05-01 | 2022-07-19 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| TW202122572A (zh) | 2019-08-09 | 2021-06-16 | 日商宇部興產股份有限公司 | 胞外體的產生方法 |
| TW202122569A (zh) | 2019-08-09 | 2021-06-16 | 日商宇部興產股份有限公司 | 應用小片多孔膜的細胞培養法 |
| US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| JP2023511444A (ja) | 2020-01-24 | 2023-03-17 | ウィスコンシン アルムニ リサーチ ファンデイション | 安定化されたｎａを有する組換えインフルエンザウイルス |
| WO2021195410A1 (en) | 2020-03-25 | 2021-09-30 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| CN111850169B (zh) * | 2020-07-16 | 2022-09-27 | 华农（肇庆）生物产业技术研究院有限公司 | 一种计算AIV在MDCK-sus细胞中细胞单位均产毒量的方法 |
| GB2619893A (en) | 2021-03-23 | 2023-12-20 | Terumo Bct Inc | Cell capture and expansion |
| US12209689B2 (en) | 2022-02-28 | 2025-01-28 | Terumo Kabushiki Kaisha | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4525349A (en) | 1981-12-29 | 1985-06-25 | Societe Anonyme Dite: Institut Merueux | Process for the large-scale production of a vaccine against poliomyelitis and the resulting vaccine |
| US5719051A (en) * | 1989-12-22 | 1998-02-17 | Immuno Aktiengesellschaft | Perfusion system and a method for the large scale production of virus or virus antigen |
| AT393356B (de) | 1989-12-22 | 1991-10-10 | Immuno Ag | Verfahren zur herstellung von fsme-virus-antigen |
| FR2723740B1 (fr) | 1994-08-16 | 1996-11-08 | Pasteur Merieux Serums Vacc | Procede de preparation d'antigenes du virus grippal, antigenes obtenus et leurs applications |
| US5824536A (en) * | 1994-08-23 | 1998-10-20 | St. Jude Children's Research Hospital | Influenza virus replicated in mammalian cell culture and vaccine production |
| ES2323490T3 (es) | 1994-11-10 | 2009-07-17 | Baxter Healthcare Sa | Procedimiento de produccion de agentes biologicos en un medio de cultivo sin proteinas. |
| DE19612966B4 (de) * | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
| GB2319413B (en) * | 1996-11-12 | 2001-06-06 | Lsi Logic Corp | Driver circuits |
| US6168944B1 (en) * | 1997-01-31 | 2001-01-02 | Schering Corporation | Methods for cultivating cells and propagating viruses |
| EP0981601B1 (en) * | 1997-01-31 | 2006-09-06 | Schering Corporation | Methods for cultivating cells and propagating viruses |
| AT407255B (de) | 1997-06-20 | 2001-02-26 | Immuno Ag | Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons |
| US5994134A (en) * | 1998-05-04 | 1999-11-30 | Canji, Inc. | Viral production process |
| US6951752B2 (en) * | 2001-12-10 | 2005-10-04 | Bexter Healthcare S.A. | Method for large scale production of virus antigen |
| US6855535B2 (en) * | 2001-12-10 | 2005-02-15 | Baxter Healthcare S.A. | Method of large scale production of Hepatitis A virus |
-
2001
- 2001-12-10 US US10/006,881 patent/US6951752B2/en not_active Expired - Lifetime
-
2002
- 2002-12-10 EP EP10011842.1A patent/EP2330189B1/en not_active Expired - Lifetime
- 2002-12-10 CN CN2007101271424A patent/CN101100657B/zh not_active Expired - Lifetime
- 2002-12-10 DK DK10011842.1T patent/DK2330189T3/da active
- 2002-12-10 ES ES10011842.1T patent/ES2488818T3/es not_active Expired - Lifetime
- 2002-12-10 DE DE60234211T patent/DE60234211D1/de not_active Expired - Lifetime
- 2002-12-10 MX MXPA04005644A patent/MXPA04005644A/es active IP Right Grant
- 2002-12-10 DE DE122010000025C patent/DE122010000025I1/de active Pending
- 2002-12-10 AT AT02792957T patent/ATE447010T2/de active
- 2002-12-10 ES ES02792957.9T patent/ES2335395T5/es not_active Expired - Lifetime
- 2002-12-10 EP EP07021348A patent/EP1894998A1/en not_active Withdrawn
- 2002-12-10 CA CA2469644A patent/CA2469644C/en not_active Expired - Lifetime
- 2002-12-10 RU RU2004121178/13A patent/RU2314344C2/ru not_active IP Right Cessation
- 2002-12-10 WO PCT/EP2002/014011 patent/WO2003054174A1/en not_active Ceased
- 2002-12-10 JP JP2003554878A patent/JP4370511B2/ja not_active Expired - Lifetime
- 2002-12-10 EP EP02792957.9A patent/EP1453956B2/en not_active Expired - Lifetime
- 2002-12-10 CN CNB028279778A patent/CN100335619C/zh not_active Expired - Lifetime
- 2002-12-10 AU AU2002358662A patent/AU2002358662B2/en not_active Expired
- 2002-12-10 HU HU0402415A patent/HU225791B1/hu not_active IP Right Cessation
- 2002-12-10 PL PL373487A patent/PL208232B1/pl unknown
- 2002-12-10 DK DK02792957T patent/DK1453956T3/da active
-
2004
- 2004-07-09 NO NO20042910A patent/NO20042910L/no not_active Application Discontinuation
-
2005
- 2005-03-17 US US11/084,485 patent/US7524676B2/en not_active Expired - Lifetime
-
2009
- 2009-07-02 JP JP2009157882A patent/JP5021000B2/ja not_active Expired - Lifetime
-
2010
- 2010-04-16 FR FR10C0026C patent/FR10C0026I1/fr active Active
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