ATE370988T1 - Polymermicellenzusammensetzung mit verbesserter stabilität - Google Patents
Polymermicellenzusammensetzung mit verbesserter stabilitätInfo
- Publication number
- ATE370988T1 ATE370988T1 AT02781954T AT02781954T ATE370988T1 AT E370988 T1 ATE370988 T1 AT E370988T1 AT 02781954 T AT02781954 T AT 02781954T AT 02781954 T AT02781954 T AT 02781954T AT E370988 T1 ATE370988 T1 AT E370988T1
- Authority
- AT
- Austria
- Prior art keywords
- polylactic acid
- improved stability
- polymer micelle
- micelle composition
- tri
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000000693 micelle Substances 0.000 title abstract 2
- 229920000642 polymer Polymers 0.000 title 1
- 229920000747 poly(lactic acid) Polymers 0.000 abstract 3
- 239000004626 polylactic acid Substances 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229910021645 metal ion Inorganic materials 0.000 abstract 2
- 229920000469 amphiphilic block copolymer Polymers 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
- C08L53/005—Modified block copolymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Biological Depolymerization Polymers (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Polyesters Or Polycarbonates (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20010064468 | 2001-10-18 | ||
KR20010076213 | 2001-12-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE370988T1 true ATE370988T1 (de) | 2007-09-15 |
Family
ID=36293229
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02781954T ATE370988T1 (de) | 2001-10-18 | 2002-10-17 | Polymermicellenzusammensetzung mit verbesserter stabilität |
Country Status (12)
Country | Link |
---|---|
US (1) | US7879317B2 (de) |
EP (1) | EP1448707B1 (de) |
JP (1) | JP3955846B2 (de) |
CN (1) | CN1303155C (de) |
AT (1) | ATE370988T1 (de) |
AU (1) | AU2002348660B2 (de) |
CA (1) | CA2463172C (de) |
DE (1) | DE60222007T2 (de) |
ES (1) | ES2292827T3 (de) |
MX (1) | MXPA04003621A (de) |
NZ (1) | NZ532198A (de) |
WO (1) | WO2003033592A1 (de) |
Families Citing this family (62)
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KR100502840B1 (ko) * | 2002-09-04 | 2005-07-21 | 학교법인 포항공과대학교 | 약물 담지능력이 우수한 블록 공중합체 미셀 조성물 |
JP4939936B2 (ja) * | 2003-06-27 | 2012-05-30 | 株式會社アモーレパシフィック | 生理活性成分を含有する自己集合性高分子ナノ粒子の製造方法、及び得られた自己集合性高分子ナノ粒子を含有する外用剤組成物 |
JP2006199590A (ja) * | 2003-09-04 | 2006-08-03 | Nano Career Kk | 水溶性の塩基性薬物内包ナノ粒子含有組成物 |
ITMI20031872A1 (it) * | 2003-09-30 | 2005-04-01 | Mediolanum Farmaceutici Srl | Copolimeri di poliesteri e polivinilpirrolidone. |
WO2005040247A1 (en) * | 2003-10-24 | 2005-05-06 | Samyang Corporation | Polymeric composition for drug delivery |
JP4235226B2 (ja) | 2003-10-10 | 2009-03-11 | サムヤン コーポレイション | 両親媒性ブロック共重合体及びそれを含む薬剤送達用高分子組成物 |
US7311901B2 (en) | 2003-10-10 | 2007-12-25 | Samyang Corporation | Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery |
KR20050064075A (ko) * | 2003-12-23 | 2005-06-29 | 주식회사 삼양사 | 이트라코나졸을 유효성분으로 하는 약학적 조성물 |
CA2549966A1 (en) * | 2003-12-24 | 2005-07-07 | Ltt Bio-Pharma Co., Ltd. | Drug-containing nanoparticle, process for producing the same and parenterally administered preparation from the nanoparticle |
