JP2001514618A - ヒドロキシ酸から誘導されたモノマー及びそれから調製されたポリマー - Google Patents
ヒドロキシ酸から誘導されたモノマー及びそれから調製されたポリマーInfo
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
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- C08G63/66—Polyesters containing oxygen in the form of ether groups
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- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
- C08G63/685—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen
- C08G63/6854—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/6856—Dicarboxylic acids and dihydroxy compounds
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- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
- C08G63/685—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen
- C08G63/6854—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/6858—Polycarboxylic acids and polyhydroxy compounds in which at least one of the two components contains aliphatic unsaturation
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- C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
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- C08G64/04—Aromatic polycarbonates
- C08G64/06—Aromatic polycarbonates not containing aliphatic unsaturation
- C08G64/08—Aromatic polycarbonates not containing aliphatic unsaturation containing atoms other than carbon, hydrogen or oxygen
- C08G64/12—Aromatic polycarbonates not containing aliphatic unsaturation containing atoms other than carbon, hydrogen or oxygen containing nitrogen
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- C08G64/16—Aliphatic-aromatic or araliphatic polycarbonates
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- C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
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- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/3311—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing a hydroxy group
- C08G65/3314—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing a hydroxy group cyclic
- C08G65/3315—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing a hydroxy group cyclic aromatic
- C08G65/3317—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing a hydroxy group cyclic aromatic phenolic
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- A61K38/00—Medicinal preparations containing peptides
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- A61K9/2004—Excipients; Inactive ingredients
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- A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.以下の式: (但し、式中、 R1及びR2は、独立に、水素及び18個までの炭素原子を有する直鎖又は分 岐アルキル基からなる群から選択され、 R3は、−CH=CH−及び(−CH2−)k(kは0と6との間にある)か らなる群から選択され、 各Zは、独立に、臭素又はヨウ素であり、 d及びnは、独立に、0、1又は2であり、そして Xは、水素であるか、又は、式:−C(=O)O−Y (但し、式中、Yは、18個までの炭素原子を有する直鎖又は分岐アルキル基 及びアルキルアリール基からなる群から選択される。) で示される側鎖基である。) で示されるジヒドロキシ化合物。 2.nが0であり、かつR1及びR2が独立に、水素及びメチル基からなる群から 選択される請求項1に記載のジヒドロキシ化合物。 3.R1及びR2が共に水素である請求項2に記載のジヒドロキシ化合物。 4.R1及びR2の一方が水素であり、他方がメチル基である請求項2に記載のジ ヒドロキシ化合物。 5.Xが側鎖基であり、かつYがエチル、ブチル、ヘキシル、オクチル及びベン ジル基からなる群から選択される請求項1に記載のジヒドロキシ化合物。 6.R3が−CH2−であり、かつYがエチル基である請求項5に記載のジヒドロ キシ化合物。 7.