PL373487A1 - Method for large scale production of virus antigen - Google Patents

Method for large scale production of virus antigen

Info

Publication number
PL373487A1
PL373487A1 PL02373487A PL37348702A PL373487A1 PL 373487 A1 PL373487 A1 PL 373487A1 PL 02373487 A PL02373487 A PL 02373487A PL 37348702 A PL37348702 A PL 37348702A PL 373487 A1 PL373487 A1 PL 373487A1
Authority
PL
Poland
Prior art keywords
large scale
scale production
virus antigen
cell culture
directed
Prior art date
Application number
PL02373487A
Other languages
Polish (pl)
Other versions
PL208232B1 (en
Inventor
Manfred Reiter
Wolfgang Mundt
Original Assignee
Baxter Healthcare S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21723079&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL373487(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baxter Healthcare S.A. filed Critical Baxter Healthcare S.A.
Publication of PL373487A1 publication Critical patent/PL373487A1/en
Publication of PL208232B1 publication Critical patent/PL208232B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16151—Methods of production or purification of viral material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The present invention is directed to a cell culture biomass of adherent cells having increased cell density and microcarrier concentration compared to the respective confluent cell culture.
PL373487A 2001-12-10 2002-12-10 Method for large scale production of virus antigen PL208232B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/006,881 US6951752B2 (en) 2001-12-10 2001-12-10 Method for large scale production of virus antigen

Publications (2)

Publication Number Publication Date
PL373487A1 true PL373487A1 (en) 2005-09-05
PL208232B1 PL208232B1 (en) 2011-04-29

Family

ID=21723079

Family Applications (1)

Application Number Title Priority Date Filing Date
PL373487A PL208232B1 (en) 2001-12-10 2002-12-10 Method for large scale production of virus antigen

Country Status (18)

