RU2314344C2 - Способ крупномасштабного производства вирусного антигена - Google Patents

Способ крупномасштабного производства вирусного антигена Download PDF

Info

Publication number
RU2314344C2
RU2314344C2 RU2004121178/13A RU2004121178A RU2314344C2 RU 2314344 C2 RU2314344 C2 RU 2314344C2 RU 2004121178/13 A RU2004121178/13 A RU 2004121178/13A RU 2004121178 A RU2004121178 A RU 2004121178A RU 2314344 C2 RU2314344 C2 RU 2314344C2
Authority
RU
Russia
Prior art keywords
cells
virus
culture
cell
microcarrier
Prior art date
Application number
RU2004121178/13A
Other languages
English (en)
Russian (ru)
Other versions
RU2004121178A (ru
Inventor
Манфред РАЙТЕР (AT)
Манфред Райтер
Вольфганг МУНДТ (AT)
Вольфганг Мундт
Original Assignee
Бакстер Хелткэр С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21723079&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2314344(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бакстер Хелткэр С.А. filed Critical Бакстер Хелткэр С.А.
Publication of RU2004121178A publication Critical patent/RU2004121178A/ru
Application granted granted Critical
Publication of RU2314344C2 publication Critical patent/RU2314344C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16151—Methods of production or purification of viral material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
RU2004121178/13A 2001-12-10 2002-12-10 Способ крупномасштабного производства вирусного антигена RU2314344C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/006,881 US6951752B2 (en) 2001-12-10 2001-12-10 Method for large scale production of virus antigen
US10/006,881 2001-12-10

Publications (2)

Publication Number Publication Date
RU2004121178A RU2004121178A (ru) 2005-10-10
RU2314344C2 true RU2314344C2 (ru) 2008-01-10

Family

ID=21723079

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2004121178/13A RU2314344C2 (ru) 2001-12-10 2002-12-10 Способ крупномасштабного производства вирусного антигена

Country Status (17)

Country Link
US (2) US6951752B2 (enExample)
EP (3) EP2330189B1 (enExample)
JP (2) JP4370511B2 (enExample)
CN (2) CN101100657B (enExample)
AT (1) ATE447010T2 (enExample)
AU (1) AU2002358662B2 (enExample)
CA (1) CA2469644C (enExample)
DE (2) DE60234211D1 (enExample)
DK (2) DK2330189T3 (enExample)
ES (2) ES2335395T5 (enExample)
FR (1) FR10C0026I1 (enExample)
HU (1) HU225791B1 (enExample)
MX (1) MXPA04005644A (enExample)
NO (1) NO20042910L (enExample)
PL (1) PL208232B1 (enExample)
RU (1) RU2314344C2 (enExample)
WO (1) WO2003054174A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2612154C2 (ru) * 2009-12-23 2017-03-02 Санофи Пастер Способ культивирования адгезионных клеток

