JP2005506035A5 - - Google Patents

Info

Publication number

JP2005506035A5

JP2005506035A5 JP2002545640A JP2002545640A JP2005506035A5 JP 2005506035 A5 JP2005506035 A5 JP 2005506035A5 JP 2002545640 A JP2002545640 A JP 2002545640A JP 2002545640 A JP2002545640 A JP 2002545640A JP 2005506035 A5 JP2005506035 A5 JP 2005506035A5

Authority

JP

Japan

Prior art keywords

seq

protein

hodgkin

antibody

culture

Prior art date

2001-11-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108090000623 proteins and genes Proteins 0.000 claims 57
• 102000004169 proteins and genes Human genes 0.000 claims 57
• 208000017604 Hodgkin disease Diseases 0.000 claims 44
• 208000010747 Hodgkins lymphoma Diseases 0.000 claims 44
• 230000001085 cytostatic effect Effects 0.000 claims 24
• 230000001472 cytotoxic effect Effects 0.000 claims 23
• 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 22
• 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 22
• 108020004707 nucleic acids Proteins 0.000 claims 21
• 102000039446 nucleic acids Human genes 0.000 claims 21
• 150000007523 nucleic acids Chemical class 0.000 claims 21
• 125000003275 alpha amino acid group Chemical group 0.000 claims 16
• 239000000824 cytostatic agent Substances 0.000 claims 16
• 239000008194 pharmaceutical composition Substances 0.000 claims 14
• 229940104230 thymidine Drugs 0.000 claims 14
• 108090000526 Papain Proteins 0.000 claims 12
• 108090000284 Pepsin A Proteins 0.000 claims 12
• 239000004365 Protease Substances 0.000 claims 12
• 229940055729 papain Drugs 0.000 claims 12
• 235000019834 papain Nutrition 0.000 claims 12
• 102000057297 Pepsin A Human genes 0.000 claims 11
• 238000003776 cleavage reaction Methods 0.000 claims 11
• 229940111202 pepsin Drugs 0.000 claims 11
• 230000007017 scission Effects 0.000 claims 11
• 239000002773 nucleotide Substances 0.000 claims 10
• 125000003729 nucleotide group Chemical group 0.000 claims 10
• 231100000433 cytotoxic Toxicity 0.000 claims 9
• 238000010600 3H thymidine incorporation assay Methods 0.000 claims 7
• 239000002254 cytotoxic agent Substances 0.000 claims 7
• 229940127089 cytotoxic agent Drugs 0.000 claims 7
• 231100000599 cytotoxic agent Toxicity 0.000 claims 7
• 238000000034 method Methods 0.000 claims 7
• 239000003814 drug Substances 0.000 claims 6
• 108020001507 fusion proteins Proteins 0.000 claims 6
• 102000037865 fusion proteins Human genes 0.000 claims 6
• 238000004519 manufacturing process Methods 0.000 claims 6
• 230000002265 prevention Effects 0.000 claims 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
• 238000002512 chemotherapy Methods 0.000 claims 5
• 239000003937 drug carrier Substances 0.000 claims 4
• 108091026890 Coding region Proteins 0.000 claims 2
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
• 108020004414 DNA Proteins 0.000 claims 2
• 230000000295 complement effect Effects 0.000 claims 2
• 102100039652 Pepsin A-5 Human genes 0.000 claims 1
• 230000004663 cell proliferation Effects 0.000 claims 1
• 230000003013 cytotoxicity Effects 0.000 claims 1
• 231100000135 cytotoxicity Toxicity 0.000 claims 1
• 229940066716 pepsin a Drugs 0.000 claims 1
• 238000005215 recombination Methods 0.000 claims 1
• 230000006798 recombination Effects 0.000 claims 1