Country Link
US (2) US6951752B2 (en)
EP (3) EP1894998A1 (en)
JP (2) JP4370511B2 (en)
CN (2) CN100335619C (en)
AT (1) ATE447010T2 (en)
AU (1) AU2002358662B2 (en)
CA (1) CA2469644C (en)
DE (2) DE60234211D1 (en)
DK (2) DK2330189T3 (en)
ES (2) ES2488818T3 (en)
FR (1) FR10C0026I1 (en)
HK (2) HK1115609A1 (en)
HU (1) HU225791B1 (en)
MX (1) MXPA04005644A (en)
NO (1) NO20042910L (en)
PL (1) PL208232B1 (en)
RU (1) RU2314344C2 (en)
WO (1) WO2003054174A1 (en)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004022729A1 (en) 2002-09-05 2004-03-18 Bavarian Nordic A/S Method for the cultivation of primary cells and for the amplification of viruses under serum free conditions
US7445924B2 (en) 2000-11-23 2008-11-04 Bavarian Nordic A/S Modified Vaccinia Ankara virus variant and cultivation method
US6951752B2 (en) * 2001-12-10 2005-10-04 Bexter Healthcare S.A. Method for large scale production of virus antigen
SI1407006T1 (en) * 2001-12-20 2006-04-30 Bavarian Nordic As Method for the recovery and purification of poxviruses from infected cells
TWI312368B (en) * 2002-12-23 2009-07-21 Bristol Myers Squibb Compan Mammalian cell culture processes for protein production
EP1697505A1 (en) * 2003-12-23 2006-09-06 Schering Corporation Methods for producing a549 cell lines stable in serum-free medium suspension culture
AU2005214090B2 (en) 2004-02-23 2008-09-11 Crucell Holland B.V. Virus purification methods
US8221969B2 (en) * 2004-04-19 2012-07-17 Sanyo Chemical Industries, Ltd. Method of producing virus
CN101094915A (en) * 2004-05-20 2007-12-26 益得生物医学公司 Process for the production of an influenza vaccine
US7344839B2 (en) * 2004-12-23 2008-03-18 Aurx, Inc. Virus preparations and methods
EP1831353B1 (en) 2004-12-23 2012-02-29 MedImmune, LLC Non-tumorigenic mdck cell line for propagating viruses
US9254318B2 (en) 2006-03-31 2016-02-09 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
WO2008105931A2 (en) * 2006-09-15 2008-09-04 Medimmune Vaccines, Inc. Mdck cell lines supporting viral growth to high titers and bioreactor process using the same
JP5084214B2 (en) * 2006-09-29 2012-11-28 一般財団法人日本ポリオ研究所 IPV vaccine
WO2008135230A1 (en) * 2007-05-04 2008-11-13 Baxter International Inc. Two-step temperature profile for the propagation of viruses
US9474798B2 (en) 2007-06-18 2016-10-25 Wisconsin Alumni Research Foundation Influenza M2 protein mutant viruses as live influenza attenuated vaccines
EP2257634A1 (en) * 2008-03-12 2010-12-08 Wyeth LLC Method for identifying cells suitable for large-scale production of recombinant proteins
EP2318044B1 (en) * 2008-08-01 2015-12-02 Gamma Vaccines Pty Limited Influenza vaccines
CN102215865B (en) 2008-09-24 2013-10-30 米迪缪尼有限公司 Methods for purification of viruses
CN102216450B (en) * 2008-09-24 2014-05-14 米迪缪尼有限公司 Methods for cultivating cells, propagating and purifying viruses
CA2973863C (en) 2009-07-31 2022-05-17 Ge Healthcare Bio-Sciences Corp. High yield yellow fever virus strain with increased propagation in cells
JP2013507990A (en) 2009-10-26 2013-03-07 ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション High-titer recombinant influenza virus with enhanced replication in Vero cells
CN102782121A (en) * 2009-12-23 2012-11-14 赛诺菲巴斯德有限公司 Method for culturing adherent cells
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
JP2013523175A (en) 2010-04-14 2013-06-17 イーエムディー・ミリポア・コーポレーション Method for producing high-titer and high-purity virus stock and method for using the same
US9677042B2 (en) 2010-10-08 2017-06-13 Terumo Bct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
CN101979517B (en) * 2010-10-15 2011-12-28 普莱柯生物工程股份有限公司 Method for producing influenza viruses in large scale by using bioreactor
WO2012100302A1 (en) 2011-01-27 2012-08-02 Gamma Vaccines Pty Limited Combination vaccines
CN102492659A (en) * 2011-11-14 2012-06-13 成都康华生物制品有限公司 Production method for hepatitis A virus for vaccine production
US9950057B2 (en) 2013-07-15 2018-04-24 Wisconsin Alumni Research Foundation (Warf) High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs
CN103387958B (en) * 2013-08-16 2016-04-06 北京科兴中维生物技术有限公司 The application of human embryonic lung fibroblast SV-7 in virus culture
US9617506B2 (en) 2013-11-16 2017-04-11 Terumo Bct, Inc. Expanding cells in a bioreactor
EP3613841B1 (en) 2014-03-25 2022-04-20 Terumo BCT, Inc. Passive replacement of media
WO2015196150A2 (en) 2014-06-20 2015-12-23 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
EP3198006B1 (en) 2014-09-26 2021-03-24 Terumo BCT, Inc. Scheduled feed
BR112017015728A2 (en) 2015-01-26 2018-03-13 Ube Industries, Ltd. substance production method
WO2016121773A1 (en) 2015-01-26 2016-08-04 宇部興産株式会社 Method, device and kit for mass cultivation of cells using polyimide porous membrane
US10633422B2 (en) 2015-06-01 2020-04-28 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
WO2017007839A1 (en) 2015-07-06 2017-01-12 Wisconsin Alumni Research Foundation (Warf) Improved influenza virus replication for vaccine development
CN109477074B (en) 2016-02-19 2023-01-24 威斯康星旧生研究基金会 Improved influenza b virus replication for vaccine development
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
CN109477056A (en) 2016-07-25 2019-03-15 宇部兴产株式会社 Hydrocone type cultivation
JP6841282B2 (en) 2016-07-25 2021-03-10 宇部興産株式会社 Cell culture module
EP3656842A1 (en) 2017-03-31 2020-05-27 Terumo BCT, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
SG11202005528PA (en) * 2018-01-18 2020-07-29 Yisheng Biopharma Singapore Pte Ltd Method for adapting influenza viruses to vero cells
WO2019155492A1 (en) * 2018-02-07 2019-08-15 Bharat Biotech International Limited A process for enterovirus purification and inactivation and vaccine compositions obtained thereof
JP2022527235A (en) 2019-01-23 2022-06-01 義裕 河岡 Mutations that impart genetic stability to additional genes in influenza virus
KR102228267B1 (en) * 2019-01-25 2021-03-17 바이로큐어 주식회사 Methods for virus production using BHK-21 cell
WO2020153619A1 (en) * 2019-01-25 2020-07-30 바이로큐어 주식회사 Virus production method using bhk-21 cells
JP2022522112A (en) 2019-02-08 2022-04-14 ウィスコンシン アルムニ リサーチ ファンデイション Humanized cell line
SG11202108435WA (en) * 2019-02-15 2021-08-30 Ology Bioservices Inc Method for virus production
US11390649B2 (en) 2019-05-01 2022-07-19 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
TW202122572A (en) 2019-08-09 2021-06-16 日商宇部興產股份有限公司 Method for producing exosome
TW202122569A (en) 2019-08-09 2021-06-16 日商宇部興產股份有限公司 Cell culturing method using small-piece porous membrane
JP2022551805A (en) 2019-08-27 2022-12-14 ウィスコンシン アルムニ リサーチ ファンデイション Recombinant Influenza Virus with Stabilized HA for Intraovo Replication
CN111850169B (en) * 2020-07-16 2022-09-27 华农（肇庆）生物产业技术研究院有限公司 Method for calculating average cell unit toxic production of AIV in MDCK-sus cells

