ATE358160T1 - Ph-responsive biologisch abbaubare polymilchsäurederivate, die polymermicellen bilden, und deren verwendung zur zufuhr von schlecht wasserlöslichen arzneistoffen - Google Patents
Ph-responsive biologisch abbaubare polymilchsäurederivate, die polymermicellen bilden, und deren verwendung zur zufuhr von schlecht wasserlöslichen arzneistoffenInfo
- Publication number
- ATE358160T1 ATE358160T1 AT02788877T AT02788877T ATE358160T1 AT E358160 T1 ATE358160 T1 AT E358160T1 AT 02788877 T AT02788877 T AT 02788877T AT 02788877 T AT02788877 T AT 02788877T AT E358160 T1 ATE358160 T1 AT E358160T1
- Authority
- AT
- Austria
- Prior art keywords
- polylactic acid
- acid derivatives
- poorly water
- delivery
- form polymer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/08—Lactones or lactides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/78—Preparation processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Polyesters Or Polycarbonates (AREA)
- Biological Depolymerization Polymers (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20010064164 | 2001-10-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE358160T1 true ATE358160T1 (de) | 2007-04-15 |
Family
ID=19715213
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02788877T ATE358160T1 (de) | 2001-10-18 | 2002-10-17 | Ph-responsive biologisch abbaubare polymilchsäurederivate, die polymermicellen bilden, und deren verwendung zur zufuhr von schlecht wasserlöslichen arzneistoffen |
Country Status (14)
Country | Link |
---|---|
US (1) | US8778322B2 (de) |
EP (1) | EP1448710B1 (de) |
JP (1) | JP2005505675A (de) |
KR (1) | KR100517253B1 (de) |
CN (1) | CN1260294C (de) |
AT (1) | ATE358160T1 (de) |
AU (1) | AU2002353551B2 (de) |
CA (1) | CA2463517C (de) |
DE (1) | DE60219194T2 (de) |
ES (1) | ES2283623T3 (de) |
HK (1) | HK1071390A1 (de) |
MX (1) | MXPA04003513A (de) |
NZ (1) | NZ532112A (de) |
WO (1) | WO2003033593A1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003033593A1 (en) * | 2001-10-18 | 2003-04-24 | Samyang Corporation | Ph responsive biodegradable polylactic acid derivatives forming polymeric micelles and uses thereof for poorly water soluble drug delivery |
KR20050054129A (ko) | 2003-12-04 | 2005-06-10 | 주식회사 삼양사 | 고분자 미셀을 형성하는 생분해성 분지형 폴리락트산유도체, 및 그의 제조방법 및 용도 |
KR20050064075A (ko) * | 2003-12-23 | 2005-06-29 | 주식회사 삼양사 | 이트라코나졸을 유효성분으로 하는 약학적 조성물 |
ATE505503T1 (de) * | 2003-12-30 | 2011-04-15 | 3M Innovative Properties Co | Herstellungsverfahren von medizinischen zusammensetzungen |
US7151077B2 (en) | 2004-03-29 | 2006-12-19 | Halliburton Energy Services, Inc. | Polymersome compositions and associated methods of use |
JP4885846B2 (ja) * | 2004-05-06 | 2012-02-29 | サムヤン コーポレーション | 両親性ブロック共重合体及びポリ乳酸誘導体を含む高分子薬物担体に基づいた生物活性剤の細胞内伝達システム |
KR101118199B1 (ko) * | 2004-12-20 | 2012-03-15 | 주식회사 삼양홀딩스 | 타크롤리무스를 가용화하기 위한 고분자 미셀 조성물 |
