ATE405251T1 - Zusammensetzungen zur verzögerten abgabe von hydrophoben arzneimitteln und verfahren zu ihrer herstellung - Google Patents

Zusammensetzungen zur verzögerten abgabe von hydrophoben arzneimitteln und verfahren zu ihrer herstellung

Info

Publication number
ATE405251T1
ATE405251T1 AT01999357T AT01999357T ATE405251T1 AT E405251 T1 ATE405251 T1 AT E405251T1 AT 01999357 T AT01999357 T AT 01999357T AT 01999357 T AT01999357 T AT 01999357T AT E405251 T1 ATE405251 T1 AT E405251T1
Authority
AT
Austria
Prior art keywords
drug
compositions
composition
production
delayed release
Prior art date
Application number
AT01999357T
Other languages
English (en)
Inventor
Min-Hyo Seo
Yil-Woong Yi
Sang-Jun Lee
Jae-Hong Kim
Original Assignee
Samyang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samyang Corp filed Critical Samyang Corp
Application granted granted Critical
Publication of ATE405251T1 publication Critical patent/ATE405251T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
AT01999357T 2000-12-07 2001-12-07 Zusammensetzungen zur verzögerten abgabe von hydrophoben arzneimitteln und verfahren zu ihrer herstellung ATE405251T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20000074098 2000-12-07

Publications (1)

Publication Number Publication Date
ATE405251T1 true ATE405251T1 (de) 2008-09-15

Family

ID=19702771

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01999357T ATE405251T1 (de) 2000-12-07 2001-12-07 Zusammensetzungen zur verzögerten abgabe von hydrophoben arzneimitteln und verfahren zu ihrer herstellung

Country Status (10)

