NZ532198A - Polymeric micelle composition of an amphiphilic block copolymer and a polylactic acid derivative - Google Patents
Polymeric micelle composition of an amphiphilic block copolymer and a polylactic acid derivativeInfo
- Publication number
- NZ532198A NZ532198A NZ532198A NZ53219802A NZ532198A NZ 532198 A NZ532198 A NZ 532198A NZ 532198 A NZ532198 A NZ 532198A NZ 53219802 A NZ53219802 A NZ 53219802A NZ 532198 A NZ532198 A NZ 532198A
- Authority
- NZ
- New Zealand
- Prior art keywords
- polylactic acid
- acid derivative
- block copolymer
- amphiphilic block
- polymeric micelle
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 229920000747 poly(lactic acid) Polymers 0.000 title abstract 4
- 239000004626 polylactic acid Substances 0.000 title abstract 4
- 239000000693 micelle Substances 0.000 title abstract 3
- 229920000469 amphiphilic block copolymer Polymers 0.000 title abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229910021645 metal ion Inorganic materials 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
- C08L53/005—Modified block copolymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Biological Depolymerization Polymers (AREA)
- Polyesters Or Polycarbonates (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20010064468 | 2001-10-18 | ||
| KR20010076213 | 2001-12-04 | ||
| PCT/KR2002/001942 WO2003033592A1 (en) | 2001-10-18 | 2002-10-17 | Polymeric micelle composition with improved stability |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ532198A true NZ532198A (en) | 2006-03-31 |
Family
ID=36293229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ532198A NZ532198A (en) | 2001-10-18 | 2002-10-17 | Polymeric micelle composition of an amphiphilic block copolymer and a polylactic acid derivative |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7879317B2 (https=) |
| EP (1) | EP1448707B1 (https=) |
| JP (1) | JP3955846B2 (https=) |
| CN (1) | CN1303155C (https=) |
| AT (1) | ATE370988T1 (https=) |
| AU (1) | AU2002348660B2 (https=) |
| CA (1) | CA2463172C (https=) |
| DE (1) | DE60222007T2 (https=) |
| ES (1) | ES2292827T3 (https=) |
| MX (1) | MXPA04003621A (https=) |
| NZ (1) | NZ532198A (https=) |
| WO (1) | WO2003033592A1 (https=) |
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| KR100502840B1 (ko) * | 2002-09-04 | 2005-07-21 | 학교법인 포항공과대학교 | 약물 담지능력이 우수한 블록 공중합체 미셀 조성물 |
| JP4939936B2 (ja) * | 2003-06-27 | 2012-05-30 | 株式會社アモーレパシフィック | 生理活性成分を含有する自己集合性高分子ナノ粒子の製造方法、及び得られた自己集合性高分子ナノ粒子を含有する外用剤組成物 |
| JP2006199590A (ja) * | 2003-09-04 | 2006-08-03 | Nano Career Kk | 水溶性の塩基性薬物内包ナノ粒子含有組成物 |
| ITMI20031872A1 (it) * | 2003-09-30 | 2005-04-01 | Mediolanum Farmaceutici Srl | Copolimeri di poliesteri e polivinilpirrolidone. |
| EP1670838B1 (en) * | 2003-10-10 | 2015-12-09 | Samyang Biopharmaceuticals Corporation | Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery |
| US7311901B2 (en) | 2003-10-10 | 2007-12-25 | Samyang Corporation | Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery |
| AU2003272127A1 (en) * | 2003-10-24 | 2005-05-11 | Samyang Corporation | Polymeric composition for drug delivery |
| KR20050064075A (ko) * | 2003-12-23 | 2005-06-29 | 주식회사 삼양사 | 이트라코나졸을 유효성분으로 하는 약학적 조성물 |
| JP3903061B2 (ja) * | 2003-12-24 | 2007-04-11 | 株式会社Lttバイオファーマ | 薬物を含有するナノ粒子およびその製造方法、ならびに当該ナノ粒子からなる非経口投与用製剤 |
| WO2005066238A1 (en) * | 2003-12-30 | 2005-07-21 | 3M Innovative Properties Company | Medicinal compositions and method for the preparation thereof |
