DK1456361T3 - Fremgangsmåde til opsamling af krystallinske partikler fra fermenteringsmedium - Google Patents

Fremgangsmåde til opsamling af krystallinske partikler fra fermenteringsmedium

Info

Publication number
DK1456361T3
DK1456361T3 DK02781173.6T DK02781173T DK1456361T3 DK 1456361 T3 DK1456361 T3 DK 1456361T3 DK 02781173 T DK02781173 T DK 02781173T DK 1456361 T3 DK1456361 T3 DK 1456361T3
Authority
DK
Denmark
Prior art keywords
fermentation medium
crystalline particles
fermentation broth
collecting crystalline
collecting
Prior art date
Application number
DK02781173.6T
Other languages
English (en)
Inventor
Anders Rancke-Madsen
Benny Nielsen
Martin Troen Joergensen
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes As filed Critical Novozymes As
Application granted granted Critical
Publication of DK1456361T3 publication Critical patent/DK1456361T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411—Amylases
    • C12N9/2414—Alpha-amylase (3.2.1.1.)
    • C12N9/2417—Alpha-amylase (3.2.1.1.) from microbiological source
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Mushroom Cultivation (AREA)
DK02781173.6T 2001-12-11 2002-12-04 Fremgangsmåde til opsamling af krystallinske partikler fra fermenteringsmedium DK1456361T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200101847 2001-12-11
PCT/DK2002/000821 WO2003050274A2 (en) 2001-12-11 2002-12-04 Process for harvesting crystalline particles from fermentation broth

Publications (1)

Publication Number Publication Date
DK1456361T3 true DK1456361T3 (da) 2012-06-11

Family

ID=8160891

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02781173.6T DK1456361T3 (da) 2001-12-11 2002-12-04 Fremgangsmåde til opsamling af krystallinske partikler fra fermenteringsmedium

Country Status (6)

Country Link
EP (1) EP1456361B1 (da)
CN (1) CN100487114C (da)
AT (1) ATE547518T1 (da)
AU (1) AU2002349300A1 (da)
DK (1) DK1456361T3 (da)
WO (1) WO2003050274A2 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050176090A1 (en) * 2003-10-31 2005-08-11 Novozymes A/S Method for flocculation of a fermentation broth comprising a fungus
CA2548378A1 (en) * 2003-12-30 2005-07-14 Bharat Biotech International Limited A process for the preparation and purification of recombinant proteins
CN101679482A (zh) * 2006-12-22 2010-03-24 塔利克里斯生物治疗公司 用于沉淀肽的装置和方法
DE102008029401A1 (de) * 2008-06-23 2009-12-24 Bayer Technology Services Gmbh Verfahren zur Kristallisation von Peptiden und Proteinen
EP2196539B1 (en) * 2008-12-15 2022-02-09 Delft Advanced Biofuels B.V. Process for the continuous biological production of lipids, hydrocarbons or mixtures thereof
WO2011120882A1 (en) 2010-03-30 2011-10-06 Novozymes A/S Crystal metabolite recovery
CN102838552B (zh) * 2012-09-21 2015-08-05 江南大学 采用复合絮凝法生产高纯度吩嗪-1-羧酸的方法
EP2914611B1 (en) 2012-11-01 2018-08-29 Novozymes A/S Method for removal of dna
CN106146610B (zh) * 2016-09-22 2018-01-23 济南大学 一种采用絮凝法制备谷胱甘肽亚铜盐的方法
EP3606936B1 (en) * 2017-04-03 2021-10-20 Novozymes A/S Recovery process
WO2019160862A1 (en) * 2018-02-13 2019-08-22 Lygos, Inc. Method for preparation of diester derivatives of malonic acid
EP3864036A1 (en) 2018-10-10 2021-08-18 Novozymes A/S Chymotrypsin inhibitor variants and the use thereof
WO2024032881A1 (en) * 2022-08-10 2024-02-15 Arla Foods Amba Crystallisation of a protein capable of crystallizing under salting-in conditions using multiple protein feeds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659667A (en) * 1985-02-26 1987-04-21 Miles Laboratories, Inc. Process to recover crystalline enzymes and crystalline enzymes produced thereby
JP2958789B2 (ja) * 1990-01-22 1999-10-06 味の素株式会社 アミノ酸・核酸およびその誘導体の精製方法
EP0574050A1 (en) 1992-05-19 1993-12-15 Gist-Brocades N.V. Large scale separation and purification of fermentation product
DK83093D0 (da) * 1993-07-09 1993-07-09 Novo Nordisk As Fremgangsmaade
CN1114613C (zh) * 1995-06-02 2003-07-16 诺沃奇梅兹有限公司 蛋白质溶液的铝/铁处理和膜浓缩方法

Also Published As

Publication number Publication date
AU2002349300A8 (en) 2003-06-23
CN100487114C (zh) 2009-05-13
WO2003050274A2 (en) 2003-06-19
ATE547518T1 (de) 2012-03-15
AU2002349300A1 (en) 2003-06-23
EP1456361B1 (en) 2012-02-29
EP1456361A2 (en) 2004-09-15
WO2003050274A3 (en) 2003-12-11
CN1599795A (zh) 2005-03-23

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