Country Link
US (1) US7153520B2 (de)
EP (1) EP1339389B1 (de)
JP (1) JP2004514734A (de)
KR (1) KR100446101B1 (de)
CN (1) CN1234416C (de)
AT (1) ATE405251T1 (de)
AU (2) AU2273302A (de)
CA (1) CA2430481C (de)
DE (1) DE60135486D1 (de)
WO (1) WO2002045689A1 (de)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050042194A1 (en) * 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
CN1325046C (zh) * 2001-08-31 2007-07-11 麦吉尔大学 可生物降解的多聚纳米微囊及其应用
CA2463172C (en) * 2001-10-18 2009-08-18 Samyang Corporation Polymeric micelle composition with improved stability
US7649023B2 (en) 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
WO2004011054A2 (en) 2002-07-31 2004-02-05 Alza Corporation Injectable multimodal polymer depot compositions and uses thereof
US8986737B2 (en) 2002-09-05 2015-03-24 Wm. Marsh Rice University Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth
CA2497973C (en) * 2002-09-05 2012-11-06 Catherine G. Ambrose Antibiotic microspheres for treatment of infections and osteomyelitis
DE60319727T2 (de) * 2002-10-21 2009-03-12 L'oreal Verfahren zum auflösen lipophiler verbindungen, und kosmetische zusammensetzung.
AU2004241830B9 (en) * 2003-05-26 2010-04-22 Hiroshi Maeda Antitumor agent and process for producing the same
CN101862455A (zh) 2003-06-26 2010-10-20 普西维达公司 原位胶凝的药物递送系统
AR047552A1 (es) 2003-06-26 2006-01-25 Control Delivery Sys Inc Sistemas de suministro de farmacos de liberacion sostenida biodegradables
JP4939936B2 (ja) * 2003-06-27 2012-05-30 株式會社アモーレパシフィック 生理活性成分を含有する自己集合性高分子ナノ粒子の製造方法、及び得られた自己集合性高分子ナノ粒子を含有する外用剤組成物
WO2005000258A1 (en) * 2003-06-27 2005-01-06 Amorepacific Corporation Self-assembled polymeric nanoparticles containing physiologically active ingredients and external application containing the nanoparticles
KR101054728B1 (ko) 2004-06-16 2011-08-05 (주)아모레퍼시픽 난용성 발모 및 육모 생리활성 물질인 사이클로스포린을포함하는 나노입자 및 이를 함유하는 피부 외용제 조성물
KR100967113B1 (ko) 2003-12-03 2010-07-05 (주)아모레퍼시픽 코엔자임 ｑ10을 함유한 자기회합성 고분자 나노입자 및이를 함유한 피부 외용제 조성물
KR20050064075A (ko) * 2003-12-23 2005-06-29 주식회사 삼양사 이트라코나졸을 유효성분으로 하는 약학적 조성물
GB0412866D0 (en) * 2004-06-09 2004-07-14 Novartis Ag Organic compounds
US8980300B2 (en) 2004-08-05 2015-03-17 Advanced Cardiovascular Systems, Inc. Plasticizers for coating compositions
US20060034889A1 (en) * 2004-08-16 2006-02-16 Macromed, Inc. Biodegradable diblock copolymers having reverse thermal gelation properties and methods of use thereof
CA2585754C (en) 2004-11-02 2014-12-23 Tel-Aviv University Future Technology Development L.P. Formulations of water insoluble or poorly water soluble drugs in lipidated glycosaminoglycan particles and their use for diagnostics and therapy
EP2348096A3 (de) * 2005-01-04 2011-11-09 Intezyne Technologies Inc. Synthese aus Hybridblockcopolymeren und Verwendungen davon.
JP2007023023A (ja) * 2005-06-15 2007-02-01 Kanagawa Acad Of Sci & Technol 組織接着性薬剤放出ゲル形成用組成物
EP2063970A1 (de) * 2006-09-19 2009-06-03 FUJIFILM Manufacturing Europe B.V. Herstellung von feinen teilchen
JP2010504318A (ja) * 2006-09-22 2010-02-12 ラボファーム インコーポレイテッド ｐＨ標的化薬剤送達のための組成物及び方法
KR100946275B1 (ko) * 2006-09-26 2010-03-08 주식회사 삼양사 수 난용성 캄토테신 유도체의 미세 나노입자 및 그의제조방법
US20090004243A1 (en) 2007-06-29 2009-01-01 Pacetti Stephen D Biodegradable triblock copolymers for implantable devices
GB0714223D0 (en) * 2007-07-20 2007-08-29 Fujifilm Mfg Europe Bv Preparation of fine particles
GB0720716D0 (en) * 2007-10-23 2007-12-05 York Pharma Plc Novel formulation
US8642062B2 (en) * 2007-10-31 2014-02-04 Abbott Cardiovascular Systems Inc. Implantable device having a slow dissolving polymer
WO2009064442A1 (en) 2007-11-13 2009-05-22 Brookwood Pharmaceuticals, Inc. Viscous terpolymers as drug delivery platform
BRPI0821619B1 (pt) * 2007-12-31 2018-12-18 Samyang Biopharmaceuticals método para preparação de um copolímero de bloco anfifílico
US9801818B2 (en) 2007-12-31 2017-10-31 Samyang Biopharmaceuticals Corporation Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug
KR101024742B1 (ko) * 2007-12-31 2011-03-24 주식회사 삼양사 탁산 함유 양친성 블록 공중합체 미셀 조성물 및 그 제조방법
CN101909601B (zh) * 2008-01-18 2013-06-26 陶氏环球技术公司 使用甲氧基聚乙二醇增强难溶性活性剂的水溶解度的方法
CN101932311B (zh) 2008-02-22 2014-07-16 东丽株式会社 微粒及其药物组合物
US8858995B2 (en) * 2008-03-10 2014-10-14 University Of Louisville Research Foundation, Inc. Methods and compositions for controlled delivery of phytochemical agents
EP2103313A1 (de) * 2008-03-19 2009-09-23 Koninklijke Philips Electronics N.V. Verfahren für die Synthese von Hohlkugeln
TWI388591B (zh) * 2008-03-28 2013-03-11 Ind Tech Res Inst 溫度敏感性材料
US8916188B2 (en) 2008-04-18 2014-12-23 Abbott Cardiovascular Systems Inc. Block copolymer comprising at least one polyester block and a poly (ethylene glycol) block
US8613951B2 (en) 2008-06-16 2013-12-24 Bind Therapeutics, Inc. Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same
WO2010005725A2 (en) 2008-06-16 2010-01-14 Bind Biosciences, Inc. Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same
JP2012501965A (ja) 2008-06-16 2012-01-26 バインド バイオサイエンシズ インコーポレイテッド 薬剤を装填したポリマーナノ粒子及びその製造方法と使用方法
PT2323623T (pt) 2008-08-12 2016-11-04 Novartis Ag Composições farmacêuticas
EP2172189A1 (de) * 2008-10-01 2010-04-07 Novartis AG Pharmazeutische Zusammensetzungen
JP2010065067A (ja) * 2008-09-08 2010-03-25 Tokyo Univ Of Agriculture & Technology 粒子およびその製造方法、ならびにゲル
CA2738766A1 (en) * 2008-09-25 2010-04-01 Invivo Therapeutics Corporation Spinal cord injury, inflammation, and immune-disease: local controlled release of therapeutic agents
EP2370064A4 (de) * 2008-12-11 2012-09-19 A P Pharma Inc Verfahren zur erhöhung der stabilität von polyorthoestern und ihren formulierungen
TWI372057B (en) * 2008-12-11 2012-09-11 Dev Center Biotechnology Sustained release implant for granisetron
WO2010075072A2 (en) 2008-12-15 2010-07-01 Bind Biosciences Long circulating nanoparticles for sustained release of therapeutic agents
US8951546B2 (en) 2008-12-23 2015-02-10 Surmodics Pharmaceuticals, Inc. Flexible implantable composites and implants comprising same
US20100158978A1 (en) * 2008-12-23 2010-06-24 Peter Markland Bioactive spray coating compositions and methods of making and uses thereof
US9415197B2 (en) 2008-12-23 2016-08-16 Surmodics, Inc. Implantable suction cup composites and implants comprising same
US9480643B2 (en) * 2008-12-23 2016-11-01 Surmodics Pharmaceuticals, Inc. Implantable composites and implants comprising same
US8974808B2 (en) 2008-12-23 2015-03-10 Surmodics, Inc. Elastic implantable composites and implants comprising same
EP2201935B1 (de) * 2008-12-26 2020-07-08 Samyang Biopharmaceuticals Corporation Polymere Mizellenzusammensetzung, die ein schlecht lösliches Arzneimittel enthält, und zugehöriges Herstellungsverfahren
TWI374903B (en) * 2008-12-31 2012-10-21 Ind Tech Res Inst Biodegradable copolymer hydrogel materials
US20100203150A1 (en) * 2009-02-06 2010-08-12 National Tsing Hua University Novel amphiphilic copolymers and fabrication method thereof
WO2010114768A1 (en) * 2009-03-30 2010-10-07 Cerulean Pharma Inc. Polymer-epothilone conjugates, particles, compositions, and related methods of use
CA2756072A1 (en) * 2009-03-30 2010-10-14 Cerulean Pharma Inc. Polymer-agent conjugates, particles, compositions, and related methods of use
CA2940931C (en) 2009-10-01 2019-04-30 Adare Pharmaceuticals, Inc. Orally administered corticosteroid compositions
EP2509634B1 (de) 2009-12-11 2019-03-06 Pfizer Inc Stabile formulierungen zur lyophilisation therapeutischer partikel
JP5965844B2 (ja) * 2009-12-15 2016-08-10 バインド セラピューティックス インコーポレイテッド 高いガラス転移温度または高分子量のコポリマーを有する治療用ポリマーナノ粒子組成物
US20110237686A1 (en) 2010-03-26 2011-09-29 Cerulean Pharma Inc Formulations and methods of use
UA111162C2 (uk) 2010-08-04 2016-04-11 Флекшен Терап'Ютікс, Інк. Ін'єкційна композиція ацетоніду триамцинолону для лікування болю
WO2012030819A1 (en) 2010-08-30 2012-03-08 Surmodics Pharmaceuticals, Inc. Terpolymers as pressure-sensitive adhesives
PT2658525T (pt) 2010-12-29 2017-11-30 Medincell Composições biodegradáveis de entrega de fármaco
WO2012177825A1 (en) 2011-06-21 2012-12-27 Bvw Holding Ag Medical device comprising boswellic acid
WO2013148682A1 (en) * 2012-03-26 2013-10-03 University Of Louisville Research Foundation, Inc. Methods and compositions for controlled delivery of phytochemical agents
CU24287B1 (es) * 2012-06-27 2017-12-08 Medincell Suministro de fármaco biodegradable para las composiciones hidrofóbicas
ES2732377T3 (es) 2012-09-17 2019-11-22 Pfizer Procedimiento de preparación de nanopartículas terapéuticas
US20150104520A1 (en) * 2013-04-05 2015-04-16 Vuong Trieu Nanoparticle Formulations in Biomarker Detection
WO2015034678A2 (en) 2013-09-06 2015-03-12 Aptalis Pharmatech, Inc. Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis
CN104758256B (zh) * 2014-02-14 2016-05-04 苏州海特比奥生物技术有限公司 一种多西他赛纳米聚合物胶束冻干制剂及其制备方法
BR112016021130A2 (pt) 2014-03-14 2017-08-15 Pfizer Nanopartículas terapêuticas, composição farmacêutica compreendendo as referidas nanopartículas, processo para a preparação e uso das mesmas
WO2016205652A1 (en) * 2015-06-18 2016-12-22 Acuitybio Corporation Implantable drug delivery compositions and methods of use thereof
PT3377041T (pt) 2015-11-16 2023-12-15 Maria Pereira Da Cruz Alves Garcia Método para morcelação e/ou direcionamento de princípios farmaceuticamente ativos ao tecido sinovial
TWI777515B (zh) 2016-08-18 2022-09-11 美商愛戴爾製藥股份有限公司 治療嗜伊紅性食道炎之方法
CN106727306A (zh) * 2016-12-12 2017-05-31 温州医科大学 一种高载药量曲安奈德胶束的制备方法
CN107596380B (zh) * 2017-09-03 2020-09-11 河南师范大学 基于聚乙二醇-聚碳酸酯的还原敏感性喜树碱前药及其制备方法和应用
KR102072419B1 (ko) * 2018-04-19 2020-02-03 중앙대학교 산학협력단 항암제 봉입 마이셀 제제 조성물
WO2021146215A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods
BR112022020991A2 (pt) * 2020-08-31 2023-03-07 Vaim Co Ltd Dispersão de polímero biodegradável, composição compreendendo a mesma e sistema de melhoria da pele
CN114903904B (zh) * 2021-02-08 2024-02-09 宜昌人福药业有限责任公司 瑞马唑仑药用盐和阿片样物质的注射用药物组合物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2080682B (en) * 1980-07-30 1984-03-28 Ciba Geigy Ag Antiherpetically active lipstick
CA2050067C (en) * 1990-08-30 2000-05-30 Yasushi Morita Controlled drug release composition
US5543158A (en) * 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
JPH08176016A (ja) * 1994-12-19 1996-07-09 Univ Miami 生分解可能で注射可能な薬物運搬ポリマー
US5869079A (en) 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US5702717A (en) * 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
US6004573A (en) 1997-10-03 1999-12-21 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US20020164374A1 (en) * 1997-10-29 2002-11-07 John Jackson Polymeric systems for drug delivery and uses thereof
KR100289074B1 (ko) * 1998-02-04 2001-07-12 김윤 난용성약물함유시스템
US7128927B1 (en) * 1998-04-14 2006-10-31 Qlt Usa, Inc. Emulsions for in-situ delivery systems
KR100274842B1 (ko) * 1998-10-01 2001-03-02 김효근 미립구를 이용한 레티노익산의 서방형 약물방출 시스템
KR100360827B1 (ko) * 1999-08-14 2002-11-18 주식회사 삼양사 난용성 약물을 가용화하기 위한 고분자 조성물 및 그의 제조방법
US7550157B2 (en) * 2000-05-12 2009-06-23 Samyang Corporation Method for the preparation of polymeric micelle via phase separation of block copolymer
US7217770B2 (en) * 2000-05-17 2007-05-15 Samyang Corporation Stable polymeric micelle-type drug composition and method for the preparation thereof

Also Published As

Publication number Publication date
EP1339389A1 (de) 2003-09-03
CN1477952A (zh) 2004-02-25
EP1339389A4 (de) 2007-08-08
CA2430481A1 (en) 2002-06-13
KR20020045569A (ko) 2002-06-19
EP1339389B1 (de) 2008-08-20
WO2002045689A1 (en) 2002-06-13
CA2430481C (en) 2008-07-22
DE60135486D1 (de) 2008-10-02
AU2273302A (en) 2002-06-18
US7153520B2 (en) 2006-12-26
JP2004514734A (ja) 2004-05-20
KR100446101B1 (ko) 2004-08-30
CN1234416C (zh) 2006-01-04
AU2002222733B2 (en) 2006-03-30
US20040037885A1 (en) 2004-02-26

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