次式: (但し、式中、R1及びR2は、独立に、水素及び18個までの炭素原子を有す る直鎖又は分岐アルキル基からなる群から選択され、 R3は、−CH=CH−及び(−CH2−)k(kは0と6との間にある)か らなる群から選択され、 各Zは、独立に、臭素又はヨウ素であり、 d及びnは、独立に、0、1又は2であり、そして Xは、水素であるか、又は、式:−C(=O)O−Y (但し、式中、Yは、水素及び18個までの炭素原子を有する直鎖又は分岐ア ルキル基及びアルキルアリール基からなる群から選択される。) で示される側鎖基である。) で示される1以上の繰り返し構造単位を特徴とするポリ(アミドカーボネート)。 8.nが0であり、かつR1及びR2が独立に、水素及びメチル基からなる群か ら選択される請求項7に記載のポリ(アミドカーボネート)。 9.R1及びR2が共に水素である請求項8に記載のポリ(アミドカーボネート)。 10.R1及びR2の一方が水素であり、他方かメチル基である請求項8に記載のポ リ(アミドカーボネート)。 11.Xが前記側鎖基であり、かつYがエチル、ブチル、ヘキシル、オクチル及び ベンジル基からなる群から選択される請求項7に記載のジヒドロキシ化合物。 12.R3が−CH2−であり、かつYがエチル基である請求項11に記載のポリ( アミドカーボネート)。 13.請求項7に記載のポリ(アミドカーボネート)から調製された成形物品。 14.生物学的又は調剤学的活性剤と物理的に混台された、請求項7に記載のポリ (アミドカーボネート)から調製された、調整された薬物送達系。 15.生物学的又は調剤学的活性剤が、請求項7に記載のポリ(アミドカーボネー ト)から形成されたポリマーマトリックス中に物理的に固定又は分散された、 調整された薬物送達系。 16.インビトロ又はインビボのいずれかにおいて、細胞の付着又は増殖のための 多孔性構造を有する組織骨格であって、請求項7に記載のポリ(アミドカーボ ネート)から形成された組織骨格。 17.次式: (但し、式中、R1及びR2は、独立に、水素及び18個までの炭素原子を有す る直鎖又は分岐アルキル基からなる群から選択され、 R3は、−CH=CH−及び(−CH2−)k(kは0と6との間にある)か らなる群から選択され、 各Zは、独立に、臭素又はヨウ素であり、 d及びnは、独立に、0、1又は2であり、 Xは、水素であるか、又は、式:−C(=O)O−Y (但し、式中、Yは、18個までの炭素原子を有する直鎖又は分岐アルキル基 及びアルキルアリール基からなる群から選択される。) で示される側鎖基である。)、そして Rは、飽和若しくは不飽和、置換若しくは非置換の、24個の炭素原子を有 するアルキル基、アリール基及びアルキルアリール基からなる群から選択され る) で示される1以上の繰り返し構造単位を特徴とするポリ(エステルアミド)。 18.nが0であり、かつR1及びR2が独立に、水素及びメチル基からなる群から 選択される請求項17に記載のポリ(エステルアミド)。 19.R1及びR2が共に水素である請求項18に記載のポリ(エステルアミド)。 20.R1及びR2の一方が水素であり、他方がメチル基である請求項18に記載の ポリ(エステルアミド)。 21.Xが前記側鎖基であり、かつYがエチル、ブチル、ヘキシル、オクチル及び ベンジル基からなる群から選択される請求項17に記載のポリ(エステルアミ ド)。 22.R3が−CH2−であり、かつYがエチル基である請求項21に記載のポリ( エステルアミド)。 23.Rが、飽和若しくは不飽和、置換若しくは非置換の、8個の炭素原子を有す るアルキル基からなる群から選択される請求項17に記載のポリ(エステルア ミド)。 24.Rが、−CH2−C(=O)−、−CH2−CH2−C(=O)−、−CH= CH−及び(−CH2−)Q(Qは0と8との間にある)からなる群から選択さ れる請求項23に記載のポリ(エステルアミド)。 25.Rが、13〜20個の炭素原子を有する、置換及び非置換アリール及びアル キルアリール基からなる群から選択される請求項17に記載のポリ(エステル アミド)。 26.請求項17に記載のポリ(エステルアミド)から調製された成形物品。 27.生物学的又は調剤学的活性剤と物理的に混合された、請求項17に記載のポ リ(エステルアミド)から調製された、調整された薬物送達系。 28.生物学的又は調剤学的活性剤が、請求項17に記載のポリ(エステルアミド )から形成されるポリマーマトリックス中に物理的に固定又は分散された、調 整された薬物送達系。 29.インビトロ又はインビボのいずれかにおいて、細胞の付着又は増殖のための 多孔性構造を有する組織骨格であって、請求項7に記載のポリ(エステルアミ ド)から形成された組織骨格。
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3821397P | 1997-02-18 | 1997-02-18 | |
US60/038,213 | 1997-02-18 | ||
US6490597P | 1997-11-07 | 1997-11-07 | |
US6465697P | 1997-11-07 | 1997-11-07 | |
US60/064,656 | 1997-11-07 | ||
US60/064,905 | 1997-11-07 | ||
PCT/US1998/003127 WO1998036013A1 (en) | 1997-02-18 | 1998-02-18 | Monomers derived from hydroxy acids and polymers prepared therefrom |
Related Child Applications (1)
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JP2008178161A Division JP4411355B2 (ja) | 1997-02-18 | 2008-07-08 | ヒドロキシ酸から誘導されたモノマー及びそれから調製されたポリマー |
Publications (3)
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JP2001514618A true JP2001514618A (ja) | 2001-09-11 |
JP2001514618A5 JP2001514618A5 (ja) | 2005-10-06 |
JP4410857B2 JP4410857B2 (ja) | 2010-02-03 |
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JP53600898A Expired - Fee Related JP4410857B2 (ja) | 1997-02-18 | 1998-02-18 | ヒドロキシ酸から誘導されたモノマー及びそれから調製されたポリマー |
JP2008178161A Expired - Fee Related JP4411355B2 (ja) | 1997-02-18 | 2008-07-08 | ヒドロキシ酸から誘導されたモノマー及びそれから調製されたポリマー |
JP2009188682A Pending JP2010006820A (ja) | 1997-02-18 | 2009-08-17 | ヒドロキシ酸から誘導されたモノマー及びそれから調製されたポリマー |
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JP2008178161A Expired - Fee Related JP4411355B2 (ja) | 1997-02-18 | 2008-07-08 | ヒドロキシ酸から誘導されたモノマー及びそれから調製されたポリマー |