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7445924B2 (en) 2000-11-23 2008-11-04 Bavarian Nordic A/S Modified Vaccinia Ankara virus variant and cultivation method
US6951752B2 (en) * 2001-12-10 2005-10-04 Bexter Healthcare S.A. Method for large scale production of virus antigen
SI1407006T1 (sl) * 2001-12-20 2006-04-30 Bavarian Nordic As Postopek za ponovno pridobivanje in ciscenje poksvirusov iz inficiranih celic
ATE393212T2 (de) 2002-09-05 2008-05-15 Bavarian Nordic As Verfahren zur amplifikation von einem poxvirus in serumfreien verhältnissen
CA2511520A1 (en) * 2002-12-23 2004-07-15 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
EP1697505A1 (en) * 2003-12-23 2006-09-06 Schering Corporation Methods for producing a549 cell lines stable in serum-free medium suspension culture
CN1922308A (zh) 2004-02-23 2007-02-28 克鲁塞尔荷兰公司 病毒纯化方法
CN1914314B (zh) * 2004-04-19 2012-06-27 电化生研株式会社 病毒的生产方法
WO2005113758A1 (en) * 2004-05-20 2005-12-01 Id Biomedical Corporation Process for the production of an influenza vaccine
US7670837B2 (en) 2004-12-23 2010-03-02 Medimmune, Llc Non-tumorigenic MDCK cell line for propagating viruses
US7344839B2 (en) * 2004-12-23 2008-03-18 Aurx, Inc. Virus preparations and methods
EP2010557B1 (en) 2006-03-31 2014-02-26 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
US20080286850A1 (en) 2006-09-15 2008-11-20 Medimmune Vaccines, Inc. Mdck cell lines supporting viral growth to high titers and bioreactor process using the same
JP5084214B2 (ja) * 2006-09-29 2012-11-28 一般財団法人日本ポリオ研究所 Ｉｐｖワクチン
US8426124B2 (en) * 2007-05-04 2013-04-23 Baxter International Inc. Two-step temperature profile for the propagation of viruses
US9474798B2 (en) 2007-06-18 2016-10-25 Wisconsin Alumni Research Foundation Influenza M2 protein mutant viruses as live influenza attenuated vaccines
WO2009114693A1 (en) * 2008-03-12 2009-09-17 Wyeth Method for identifying cells suitable for large-scale production of recombinant proteins
RU2011107757A (ru) * 2008-08-01 2012-09-10 Гамма Ваксинс Пти Лимитед (Au) Вакцины против гриппа
JP5548207B2 (ja) 2008-09-24 2014-07-16 メディミューン，エルエルシー ウイルスの精製方法
WO2010036760A1 (en) * 2008-09-24 2010-04-01 Medimmune, Llc Methods for cultivating cells, propagating and purifying viruses
DK2459709T3 (en) 2009-07-31 2014-12-01 Ge Healthcare Bio Sciences HIGH-REPLACED YELLOW FEBER VIRUS TREASURY WITH INCREASED CELL STORAGE
US9109013B2 (en) 2009-10-26 2015-08-18 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses with enhanced replication in vero cells
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
WO2011130119A2 (en) 2010-04-14 2011-10-20 Millipore Corporation Methods of producing high titer, high purity virus stocks and methods of use thereof
US9677042B2 (en) 2010-10-08 2017-06-13 Terumo Bct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
CN101979517B (zh) * 2010-10-15 2011-12-28 普莱柯生物工程股份有限公司 一种利用生物反应器大规模生产流感病毒的方法
EP2667891B1 (en) 2011-01-27 2021-10-06 Gamma Vaccines Pty Limited Combination vaccines
WO2013032942A1 (en) 2011-08-26 2013-03-07 Yoshihiro Kawaoka Influenza viruses with mutant pb2 gene segment as live attenuated vaccines
CN102492659A (zh) * 2011-11-14 2012-06-13 成都康华生物制品有限公司 一种疫苗生产用甲肝病毒的生产方法
EP3022296B1 (en) 2013-07-15 2022-12-28 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs
CN103387958B (zh) * 2013-08-16 2016-04-06 北京科兴中维生物技术有限公司 人胚肺成纤维细胞sv-7在病毒培养中的应用
EP3068867B1 (en) 2013-11-16 2018-04-18 Terumo BCT, Inc. Expanding cells in a bioreactor
CN106232800B (zh) 2014-03-25 2020-07-03 泰尔茂比司特公司 介质的被动替代
WO2015196150A2 (en) 2014-06-20 2015-12-23 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
EP3198006B1 (en) 2014-09-26 2021-03-24 Terumo BCT, Inc. Scheduled feed
SG11201706066RA (en) 2015-01-26 2017-08-30 Ube Industries Method of producing substance
SG11201705866XA (en) 2015-01-26 2017-08-30 Ube Industries Method, device and kit for mass cultivation of cells using polyimide porous membrane
US10633422B2 (en) 2015-06-01 2020-04-28 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
WO2017007839A1 (en) 2015-07-06 2017-01-12 Wisconsin Alumni Research Foundation (Warf) Improved influenza virus replication for vaccine development
