JP2005505674A5 - - Google Patents

Download PDF

Info

Publication number
JP2005505674A5
JP2005505674A5 JP2003536325A JP2003536325A JP2005505674A5 JP 2005505674 A5 JP2005505674 A5 JP 2005505674A5 JP 2003536325 A JP2003536325 A JP 2003536325A JP 2003536325 A JP2003536325 A JP 2003536325A JP 2005505674 A5 JP2005505674 A5 JP 2005505674A5
Authority
JP
Japan
Prior art keywords
group
acid
polymer composition
copolymer
polylactic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2003536325A
Other languages
English (en)
Japanese (ja)
Other versions
JP3955846B2 (ja
JP2005505674A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/KR2002/001942 external-priority patent/WO2003033592A1/en
Publication of JP2005505674A publication Critical patent/JP2005505674A/ja
Publication of JP2005505674A5 publication Critical patent/JP2005505674A5/ja
Application granted granted Critical
Publication of JP3955846B2 publication Critical patent/JP3955846B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2003536325A 2001-10-18 2002-10-17 安定性を向上した高分子ミセル組成物 Expired - Lifetime JP3955846B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20010064468 2001-10-18
KR20010076213 2001-12-04
PCT/KR2002/001942 WO2003033592A1 (en) 2001-10-18 2002-10-17 Polymeric micelle composition with improved stability

Publications (3)

Publication Number Publication Date
JP2005505674A JP2005505674A (ja) 2005-02-24
JP2005505674A5 true JP2005505674A5 (https=) 2006-01-12
JP3955846B2 JP3955846B2 (ja) 2007-08-08

Family

ID=36293229

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003536325A Expired - Lifetime JP3955846B2 (ja) 2001-10-18 2002-10-17 安定性を向上した高分子ミセル組成物

Country Status (12)

Country Link
US (1) US7879317B2 (https=)
EP (1) EP1448707B1 (https=)
JP (1) JP3955846B2 (https=)
CN (1) CN1303155C (https=)
AT (1) ATE370988T1 (https=)
AU (1) AU2002348660B2 (https=)
CA (1) CA2463172C (https=)
DE (1) DE60222007T2 (https=)
ES (1) ES2292827T3 (https=)
MX (1) MXPA04003621A (https=)
NZ (1) NZ532198A (https=)
WO (1) WO2003033592A1 (https=)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100502840B1 (ko) * 2002-09-04 2005-07-21 학교법인 포항공과대학교 약물 담지능력이 우수한 블록 공중합체 미셀 조성물
JP4939936B2 (ja) * 2003-06-27 2012-05-30 株式會社アモーレパシフィック 生理活性成分を含有する自己集合性高分子ナノ粒子の製造方法、及び得られた自己集合性高分子ナノ粒子を含有する外用剤組成物
JP2006199590A (ja) * 2003-09-04 2006-08-03 Nano Career Kk 水溶性の塩基性薬物内包ナノ粒子含有組成物
ITMI20031872A1 (it) * 2003-09-30 2005-04-01 Mediolanum Farmaceutici Srl Copolimeri di poliesteri e polivinilpirrolidone.
EP1670838B1 (en) * 2003-10-10 2015-12-09 Samyang Biopharmaceuticals Corporation Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery
US7311901B2 (en) 2003-10-10 2007-12-25 Samyang Corporation Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery
AU2003272127A1 (en) * 2003-10-24 2005-05-11 Samyang Corporation Polymeric composition for drug delivery
KR20050064075A (ko) * 2003-12-23 2005-06-29 주식회사 삼양사 이트라코나졸을 유효성분으로 하는 약학적 조성물
JP3903061B2 (ja) * 2003-12-24 2007-04-11 株式会社Lttバイオファーマ 薬物を含有するナノ粒子およびその製造方法、ならびに当該ナノ粒子からなる非経口投与用製剤
WO2005066238A1 (en) * 2003-12-30 2005-07-21 3M Innovative Properties Company Medicinal compositions and method for the preparation thereof
US7151077B2 (en) 2004-03-29 2006-12-19 Halliburton Energy Services, Inc. Polymersome compositions and associated methods of use
US7345093B2 (en) 2004-04-27 2008-03-18 Formatech, Inc. Methods of enhancing solubility of compounds
US7659310B2 (en) 2004-04-27 2010-02-09 Formatech, Inc. Methods of enhancing solubility of agents
CA2564719C (en) * 2004-05-06 2011-11-01 Samyang Corporation Delivery system for bioactive agents on the basis of a polymeric drug carrier comprising an amphiphilic block polymer and a polylactic acid derivative
US9492400B2 (en) 2004-11-04 2016-11-15 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
CA2526541C (en) * 2004-12-01 2013-09-03 Tyco Healthcare Group Lp Novel biomaterial drug delivery and surface modification compositions
US7662753B2 (en) 2005-05-12 2010-02-16 Halliburton Energy Services, Inc. Degradable surfactants and methods for use
US7608567B2 (en) 2005-05-12 2009-10-27 Halliburton Energy Services, Inc. Degradable surfactants and methods for use
US7677315B2 (en) 2005-05-12 2010-03-16 Halliburton Energy Services, Inc. Degradable surfactants and methods for use
US9267937B2 (en) 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
KR100858508B1 (ko) * 2005-12-23 2008-09-12 주식회사 삼양사 아졸계 항진균제를 포함하는 조성물 및 그의 제조방법
KR100754326B1 (ko) * 2006-02-15 2007-09-03 삼성전기주식회사 금속 나노입자의 제조방법
US8367113B2 (en) * 2006-05-15 2013-02-05 Massachusetts Institute Of Technology Polymers for functional particles
WO2007150030A2 (en) 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
US9217129B2 (en) 2007-02-09 2015-12-22 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
EP2136788B1 (en) * 2007-03-30 2011-10-26 Bind Biosciences, Inc. Cancer cell targeting using nanoparticles
WO2008124632A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Amphiphilic compound assisted nanoparticles for targeted delivery
WO2008137733A2 (en) * 2007-05-02 2008-11-13 Emory University Micellar structures, methods of making micellar structures, methods of imaging, and methods of delivering agents
FR2921068B1 (fr) * 2007-09-19 2010-12-24 Arkema France Composition renfermant un homopolymere d'acide lactique et un copolymere a blocs
EP2630966B1 (en) 2007-10-12 2017-04-19 Massachusetts Institute of Technology Vaccine nanotechnology
KR101024742B1 (ko) * 2007-12-31 2011-03-24 주식회사 삼양사 탁산 함유 양친성 블록 공중합체 미셀 조성물 및 그 제조방법
US9801818B2 (en) 2007-12-31 2017-10-31 Samyang Biopharmaceuticals Corporation Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug
RU2459840C2 (ru) * 2007-12-31 2012-08-27 Самъянг Корпорейшн АМФИФИЛЬНЫЙ СОПОЛИМЕР ВЫСОКОЙ ЧИСТОТЫ, СОДЕРЖАЩИЙ ГИДРОФОБНЫЙ БЛОК ИЗ α-ГИДРОКСИКИСЛОТЫ, И СПОСОБ ЕГО ПОЛУЧЕНИЯ
US8652506B2 (en) * 2008-06-05 2014-02-18 Boston Scientific Scimed, Inc. Bio-degradable block co-polymers for controlled release
JP2010065067A (ja) * 2008-09-08 2010-03-25 Tokyo Univ Of Agriculture & Technology 粒子およびその製造方法、ならびにゲル
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
EP2359860B1 (en) * 2008-11-21 2014-08-06 Samyang Biopharmaceuticals Corporation Polymer micelle composition for treatment of resistant cancer cells
NZ593735A (en) * 2008-12-26 2013-08-30 Samyang Biopharmaceuticals Preparation method of polymeric micellar nanoparticles composition containing a poorly water-soluble drug
EP2201935B1 (en) 2008-12-26 2020-07-08 Samyang Biopharmaceuticals Corporation Polymeric micelle composition containing a poorly soluble drug and preparation method of the same
US20150359777A1 (en) * 2008-12-26 2015-12-17 Samyang Biopharmaceuticals Corporation Preparation method of polymeric micellar nanoparticles composition containing a poorly water-soluble drug
WO2010114768A1 (en) * 2009-03-30 2010-10-07 Cerulean Pharma Inc. Polymer-epothilone conjugates, particles, compositions, and related methods of use
CN103932972A (zh) * 2009-03-30 2014-07-23 天蓝制药公司 聚合物-药剂缀合物、颗粒、组合物和相关使用方法
US8524784B2 (en) 2009-04-30 2013-09-03 Intezyne Technologies, Incorporated Polymer micelles containing anthracylines for the treatment of cancer
US8524783B2 (en) 2009-04-30 2013-09-03 Intezyne Technologies, Incorporated Polymer micelles containing anthracylines for the treatment of cancer
CA2781529C (en) 2009-09-23 2017-10-24 Indu Javeri Methods for the preparation of liposomes comprising docetaxel
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
KR101224004B1 (ko) * 2009-12-29 2013-01-22 주식회사 삼양바이오팜 단백질, 폴리펩타이드 또는 펩타이드 약물 전달용 고분자 및 그 제조방법, 및 단백질, 폴리펩타이드 또는 펩타이드 약물의 서방형 조성물 및 그 제조 방법
KR101267813B1 (ko) 2009-12-30 2013-06-04 주식회사 삼양바이오팜 향상된 수용해도를 갖는 라파마이신 함유 고분자나노입자 주사제형 조성물 및 그 제조방법, 및 방사선 요법과 병용하기 위한 항암 조성물
KR101424163B1 (ko) 2010-12-24 2014-08-01 주식회사 삼양바이오팜 수난용성 약물 함유 서방성 마이크로입자 및 그 제조방법
KR101508275B1 (ko) 2011-12-16 2015-04-08 주식회사 삼양바이오팜 고분자 나노입자 수용액 조성물 및 그 제조방법
CN103479573B (zh) * 2013-07-26 2017-04-19 中国科学院长春应用化学研究所 聚乙二醇单甲醚‑聚酯两嵌段共聚物胶束及载药胶束的制备方法
CN104086726A (zh) * 2014-07-08 2014-10-08 成都市绿科华通科技有限公司 聚乳酸星型二嵌段共聚物药用功能材料
CN107106496B (zh) * 2014-12-30 2020-09-15 株式会社三养生物制药 聚合物纳米粒子冷冻干燥物及其制备方法
WO2016110839A1 (en) * 2015-01-05 2016-07-14 B.G. Negev Technologies And Applications Ltd., At Ben-Gurion University Nanoparticles and methods for preparation thereof
KR101787451B1 (ko) * 2015-07-28 2017-10-19 주식회사 삼양바이오팜 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법
KR101748191B1 (ko) * 2015-07-28 2017-06-19 주식회사 삼양바이오팜 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법
KR101787453B1 (ko) * 2015-07-28 2017-10-19 주식회사 삼양바이오팜 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법
KR101745429B1 (ko) 2015-07-28 2017-06-12 주식회사 삼양바이오팜 양친성 블록 공중합체의 정제방법, 이로부터 얻어지는 양친성 블록 공중합체, 및 이를 포함하는 약학 조성물
KR101787447B1 (ko) * 2015-07-28 2017-10-19 주식회사 삼양바이오팜 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법
KR101971672B1 (ko) * 2016-11-18 2019-04-23 주식회사 삼양바이오팜 화학색전용 에멀전 조성물 및 그의 제조방법
US10457772B2 (en) 2017-09-08 2019-10-29 International Business Machines Corporation Preparation of robust polythioaminal carriers
CN110156971A (zh) * 2018-02-13 2019-08-23 上海时莱生物技术有限公司 一种两亲性嵌段共聚物及其制备方法和纳米胶束载药系统

