FR2723740B1 - Procede de preparation d'antigenes du virus grippal, antigenes obtenus et leurs applications - Google Patents

Procede de preparation d'antigenes du virus grippal, antigenes obtenus et leurs applications

Info

Publication number
FR2723740B1
FR2723740B1 FR9410039A FR9410039A FR2723740B1 FR 2723740 B1 FR2723740 B1 FR 2723740B1 FR 9410039 A FR9410039 A FR 9410039A FR 9410039 A FR9410039 A FR 9410039A FR 2723740 B1 FR2723740 B1 FR 2723740B1
Authority
FR
France
Prior art keywords
antigens
applications
preparation
influenza virus
virus antigens
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9410039A
Other languages
English (en)
Other versions
FR2723740A1 (fr
Inventor
Jean Michel Violay
Guy Court
Catherine Gerdil
Herve Chalumeau
Patrick Mcverry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur SA
Original Assignee
Pasteur Merieux Serum et Vaccines SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9410039A priority Critical patent/FR2723740B1/fr
Application filed by Pasteur Merieux Serum et Vaccines SA filed Critical Pasteur Merieux Serum et Vaccines SA
Priority to PCT/FR1995/000727 priority patent/WO1996005294A1/fr
Priority to JP8507053A priority patent/JPH10504033A/ja
Priority to AU27412/95A priority patent/AU701024B2/en
Priority to MX9701183A priority patent/MX9701183A/es
Priority to EP95922563A priority patent/EP0776362A1/fr
Priority to US08/793,373 priority patent/US6048537A/en
Priority to NZ288254A priority patent/NZ288254A/xx
Priority to CA002197683A priority patent/CA2197683C/fr
Priority to ZA9506797A priority patent/ZA956797B/xx
Publication of FR2723740A1 publication Critical patent/FR2723740A1/fr
Application granted granted Critical
Publication of FR2723740B1 publication Critical patent/FR2723740B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16161—Methods of inactivation or attenuation
    • C12N2760/16163—Methods of inactivation or attenuation by chemical treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
FR9410039A 1994-08-16 1994-08-16 Procede de preparation d'antigenes du virus grippal, antigenes obtenus et leurs applications Expired - Lifetime FR2723740B1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR9410039A FR2723740B1 (fr) 1994-08-16 1994-08-16 Procede de preparation d'antigenes du virus grippal, antigenes obtenus et leurs applications
CA002197683A CA2197683C (fr) 1994-08-16 1995-06-06 Methode pour preparer le virus de la grippe; antigenes obtenus et appliccations
AU27412/95A AU701024B2 (en) 1994-08-16 1995-06-06 Method for preparing an influenza virus, antigens obtained and applications thereof
MX9701183A MX9701183A (es) 1994-08-16 1995-06-06 Procedimiento de preparacion del virus gripal, antigenos obtenidos y sus aplicaciones.
EP95922563A EP0776362A1 (fr) 1994-08-16 1995-06-06 Procede de preparation du virus grippal, antigens obtenus et leurs applications
US08/793,373 US6048537A (en) 1994-08-16 1995-06-06 Method for preparing an influenza virus, antigens obtained and applications thereof
PCT/FR1995/000727 WO1996005294A1 (fr) 1994-08-16 1995-06-06 Procede de preparation du virus grippal, antigens obtenus et leurs applications
JP8507053A JPH10504033A (ja) 1994-08-16 1995-06-06 インフルエンザウィルスの調製方法と、それによって得られる抗原と、抗原の利用
NZ288254A NZ288254A (en) 1994-08-16 1995-06-06 Method, including an ultracentrifugation step, for preparing an influenza virus, antigens obtained and applications thereof
ZA9506797A ZA956797B (en) 1994-08-16 1995-08-15 Method for preparing influenza virus, antigens obtained and the applications.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9410039A FR2723740B1 (fr) 1994-08-16 1994-08-16 Procede de preparation d'antigenes du virus grippal, antigenes obtenus et leurs applications

Publications (2)

Publication Number Publication Date
FR2723740A1 FR2723740A1 (fr) 1996-02-23
FR2723740B1 true FR2723740B1 (fr) 1996-11-08

Family

ID=9466323

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9410039A Expired - Lifetime FR2723740B1 (fr) 1994-08-16 1994-08-16 Procede de preparation d'antigenes du virus grippal, antigenes obtenus et leurs applications

Country Status (10)

