ATE370988T1 - Polymermicellenzusammensetzung mit verbesserter stabilität - Google Patents

Polymermicellenzusammensetzung mit verbesserter stabilität

Info

Publication number
ATE370988T1
ATE370988T1 AT02781954T AT02781954T ATE370988T1 AT E370988 T1 ATE370988 T1 AT E370988T1 AT 02781954 T AT02781954 T AT 02781954T AT 02781954 T AT02781954 T AT 02781954T AT E370988 T1 ATE370988 T1 AT E370988T1
Authority
AT
Austria
Prior art keywords
polylactic acid
improved stability
polymer micelle
micelle composition
tri
Prior art date
Application number
AT02781954T
Other languages
German (de)
English (en)
Inventor
Min-Hyo Seo
Sa-Won Lee
Hee-Jo Kim
Jeong-Kyung Kim
Myung-Han Huyn
Jeong-Il Yu
Kim Bong-Oh
Original Assignee
Samyang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samyang Corp filed Critical Samyang Corp
Application granted granted Critical
Publication of ATE370988T1 publication Critical patent/ATE370988T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L53/00Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L53/00Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C08L53/005Modified block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
AT02781954T 2001-10-18 2002-10-17 Polymermicellenzusammensetzung mit verbesserter stabilität ATE370988T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20010064468 2001-10-18
KR20010076213 2001-12-04

Publications (1)

Publication Number Publication Date
ATE370988T1 true ATE370988T1 (de) 2007-09-15

Family

ID=36293229

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02781954T ATE370988T1 (de) 2001-10-18 2002-10-17 Polymermicellenzusammensetzung mit verbesserter stabilität

Country Status (12)