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4525349A (en) 1981-12-29 1985-06-25 Societe Anonyme Dite: Institut Merueux Process for the large-scale production of a vaccine against poliomyelitis and the resulting vaccine
AT393356B (en) 1989-12-22 1991-10-10 Immuno Ag METHOD FOR PRODUCING TBE VIRUS ANTIGES
US5719051A (en) * 1989-12-22 1998-02-17 Immuno Aktiengesellschaft Perfusion system and a method for the large scale production of virus or virus antigen
FR2723740B1 (en) 1994-08-16 1996-11-08 Pasteur Merieux Serums Vacc PROCESS FOR THE PREPARATION OF INFLUENZA VIRUS ANTIGENS, ANTIGENS OBTAINED AND THEIR APPLICATIONS
US5824536A (en) * 1994-08-23 1998-10-20 St. Jude Children's Research Hospital Influenza virus replicated in mammalian cell culture and vaccine production
WO1996015231A2 (en) 1994-11-10 1996-05-23 Immuno Aktiengesellschaft Method for producing biologicals in protein-free culture
DE19612966B4 (en) * 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK cells and methods of propagating influenza viruses
GB2319413B (en) * 1996-11-12 2001-06-06 Lsi Logic Corp Driver circuits
US6168944B1 (en) * 1997-01-31 2001-01-02 Schering Corporation Methods for cultivating cells and propagating viruses
WO1998033886A1 (en) * 1997-01-31 1998-08-06 Schering Corporation Methods for cultivating cells and propagating viruses
AT407255B (en) 1997-06-20 2001-02-26 Immuno Ag RECOMBINANT CELL CLONE WITH INCREASED STABILITY IN SERUM- AND PROTEIN-FREE MEDIUM AND METHOD FOR OBTAINING THE STABLE CELL CLONE
US5994134A (en) * 1998-05-04 1999-11-30 Canji, Inc. Viral production process
US6951752B2 (en) * 2001-12-10 2005-10-04 Bexter Healthcare S.A. Method for large scale production of virus antigen
US6855535B2 (en) * 2001-12-10 2005-02-15 Baxter Healthcare S.A. Method of large scale production of Hepatitis A virus