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2709516B2 (ja) 1989-07-12 1998-02-04 多木化学株式会社 医用組成物
IT1243390B (it) * 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
CA2087125A1 (en) * 1992-01-23 1993-07-24 Mridula Nair Chemically fixed micelles
JP3107451B2 (ja) 1992-03-31 2000-11-06 竹本油脂株式会社 ポリカーボネート樹脂用帯電防止剤及びこれを含有するポリカーボネート樹脂組成物
KR940003548U (ko) * 1992-08-14 1994-02-21 김형술 세탁물 건조기
JP3270592B2 (ja) 1992-10-26 2002-04-02 日本化薬株式会社 ブロック共重合体−抗癌剤複合体医薬製剤
JPH0769917A (ja) 1993-06-24 1995-03-14 Takeda Chem Ind Ltd 抗エンドセリン物質の徐放性製剤
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
US6447796B1 (en) * 1994-05-16 2002-09-10 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
JPH10110019A (ja) 1996-10-08 1998-04-28 Kazunori Kataoka 安定化高分子ミセルおよび生理活性物質のキヤリヤーとしてのその使用
ZA9811377B (en) 1997-12-12 1999-08-27 Expression Genetics Inc Positively charged poly[alpha-(omega-aminoalkyl) glycolic acid[ for the delivery of a bioactive agent via tissue and cellular uptake.
KR100360827B1 (ko) 1999-08-14 2002-11-18 주식회사 삼양사 난용성 약물을 가용화하기 위한 고분자 조성물 및 그의 제조방법
US6743446B2 (en) * 1999-12-15 2004-06-01 The Ohio State University Research Foundation Methods for stabilizing biologically active agents encapsulated in biodegradable controlled-release polymers
KR100416242B1 (ko) * 1999-12-22 2004-01-31 주식회사 삼양사 약물전달체용 생분해성 블록 공중합체의 액체 조성물 및이의 제조방법
US7217770B2 (en) 2000-05-17 2007-05-15 Samyang Corporation Stable polymeric micelle-type drug composition and method for the preparation thereof
KR100446101B1 (ko) * 2000-12-07 2004-08-30 주식회사 삼양사 수난용성 약물의 서방성 제형 조성물

Similar Documents

Publication Publication Date Title
JP2005505674A5 (https=)
JP5579406B2 (ja) 高分子ミセルを形成する生分解性化合物、並びにその製造方法及びこの化合物を含有する薬剤組成物
US6730772B2 (en) Degradable polymers from derivatized ring-opened epoxides
Rainbolt et al. Recent developments in micellar drug carriers featuring substituted poly (ε-caprolactone) s
JP2644971B2 (ja) 医療用生分解性コポリマー
JP3955846B2 (ja) 安定性を向上した高分子ミセル組成物
JP6002290B2 (ja) 水難溶性薬物含有徐放性微小粒子及びその製造方法
JP2001514618A (ja) ヒドロキシ酸から誘導されたモノマー及びそれから調製されたポリマー
US8853351B2 (en) Highly pure amphiphilic copolymer comprising hydrophobic block from alpha-hydroxy acid and process for the preparation thereof
CA2463517A1 (en) Ph responsive biodegradable polylactic acid derivatives forming polymeric micelles and uses thereof for poorly water soluble drug delivery
JP5567581B2 (ja) 高純度ポリ乳酸、その塩またはその誘導体、及びその精製方法
Trimaille et al. Poly (hexyl‐substituted lactides): Novel injectable hydrophobic drug delivery systems
Hao et al. Synthesis of functionalized poly (caprolactone) s and their application as micellar drug delivery systems
CN103936973B (zh) 一种多官能团聚环氧乙烷-b-脂肪族聚酯嵌段共聚物及其制备方法与应用
CN103298838A (zh) pH敏感的透明质酸衍生物和其应用
ES2625173T3 (es) Conjugados poliméricos de principios activos, su procedimiento de preparación y sus intermedios poliméricos
Bramfeldt et al. Characterization, degradation, and mechanical strength of poly (d, l‐lactide‐co‐ϵ‐caprolactone)‐poly (ethylene glycol)‐poly (d, l‐lactide‐co‐ϵ‐caprolactone)
CN103893769B (zh) 含聚乙丙交酯靶向高分子药物载体及其制备方法
CN103965455A (zh) 一种负载药物的可生物降解聚合物及其制备方法和应用
US8633296B1 (en) Composite hydrogels for delivery of biologically active materials
US8834861B2 (en) Polycarbonates for delivery of drugs and methods of preparation thereof
CN106620714B (zh) 7-乙基-10-羟基喜树碱-聚合物偶联药物及其纳米制剂制备方法
KR100492805B1 (ko) 안정성이 향상된 고분자 미셀 조성물
JP2023136318A (ja) ポリマーの製造方法
JP3487703B2 (ja) 生体吸収性ポリエステル及びその製造方法