Country Link
US (1) US7879317B2 (https=)
EP (1) EP1448707B1 (https=)
JP (1) JP3955846B2 (https=)
CN (1) CN1303155C (https=)
AT (1) ATE370988T1 (https=)
AU (1) AU2002348660B2 (https=)
CA (1) CA2463172C (https=)
DE (1) DE60222007T2 (https=)
ES (1) ES2292827T3 (https=)
MX (1) MXPA04003621A (https=)
NZ (1) NZ532198A (https=)
WO (1) WO2003033592A1 (https=)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100502840B1 (ko) * 2002-09-04 2005-07-21 학교법인 포항공과대학교 약물 담지능력이 우수한 블록 공중합체 미셀 조성물
JP4939936B2 (ja) * 2003-06-27 2012-05-30 株式會社アモーレパシフィック 生理活性成分を含有する自己集合性高分子ナノ粒子の製造方法、及び得られた自己集合性高分子ナノ粒子を含有する外用剤組成物
JP2006199590A (ja) * 2003-09-04 2006-08-03 Nano Career Kk 水溶性の塩基性薬物内包ナノ粒子含有組成物
ITMI20031872A1 (it) * 2003-09-30 2005-04-01 Mediolanum Farmaceutici Srl Copolimeri di poliesteri e polivinilpirrolidone.
KR100703872B1 (ko) * 2003-10-10 2007-04-09 주식회사 삼양사 양친성 블록 공중합체 및 이를 포함하는 약물 전달용고분자 조성물
US7311901B2 (en) 2003-10-10 2007-12-25 Samyang Corporation Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery
AU2003272127A1 (en) * 2003-10-24 2005-05-11 Samyang Corporation Polymeric composition for drug delivery
KR20050064075A (ko) * 2003-12-23 2005-06-29 주식회사 삼양사 이트라코나졸을 유효성분으로 하는 약학적 조성물
JP3903061B2 (ja) * 2003-12-24 2007-04-11 株式会社Lttバイオファーマ 薬物を含有するナノ粒子およびその製造方法、ならびに当該ナノ粒子からなる非経口投与用製剤
DE602004032265D1 (de) * 2003-12-30 2011-05-26 3M Innovative Properties Co Herstellungsverfahren von medizinischen zusammensetzungen
US7151077B2 (en) 2004-03-29 2006-12-19 Halliburton Energy Services, Inc. Polymersome compositions and associated methods of use
US7659310B2 (en) 2004-04-27 2010-02-09 Formatech, Inc. Methods of enhancing solubility of agents
US7345093B2 (en) 2004-04-27 2008-03-18 Formatech, Inc. Methods of enhancing solubility of compounds
ATE531391T1 (de) * 2004-05-06 2011-11-15 Samyang Corp Abgabesystem für biologisch wirksame mittel auf basis eines polymeren arzneiträgers mit einem ampiphilen blockpolymer und einem polymilchsäure- derivat
WO2007001448A2 (en) 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
CA2526541C (en) * 2004-12-01 2013-09-03 Tyco Healthcare Group Lp Novel biomaterial drug delivery and surface modification compositions
US7677315B2 (en) 2005-05-12 2010-03-16 Halliburton Energy Services, Inc. Degradable surfactants and methods for use
US7608567B2 (en) 2005-05-12 2009-10-27 Halliburton Energy Services, Inc. Degradable surfactants and methods for use
US7662753B2 (en) 2005-05-12 2010-02-16 Halliburton Energy Services, Inc. Degradable surfactants and methods for use
WO2007070682A2 (en) 2005-12-15 2007-06-21 Massachusetts Institute Of Technology System for screening particles
KR100858508B1 (ko) * 2005-12-23 2008-09-12 주식회사 삼양사 아졸계 항진균제를 포함하는 조성물 및 그의 제조방법
KR100754326B1 (ko) * 2006-02-15 2007-09-03 삼성전기주식회사 금속 나노입자의 제조방법
JP5630998B2 (ja) * 2006-05-15 2014-11-26 マサチューセッツ インスティテュート オブ テクノロジー 機能的粒子のためのポリマー
WO2007150030A2 (en) 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
EP2134830A2 (en) 2007-02-09 2009-12-23 Massachusetts Institute of Technology Oscillating cell culture bioreactor
JP2010523595A (ja) 2007-04-04 2010-07-15 マサチューセッツ インスティテュート オブ テクノロジー ポリ(アミノ酸)ターゲッティング部分
WO2008137733A2 (en) * 2007-05-02 2008-11-13 Emory University Micellar structures, methods of making micellar structures, methods of imaging, and methods of delivering agents
FR2921068B1 (fr) 2007-09-19 2010-12-24 Arkema France Composition renfermant un homopolymere d'acide lactique et un copolymere a blocs
EP2436376B1 (en) * 2007-09-28 2014-07-09 BIND Therapeutics, Inc. Cancer cell targeting using nanoparticles
JP2011500569A (ja) 2007-10-12 2011-01-06 マサチューセッツ インスティテュート オブ テクノロジー ワクチンナノテクノロジー
CN101910246B (zh) 2007-12-31 2013-01-02 株式会社三养生物制药 包含源自α-羟酸的疏水嵌段的高纯两亲共聚物及其制备方法
US9801818B2 (en) 2007-12-31 2017-10-31 Samyang Biopharmaceuticals Corporation Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug
KR101024742B1 (ko) * 2007-12-31 2011-03-24 주식회사 삼양사 탁산 함유 양친성 블록 공중합체 미셀 조성물 및 그 제조방법
US8652506B2 (en) * 2008-06-05 2014-02-18 Boston Scientific Scimed, Inc. Bio-degradable block co-polymers for controlled release
JP2010065067A (ja) * 2008-09-08 2010-03-25 Tokyo Univ Of Agriculture & Technology 粒子およびその製造方法、ならびにゲル
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
JP5449388B2 (ja) * 2008-11-21 2014-03-19 サミャン バイオファーマシューティカルズ コーポレイション 耐性がん治療用高分子ミセル組成物及びその製造方法
US20150359777A1 (en) * 2008-12-26 2015-12-17 Samyang Biopharmaceuticals Corporation Preparation method of polymeric micellar nanoparticles composition containing a poorly water-soluble drug
EP2201935B1 (en) 2008-12-26 2020-07-08 Samyang Biopharmaceuticals Corporation Polymeric micelle composition containing a poorly soluble drug and preparation method of the same
US20110257253A1 (en) * 2008-12-26 2011-10-20 Samyang Corporation Preparation method of polymeric micellar nanoparticles composition containing a poorly water-soluble drug
CA2756072A1 (en) * 2009-03-30 2010-10-14 Cerulean Pharma Inc. Polymer-agent conjugates, particles, compositions, and related methods of use
WO2010114768A1 (en) * 2009-03-30 2010-10-07 Cerulean Pharma Inc. Polymer-epothilone conjugates, particles, compositions, and related methods of use
WO2010127271A1 (en) 2009-04-30 2010-11-04 Intezyne Technologies, Incorporated Polymer micelles containing anthracylines for the treatment of cancer
US8524784B2 (en) 2009-04-30 2013-09-03 Intezyne Technologies, Incorporated Polymer micelles containing anthracylines for the treatment of cancer
CA2781527C (en) 2009-09-23 2017-10-24 Indu Javeri Methods for the preparation of liposomes
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
KR101224004B1 (ko) * 2009-12-29 2013-01-22 주식회사 삼양바이오팜 단백질, 폴리펩타이드 또는 펩타이드 약물 전달용 고분자 및 그 제조방법, 및 단백질, 폴리펩타이드 또는 펩타이드 약물의 서방형 조성물 및 그 제조 방법
KR101267813B1 (ko) 2009-12-30 2013-06-04 주식회사 삼양바이오팜 향상된 수용해도를 갖는 라파마이신 함유 고분자나노입자 주사제형 조성물 및 그 제조방법, 및 방사선 요법과 병용하기 위한 항암 조성물
KR101424163B1 (ko) * 2010-12-24 2014-08-01 주식회사 삼양바이오팜 수난용성 약물 함유 서방성 마이크로입자 및 그 제조방법
KR101508275B1 (ko) * 2011-12-16 2015-04-08 주식회사 삼양바이오팜 고분자 나노입자 수용액 조성물 및 그 제조방법
CN103479573B (zh) * 2013-07-26 2017-04-19 中国科学院长春应用化学研究所 聚乙二醇单甲醚‑聚酯两嵌段共聚物胶束及载药胶束的制备方法
CN104086726A (zh) * 2014-07-08 2014-10-08 成都市绿科华通科技有限公司 聚乳酸星型二嵌段共聚物药用功能材料
WO2016108534A1 (ko) * 2014-12-30 2016-07-07 주식회사 삼양바이오팜 고분자 나노입자 동결건조물 및 그 제조방법
WO2016110839A1 (en) * 2015-01-05 2016-07-14 B.G. Negev Technologies And Applications Ltd., At Ben-Gurion University Nanoparticles and methods for preparation thereof
KR101787451B1 (ko) * 2015-07-28 2017-10-19 주식회사 삼양바이오팜 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법
KR101787453B1 (ko) * 2015-07-28 2017-10-19 주식회사 삼양바이오팜 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법
KR101745429B1 (ko) 2015-07-28 2017-06-12 주식회사 삼양바이오팜 양친성 블록 공중합체의 정제방법, 이로부터 얻어지는 양친성 블록 공중합체, 및 이를 포함하는 약학 조성물
KR101787447B1 (ko) * 2015-07-28 2017-10-19 주식회사 삼양바이오팜 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법
KR101748191B1 (ko) * 2015-07-28 2017-06-19 주식회사 삼양바이오팜 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법
KR101971672B1 (ko) 2016-11-18 2019-04-23 주식회사 삼양바이오팜 화학색전용 에멀전 조성물 및 그의 제조방법
US10457772B2 (en) 2017-09-08 2019-10-29 International Business Machines Corporation Preparation of robust polythioaminal carriers
CN110156971A (zh) * 2018-02-13 2019-08-23 上海时莱生物技术有限公司 一种两亲性嵌段共聚物及其制备方法和纳米胶束载药系统