ATE505503T1 (de) * | 2003-12-30 | 2011-04-15 | 3M Innovative Properties Co | Herstellungsverfahren von medizinischen zusammensetzungen |
US7151077B2 (en) | 2004-03-29 | 2006-12-19 | Halliburton Energy Services, Inc. | Polymersome compositions and associated methods of use |
US7659310B2 (en) | 2004-04-27 | 2010-02-09 | Formatech, Inc. | Methods of enhancing solubility of agents |
US7345093B2 (en) | 2004-04-27 | 2008-03-18 | Formatech, Inc. | Methods of enhancing solubility of compounds |
JP4885846B2 (ja) * | 2004-05-06 | 2012-02-29 | サムヤン コーポレーション | 両親性ブロック共重合体及びポリ乳酸誘導体を含む高分子薬物担体に基づいた生物活性剤の細胞内伝達システム |
WO2007001448A2 (en) | 2004-11-04 | 2007-01-04 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
CA2526541C (en) * | 2004-12-01 | 2013-09-03 | Tyco Healthcare Group Lp | Novel biomaterial drug delivery and surface modification compositions |
US7677315B2 (en) | 2005-05-12 | 2010-03-16 | Halliburton Energy Services, Inc. | Degradable surfactants and methods for use |
US7662753B2 (en) | 2005-05-12 | 2010-02-16 | Halliburton Energy Services, Inc. | Degradable surfactants and methods for use |
US9267937B2 (en) | 2005-12-15 | 2016-02-23 | Massachusetts Institute Of Technology | System for screening particles |
KR100858508B1 (ko) * | 2005-12-23 | 2008-09-12 | 주식회사 삼양사 | 아졸계 항진균제를 포함하는 조성물 및 그의 제조방법 |
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CN101573141B (zh) * | 2006-05-15 | 2016-05-04 | 麻省理工学院 | 用于功能性颗粒的聚合物 |
WO2007150030A2 (en) | 2006-06-23 | 2007-12-27 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
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EP2144600A4 (de) | 2007-04-04 | 2011-03-16 | Massachusetts Inst Technology | Poly (aminsäure)-zielmoleküle |
WO2008137733A2 (en) * | 2007-05-02 | 2008-11-13 | Emory University | Micellar structures, methods of making micellar structures, methods of imaging, and methods of delivering agents |
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EP2620157A3 (de) | 2007-10-12 | 2013-10-16 | Massachusetts Institute of Technology | Impfstoffnanotechnologie |
US9801818B2 (en) | 2007-12-31 | 2017-10-31 | Samyang Biopharmaceuticals Corporation | Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug |
KR101187487B1 (ko) * | 2007-12-31 | 2012-10-02 | 주식회사 삼양바이오팜 | 고순도의 폴리 알파(α)-히드록시산의 소수성 고분자 블록을 포함하는 양친성 블록 공중합체 및 그의 제조방법 |
KR101024742B1 (ko) * | 2007-12-31 | 2011-03-24 | 주식회사 삼양사 | 탁산 함유 양친성 블록 공중합체 미셀 조성물 및 그 제조방법 |
US8652506B2 (en) * | 2008-06-05 | 2014-02-18 | Boston Scientific Scimed, Inc. | Bio-degradable block co-polymers for controlled release |
JP2010065067A (ja) * | 2008-09-08 | 2010-03-25 | Tokyo Univ Of Agriculture & Technology | 粒子およびその製造方法、ならびにゲル |
US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
CN102292109A (zh) * | 2008-11-21 | 2011-12-21 | 株式会社三奍社 | 用于治疗耐受性癌症的聚合物胶束组合物及其制备方法 |
EP2201935B1 (de) | 2008-12-26 | 2020-07-08 | Samyang Biopharmaceuticals Corporation | Polymere Mizellenzusammensetzung, die ein schlecht lösliches Arzneimittel enthält, und zugehöriges Herstellungsverfahren |
US20150359777A1 (en) * | 2008-12-26 | 2015-12-17 | Samyang Biopharmaceuticals Corporation | Preparation method of polymeric micellar nanoparticles composition containing a poorly water-soluble drug |