Also Published As

Publication number Publication date
MXPA04005644A (en) 2005-04-19
US6951752B2 (en) 2005-10-04
DK1453956T3 (en) 2010-01-11
EP2330189A1 (en) 2011-06-08
FR10C0026I1 (en) 2011-01-14
US7524676B2 (en) 2009-04-28
CA2469644A1 (en) 2003-07-03
DE60234211D1 (en) 2009-12-10
ES2335395T3 (en) 2010-03-26
CA2469644C (en) 2013-07-23
AU2002358662A1 (en) 2003-07-09
HUP0402415A3 (en) 2005-07-28
US20050181495A1 (en) 2005-08-18
JP4370511B2 (en) 2009-11-25
NO20042910L (en) 2004-07-09
EP1453956B1 (en) 2009-10-28
EP1453956A1 (en) 2004-09-08
ES2335395T5 (en) 2017-08-31
EP1453956B8 (en) 2010-02-10
ATE447010T2 (en) 2009-11-15
RU2004121178A (en) 2005-10-10
US20030108860A1 (en) 2003-06-12
CN101100657B (en) 2012-05-30
EP1453956B2 (en) 2017-01-18
RU2314344C2 (en) 2008-01-10
HK1115609A1 (en) 2008-12-05
AU2002358662B2 (en) 2008-05-15
EP1894998A8 (en) 2008-04-23
ES2488818T3 (en) 2014-08-29
HUP0402415A2 (en) 2005-02-28
EP2330189B1 (en) 2014-05-21
EP1894998A1 (en) 2008-03-05
JP2009261410A (en) 2009-11-12
DK2330189T3 (en) 2014-06-16
JP2005512564A (en) 2005-05-12
HK1158691A1 (en) 2012-07-20
JP5021000B2 (en) 2012-09-05
CN1617924A (en) 2005-05-18
HU225791B1 (en) 2007-09-28
CN100335619C (en) 2007-09-05
WO2003054174A1 (en) 2003-07-03
PL208232B1 (en) 2011-04-29
CN101100657A (en) 2008-01-09
DE122010000025I1 (en) 2010-08-12

Similar Documents

Publication Publication Date Title
EP1453956B8 (en) Method for large scale production of virus antigen
DE60043534D1 (en) METHOD AND DEVICE FOR STABILIZING AND EXPANSIONING HEMATOPOIETIC STEM CELLS AND / OR PRE-CELL CELLS
SI1428878T1 (en) Process for the production and purification of erythropoietin
ATE452664T1 (en) METHOD AND DEVICE FOR GROWING CELLS
DE69329154D1 (en) INCREASED PRODUCTION OF TAXOL AND TAXANES BY MEANS OF TAXUS-SPECIFIC CELL CULTURES
DE59900442D1 (en) SOLID STATE FERMENTER AND METHOD FOR SOLID STATE FERMENTATION
HRP20060398A2 (en) Method and fermenter for the anaerobic fermentation of biological waste
DE69813042D1 (en) METHOD FOR IMPROVING THE EXPLOITATION OF A PHOTOBIO REACTOR
HK1093755A1 (en) Method for differentiating mesenchymal stem cell into neural cell
AU2002212275A1 (en) Bio-reactor for the cultivation of micro-organisms and method for the production thereof
ATE309267T1 (en) METHOD FOR PROLIFERATION AND DIFFERENTIATION OF B CELLS AND USES THEREOF
ATE336567T1 (en) CELL CULTURE MEDIA
ATE479743T1 (en) METHOD FOR PRODUCING CELL CULTURES FROM BIOLOGICAL PREPARATIONS FOR CHEMOTHERAPEUTIC AND OTHER ASSAY
WO2000077236A3 (en) Methods for enhancing the production of cytokines in cell cultur e
WO2003049767A3 (en) Method of large scale production of hepatitis a virus
DE60032791D1 (en) TEST FOR MICROORGANISMS IN CELL CULTURES
AU2003206926A8 (en) Cultivation method for micro-organisms and bioreactor
NO20015494D0 (en) Method of culturing cells
ATE486124T1 (en) KERATINOCYTE CULTURE METHOD AND USE THEREOF
ATE359359T1 (en) MYELOMA CELL CULTURE IN A TRANSFERRIN-FREE MEDIUM WITH LOW IRON
ATE423841T1 (en) USE OF GLUTAMINE-FREE MEDIUM
WO2002064811A3 (en) Method for producing recombinant proteins marked with at least one isotope
ATE521364T1 (en) COMPOSITION AND METHOD FOR INCREASE CELL DENSITY IN CELL CULTURES INFECTED WITH LENTIVIRUS
TWI266804B (en) Method of generating neurons from stem cells and medium for culturing stem cells
KR960006940A (en) Production method of Newcastle disease vaccine using animal cell culture method