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2709516B2 (ja) 1989-07-12 1998-02-04 多木化学株式会社 医用組成物
IT1243390B (it) * 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
CA2087125A1 (en) * 1992-01-23 1993-07-24 Mridula Nair Chemically fixed micelles
JP3107451B2 (ja) 1992-03-31 2000-11-06 竹本油脂株式会社 ポリカーボネート樹脂用帯電防止剤及びこれを含有するポリカーボネート樹脂組成物
KR940003548U (ko) * 1992-08-14 1994-02-21 김형술 세탁물 건조기
JP3270592B2 (ja) 1992-10-26 2002-04-02 日本化薬株式会社 ブロック共重合体−抗癌剤複合体医薬製剤
JPH0769917A (ja) 1993-06-24 1995-03-14 Takeda Chem Ind Ltd 抗エンドセリン物質の徐放性製剤
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
US6447796B1 (en) * 1994-05-16 2002-09-10 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
JPH10110019A (ja) 1996-10-08 1998-04-28 Kazunori Kataoka 安定化高分子ミセルおよび生理活性物質のキヤリヤーとしてのその使用
AU1819499A (en) * 1997-12-12 1999-06-28 Samyang Corporation Positively-charged poly{alpha-(omega-aminoalkyl)glycolic acid} for the delivery of a bioactive agent via tissue and cellular uptake
KR100360827B1 (ko) * 1999-08-14 2002-11-18 주식회사 삼양사 난용성 약물을 가용화하기 위한 고분자 조성물 및 그의 제조방법
US6743446B2 (en) * 1999-12-15 2004-06-01 The Ohio State University Research Foundation Methods for stabilizing biologically active agents encapsulated in biodegradable controlled-release polymers
KR100416242B1 (ko) * 1999-12-22 2004-01-31 주식회사 삼양사 약물전달체용 생분해성 블록 공중합체의 액체 조성물 및이의 제조방법
US7217770B2 (en) 2000-05-17 2007-05-15 Samyang Corporation Stable polymeric micelle-type drug composition and method for the preparation thereof
KR100446101B1 (ko) * 2000-12-07 2004-08-30 주식회사 삼양사 수난용성 약물의 서방성 제형 조성물