CN102264350A (zh) * | 2008-12-26 | 2011-11-30 | 株式会社三养社 | 包含水溶性差的药物的聚合胶束纳米粒子组合物的制备方法 |
WO2010117668A1 (en) * | 2009-03-30 | 2010-10-14 | Cerulean Pharma Inc. | Polymer-agent conjugates, particles, compositions, and related methods of use |
WO2010114768A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-epothilone conjugates, particles, compositions, and related methods of use |
US8524783B2 (en) | 2009-04-30 | 2013-09-03 | Intezyne Technologies, Incorporated | Polymer micelles containing anthracylines for the treatment of cancer |
US8524784B2 (en) | 2009-04-30 | 2013-09-03 | Intezyne Technologies, Incorporated | Polymer micelles containing anthracylines for the treatment of cancer |
US20110070293A1 (en) | 2009-09-23 | 2011-03-24 | Javeri Indu | Methods for the Preparation of Liposomes Comprising Docetaxel |
US10143652B2 (en) | 2009-09-23 | 2018-12-04 | Curirx Inc. | Methods for the preparation of liposomes |
KR101224004B1 (ko) * | 2009-12-29 | 2013-01-22 | 주식회사 삼양바이오팜 | 단백질, 폴리펩타이드 또는 펩타이드 약물 전달용 고분자 및 그 제조방법, 및 단백질, 폴리펩타이드 또는 펩타이드 약물의 서방형 조성물 및 그 제조 방법 |
KR101267813B1 (ko) | 2009-12-30 | 2013-06-04 | 주식회사 삼양바이오팜 | 향상된 수용해도를 갖는 라파마이신 함유 고분자나노입자 주사제형 조성물 및 그 제조방법, 및 방사선 요법과 병용하기 위한 항암 조성물 |
KR101424163B1 (ko) | 2010-12-24 | 2014-08-01 | 주식회사 삼양바이오팜 | 수난용성 약물 함유 서방성 마이크로입자 및 그 제조방법 |
KR101508275B1 (ko) * | 2011-12-16 | 2015-04-08 | 주식회사 삼양바이오팜 | 고분자 나노입자 수용액 조성물 및 그 제조방법 |
CN103479573B (zh) * | 2013-07-26 | 2017-04-19 | 中国科学院长春应用化学研究所 | 聚乙二醇单甲醚‑聚酯两嵌段共聚物胶束及载药胶束的制备方法 |
CN104086726A (zh) * | 2014-07-08 | 2014-10-08 | 成都市绿科华通科技有限公司 | 聚乳酸星型二嵌段共聚物药用功能材料 |
US10765753B2 (en) * | 2014-12-30 | 2020-09-08 | Samyang Biopharmaceuticals Corporation | Polymer nanoparticle freeze-dried product, and preparation method therefor |
US11246934B2 (en) | 2015-01-05 | 2022-02-15 | B.G. Negev Technologies & Applications Ltd. At Ben-Gurion University | Nanoparticles and methods for preparation thereof |
KR101787453B1 (ko) * | 2015-07-28 | 2017-10-19 | 주식회사 삼양바이오팜 | 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법 |
KR101748191B1 (ko) * | 2015-07-28 | 2017-06-19 | 주식회사 삼양바이오팜 | 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법 |
KR101787451B1 (ko) * | 2015-07-28 | 2017-10-19 | 주식회사 삼양바이오팜 | 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법 |
KR101745429B1 (ko) * | 2015-07-28 | 2017-06-12 | 주식회사 삼양바이오팜 | 양친성 블록 공중합체의 정제방법, 이로부터 얻어지는 양친성 블록 공중합체, 및 이를 포함하는 약학 조성물 |
KR101787447B1 (ko) * | 2015-07-28 | 2017-10-19 | 주식회사 삼양바이오팜 | 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법 |
KR101971672B1 (ko) | 2016-11-18 | 2019-04-23 | 주식회사 삼양바이오팜 | 화학색전용 에멀전 조성물 및 그의 제조방법 |
US10457772B2 (en) | 2017-09-08 | 2019-10-29 | International Business Machines Corporation | Preparation of robust polythioaminal carriers |
CN110156971A (zh) * | 2018-02-13 | 2019-08-23 | 上海时莱生物技术有限公司 | 一种两亲性嵌段共聚物及其制备方法和纳米胶束载药系统 |
Family Cites Families (16)
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JP2709516B2 (ja) | 1989-07-12 | 1998-02-04 | 多木化学株式会社 | 医用組成物 |
IT1243390B (it) * | 1990-11-22 | 1994-06-10 | Vectorpharma Int | Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione. |
CA2087125A1 (en) | 1992-01-23 | 1993-07-24 | Mridula Nair | Chemically fixed micelles |
JP3107451B2 (ja) | 1992-03-31 | 2000-11-06 | 竹本油脂株式会社 | ポリカーボネート樹脂用帯電防止剤及びこれを含有するポリカーボネート樹脂組成物 |
KR940003548U (ko) | 1992-08-14 | 1994-02-21 | 김형술 | 세탁물 건조기 |
JP3270592B2 (ja) | 1992-10-26 | 2002-04-02 | 日本化薬株式会社 | ブロック共重合体−抗癌剤複合体医薬製剤 |
JPH0769917A (ja) | 1993-06-24 | 1995-03-14 | Takeda Chem Ind Ltd | 抗エンドセリン物質の徐放性製剤 |
US5565215A (en) * | 1993-07-23 | 1996-10-15 | Massachusettes Institute Of Technology | Biodegradable injectable particles for imaging |
US6447796B1 (en) * | 1994-05-16 | 2002-09-10 | The United States Of America As Represented By The Secretary Of The Army | Sustained release hydrophobic bioactive PLGA microspheres |
JPH10110019A (ja) | 1996-10-08 | 1998-04-28 | Kazunori Kataoka | 安定化高分子ミセルおよび生理活性物質のキヤリヤーとしてのその使用 |
ZA9811377B (en) | 1997-12-12 | 1999-08-27 | Expression Genetics Inc | Positively charged poly[alpha-(omega-aminoalkyl) glycolic acid[ for the delivery of a bioactive agent via tissue and cellular uptake. |
KR100360827B1 (ko) * | 1999-08-14 | 2002-11-18 | 주식회사 삼양사 | 난용성 약물을 가용화하기 위한 고분자 조성물 및 그의 제조방법 |
US6743446B2 (en) * | 1999-12-15 | 2004-06-01 | The Ohio State University Research Foundation | Methods for stabilizing biologically active agents encapsulated in biodegradable controlled-release polymers |
KR100416242B1 (ko) * | 1999-12-22 | 2004-01-31 | 주식회사 삼양사 | 약물전달체용 생분해성 블록 공중합체의 액체 조성물 및이의 제조방법 |
US7217770B2 (en) | 2000-05-17 | 2007-05-15 | Samyang Corporation | Stable polymeric micelle-type drug composition and method for the preparation thereof |
KR100446101B1 (ko) * | 2000-12-07 | 2004-08-30 | 주식회사 삼양사 | 수난용성 약물의 서방성 제형 조성물 |
-
2002
- 2002-10-17 MX MXPA04003621A patent/MXPA04003621A/es active IP Right Grant
- 2002-10-17 ES ES02781954T patent/ES2292827T3/es not_active Expired - Lifetime
- 2002-10-17 EP EP02781954A patent/EP1448707B1/de not_active Expired - Lifetime
- 2002-10-17 AT AT02781954T patent/ATE370988T1/de not_active IP Right Cessation
- 2002-10-17 WO PCT/KR2002/001942 patent/WO2003033592A1/en active IP Right Grant
- 2002-10-17 US US10/493,043 patent/US7879317B2/en active Active
- 2002-10-17 CA CA2463172A patent/CA2463172C/en not_active Expired - Lifetime
- 2002-10-17 NZ NZ532198A patent/NZ532198A/xx not_active IP Right Cessation
- 2002-10-17 AU AU2002348660A patent/AU2002348660B2/en not_active Expired
- 2002-10-17 DE DE60222007T patent/DE60222007T2/de not_active Expired - Lifetime
- 2002-10-17 CN CNB028205731A patent/CN1303155C/zh not_active Expired - Lifetime
- 2002-10-17 JP JP2003536325A patent/JP3955846B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2463172A1 (en) | 2003-04-24 |
ES2292827T3 (es) | 2008-03-16 |
AU2002348660B2 (en) | 2006-01-12 |
US20040253195A1 (en) | 2004-12-16 |
WO2003033592A1 (en) | 2003-04-24 |
DE60222007D1 (de) | 2007-10-04 |
NZ532198A (en) | 2006-03-31 |
EP1448707A1 (de) | 2004-08-25 |
JP3955846B2 (ja) | 2007-08-08 |
DE60222007T2 (de) | 2008-05-15 |
EP1448707B1 (de) | 2007-08-22 |
CN1571816A (zh) | 2005-01-26 |
MXPA04003621A (es) | 2004-07-30 |
CN1303155C (zh) | 2007-03-07 |
JP2005505674A (ja) | 2005-02-24 |
CA2463172C (en) | 2009-08-18 |
US7879317B2 (en) | 2011-02-01 |
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