| US7151077B2 (en) | 2004-03-29 | 2006-12-19 | Halliburton Energy Services, Inc. | Polymersome compositions and associated methods of use |
| US7345093B2 (en) | 2004-04-27 | 2008-03-18 | Formatech, Inc. | Methods of enhancing solubility of compounds |
| US7659310B2 (en) | 2004-04-27 | 2010-02-09 | Formatech, Inc. | Methods of enhancing solubility of agents |
| CA2564719C (en) * | 2004-05-06 | 2011-11-01 | Samyang Corporation | Delivery system for bioactive agents on the basis of a polymeric drug carrier comprising an amphiphilic block polymer and a polylactic acid derivative |
| US9492400B2 (en) | 2004-11-04 | 2016-11-15 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
| CA2526541C (en) * | 2004-12-01 | 2013-09-03 | Tyco Healthcare Group Lp | Novel biomaterial drug delivery and surface modification compositions |
| US7662753B2 (en) | 2005-05-12 | 2010-02-16 | Halliburton Energy Services, Inc. | Degradable surfactants and methods for use |
| US7608567B2 (en) | 2005-05-12 | 2009-10-27 | Halliburton Energy Services, Inc. | Degradable surfactants and methods for use |
| US7677315B2 (en) | 2005-05-12 | 2010-03-16 | Halliburton Energy Services, Inc. | Degradable surfactants and methods for use |
| US9267937B2 (en) | 2005-12-15 | 2016-02-23 | Massachusetts Institute Of Technology | System for screening particles |
| KR100858508B1 (ko) * | 2005-12-23 | 2008-09-12 | 주식회사 삼양사 | 아졸계 항진균제를 포함하는 조성물 및 그의 제조방법 |
| KR100754326B1 (ko) * | 2006-02-15 | 2007-09-03 | 삼성전기주식회사 | 금속 나노입자의 제조방법 |
| US8367113B2 (en) * | 2006-05-15 | 2013-02-05 | Massachusetts Institute Of Technology | Polymers for functional particles |
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| EP2136788B1 (en) * | 2007-03-30 | 2011-10-26 | Bind Biosciences, Inc. | Cancer cell targeting using nanoparticles |
| WO2008124632A1 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Amphiphilic compound assisted nanoparticles for targeted delivery |
| WO2008137733A2 (en) * | 2007-05-02 | 2008-11-13 | Emory University | Micellar structures, methods of making micellar structures, methods of imaging, and methods of delivering agents |
| FR2921068B1 (fr) * | 2007-09-19 | 2010-12-24 | Arkema France | Composition renfermant un homopolymere d'acide lactique et un copolymere a blocs |
| EP2630966B1 (en) | 2007-10-12 | 2017-04-19 | Massachusetts Institute of Technology | Vaccine nanotechnology |
| KR101024742B1 (ko) * | 2007-12-31 | 2011-03-24 | 주식회사 삼양사 | 탁산 함유 양친성 블록 공중합체 미셀 조성물 및 그 제조방법 |
| US9801818B2 (en) | 2007-12-31 | 2017-10-31 | Samyang Biopharmaceuticals Corporation | Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug |
| RU2459840C2 (ru) * | 2007-12-31 | 2012-08-27 | Самъянг Корпорейшн | АМФИФИЛЬНЫЙ СОПОЛИМЕР ВЫСОКОЙ ЧИСТОТЫ, СОДЕРЖАЩИЙ ГИДРОФОБНЫЙ БЛОК ИЗ α-ГИДРОКСИКИСЛОТЫ, И СПОСОБ ЕГО ПОЛУЧЕНИЯ |
| US8652506B2 (en) * | 2008-06-05 | 2014-02-18 | Boston Scientific Scimed, Inc. | Bio-degradable block co-polymers for controlled release |
| JP2010065067A (ja) * | 2008-09-08 | 2010-03-25 | Tokyo Univ Of Agriculture & Technology | 粒子およびその製造方法、ならびにゲル |
| US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
| US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
| EP2359860B1 (en) * | 2008-11-21 | 2014-08-06 | Samyang Biopharmaceuticals Corporation | Polymer micelle composition for treatment of resistant cancer cells |
| NZ593735A (en) * | 2008-12-26 | 2013-08-30 | Samyang Biopharmaceuticals | Preparation method of polymeric micellar nanoparticles composition containing a poorly water-soluble drug |
| EP2201935B1 (en) | 2008-12-26 | 2020-07-08 | Samyang Biopharmaceuticals Corporation | Polymeric micelle composition containing a poorly soluble drug and preparation method of the same |
| US20150359777A1 (en) * | 2008-12-26 | 2015-12-17 | Samyang Biopharmaceuticals Corporation | Preparation method of polymeric micellar nanoparticles composition containing a poorly water-soluble drug |
| WO2010114768A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-epothilone conjugates, particles, compositions, and related methods of use |
| CN103932972A (zh) * | 2009-03-30 | 2014-07-23 | 天蓝制药公司 | 聚合物-药剂缀合物、颗粒、组合物和相关使用方法 |
| US8524784B2 (en) | 2009-04-30 | 2013-09-03 | Intezyne Technologies, Incorporated | Polymer micelles containing anthracylines for the treatment of cancer |
| US8524783B2 (en) | 2009-04-30 | 2013-09-03 | Intezyne Technologies, Incorporated | Polymer micelles containing anthracylines for the treatment of cancer |
| CA2781529C (en) | 2009-09-23 | 2017-10-24 | Indu Javeri | Methods for the preparation of liposomes comprising docetaxel |
| US10143652B2 (en) | 2009-09-23 | 2018-12-04 | Curirx Inc. | Methods for the preparation of liposomes |
| KR101224004B1 (ko) * | 2009-12-29 | 2013-01-22 | 주식회사 삼양바이오팜 | 단백질, 폴리펩타이드 또는 펩타이드 약물 전달용 고분자 및 그 제조방법, 및 단백질, 폴리펩타이드 또는 펩타이드 약물의 서방형 조성물 및 그 제조 방법 |
| KR101267813B1 (ko) | 2009-12-30 | 2013-06-04 | 주식회사 삼양바이오팜 | 향상된 수용해도를 갖는 라파마이신 함유 고분자나노입자 주사제형 조성물 및 그 제조방법, 및 방사선 요법과 병용하기 위한 항암 조성물 |
| KR101424163B1 (ko) | 2010-12-24 | 2014-08-01 | 주식회사 삼양바이오팜 | 수난용성 약물 함유 서방성 마이크로입자 및 그 제조방법 |
| KR101508275B1 (ko) | 2011-12-16 | 2015-04-08 | 주식회사 삼양바이오팜 | 고분자 나노입자 수용액 조성물 및 그 제조방법 |
| CN103479573B (zh) * | 2013-07-26 | 2017-04-19 | 中国科学院长春应用化学研究所 | 聚乙二醇单甲醚‑聚酯两嵌段共聚物胶束及载药胶束的制备方法 |
| CN104086726A (zh) * | 2014-07-08 | 2014-10-08 | 成都市绿科华通科技有限公司 | 聚乳酸星型二嵌段共聚物药用功能材料 |
| CN107106496B (zh) * | 2014-12-30 | 2020-09-15 | 株式会社三养生物制药 | 聚合物纳米粒子冷冻干燥物及其制备方法 |
| WO2016110839A1 (en) * | 2015-01-05 | 2016-07-14 | B.G. Negev Technologies And Applications Ltd., At Ben-Gurion University | Nanoparticles and methods for preparation thereof |
| KR101787451B1 (ko) * | 2015-07-28 | 2017-10-19 | 주식회사 삼양바이오팜 | 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법 |
| KR101748191B1 (ko) * | 2015-07-28 | 2017-06-19 | 주식회사 삼양바이오팜 | 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법 |
| KR101787453B1 (ko) * | 2015-07-28 | 2017-10-19 | 주식회사 삼양바이오팜 | 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법 |
| KR101745429B1 (ko) | 2015-07-28 | 2017-06-12 | 주식회사 삼양바이오팜 | 양친성 블록 공중합체의 정제방법, 이로부터 얻어지는 양친성 블록 공중합체, 및 이를 포함하는 약학 조성물 |
| KR101787447B1 (ko) * | 2015-07-28 | 2017-10-19 | 주식회사 삼양바이오팜 | 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법 |
| KR101971672B1 (ko) * | 2016-11-18 | 2019-04-23 | 주식회사 삼양바이오팜 | 화학색전용 에멀전 조성물 및 그의 제조방법 |
| US10457772B2 (en) | 2017-09-08 | 2019-10-29 | International Business Machines Corporation | Preparation of robust polythioaminal carriers |
| CN110156971A (zh) * | 2018-02-13 | 2019-08-23 | 上海时莱生物技术有限公司 | 一种两亲性嵌段共聚物及其制备方法和纳米胶束载药系统 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2709516B2 (ja) | 1989-07-12 | 1998-02-04 | 多木化学株式会社 | 医用組成物 |