US7677315B2 (en) | 2005-05-12 | 2010-03-16 | Halliburton Energy Services, Inc. | Degradable surfactants and methods for use |
US7662753B2 (en) | 2005-05-12 | 2010-02-16 | Halliburton Energy Services, Inc. | Degradable surfactants and methods for use |
WO2009073216A1 (en) * | 2007-12-06 | 2009-06-11 | Bend Research, Inc. | Nanoparticles comprising a non-ionizable polymer and an amine-functionalized methacrylate copolymer |
KR101187487B1 (ko) * | 2007-12-31 | 2012-10-02 | 주식회사 삼양바이오팜 | 고순도의 폴리 알파(α)-히드록시산의 소수성 고분자 블록을 포함하는 양친성 블록 공중합체 및 그의 제조방법 |
DE102008002471A1 (de) * | 2008-06-17 | 2009-12-24 | Biotronik Vi Patent Ag | Stent mit einer Beschichtung oder einem Grundkörper, der ein Lithiumsalz enthält, und Verwendung von Lithiumsalzen zur Restenoseprophylaxe |
KR101224004B1 (ko) * | 2009-12-29 | 2013-01-22 | 주식회사 삼양바이오팜 | 단백질, 폴리펩타이드 또는 펩타이드 약물 전달용 고분자 및 그 제조방법, 및 단백질, 폴리펩타이드 또는 펩타이드 약물의 서방형 조성물 및 그 제조 방법 |
KR101424163B1 (ko) * | 2010-12-24 | 2014-08-01 | 주식회사 삼양바이오팜 | 수난용성 약물 함유 서방성 마이크로입자 및 그 제조방법 |
KR101411349B1 (ko) | 2010-12-24 | 2014-06-25 | 주식회사 삼양바이오팜 | 생리활성 펩타이드를 포함하는 마이크로입자 및 그의 제조방법, 및 그를 포함하는 약제학적 조성물 |
KR101508275B1 (ko) | 2011-12-16 | 2015-04-08 | 주식회사 삼양바이오팜 | 고분자 나노입자 수용액 조성물 및 그 제조방법 |
US9260601B2 (en) | 2012-09-26 | 2016-02-16 | General Electric Company | Single drum oil and aqueous products and methods of use |
CA2881292C (en) | 2012-08-14 | 2021-01-12 | General Electric Company | Demulsifying compositions and methods of use |
JP6564369B2 (ja) | 2013-12-09 | 2019-08-21 | デュレクト コーポレイション | 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法 |
US10160896B2 (en) | 2015-04-27 | 2018-12-25 | Halliburton Energy Services, Inc. | Delayed-release additives in a degradable matrix |
WO2017041095A1 (en) * | 2015-09-03 | 2017-03-09 | Allegheny-Singer Research Institute | Hydrophilic fentanyl derivatives |
KR101971672B1 (ko) | 2016-11-18 | 2019-04-23 | 주식회사 삼양바이오팜 | 화학색전용 에멀전 조성물 및 그의 제조방법 |
CN112791068B (zh) * | 2021-02-08 | 2022-06-21 | 郑州大学 | 一种co2响应性微纳米给药系统的制备方法及其应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
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US4010196A (en) * | 1975-06-25 | 1977-03-01 | American Home Products Corporation | Linear polyester salts |
JPS588098A (ja) * | 1981-07-03 | 1983-01-18 | Nisshin Oil Mills Ltd:The | エステル化生成物ならびにこれらを含む化粧料及び外用剤 |
US4479911A (en) * | 1982-01-28 | 1984-10-30 | Sandoz, Inc. | Process for preparation of microspheres and modification of release rate of core material |
JP2670680B2 (ja) * | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | 生理活性物質含有ポリ乳酸系微小球およびその製造法 |
US5023349A (en) * | 1990-05-08 | 1991-06-11 | E. I. Du Pont De Nemours And Company | Continuous process for rapid conversion of oligomers to cyclic esters |
JP3353853B2 (ja) * | 1994-06-01 | 2002-12-03 | 東洋紡績株式会社 | 実質的に全末端水酸基をエステル封鎖したポリ乳酸およびその製造法 |
US6447796B1 (en) * | 1994-05-16 | 2002-09-10 | The United States Of America As Represented By The Secretary Of The Army | Sustained release hydrophobic bioactive PLGA microspheres |
KR100369764B1 (ko) * | 1994-07-20 | 2003-05-22 | 키너톤 리미티드 | 생분해성폴리에스테르및생활성폴리펩티드의이온성분자결합체 |
JP3426432B2 (ja) * | 1995-02-22 | 2003-07-14 | ベーガン通商株式会社 | 繊維柔軟処理剤及び繊維や繊維製品の柔軟処理方法 |
CA2229068A1 (en) * | 1995-08-10 | 1997-02-20 | Masao Kato | Block polymer having functional groups on its both ends |
JPH0959218A (ja) * | 1995-08-25 | 1997-03-04 | Shimadzu Corp | L−乳酸オリゴマー誘導体 |
US5665428A (en) * | 1995-10-25 | 1997-09-09 | Macromed, Inc. | Preparation of peptide containing biodegradable microspheres by melt process |
KR100190230B1 (ko) * | 1996-06-19 | 1999-06-01 | 김윤 | 생분해성 폴리락트산의 제조방법 |
JPH10110019A (ja) * | 1996-10-08 | 1998-04-28 | Kazunori Kataoka | 安定化高分子ミセルおよび生理活性物質のキヤリヤーとしてのその使用 |
WO2003033593A1 (en) * | 2001-10-18 | 2003-04-24 | Samyang Corporation | Ph responsive biodegradable polylactic acid derivatives forming polymeric micelles and uses thereof for poorly water soluble drug delivery |
KR100492805B1 (ko) * | 2001-10-18 | 2005-06-07 | 주식회사 삼양사 | 안정성이 향상된 고분자 미셀 조성물 |
KR20050054129A (ko) * | 2003-12-04 | 2005-06-10 | 주식회사 삼양사 | 고분자 미셀을 형성하는 생분해성 분지형 폴리락트산유도체, 및 그의 제조방법 및 용도 |
-
2002
- 2002-10-17 WO PCT/KR2002/001943 patent/WO2003033593A1/en active IP Right Grant
- 2002-10-17 AT AT02788877T patent/ATE358160T1/de not_active IP Right Cessation
- 2002-10-17 CN CNB028206185A patent/CN1260294C/zh not_active Expired - Lifetime
- 2002-10-17 DE DE60219194T patent/DE60219194T2/de not_active Expired - Lifetime
- 2002-10-17 MX MXPA04003513A patent/MXPA04003513A/es active IP Right Grant
- 2002-10-17 US US10/492,091 patent/US8778322B2/en active Active
- 2002-10-17 NZ NZ532112A patent/NZ532112A/en not_active IP Right Cessation
- 2002-10-17 CA CA2463517A patent/CA2463517C/en not_active Expired - Lifetime
- 2002-10-17 JP JP2003536326A patent/JP2005505675A/ja active Pending
- 2002-10-17 AU AU2002353551A patent/AU2002353551B2/en not_active Ceased
- 2002-10-17 EP EP02788877A patent/EP1448710B1/de not_active Expired - Lifetime
- 2002-10-17 ES ES02788877T patent/ES2283623T3/es not_active Expired - Lifetime
- 2002-10-18 KR KR10-2002-0063955A patent/KR100517253B1/ko active IP Right Grant
-
2005
- 2005-02-24 HK HK05101567A patent/HK1071390A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR20030032896A (ko) | 2003-04-26 |
KR100517253B1 (ko) | 2005-09-28 |
US8778322B2 (en) | 2014-07-15 |
EP1448710A1 (de) | 2004-08-25 |
AU2002353551B2 (en) | 2005-09-08 |
US20040247561A1 (en) | 2004-12-09 |
EP1448710B1 (de) | 2007-03-28 |
WO2003033593A1 (en) | 2003-04-24 |
CN1260294C (zh) | 2006-06-21 |
MXPA04003513A (es) | 2004-07-23 |
HK1071390A1 (en) | 2005-07-15 |
JP2005505675A (ja) | 2005-02-24 |
DE60219194D1 (de) | 2007-05-10 |
CN1571817A (zh) | 2005-01-26 |
CA2463517C (en) | 2010-03-16 |
DE60219194T2 (de) | 2008-01-03 |
CA2463517A1 (en) | 2003-04-24 |
NZ532112A (en) | 2005-09-30 |
ES2283623T3 (es) | 2007-11-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |