DE60141043D1 - Rekombinante anti-cd30-antikörper und deren verwendungen - Google Patents
Rekombinante anti-cd30-antikörper und deren verwendungenInfo
- Publication number
- DE60141043D1 DE60141043D1 DE60141043T DE60141043T DE60141043D1 DE 60141043 D1 DE60141043 D1 DE 60141043D1 DE 60141043 T DE60141043 T DE 60141043T DE 60141043 T DE60141043 T DE 60141043T DE 60141043 D1 DE60141043 D1 DE 60141043D1
- Authority
- DE
- Germany
- Prior art keywords
- proteins
- hodgkin
- disease
- antibodies
- hefi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 208000017604 Hodgkin disease Diseases 0.000 abstract 3
- 208000010747 Hodgkins lymphoma Diseases 0.000 abstract 3
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 abstract 2
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940044683 chemotherapy drug Drugs 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 239000002254 cytotoxic agent Substances 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/724,406 US7090843B1 (en) | 2000-11-28 | 2000-11-28 | Recombinant anti-CD30 antibodies and uses thereof |
| PCT/US2001/044811 WO2002043661A2 (en) | 2000-11-28 | 2001-11-28 | Recombinant anti-cd30 antibodies and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60141043D1 true DE60141043D1 (de) | 2010-02-25 |
Family
ID=24910311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60141043T Expired - Lifetime DE60141043D1 (de) | 2000-11-28 | 2001-11-28 | Rekombinante anti-cd30-antikörper und deren verwendungen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7090843B1 (OSRAM) |
| EP (1) | EP1347730B2 (OSRAM) |
| JP (1) | JP4303964B2 (OSRAM) |
| AT (1) | ATE454124T1 (OSRAM) |
| AU (2) | AU3651802A (OSRAM) |
| CA (1) | CA2430135C (OSRAM) |
| CY (1) | CY1110700T1 (OSRAM) |
| DE (1) | DE60141043D1 (OSRAM) |
| DK (1) | DK1347730T4 (OSRAM) |
| ES (1) | ES2339333T5 (OSRAM) |
| PT (1) | PT1347730E (OSRAM) |
| WO (1) | WO2002043661A2 (OSRAM) |
Families Citing this family (131)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040018194A1 (en) * | 2000-11-28 | 2004-01-29 | Francisco Joseph A. | Recombinant anti-CD30 antibodies and uses thereof |
| US7090843B1 (en) † | 2000-11-28 | 2006-08-15 | Seattle Genetics, Inc. | Recombinant anti-CD30 antibodies and uses thereof |
| US20110313230A1 (en) | 2001-05-11 | 2011-12-22 | Terrance Grant Johns | Specific binding proteins and uses thereof |
| US20050123536A1 (en) * | 2001-11-20 | 2005-06-09 | Che-Leung Law | Treatment of immunological disorders using anti-dc30 antibodies |
| JP2005517674A (ja) * | 2002-01-03 | 2005-06-16 | フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー | 腫瘍の処置に有用な新規免疫コンジュゲート |
| EP1471938A4 (en) | 2002-01-09 | 2008-03-05 | Medarex Inc | HUMAN MONOCLONAL ANTIBODIES AGAINST CD30 |
| US20070148171A1 (en) * | 2002-09-27 | 2007-06-28 | Xencor, Inc. | Optimized anti-CD30 antibodies |
| PT2357006E (pt) * | 2002-07-31 | 2016-01-22 | Seattle Genetics Inc | Conjugados de fármacos e sua utilização para tratamento do cancro, de uma doença autoimune ou de uma doença infeciosa |
| SG149815A1 (en) | 2003-11-06 | 2009-02-27 | Seattle Genetics Inc | Monomethylvaline compounds capable of conjugation to ligands |
| AU2005292227A1 (en) | 2004-10-01 | 2006-04-13 | Medarex, Inc. | Methods of treating CD30 positive lymphomas |
| ES2498794T3 (es) | 2005-02-18 | 2014-09-25 | Medarex, L.L.C. | Anticuerpos monoclonales contra CD30 que carecen de restos fucosilo |
| JP4860703B2 (ja) | 2005-10-06 | 2012-01-25 | ゼンコー・インコーポレイテッド | 最適化された抗ｃｄ３０抗体 |
| US8257706B2 (en) * | 2006-08-25 | 2012-09-04 | Seattle Genetics, Inc. | CD30 binding agents and uses thereof |
| AR067543A1 (es) | 2007-07-16 | 2009-10-14 | Genentech Inc | Anticuerpos anti-cd79b e inmunoconjugados humanizados y metodos de uso |
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| DE19640733A1 (de) * | 1996-10-02 | 1998-04-09 | Abken Hinrich | Verfahren zur Hemmung der unbegrenzten Profileration, Tumorbildung oder Metastasierung CD30 Antigen exprimierender Zellen |
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-
2000
- 2000-11-28 US US09/724,406 patent/US7090843B1/en not_active Expired - Lifetime
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2001
- 2001-11-28 JP JP2002545640A patent/JP4303964B2/ja not_active Expired - Lifetime
- 2001-11-28 PT PT01986050T patent/PT1347730E/pt unknown
- 2001-11-28 ES ES01986050T patent/ES2339333T5/es not_active Expired - Lifetime
- 2001-11-28 DE DE60141043T patent/DE60141043D1/de not_active Expired - Lifetime
- 2001-11-28 AT AT01986050T patent/ATE454124T1/de active
- 2001-11-28 AU AU3651802A patent/AU3651802A/xx active Pending
- 2001-11-28 AU AU2002236518A patent/AU2002236518B2/en active Active
- 2001-11-28 DK DK01986050.1T patent/DK1347730T4/da active
- 2001-11-28 CA CA2430135A patent/CA2430135C/en not_active Expired - Lifetime
- 2001-11-28 WO PCT/US2001/044811 patent/WO2002043661A2/en not_active Ceased
- 2001-11-28 EP EP01986050.1A patent/EP1347730B2/en not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| EP1347730B1 (en) | 2010-01-06 |
| CA2430135A1 (en) | 2002-06-06 |
| AU2002236518B2 (en) | 2006-10-26 |
| ES2339333T3 (es) | 2010-05-19 |
| WO2002043661A3 (en) | 2003-01-16 |
| US7090843B1 (en) | 2006-08-15 |
| ES2339333T5 (es) | 2013-09-26 |
| PT1347730E (pt) | 2010-03-03 |
| CY1110700T1 (el) | 2015-06-10 |
| DK1347730T4 (da) | 2020-04-27 |
| DK1347730T3 (da) | 2010-02-01 |
| EP1347730A2 (en) | 2003-10-01 |
| WO2002043661B1 (en) | 2003-03-06 |
| WO2002043661A2 (en) | 2002-06-06 |
| EP1347730A4 (en) | 2005-08-17 |
| JP2005506035A (ja) | 2005-03-03 |
| EP1347730B2 (en) | 2013-05-29 |
| JP4303964B2 (ja) | 2009-07-29 |
| ATE454124T1 (de) | 2010-01-15 |
| AU3651802A (en) | 2002-06-11 |
| CA2430135C (en) | 2012-10-02 |
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