JP2005500266A5 - - Google Patents

Info

Publication number

JP2005500266A5

JP2005500266A5 JP2002590924A JP2002590924A JP2005500266A5 JP 2005500266 A5 JP2005500266 A5 JP 2005500266A5 JP 2002590924 A JP2002590924 A JP 2002590924A JP 2002590924 A JP2002590924 A JP 2002590924A JP 2005500266 A5 JP2005500266 A5 JP 2005500266A5

Authority

JP

Japan

Prior art keywords

substituted

alkyl

heterocycle

arylalkyl

aryl

Prior art date

2002-05-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 125000000623 heterocyclic group Chemical group 0.000 claims 215
• 125000003710 aryl alkyl group Chemical group 0.000 claims 180
• 229910052739 hydrogen Inorganic materials 0.000 claims 128
• 239000001257 hydrogen Substances 0.000 claims 128
• 150000001875 compounds Chemical class 0.000 claims 115
• 125000000217 alkyl group Chemical group 0.000 claims 95
• 125000003118 aryl group Chemical group 0.000 claims 91
• 125000000547 substituted alkyl group Chemical group 0.000 claims 90
• 150000002431 hydrogen Chemical class 0.000 claims 87
• 125000003107 substituted aryl group Chemical group 0.000 claims 71
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 54
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 41
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 39
• 229910052760 oxygen Inorganic materials 0.000 claims 39
• 239000001301 oxygen Substances 0.000 claims 39
• 125000005343 heterocyclic alkyl group Chemical group 0.000 claims 32
• 229910052736 halogen Inorganic materials 0.000 claims 17
• 150000002367 halogens Chemical class 0.000 claims 17
• 229910052757 nitrogen Inorganic materials 0.000 claims 17
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 17
• 239000003814 drug Substances 0.000 claims 14
• 239000000651 prodrug Substances 0.000 claims 13
• 229940002612 prodrug Drugs 0.000 claims 13
• 150000003839 salts Chemical class 0.000 claims 13
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 12
• 229910052717 sulfur Chemical group 0.000 claims 12
• 239000011593 sulfur Chemical group 0.000 claims 12
• 241001465754 Metazoa Species 0.000 claims 10
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
• 239000003112 inhibitor Substances 0.000 claims 8
• 229910052794 bromium Inorganic materials 0.000 claims 6
• 229910052801 chlorine Inorganic materials 0.000 claims 6
• 229910052740 iodine Inorganic materials 0.000 claims 6
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
• 125000004103 aminoalkyl group Chemical group 0.000 claims 4
• 239000003795 chemical substances by application Substances 0.000 claims 4
• 230000000694 effects Effects 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• 229920001184 polypeptide Polymers 0.000 claims 4
• 102000004196 processed proteins & peptides Human genes 0.000 claims 4
• 108090000765 processed proteins & peptides Proteins 0.000 claims 4
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 4
• 208000023275 Autoimmune disease Diseases 0.000 claims 2
• 208000006673 asthma Diseases 0.000 claims 2
• 208000027866 inflammatory disease Diseases 0.000 claims 2
• 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 208000010067 Pituitary ACTH Hypersecretion Diseases 0.000 claims 1
• 208000020627 Pituitary-dependent Cushing syndrome Diseases 0.000 claims 1
• 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 1
• 206010040070 Septic Shock Diseases 0.000 claims 1
• 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 1
• 230000033115 angiogenesis Effects 0.000 claims 1
• 206010003246 arthritis Diseases 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• -1 dialkyl Chemical group 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 108020001507 fusion proteins Proteins 0.000 claims 1
• 102000037865 fusion proteins Human genes 0.000 claims 1
• 239000003862 glucocorticoid Substances 0.000 claims 1
• 125000004404 heteroalkyl group Chemical group 0.000 claims 1
• 230000028993 immune response Effects 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 239000003550 marker Substances 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 201000008482 osteoarthritis Diseases 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 238000012216 screening Methods 0.000 claims 1
• 230000036303 septic shock Effects 0.000 claims 1