DE60135486D1 - Zusammensetzungen zur verzögerten abgabe von hydrophoben arzneimitteln und verfahren zu ihrer herstellung - Google Patents
Zusammensetzungen zur verzögerten abgabe von hydrophoben arzneimitteln und verfahren zu ihrer herstellungInfo
- Publication number
- DE60135486D1 DE60135486D1 DE60135486T DE60135486T DE60135486D1 DE 60135486 D1 DE60135486 D1 DE 60135486D1 DE 60135486 T DE60135486 T DE 60135486T DE 60135486 T DE60135486 T DE 60135486T DE 60135486 D1 DE60135486 D1 DE 60135486D1
- Authority
- DE
- Germany
- Prior art keywords
- drug
- composition
- compositions
- production
- delayed delivery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 206010012186 Delayed delivery Diseases 0.000 title 1
- 230000002209 hydrophobic effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 229940079593 drug Drugs 0.000 abstract 5
- 239000007943 implant Substances 0.000 abstract 2
- -1 poly(ethylene glycol) Polymers 0.000 abstract 2
- 229920002988 biodegradable polymer Polymers 0.000 abstract 1
- 239000004621 biodegradable polymer Substances 0.000 abstract 1
- 229920000359 diblock copolymer Polymers 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000693 micelle Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Biological Depolymerization Polymers (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20000074098 | 2000-12-07 | ||
PCT/KR2001/002121 WO2002045689A1 (en) | 2000-12-07 | 2001-12-07 | Compositions for sustained delivery of hydrophobic drugs and process for the preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60135486D1 true DE60135486D1 (de) | 2008-10-02 |
Family
ID=19702771
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60135486T Expired - Lifetime DE60135486D1 (de) | 2000-12-07 | 2001-12-07 | Zusammensetzungen zur verzögerten abgabe von hydrophoben arzneimitteln und verfahren zu ihrer herstellung |
Country Status (10)
Country | Link |
---|---|
US (1) | US7153520B2 (de) |
EP (1) | EP1339389B1 (de) |
JP (1) | JP2004514734A (de) |
KR (1) | KR100446101B1 (de) |
CN (1) | CN1234416C (de) |
AT (1) | ATE405251T1 (de) |
AU (2) | AU2002222733B2 (de) |
CA (1) | CA2430481C (de) |
DE (1) | DE60135486D1 (de) |
WO (1) | WO2002045689A1 (de) |
Families Citing this family (84)
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US20050042194A1 (en) * | 2000-05-11 | 2005-02-24 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
WO2003017987A1 (en) * | 2001-08-31 | 2003-03-06 | Mcgill University | Biodegradable polymeric nanocapsules and uses thereof |
MXPA04003621A (es) * | 2001-10-18 | 2004-07-30 | Samyang Corp | Composicion de micela polimerica con estabilidad mejorada. |
US7649023B2 (en) | 2002-06-11 | 2010-01-19 | Novartis Ag | Biodegradable block copolymeric compositions for drug delivery |
US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
NZ537953A (en) | 2002-07-31 | 2007-02-23 | Alza Corp | Injectable multimodal polymer depot compositions and uses thereof |
AU2003272284B2 (en) * | 2002-09-05 | 2009-03-05 | Catherine G. Ambrose | Antibiotic microspheres for treatment of infections and osteomyelitis |
US8986737B2 (en) | 2002-09-05 | 2015-03-24 | Wm. Marsh Rice University | Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth |
EP1555984B1 (de) * | 2002-10-21 | 2008-03-12 | L'oreal | Verfahren zum auflösen lipophiler verbindungen, und kosmetische zusammensetzung. |
EP1627645B1 (de) * | 2003-05-26 | 2017-08-23 | Hiroshi Maeda | Antitumorales mittel und verfahren zu seiner herstellung |
EP1635875B8 (de) * | 2003-06-26 | 2008-12-24 | pSivida Inc | In-situ gelierendes arzneimittelabgabesystem |
WO2005000268A2 (en) | 2003-06-26 | 2005-01-06 | Control Delivery Systems, Inc. | Bioerodible sustained release drug delivery systems |
KR101054728B1 (ko) | 2004-06-16 | 2011-08-05 | (주)아모레퍼시픽 | 난용성 발모 및 육모 생리활성 물질인 사이클로스포린을포함하는 나노입자 및 이를 함유하는 피부 외용제 조성물 |
JP4939936B2 (ja) * | 2003-06-27 | 2012-05-30 | 株式會社アモーレパシフィック | 生理活性成分を含有する自己集合性高分子ナノ粒子の製造方法、及び得られた自己集合性高分子ナノ粒子を含有する外用剤組成物 |
WO2005000258A1 (en) * | 2003-06-27 | 2005-01-06 | Amorepacific Corporation | Self-assembled polymeric nanoparticles containing physiologically active ingredients and external application containing the nanoparticles |
KR100967113B1 (ko) | 2003-12-03 | 2010-07-05 | (주)아모레퍼시픽 | 코엔자임 q10을 함유한 자기회합성 고분자 나노입자 및이를 함유한 피부 외용제 조성물 |
KR20050064075A (ko) * | 2003-12-23 | 2005-06-29 | 주식회사 삼양사 | 이트라코나졸을 유효성분으로 하는 약학적 조성물 |
GB0412866D0 (en) * | 2004-06-09 | 2004-07-14 | Novartis Ag | Organic compounds |
US8980300B2 (en) | 2004-08-05 | 2015-03-17 | Advanced Cardiovascular Systems, Inc. | Plasticizers for coating compositions |
US20060034889A1 (en) * | 2004-08-16 | 2006-02-16 | Macromed, Inc. | Biodegradable diblock copolymers having reverse thermal gelation properties and methods of use thereof |
EP1827395A2 (de) | 2004-11-02 | 2007-09-05 | Tel-Aviv University Future Technology Development L.P. | Formulierungen von wasserunlöslichen oder schwer wasserlöslichen arzneimitteln in lipidierten glykosaminoglykanpartikeln, deren herstellung und deren verwendung zur diagnose und therapie |
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US20090004243A1 (en) | 2007-06-29 | 2009-01-01 | Pacetti Stephen D | Biodegradable triblock copolymers for implantable devices |
GB0714223D0 (en) * | 2007-07-20 | 2007-08-29 | Fujifilm Mfg Europe Bv | Preparation of fine particles |
GB0720716D0 (en) * | 2007-10-23 | 2007-12-05 | York Pharma Plc | Novel formulation |
US8642062B2 (en) * | 2007-10-31 | 2014-02-04 | Abbott Cardiovascular Systems Inc. | Implantable device having a slow dissolving polymer |
US9090737B2 (en) | 2007-11-13 | 2015-07-28 | Surmodics, Inc. | Viscous terpolymers as drug delivery platform |
US9801818B2 (en) | 2007-12-31 | 2017-10-31 | Samyang Biopharmaceuticals Corporation | Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug |
KR101024742B1 (ko) * | 2007-12-31 | 2011-03-24 | 주식회사 삼양사 | 탁산 함유 양친성 블록 공중합체 미셀 조성물 및 그 제조방법 |
JP5576291B2 (ja) * | 2007-12-31 | 2014-08-20 | サムヤン バイオファーマシューティカルズ コーポレイション | ポリ(α−ヒドロキシ酸)の疎水性高分子ブロックを含む高純度の両親媒性ブロック共重合体及びその製造方法 |
CN101909601B (zh) * | 2008-01-18 | 2013-06-26 | 陶氏环球技术公司 | 使用甲氧基聚乙二醇增强难溶性活性剂的水溶解度的方法 |
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US8858995B2 (en) * | 2008-03-10 | 2014-10-14 | University Of Louisville Research Foundation, Inc. | Methods and compositions for controlled delivery of phytochemical agents |
EP2103313A1 (de) * | 2008-03-19 | 2009-09-23 | Koninklijke Philips Electronics N.V. | Verfahren für die Synthese von Hohlkugeln |
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EP2309991B1 (de) | 2008-06-16 | 2019-03-06 | Pfizer Inc | Therapeutische polymernanopartikel mit vincaalkaloiden sowie verfahren zu ihrer herstellung und verwendung |
US8613951B2 (en) | 2008-06-16 | 2013-12-24 | Bind Therapeutics, Inc. | Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same |
PT2774608T (pt) | 2008-06-16 | 2020-01-17 | Pfizer | Nanopartículas poliméricas carregadas com fármaco e métodos de produção e utilização das mesmas |
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JP2010065067A (ja) * | 2008-09-08 | 2010-03-25 | Tokyo Univ Of Agriculture & Technology | 粒子およびその製造方法、ならびにゲル |
EP2346515A4 (de) * | 2008-09-25 | 2013-01-23 | Invivo Therapeutics Corp | Rückenmarksläsion, entzündung und immunerkrankung: lokale gesteuerte freisetzung von therapeutika |
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EP2201935B1 (de) * | 2008-12-26 | 2020-07-08 | Samyang Biopharmaceuticals Corporation | Polymere Mizellenzusammensetzung, die ein schlecht lösliches Arzneimittel enthält, und zugehöriges Herstellungsverfahren |
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US20100203150A1 (en) * | 2009-02-06 | 2010-08-12 | National Tsing Hua University | Novel amphiphilic copolymers and fabrication method thereof |
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SI3403654T1 (sl) | 2009-10-01 | 2019-10-30 | Adare Dev I L P | Oralno administrirani kortikosteroidni sestavki |
JP5891175B2 (ja) | 2009-12-11 | 2016-03-22 | バインド セラピューティックス インコーポレイテッド | 治療用粒子の凍結乾燥に対する安定製剤 |
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WO2011119995A2 (en) | 2010-03-26 | 2011-09-29 | Cerulean Pharma Inc. | Formulations and methods of use |
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WO2013148682A1 (en) * | 2012-03-26 | 2013-10-03 | University Of Louisville Research Foundation, Inc. | Methods and compositions for controlled delivery of phytochemical agents |
EP2866837B1 (de) * | 2012-06-27 | 2022-12-14 | Medincell S.A. | Biologisch abbaubare wirkstofffreisetzung für hydrophobe zusammensetzungen |
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CN104761710B (zh) * | 2014-02-14 | 2016-06-29 | 苏州海特比奥生物技术有限公司 | 一种聚乙二醇单甲醚-聚乳酸嵌段共聚物及其制备方法 |
ME03435B (de) | 2014-03-14 | 2020-01-20 | Pfizer | Therapeutische nanopartikel mit einem behandlungsmittel sowie verfahren zur herstellung und verwendung davon |
AU2016280274B2 (en) * | 2015-06-18 | 2021-12-02 | Acuitybio Corporation | Implantable drug delivery compositions and methods of use thereof |
LT3377041T (lt) | 2015-11-16 | 2023-12-27 | Medincell S.A. | Farmaciškai aktyvių komponentų suskaidymo ir (arba) nukreipimo į sinovinį audinį būdas |
TWI777515B (zh) | 2016-08-18 | 2022-09-11 | 美商愛戴爾製藥股份有限公司 | 治療嗜伊紅性食道炎之方法 |
CN106727306A (zh) * | 2016-12-12 | 2017-05-31 | 温州医科大学 | 一种高载药量曲安奈德胶束的制备方法 |
CN107596380B (zh) * | 2017-09-03 | 2020-09-11 | 河南师范大学 | 基于聚乙二醇-聚碳酸酯的还原敏感性喜树碱前药及其制备方法和应用 |
KR102072419B1 (ko) * | 2018-04-19 | 2020-02-03 | 중앙대학교 산학협력단 | 항암제 봉입 마이셀 제제 조성물 |
KR20220140711A (ko) | 2020-01-13 | 2022-10-18 | 듀렉트 코퍼레이션 | 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법 |
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CN114903904B (zh) * | 2021-02-08 | 2024-02-09 | 宜昌人福药业有限责任公司 | 瑞马唑仑药用盐和阿片样物质的注射用药物组合物 |
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-
2001
- 2001-12-06 KR KR10-2001-0077044A patent/KR100446101B1/ko active IP Right Grant
- 2001-12-07 US US10/416,980 patent/US7153520B2/en not_active Expired - Lifetime
- 2001-12-07 DE DE60135486T patent/DE60135486D1/de not_active Expired - Lifetime
- 2001-12-07 JP JP2002547475A patent/JP2004514734A/ja active Pending
- 2001-12-07 CN CNB018195784A patent/CN1234416C/zh not_active Expired - Fee Related
- 2001-12-07 EP EP01999357A patent/EP1339389B1/de not_active Expired - Lifetime
- 2001-12-07 AT AT01999357T patent/ATE405251T1/de not_active IP Right Cessation
- 2001-12-07 WO PCT/KR2001/002121 patent/WO2002045689A1/en active IP Right Grant
- 2001-12-07 AU AU2002222733A patent/AU2002222733B2/en not_active Ceased
- 2001-12-07 AU AU2273302A patent/AU2273302A/xx active Pending
- 2001-12-07 CA CA002430481A patent/CA2430481C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1339389B1 (de) | 2008-08-20 |
US7153520B2 (en) | 2006-12-26 |
AU2002222733B2 (en) | 2006-03-30 |
KR100446101B1 (ko) | 2004-08-30 |
WO2002045689A1 (en) | 2002-06-13 |
CA2430481A1 (en) | 2002-06-13 |
CN1234416C (zh) | 2006-01-04 |
CA2430481C (en) | 2008-07-22 |
AU2273302A (en) | 2002-06-18 |
EP1339389A4 (de) | 2007-08-08 |
ATE405251T1 (de) | 2008-09-15 |
US20040037885A1 (en) | 2004-02-26 |
JP2004514734A (ja) | 2004-05-20 |
CN1477952A (zh) | 2004-02-25 |
KR20020045569A (ko) | 2002-06-19 |
EP1339389A1 (de) | 2003-09-03 |
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