Also Published As

Publication number Publication date
JP3955846B2 (ja) 2007-08-08
US7879317B2 (en) 2011-02-01
AU2002348660B2 (en) 2006-01-12
EP1448707B1 (en) 2007-08-22
CN1571816A (zh) 2005-01-26
EP1448707A1 (en) 2004-08-25
ES2292827T3 (es) 2008-03-16
NZ532198A (en) 2006-03-31
JP2005505674A (ja) 2005-02-24
CA2463172A1 (en) 2003-04-24
US20040253195A1 (en) 2004-12-16
CN1303155C (zh) 2007-03-07
MXPA04003621A (es) 2004-07-30
DE60222007T2 (de) 2008-05-15
CA2463172C (en) 2009-08-18
WO2003033592A1 (en) 2003-04-24
DE60222007D1 (de) 2007-10-04

Similar Documents

Publication Publication Date Title
ATE370988T1 (de) Polymermicellenzusammensetzung mit verbesserter stabilität
Insua et al. Polyion complex (PIC) particles: Preparation and biomedical applications
AU2001269178A1 (en) Use as thickeners in cosmetics of neutralized copolymers comprising weak acid units and strong acid units, and cosmetic compositions comprising same
BRPI0707465B8 (pt) composições farmacêuticas compreendendo misturas de polímeros e ingredientes ativos dificilmente solúveis em água, seu uso e seus processos de preparação, forma farmacêutica e seu processo de produção
ATE283872T1 (de) Wässrige dispersionen von wasserlöslichen polymerisaten von n-vinylcarbonsäureamiden, verfahren zu ihrer herstellung und ihre verwendung
CA2337476A1 (en) Rinse-aid formulation
PT806894E (pt) Nanoparticulas micelares
Shaikh et al. Formulation and molecular docking simulation study of luliconazole nanosuspension–based nanogel for transdermal drug delivery using modified polymer
NO20071458L (no) Nanopartikkel og fremgangsmate for fremstilling av denne
JP2001240626A (ja) 水溶性または水膨潤性架橋コポリマー
Shahriari et al. “Smart” self-assembled structures: toward intelligent dual responsive drug delivery systems
WO2007142797A3 (en) Medical electrode containing a hydrophilic polymer
WO2011034765A4 (en) Freshening compositions comprising malodor binding polymers
ATE432962T1 (de) Bioabsorbierbare polymerzusammensetzungen mit erhöhten kristallisations- und hydrolyseraten
WO2002014403A3 (en) Acid end group poly(d,l-lactide-co-glycolide) copolymers with high glycolide content
Antonio et al. Fully conducting hydro-sponges with electro-swelling properties tuned by synthetic parameters
BR112021018211A2 (pt) Revestimento reversível de nanopartículas de quitosana-ácido nucléico e métodos de seu uso
DE69116381D1 (de) Polymermischungen für wässrige dispersionen mit verbesserter gefrier-auftau-stabilität
JP2011057459A5 (https=)
BRPI0604209A (pt) copolìmero anfotérico solúvel em água, método de produção deste, e aplicação deste
DE50114576D1 (de) Kosmetische oder dermatologische Lichtschutzmittelzubereitungen
Li et al. Aggregation behavior and complex structure between triblock copolymer and anionic surfactants
Khan et al. A comparative study of interaction of ibuprofen with biocompatible polymers
Kelarakis et al. Interactions of an anionic surfactant with poly (oxyalkylene) copolymers in aqueous solution
ES2193523T3 (es) Composiciones depilatorias, su preparacion y uso.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties