DE122010000025I1 - Virale antigene - Google Patents

Virale antigene

Info

Publication number
DE122010000025I1
DE122010000025I1 DE122010000025C DE122010000025C DE122010000025I1 DE 122010000025 I1 DE122010000025 I1 DE 122010000025I1 DE 122010000025 C DE122010000025 C DE 122010000025C DE 122010000025 C DE122010000025 C DE 122010000025C DE 122010000025 I1 DE122010000025 I1 DE 122010000025I1
Authority
DE
Germany
Prior art keywords
antigene
viral
cell culture
directed
adherent cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE122010000025C
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter Healthcare SA
Original Assignee
Baxter Healthcare SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21723079&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE122010000025(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baxter Healthcare SA filed Critical Baxter Healthcare SA
Publication of DE122010000025I1 publication Critical patent/DE122010000025I1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16151—Methods of production or purification of viral material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DE122010000025C 2001-12-10 2002-12-10 Virale antigene Pending DE122010000025I1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/006,881 US6951752B2 (en) 2001-12-10 2001-12-10 Method for large scale production of virus antigen
PCT/EP2002/014011 WO2003054174A1 (en) 2001-12-10 2002-12-10 Method for large scale production of virus antigen

Publications (1)

Publication Number Publication Date
DE122010000025I1 true DE122010000025I1 (de) 2010-08-12

Family

ID=21723079

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60234211T Expired - Lifetime DE60234211D1 (de) 2001-12-10 2002-12-10 Verfahren zur produktion von viralen antigenen im grossmassstab
DE122010000025C Pending DE122010000025I1 (de) 2001-12-10 2002-12-10 Virale antigene

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60234211T Expired - Lifetime DE60234211D1 (de) 2001-12-10 2002-12-10 Verfahren zur produktion von viralen antigenen im grossmassstab

Country Status (18)