JP2009188682A Pending JP2010006820A (ja) | 1997-02-18 | 2009-08-17 | ヒドロキシ酸から誘導されたモノマー及びそれから調製されたポリマー |
Country Status (9)
Country | Link |
---|---|
US (1) | US6284862B1 (ja) |
EP (1) | EP0961801B1 (ja) |
JP (3) | JP4410857B2 (ja) |
AT (1) | ATE259386T1 (ja) |
AU (1) | AU729552B2 (ja) |
CA (1) | CA2281614C (ja) |
DE (1) | DE69821600T2 (ja) |
MX (1) | MXPA99007662A (ja) |
WO (1) | WO1998036013A1 (ja) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008506019A (ja) * | 2004-07-08 | 2008-02-28 | レヴァ メディカル、 インコーポレイテッド | 医療用途向けの側鎖結晶性ポリマー |
JP2008509722A (ja) * | 2004-08-13 | 2008-04-03 | ラトガース,ザ ステート ユニバーシティ | 放射線不透過性の高分子ステント |
JP2009203483A (ja) * | 1997-11-07 | 2009-09-10 | Rutgers The State Univ | 放射線不透過性ポリマー生体適合材料 |
JP2009299064A (ja) * | 1997-11-07 | 2009-12-24 | Rutgers The State Univ Of New Jersey | アミノ酸l−チロシンから誘導された生分解性アニオン系ポリマー |
JP2010006820A (ja) * | 1997-02-18 | 2010-01-14 | Rutgers The State Univ | ヒドロキシ酸から誘導されたモノマー及びそれから調製されたポリマー |
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1998
- 1998-02-18 US US09/367,735 patent/US6284862B1/en not_active Expired - Lifetime
- 1998-02-18 WO PCT/US1998/003127 patent/WO1998036013A1/en active IP Right Grant
- 1998-02-18 JP JP53600898A patent/JP4410857B2/ja not_active Expired - Fee Related
- 1998-02-18 AT AT98906536T patent/ATE259386T1/de not_active IP Right Cessation
- 1998-02-18 EP EP98906536A patent/EP0961801B1/en not_active Expired - Lifetime
- 1998-02-18 CA CA002281614A patent/CA2281614C/en not_active Expired - Lifetime
- 1998-02-18 MX MXPA99007662A patent/MXPA99007662A/es unknown
- 1998-02-18 AU AU61735/98A patent/AU729552B2/en not_active Expired
- 1998-02-18 DE DE69821600T patent/DE69821600T2/de not_active Expired - Lifetime
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JP2009299064A (ja) * | 1997-11-07 | 2009-12-24 | Rutgers The State Univ Of New Jersey | アミノ酸l−チロシンから誘導された生分解性アニオン系ポリマー |
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JP2008509722A (ja) * | 2004-08-13 | 2008-04-03 | ラトガース,ザ ステート ユニバーシティ | 放射線不透過性の高分子ステント |
JP2010530921A (ja) * | 2007-06-21 | 2010-09-16 | タイレックス・ファーマ・インコーポレイテッド | ポリマーの吸収性を高めるためのフェニルエステル側鎖 |
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JP2015045025A (ja) * | 2007-06-21 | 2015-03-12 | タイレックス・インコーポレイテッドTyrx Inc. | ポリマーの吸収性を高めるためのフェニルエステル側鎖 |
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JP2013501106A (ja) * | 2009-07-31 | 2013-01-10 | ラトガース,ザ ステート ユニバーシティ オブ ニュー ジャージー | 天然代謝産物のモノマー類似体から合成された生体吸収性ポリマー |
Also Published As
Publication number | Publication date |
---|---|
ATE259386T1 (de) | 2004-02-15 |
JP4411355B2 (ja) | 2010-02-10 |
DE69821600T2 (de) | 2005-01-05 |
JP2010006820A (ja) | 2010-01-14 |
CA2281614C (en) | 2008-11-18 |
US6284862B1 (en) | 2001-09-04 |
DE69821600D1 (de) | 2004-03-18 |
JP4410857B2 (ja) | 2010-02-03 |
JP2009019040A (ja) | 2009-01-29 |
AU729552B2 (en) | 2001-02-01 |
CA2281614A1 (en) | 1998-08-20 |
AU6173598A (en) | 1998-09-08 |
WO1998036013A1 (en) | 1998-08-20 |
EP0961801A1 (en) | 1999-12-08 |
EP0961801A4 (en) | 2000-05-03 |
EP0961801B1 (en) | 2004-02-11 |
MXPA99007662A (es) | 2002-07-22 |
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