EP3417056A1 (en) 2016-02-19 2018-12-26 Wisconsin Alumni Research Foundation (WARF) Improved influenza b virus replication for vaccine development
CN109415696A (zh) 2016-05-25 2019-03-01 泰尔茂比司特公司 细胞扩增
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
CA3031915A1 (en) 2016-07-25 2018-02-01 Ube Industries, Ltd. Cell culture module comprising a polymer porous film
EP3489342B1 (en) 2016-07-25 2022-01-26 UBE Industries, Ltd. Siphon type cultivation method
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
WO2018184028A2 (en) 2017-03-31 2018-10-04 Terumo Bct, Inc. Cell expansion
JP2021500891A (ja) 2017-10-25 2021-01-14 ウィスコンシン アルムニ リサーチ ファンデイション 卵における複製のための安定化されたｈａを有する組換えインフルエンザウイルス
WO2019143291A1 (en) * 2018-01-18 2019-07-25 Yisheng Biopharma (Singapore) Pte. Ltd. Method for adapting influenza viruses to vero cells
EP3749757A4 (en) * 2018-02-07 2021-11-24 Bharat Biotech International Limited PROCESS FOR PURIFICATION AND INACTIVATION OF ENTERVIRUSES AND VACCINE COMPOSITIONS OBTAINED THEREOF
US12343390B2 (en) 2018-08-07 2025-07-01 Wisconsin Alumni Research Foundation (Warf) Recombinant biologically contained filovirus vaccine
JP7655849B2 (ja) 2018-08-20 2025-04-02 ウィスコンシン アルムニ リサーチ ファンデイション ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター
US11241492B2 (en) 2019-01-23 2022-02-08 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to genes in influenza viruses
KR102228267B1 (ko) * 2019-01-25 2021-03-17 바이로큐어 주식회사 Bhk-21 세포를 이용한 바이러스 생산방법
WO2020153619A1 (ko) * 2019-01-25 2020-07-30 바이로큐어 주식회사 Bhk-21 세포를 이용한 바이러스 생산방법
EP3921413A1 (en) 2019-02-08 2021-12-15 Wisconsin Alumni Research Foundation (WARF) Humanized cell line
EP3924469A4 (en) * 2019-02-15 2022-12-14 Ology Bioservices, Inc. VIRUS PRODUCTION METHOD
US11390649B2 (en) 2019-05-01 2022-07-19 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
TW202122572A (zh) 2019-08-09 2021-06-16 日商宇部興產股份有限公司 胞外體的產生方法
TW202122569A (zh) 2019-08-09 2021-06-16 日商宇部興產股份有限公司 應用小片多孔膜的細胞培養法
WO2021041624A2 (en) 2019-08-27 2021-03-04 Yoshihiro Kawaoka Recombinant influenza viruses with stabilized ha for replication in eggs
JP2023511444A (ja) 2020-01-24 2023-03-17 ウィスコンシン アルムニ リサーチ ファンデイション 安定化されたｎａを有する組換えインフルエンザウイルス
US12290562B2 (en) 2020-03-25 2025-05-06 Wisconsin Alumni Research Foundation (Warf) Recombinant multivalent influenza viruses
CN111850169B (zh) * 2020-07-16 2022-09-27 华农（肇庆）生物产业技术研究院有限公司 一种计算AIV在MDCK-sus细胞中细胞单位均产毒量的方法
JP7705950B2 (ja) 2021-03-23 2025-07-10 テルモ ビーシーティー、インコーポレーテッド 細胞を増殖する方法
US12209689B2 (en) 2022-02-28 2025-01-28 Terumo Kabushiki Kaisha Multiple-tube pinch valve assembly
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4525349A (en) 1981-12-29 1985-06-25 Societe Anonyme Dite: Institut Merueux Process for the large-scale production of a vaccine against poliomyelitis and the resulting vaccine
US5719051A (en) * 1989-12-22 1998-02-17 Immuno Aktiengesellschaft Perfusion system and a method for the large scale production of virus or virus antigen
AT393356B (de) 1989-12-22 1991-10-10 Immuno Ag Verfahren zur herstellung von fsme-virus-antigen
FR2723740B1 (fr) 1994-08-16 1996-11-08 Pasteur Merieux Serums Vacc Procede de preparation d'antigenes du virus grippal, antigenes obtenus et leurs applications
US5824536A (en) * 1994-08-23 1998-10-20 St. Jude Children's Research Hospital Influenza virus replicated in mammalian cell culture and vaccine production
CA2205015C (en) 1994-11-10 2003-04-08 Otfried Kistner Method for producing biologicals in protein-free culture
DE19612966B4 (de) * 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
GB2319413B (en) * 1996-11-12 2001-06-06 Lsi Logic Corp Driver circuits
JP2001509675A (ja) * 1997-01-31 2001-07-24 シェーリング コーポレイション 細胞培養およびウイルス増殖のための方法
US6168944B1 (en) * 1997-01-31 2001-01-02 Schering Corporation Methods for cultivating cells and propagating viruses
AT407255B (de) 1997-06-20 2001-02-26 Immuno Ag Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons
US5994134A (en) * 1998-05-04 1999-11-30 Canji, Inc. Viral production process
US6951752B2 (en) * 2001-12-10 2005-10-04 Bexter Healthcare S.A. Method for large scale production of virus antigen
US6855535B2 (en) * 2001-12-10 2005-02-15 Baxter Healthcare S.A. Method of large scale production of Hepatitis A virus