| IT1243390B (it) * | 1990-11-22 | 1994-06-10 | Vectorpharma Int | Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione. |
| CA2087125A1 (en) * | 1992-01-23 | 1993-07-24 | Mridula Nair | Chemically fixed micelles |
| JP3107451B2 (ja) | 1992-03-31 | 2000-11-06 | 竹本油脂株式会社 | ポリカーボネート樹脂用帯電防止剤及びこれを含有するポリカーボネート樹脂組成物 |
| KR940003548U (ko) * | 1992-08-14 | 1994-02-21 | 김형술 | 세탁물 건조기 |
| JP3270592B2 (ja) | 1992-10-26 | 2002-04-02 | 日本化薬株式会社 | ブロック共重合体−抗癌剤複合体医薬製剤 |
| JPH0769917A (ja) | 1993-06-24 | 1995-03-14 | Takeda Chem Ind Ltd | 抗エンドセリン物質の徐放性製剤 |
| US5565215A (en) * | 1993-07-23 | 1996-10-15 | Massachusettes Institute Of Technology | Biodegradable injectable particles for imaging |
| US6447796B1 (en) * | 1994-05-16 | 2002-09-10 | The United States Of America As Represented By The Secretary Of The Army | Sustained release hydrophobic bioactive PLGA microspheres |
| JPH10110019A (ja) | 1996-10-08 | 1998-04-28 | Kazunori Kataoka | 安定化高分子ミセルおよび生理活性物質のキヤリヤーとしてのその使用 |
| ZA9811377B (en) | 1997-12-12 | 1999-08-27 | Expression Genetics Inc | Positively charged poly[alpha-(omega-aminoalkyl) glycolic acid[ for the delivery of a bioactive agent via tissue and cellular uptake. |
| KR100360827B1 (ko) | 1999-08-14 | 2002-11-18 | 주식회사 삼양사 | 난용성 약물을 가용화하기 위한 고분자 조성물 및 그의 제조방법 |
| US6743446B2 (en) * | 1999-12-15 | 2004-06-01 | The Ohio State University Research Foundation | Methods for stabilizing biologically active agents encapsulated in biodegradable controlled-release polymers |
| KR100416242B1 (ko) * | 1999-12-22 | 2004-01-31 | 주식회사 삼양사 | 약물전달체용 생분해성 블록 공중합체의 액체 조성물 및이의 제조방법 |
| US7217770B2 (en) | 2000-05-17 | 2007-05-15 | Samyang Corporation | Stable polymeric micelle-type drug composition and method for the preparation thereof |
| KR100446101B1 (ko) * | 2000-12-07 | 2004-08-30 | 주식회사 삼양사 | 수난용성 약물의 서방성 제형 조성물 |
-
2002
- 2002-10-17 US US10/493,043 patent/US7879317B2/en not_active Expired - Lifetime
- 2002-10-17 EP EP02781954A patent/EP1448707B1/en not_active Expired - Lifetime
- 2002-10-17 CN CNB028205731A patent/CN1303155C/zh not_active Expired - Lifetime
- 2002-10-17 AU AU2002348660A patent/AU2002348660B2/en not_active Expired
- 2002-10-17 WO PCT/KR2002/001942 patent/WO2003033592A1/en not_active Ceased
- 2002-10-17 JP JP2003536325A patent/JP3955846B2/ja not_active Expired - Lifetime
- 2002-10-17 CA CA2463172A patent/CA2463172C/en not_active Expired - Lifetime
- 2002-10-17 ES ES02781954T patent/ES2292827T3/es not_active Expired - Lifetime
- 2002-10-17 DE DE60222007T patent/DE60222007T2/de not_active Expired - Lifetime
- 2002-10-17 NZ NZ532198A patent/NZ532198A/xx not_active IP Right Cessation
- 2002-10-17 AT AT02781954T patent/ATE370988T1/de not_active IP Right Cessation
- 2002-10-17 MX MXPA04003621A patent/MXPA04003621A/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JP3955846B2 (ja) | 2007-08-08 |
| EP1448707A1 (en) | 2004-08-25 |
| US7879317B2 (en) | 2011-02-01 |
| CN1303155C (zh) | 2007-03-07 |
| DE60222007D1 (de) | 2007-10-04 |
| CA2463172C (en) | 2009-08-18 |
| WO2003033592A1 (en) | 2003-04-24 |
| DE60222007T2 (de) | 2008-05-15 |
| US20040253195A1 (en) | 2004-12-16 |
| AU2002348660B2 (en) | 2006-01-12 |
| ES2292827T3 (es) | 2008-03-16 |
| ATE370988T1 (de) | 2007-09-15 |
| CN1571816A (zh) | 2005-01-26 |
| MXPA04003621A (es) | 2004-07-30 |
| EP1448707B1 (en) | 2007-08-22 |
| JP2005505674A (ja) | 2005-02-24 |
| CA2463172A1 (en) | 2003-04-24 |
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