Country Link
US (1) US6048537A (fr)
EP (1) EP0776362A1 (fr)
JP (1) JPH10504033A (fr)
AU (1) AU701024B2 (fr)
CA (1) CA2197683C (fr)
FR (1) FR2723740B1 (fr)
MX (1) MX9701183A (fr)
NZ (1) NZ288254A (fr)
WO (1) WO1996005294A1 (fr)
ZA (1) ZA956797B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19938767C2 (de) * 1999-08-16 2002-10-24 Tad Pharma Gmbh Spaltimpfstoffe
GB9924351D0 (en) 1999-10-14 1999-12-15 Brennan Frank Immunomodulation methods and compositions
EP1103610A1 (fr) * 1999-11-26 2001-05-30 Introgene B.V. Production de vaccins de lignées de cellules mammifère immortalisées
US6951752B2 (en) 2001-12-10 2005-10-04 Bexter Healthcare S.A. Method for large scale production of virus antigen
KR100473070B1 (ko) * 2002-08-31 2005-03-10 박승국 시각적 유도장치를 이용한 외국어 학습 및 교습 시스템
MXPA05005306A (es) * 2003-06-20 2005-10-26 Microbix Biosystems Inc Mejoramientos en la produccion de virus.
NZ551640A (en) * 2004-05-20 2010-05-28 Id Biomedical Corp Process for the production of an influenza vaccine
US7691368B2 (en) 2005-04-15 2010-04-06 Merial Limited Vaccine formulations
AR054822A1 (es) 2005-07-07 2007-07-18 Sanofi Pasteur Emulsion inmuno adyuvante
US20080241184A1 (en) 2005-08-25 2008-10-02 Jules Maarten Minke Canine influenza vaccines
BRPI0618254A2 (pt) * 2005-11-04 2011-08-23 Novartis Vaccines & Diagnostic emulsões com agente tensoativo de fase aquosa livre para fornecer adjuvante às vacinas contra influenza dividido
WO2007096418A1 (fr) * 2006-02-23 2007-08-30 Ovagen International Limited Procédés améliorés de production d'oeufs aviaires et d'oiseaux présentant un état spécifié exempt de germes
CA2685308A1 (fr) * 2007-04-27 2009-01-29 Dow Global Technologies Inc. Production amelioree et assemblage in vivo de particules icosaedriques solubles recombinees analogues a un virus
CN101688186A (zh) * 2007-05-04 2010-03-31 巴克斯特国际公司 用于病毒增殖的两阶段温度分布
CA2696090C (fr) * 2007-08-28 2017-06-13 Baxter International Inc. Procede pour produire des vaccins viraux
TW200936758A (en) * 2007-11-02 2009-09-01 Intervet Int Bv Orthomyxoviridae propagation
TWI444384B (zh) * 2008-02-20 2014-07-11 Gilead Sciences Inc 核苷酸類似物及其在治療惡性腫瘤上的用途
BRPI0909820A2 (pt) * 2008-03-05 2015-08-11 Sanofi Pasteur Processo para estabilização de composição de vacina contra gripe, para estabilização de composição de vacina contendo adjuvante e para preparação de vacina, composições de vacina, kit de vacina e método de estocagem de uma matéria prima
EP2889042A3 (fr) 2008-03-18 2015-10-14 Novartis AG Améliorations dans la préparation d'antigènes de vaccin contre le virus de la grippe
CA2750055A1 (fr) 2009-02-06 2010-08-12 Glaxosmithkline Biologicals S.A. Procede de purification de virus au moyen d'un gradient de densite
EA201171491A1 (ru) * 2009-05-29 2012-07-30 Новартис Аг Анализы гемагглютининов вируса гриппа
ES2600929T3 (es) 2009-09-10 2017-02-13 Merial, Inc. Nuevas formulaciones de vacuna que comprenden adyuvantes que contienen saponina
BR112012026095A2 (pt) 2010-04-14 2015-09-15 Emd Millipore Corp métodos de produção de estoques de vírus de alta pureza e altos títulos e métodos de uso dos mesmos.
DK2741740T3 (en) 2011-08-12 2017-06-06 Merial Inc VACUUM-SUPPORTED CONSERVATION OF BIOLOGICAL PRODUCTS, IN PARTICULAR OF VACCINES
FR3025107B1 (fr) 2014-08-29 2018-10-05 Calixar Procede de preparation d'un antigene vaccinal, antigene vaccinal obtenu et utilisations
TWI745278B (zh) 2014-10-10 2021-11-11 以色列商艾畢克生物實驗有限公司 發泡性降低之疫苗組合物
KR20190044052A (ko) 2016-06-17 2019-04-29 메리얼 인코포레이티드 선형 또는 분지형 폴리아크릴산 폴리머 아쥬반트를 포함하는 신규한 면역원성 제형

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4064232A (en) * 1974-01-14 1977-12-20 Sandoz Ltd. Process for isolating the immunogenic components of influenza viruses
US4000257A (en) * 1975-12-22 1976-12-28 American Cyanamid Company Process for the purification of influenza virus vaccine
US4057626A (en) * 1976-10-08 1977-11-08 Richardson-Merrell Inc. Process for detoxifying influenza B virus
FR2475572A1 (fr) * 1980-02-11 1981-08-14 Pasteur Institut Procede pour l'obtention de fragments de virus a enveloppe lipidique, en particulier d'antigenes utilisables comme vaccins, produits obtenus et applications
DE3014189A1 (de) * 1980-04-14 1981-10-15 Europäisches Laboratorium für Molekularbiologie (EMBL), 6900 Heidelberg Verfahren zur herstellung eines immunogenen membranproteinaggregats von influenza-, parainfluenza- und rhabdo-viren
FR2483779A1 (fr) * 1980-06-05 1981-12-11 Synthelabo Procede pour isoler des antigenes glycoproteiques viraux et son application a la preparation de vaccins
US4327182A (en) * 1981-01-22 1982-04-27 Connaught Laboratories Incorporated Purification of influenza sub-unit vaccine
FR2671974A1 (fr) * 1991-01-24 1992-07-31 Pasteur Merieux Serums Vacc Composition vaccinale contre la grippe, a effet synergique, contenant comme additif du core de virus grippal.

Also Published As

Publication number Publication date
CA2197683C (fr) 2008-12-30
NZ288254A (en) 1999-01-28
ZA956797B (en) 1997-02-17
EP0776362A1 (fr) 1997-06-04
AU701024B2 (en) 1999-01-21
WO1996005294A1 (fr) 1996-02-22
FR2723740A1 (fr) 1996-02-23
AU2741295A (en) 1996-03-07
US6048537A (en) 2000-04-11
CA2197683A1 (fr) 1996-02-22
MX9701183A (es) 1997-05-31
JPH10504033A (ja) 1998-04-14

Similar Documents

Publication Publication Date Title
FR2723740B1 (fr) Procede de preparation d'antigenes du virus grippal, antigenes obtenus et leurs applications
PT98944A (pt) Processo de preparacao de anticorpos alterados e de composicoes farmaceuticas para a prevencao e tratamento de infeccoes
MA23850A1 (fr) Procede de preparation de compositions vaccinantes
MA23918A1 (fr) Procede de preparation de compositions vaccinantes
MA23814A1 (fr) Procede de preparation de compositions vaccinantes
FI972945A (fi) Antigeenien antamiseen soveltuvia koostumuksia
MA22842A1 (fr) Procede de preparation de compositions de vaccin.
NO981800L (no) FremgangsmÕte for fremstilling av 1,1,1,3,3-pentafluorpentan
MA24291A1 (fr) Procede pour la preparation de compositions de vaccin
MA24339A1 (fr) Procede de preparation de medicaments destines au traitement d'infections bacteriennes en pediaterie
FR2643073B1 (fr) Procede de preparation d'extraits polyphenoliques de type flavane-3-ol purifies et extraits obtenus
EE03351B1 (et) Meetod lerkanidipiinhüdrokloriidi valmistamiseks
DK0805797T3 (da) Fremgangsmåde til fremstilling af N-aryl- og N-hetarylhydroxylaminer
NO971540D0 (no) Fremgangsmåte for fremstilling av oligoaminer eller polyaminer
FR2728895B1 (fr) Procede de preparation du difluoromethane
FI934748A (fi) Foerfarande foer framstaellning av L-5-(2-acetoxipropionylamino)-2,4,6-trijod-isoftalsyradiklorid
MA23663A1 (fr) Procede de preparation de formulations pharmaceutiques
FR2666334B1 (fr) Procede continu de preparation d'acrylamides et de methacrylamides n-substitues.
MX9200469A (es) Proceso de dos etapas para la preparacion de 2,2,6,6-tetrametil-4-piperidilaminas
NO962979D0 (no) Fremgangsmåte for fremstilling av jern(III)sulfat
FR2736914B1 (fr) Nouveaux derives d'acide aminophenylphosphonique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DK0815092T3 (da) Fremgangsmåde til fremstilling af 1,2-benzisothiazolin-3-oner
FR2739373B1 (fr) Procede de preparation de catalyseurs d'ammoxydation
FR2728268B1 (fr) Procede de preparation de gamma-cyclodextrine
NL194271B (nl) Werkwijze voor de bereiding van de verbinding L-5-(2-acetoxy-propionylamino)-2,4,6-trijood-isoftaalzuur-bis-(1,3- -dihydropropylamide).

Legal Events

Date Code Title Description
CD Change of name or company name