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BARRETT N. et al. Large-scale production and purification of a vaccinia recombinant-derived HIV-1 gp 160 and analysis of its immunogenicity. AIDS Res. Hum. Retroviruses. 1989 Apr; 5(2):159-71. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2612154C2 (ru) * 2009-12-23 2017-03-02 Санофи Пастер Способ культивирования адгезионных клеток

Also Published As

Publication number Publication date
EP1453956B1 (en) 2009-10-28
WO2003054174A1 (en) 2003-07-03
DE60234211D1 (de) 2009-12-10
HUP0402415A2 (hu) 2005-02-28
EP2330189A1 (en) 2011-06-08
EP2330189B1 (en) 2014-05-21
PL373487A1 (en) 2005-09-05
EP1894998A8 (en) 2008-04-23
JP4370511B2 (ja) 2009-11-25
RU2004121178A (ru) 2005-10-10
US20030108860A1 (en) 2003-06-12
DK2330189T3 (da) 2014-06-16
ES2335395T3 (es) 2010-03-26
CA2469644A1 (en) 2003-07-03
HK1158691A1 (en) 2012-07-20
MXPA04005644A (es) 2005-04-19
HU225791B1 (en) 2007-09-28
HUP0402415A3 (en) 2005-07-28
ES2488818T3 (es) 2014-08-29
PL208232B1 (pl) 2011-04-29
US7524676B2 (en) 2009-04-28
JP2009261410A (ja) 2009-11-12
CN101100657A (zh) 2008-01-09
NO20042910L (no) 2004-07-09
CN1617924A (zh) 2005-05-18
DE122010000025I1 (de) 2010-08-12
CA2469644C (en) 2013-07-23
EP1453956A1 (en) 2004-09-08
EP1453956B8 (en) 2010-02-10
EP1453956B2 (en) 2017-01-18
CN101100657B (zh) 2012-05-30
FR10C0026I1 (fr) 2011-01-14
AU2002358662A1 (en) 2003-07-09
JP2005512564A (ja) 2005-05-12
JP5021000B2 (ja) 2012-09-05
EP1894998A1 (en) 2008-03-05
CN100335619C (zh) 2007-09-05
AU2002358662B2 (en) 2008-05-15
HK1115609A1 (en) 2008-12-05
ATE447010T2 (de) 2009-11-15
US20050181495A1 (en) 2005-08-18
US6951752B2 (en) 2005-10-04
ES2335395T5 (es) 2017-08-31
DK1453956T3 (da) 2010-01-11

Similar Documents

Publication Publication Date Title
RU2314344C2 (ru) Способ крупномасштабного производства вирусного антигена
CA2455189C (en) Methods for producing an active constituent of a pharmaceutical or a diagnostic agent in an mdck cell suspension culture
AU2002338666B2 (en) Multiplication of viruses in a cell culture
HK1115609B (en) Method for large scale production of virus antigen
HK1158691B (en) Method for large scale production of virus
HK1116825A (en) Method for large scale production of virus
KR20100017593A (ko) 바이러스의 증식을 위한 ２-단계 온도 프로파일

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20161211