Country Link
US (2) US6951752B2 (de)
EP (3) EP1894998A1 (de)
JP (2) JP4370511B2 (de)
CN (2) CN100335619C (de)
AT (1) ATE447010T2 (de)
AU (1) AU2002358662B2 (de)
CA (1) CA2469644C (de)
DE (2) DE60234211D1 (de)
DK (2) DK2330189T3 (de)
ES (2) ES2488818T3 (de)
FR (1) FR10C0026I1 (de)
HK (2) HK1115609A1 (de)
HU (1) HU225791B1 (de)
MX (1) MXPA04005644A (de)
NO (1) NO20042910L (de)
PL (1) PL208232B1 (de)
RU (1) RU2314344C2 (de)
WO (1) WO2003054174A1 (de)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004022729A1 (en) 2002-09-05 2004-03-18 Bavarian Nordic A/S Method for the cultivation of primary cells and for the amplification of viruses under serum free conditions
US7445924B2 (en) 2000-11-23 2008-11-04 Bavarian Nordic A/S Modified Vaccinia Ankara virus variant and cultivation method
US6951752B2 (en) * 2001-12-10 2005-10-04 Bexter Healthcare S.A. Method for large scale production of virus antigen
SI1407006T1 (sl) * 2001-12-20 2006-04-30 Bavarian Nordic As Postopek za ponovno pridobivanje in ciscenje poksvirusov iz inficiranih celic
TWI312368B (en) * 2002-12-23 2009-07-21 Bristol Myers Squibb Compan Mammalian cell culture processes for protein production
EP1697505A1 (de) * 2003-12-23 2006-09-06 Schering Corporation Methoden zur herstellung von a549 zelllinien, die in serumfreiem medium in suspensionskultur stabil sind
AU2005214090B2 (en) 2004-02-23 2008-09-11 Crucell Holland B.V. Virus purification methods
US8221969B2 (en) * 2004-04-19 2012-07-17 Sanyo Chemical Industries, Ltd. Method of producing virus
CN101094915A (zh) * 2004-05-20 2007-12-26 益得生物医学公司 生产流感疫苗的方法
US7344839B2 (en) * 2004-12-23 2008-03-18 Aurx, Inc. Virus preparations and methods
EP1831353B1 (de) 2004-12-23 2012-02-29 MedImmune, LLC Nichttumorbildende mdck-zellinie zur vermehrung von viren
US9254318B2 (en) 2006-03-31 2016-02-09 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
WO2008105931A2 (en) * 2006-09-15 2008-09-04 Medimmune Vaccines, Inc. Mdck cell lines supporting viral growth to high titers and bioreactor process using the same
JP5084214B2 (ja) * 2006-09-29 2012-11-28 一般財団法人日本ポリオ研究所 Ｉｐｖワクチン
WO2008135230A1 (en) * 2007-05-04 2008-11-13 Baxter International Inc. Two-step temperature profile for the propagation of viruses
US9474798B2 (en) 2007-06-18 2016-10-25 Wisconsin Alumni Research Foundation Influenza M2 protein mutant viruses as live influenza attenuated vaccines
EP2257634A1 (de) * 2008-03-12 2010-12-08 Wyeth LLC Verfahren zur identifizierung geeigneter zellen für die massenherstellung rekombinanter proteine
EP2318044B1 (de) * 2008-08-01 2015-12-02 Gamma Vaccines Pty Limited Influenza-impfstoffe
CN102215865B (zh) 2008-09-24 2013-10-30 米迪缪尼有限公司 病毒纯化方法
CN102216450B (zh) * 2008-09-24 2014-05-14 米迪缪尼有限公司 培养细胞、增殖和纯化病毒的方法
CA2973863C (en) 2009-07-31 2022-05-17 Ge Healthcare Bio-Sciences Corp. High yield yellow fever virus strain with increased propagation in cells
JP2013507990A (ja) 2009-10-26 2013-03-07 ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション ベロ細胞において増強された複製を有する高力価の組換えインフルエンザウイルス
CN102782121A (zh) * 2009-12-23 2012-11-14 赛诺菲巴斯德有限公司 用于培养贴壁细胞的方法
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
JP2013523175A (ja) 2010-04-14 2013-06-17 イーエムディー・ミリポア・コーポレーション 高力価、高純度のウイルスストックの作製方法及びその使用方法
US9677042B2 (en) 2010-10-08 2017-06-13 Terumo Bct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
CN101979517B (zh) * 2010-10-15 2011-12-28 普莱柯生物工程股份有限公司 一种利用生物反应器大规模生产流感病毒的方法
WO2012100302A1 (en) 2011-01-27 2012-08-02 Gamma Vaccines Pty Limited Combination vaccines
CN102492659A (zh) * 2011-11-14 2012-06-13 成都康华生物制品有限公司 一种疫苗生产用甲肝病毒的生产方法
US9950057B2 (en) 2013-07-15 2018-04-24 Wisconsin Alumni Research Foundation (Warf) High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs
CN103387958B (zh) * 2013-08-16 2016-04-06 北京科兴中维生物技术有限公司 人胚肺成纤维细胞sv-7在病毒培养中的应用
US9617506B2 (en) 2013-11-16 2017-04-11 Terumo Bct, Inc. Expanding cells in a bioreactor
EP3613841B1 (de) 2014-03-25 2022-04-20 Terumo BCT, Inc. Passives ersetzen von medien
WO2015196150A2 (en) 2014-06-20 2015-12-23 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
EP3198006B1 (de) 2014-09-26 2021-03-24 Terumo BCT, Inc. Geplante fütterung
BR112017015728A2 (pt) 2015-01-26 2018-03-13 Ube Industries, Ltd. método de produção de substância
WO2016121773A1 (ja) 2015-01-26 2016-08-04 宇部興産株式会社 ポリイミド多孔質膜を用いる細胞の大量培養方法、装置及びキット
US10633422B2 (en) 2015-06-01 2020-04-28 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
WO2017007839A1 (en) 2015-07-06 2017-01-12 Wisconsin Alumni Research Foundation (Warf) Improved influenza virus replication for vaccine development
CN109477074B (zh) 2016-02-19 2023-01-24 威斯康星旧生研究基金会 用于疫苗开发的改进的乙型流感病毒复制
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
CN109477056A (zh) 2016-07-25 2019-03-15 宇部兴产株式会社 虹吸式培养法
JP6841282B2 (ja) 2016-07-25 2021-03-10 宇部興産株式会社 細胞培養モジュール
EP3656842A1 (de) 2017-03-31 2020-05-27 Terumo BCT, Inc. Zellexpansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
SG11202005528PA (en) * 2018-01-18 2020-07-29 Yisheng Biopharma Singapore Pte Ltd Method for adapting influenza viruses to vero cells
WO2019155492A1 (en) * 2018-02-07 2019-08-15 Bharat Biotech International Limited A process for enterovirus purification and inactivation and vaccine compositions obtained thereof
JP2022527235A (ja) 2019-01-23 2022-06-01 義裕 河岡 インフルエンザウイルスにおける付加的遺伝子に遺伝的安定性を付与する突然変異
KR102228267B1 (ko) * 2019-01-25 2021-03-17 바이로큐어 주식회사 Bhk-21 세포를 이용한 바이러스 생산방법
WO2020153619A1 (ko) * 2019-01-25 2020-07-30 바이로큐어 주식회사 Bhk-21 세포를 이용한 바이러스 생산방법
JP2022522112A (ja) 2019-02-08 2022-04-14 ウィスコンシン アルムニ リサーチ ファンデイション ヒト化細胞系
SG11202108435WA (en) * 2019-02-15 2021-08-30 Ology Bioservices Inc Method for virus production
US11390649B2 (en) 2019-05-01 2022-07-19 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
TW202122572A (zh) 2019-08-09 2021-06-16 日商宇部興產股份有限公司 胞外體的產生方法
TW202122569A (zh) 2019-08-09 2021-06-16 日商宇部興產股份有限公司 應用小片多孔膜的細胞培養法
JP2022551805A (ja) 2019-08-27 2022-12-14 ウィスコンシン アルムニ リサーチ ファンデイション 卵内複製のための安定化されたｈａを持つ組換えインフルエンザウイルス
CN111850169B (zh) * 2020-07-16 2022-09-27 华农（肇庆）生物产业技术研究院有限公司 一种计算AIV在MDCK-sus细胞中细胞单位均产毒量的方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4525349A (en) 1981-12-29 1985-06-25 Societe Anonyme Dite: Institut Merueux Process for the large-scale production of a vaccine against poliomyelitis and the resulting vaccine
AT393356B (de) 1989-12-22 1991-10-10 Immuno Ag Verfahren zur herstellung von fsme-virus-antigen
US5719051A (en) * 1989-12-22 1998-02-17 Immuno Aktiengesellschaft Perfusion system and a method for the large scale production of virus or virus antigen
FR2723740B1 (fr) 1994-08-16 1996-11-08 Pasteur Merieux Serums Vacc Procede de preparation d'antigenes du virus grippal, antigenes obtenus et leurs applications
US5824536A (en) * 1994-08-23 1998-10-20 St. Jude Children's Research Hospital Influenza virus replicated in mammalian cell culture and vaccine production
WO1996015231A2 (en) 1994-11-10 1996-05-23 Immuno Aktiengesellschaft Method for producing biologicals in protein-free culture
DE19612966B4 (de) * 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
GB2319413B (en) * 1996-11-12 2001-06-06 Lsi Logic Corp Driver circuits
US6168944B1 (en) * 1997-01-31 2001-01-02 Schering Corporation Methods for cultivating cells and propagating viruses
WO1998033886A1 (en) * 1997-01-31 1998-08-06 Schering Corporation Methods for cultivating cells and propagating viruses
AT407255B (de) 1997-06-20 2001-02-26 Immuno Ag Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons
US5994134A (en) * 1998-05-04 1999-11-30 Canji, Inc. Viral production process
US6951752B2 (en) * 2001-12-10 2005-10-04 Bexter Healthcare S.A. Method for large scale production of virus antigen
US6855535B2 (en) * 2001-12-10 2005-02-15 Baxter Healthcare S.A. Method of large scale production of Hepatitis A virus

Also Published As

Publication number Publication date
MXPA04005644A (es) 2005-04-19
US6951752B2 (en) 2005-10-04
DK1453956T3 (da) 2010-01-11
EP2330189A1 (de) 2011-06-08
FR10C0026I1 (fr) 2011-01-14
US7524676B2 (en) 2009-04-28
CA2469644A1 (en) 2003-07-03
DE60234211D1 (de) 2009-12-10
ES2335395T3 (es) 2010-03-26
CA2469644C (en) 2013-07-23
AU2002358662A1 (en) 2003-07-09
HUP0402415A3 (en) 2005-07-28
US20050181495A1 (en) 2005-08-18
JP4370511B2 (ja) 2009-11-25
NO20042910L (no) 2004-07-09
EP1453956B1 (de) 2009-10-28
EP1453956A1 (de) 2004-09-08
ES2335395T5 (es) 2017-08-31
EP1453956B8 (de) 2010-02-10
ATE447010T2 (de) 2009-11-15
RU2004121178A (ru) 2005-10-10
US20030108860A1 (en) 2003-06-12
CN101100657B (zh) 2012-05-30
EP1453956B2 (de) 2017-01-18
RU2314344C2 (ru) 2008-01-10
HK1115609A1 (en) 2008-12-05
AU2002358662B2 (en) 2008-05-15
EP1894998A8 (de) 2008-04-23
ES2488818T3 (es) 2014-08-29
HUP0402415A2 (hu) 2005-02-28
EP2330189B1 (de) 2014-05-21
EP1894998A1 (de) 2008-03-05
JP2009261410A (ja) 2009-11-12
DK2330189T3 (da) 2014-06-16
JP2005512564A (ja) 2005-05-12
HK1158691A1 (en) 2012-07-20
JP5021000B2 (ja) 2012-09-05
CN1617924A (zh) 2005-05-18
HU225791B1 (en) 2007-09-28
CN100335619C (zh) 2007-09-05
WO2003054174A1 (en) 2003-07-03
PL373487A1 (en) 2005-09-05
PL208232B1 (pl) 2011-04-29
CN101100657A (zh) 2008-01-09

Similar Documents

Publication Publication Date Title
DE122010000025I1 (de) Virale antigene
NO20014150L (no) Fotobioreaktor med forbedret lystilförsel ved overflateforstörrelse, bölgelengdeskiftere eller lystransport
NZ333565A (en) Anticonvulsant topiramate derivatives useful in treating manic depressive bipolar disorder
IS6515A (is) Fósturstofnfrumurækt prímata, sem laus er við sermi
DE60139429D1 (de) Pyrimidin-5-Onderivate als LDL-PLA2 Inhibitoren
CY1106135T1 (el) Μεσο για την ελευθepη απο πρωτεϊνη και ελευθepη απο ορο καλλιεργεια κυτταρων
ATE520769T1 (de) Enzymatische hydrolyse von biomassen mit hohem dm (dry matter)-gehalt
ID28122A (id) Fermenter keadaan padat dan prosedur untuk fermentasi keadaan dapat
DE60019102D1 (de) Wasserstoffrückführung und entfernung von sauren gasen unter verwendung einer membran
ATE526395T1 (de) Verwendung von il-7 und il-15 zur genetischen modifizierung von gedächtnis-t-lymphozyten
DE60223377D1 (de) Veränderung von pilzen zur verwendung von l-arabinose
ATE218753T1 (de) Elektrode aus flexiblem graphitverbund
DE69903410D1 (de) Entkarbonisierung von gasen unter verwendung von zeolithischen adsorptionsmitteln
WO2000077236A3 (en) Methods for enhancing the production of cytokines in cell cultur e
ATE530657T1 (de) Verfahren zur herstellung von zellinien mit latentem immunschwächevirus
DK1297106T3 (da) Reaktormodul med kapilærmembraner
PT86552A (de) Gama-glutamyl-transpeptidase deren herstellung und deren verwendung
ATE361975T1 (de) Tiermodell für hepatitis-virus infektion
ATE277029T1 (de) Herstellung von maleinsäureanhydrid
DE60032791D1 (de) Test für mikroorganismen in zellkulturen
DE60327536D1 (de) Infektiöse hepacivirus-pseudopartikel mit funktionellen e1-, e2-hüllproteinen
DE50103547D1 (de) Verwendung von sekundärem zellwandpolymer prokaryontischer mikroorganismen
DK1378062T3 (da) Tilbagekoblet A/D eller D/A omsætter med reduceret strömforbrug
DE50311218D1 (de) Verwendung von glutaminfreien medium
DE60130904D1 (de) Brennstoffzellenstruktur