JP2010518158A5 - - Google Patents
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- Publication number
- JP2010518158A5 JP2010518158A5 JP2009549593A JP2009549593A JP2010518158A5 JP 2010518158 A5 JP2010518158 A5 JP 2010518158A5 JP 2009549593 A JP2009549593 A JP 2009549593A JP 2009549593 A JP2009549593 A JP 2009549593A JP 2010518158 A5 JP2010518158 A5 JP 2010518158A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- hetaryl
- pharmaceutical composition
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 24
- 239000001257 hydrogen Substances 0.000 claims 24
- 125000003118 aryl group Chemical group 0.000 claims 21
- 125000001072 heteroaryl group Chemical group 0.000 claims 21
- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 102100033367 Appetite-regulating hormone Human genes 0.000 claims 12
- 101710111255 Appetite-regulating hormone Proteins 0.000 claims 12
- 239000003324 growth hormone secretagogue Substances 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical group 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 8
- -1 amino, hydroxyl Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 230000002062 proliferating effect Effects 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 2
- 125000000732 arylene group Chemical group 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 206010038038 rectal cancer Diseases 0.000 claims 2
- 201000001275 rectum cancer Diseases 0.000 claims 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 1
- KPPVNWGJXFMGAM-UUILKARUSA-N (e)-2-methyl-1-(6-methyl-3,4-dihydro-2h-quinolin-1-yl)but-2-en-1-one Chemical compound CC1=CC=C2N(C(=O)C(/C)=C/C)CCCC2=C1 KPPVNWGJXFMGAM-UUILKARUSA-N 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 0 Cc1c(C)c(*)c(*)c(*)c1* Chemical compound Cc1c(C)c(*)c(*)c(*)c1* 0.000 description 5
- YXBSPEDTBVJVAY-UHFFFAOYSA-N C1=CN=[I]C=C1 Chemical compound C1=CN=[I]C=C1 YXBSPEDTBVJVAY-UHFFFAOYSA-N 0.000 description 1
- FCEHBMOGCRZNNI-UHFFFAOYSA-N c1c[s]c2ccccc12 Chemical compound c1c[s]c2ccccc12 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 description 1
- UFWIBTONFRDIAS-UHFFFAOYSA-N c1cc2ccccc2cc1 Chemical compound c1cc2ccccc2cc1 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90160907P | 2007-02-13 | 2007-02-13 | |
| PCT/US2008/001748 WO2008100448A2 (en) | 2007-02-13 | 2008-02-08 | Method of treating cell proliferative disorders using growth hormone secretagogues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010518158A JP2010518158A (ja) | 2010-05-27 |
| JP2010518158A5 true JP2010518158A5 (enExample) | 2011-03-31 |
Family
ID=39690677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009549593A Pending JP2010518158A (ja) | 2007-02-13 | 2008-02-08 | 成長ホルモン分泌促進物質を用いた細胞増殖性障害の治療方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20080207640A1 (enExample) |
| EP (1) | EP2134341B1 (enExample) |
| JP (1) | JP2010518158A (enExample) |
| KR (1) | KR20090112720A (enExample) |
| CN (1) | CN101686966A (enExample) |
| AU (1) | AU2008216789A1 (enExample) |
| CA (1) | CA2677813A1 (enExample) |
| EA (1) | EA200970764A1 (enExample) |
| IL (1) | IL200367A0 (enExample) |
| MX (1) | MX2009008561A (enExample) |
| TW (1) | TWI450719B (enExample) |
| WO (1) | WO2008100448A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012020377B1 (pt) * | 2010-02-26 | 2019-10-08 | Raqualia Pharma Inc. | Uso de um composto ou sal farmaceuticamente aceitável do mesmo e embalagem comercial |
| JO3353B1 (ar) | 2012-04-20 | 2019-03-13 | Ono Pharmaceutical Co | شكل صلب معزول من أحادي هيدروكلوريد أناموريلين بنسبة مولارية منخفضة من الكلوريد: أناموريلين ومحتوى منخفض من مذيب عضوي متبقي |
| CN105164245B (zh) | 2013-02-08 | 2018-05-22 | 通用磨坊公司 | 低钠食品 |
| LT3188599T (lt) * | 2014-09-04 | 2019-12-10 | Helsinn Healthcare Sa | Medicininio gydymo būdai, pagrįsti anamorelinu |
| TW202246215A (zh) | 2015-12-18 | 2022-12-01 | 美商亞德利克斯公司 | 作為非全身ｔｇｒ５促效劑之經取代之４－苯基吡啶化合物 |
| US12084472B2 (en) | 2015-12-18 | 2024-09-10 | Ardelyx, Inc. | Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists |
| EP4021419A1 (en) | 2019-08-30 | 2022-07-06 | Helsinn Healthcare SA | Methods of manufacturing anamorelin tablets having improved stability |
| BR112022010561A2 (pt) | 2019-12-02 | 2022-11-16 | Storm Therapeutics Ltd | Compostos poli-heterocíclicos como inibidores de mettl3 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI962584A0 (fi) * | 1993-12-23 | 1996-06-20 | Novo Nordisk As | Kasvuhormonia vapauttavia ominaisuuksia sisältäviä yhdisteitä |
| CA2239711A1 (en) * | 1995-12-22 | 1997-07-03 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| WO1998003473A1 (en) * | 1996-07-22 | 1998-01-29 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US6566334B1 (en) * | 1997-02-06 | 2003-05-20 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Short amphipathic peptides with activity against bacteria and intracellular pathogens |
| US6286927B1 (en) * | 1997-12-25 | 2001-09-11 | Canon Kabushiki Kaisha | Ink jet element substrate and ink jet head that employs the substrate, and ink jet apparatus on which the head is mounted |
| US6494563B2 (en) * | 1997-12-25 | 2002-12-17 | Canon Kabushiki Kaisha | Ink jet element substrate and ink jet head that employs the substrate, and ink jet apparatus on which the head is mounted |
| US6083908A (en) * | 1998-01-16 | 2000-07-04 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US6303620B1 (en) * | 1998-05-11 | 2001-10-16 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US6124263A (en) | 1998-11-16 | 2000-09-26 | Asta Medica Ag | Treatment of tumors by administration of growth hormone releasing compounds and their antagonists |
| US6919315B1 (en) * | 1998-06-30 | 2005-07-19 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US6566337B1 (en) * | 1998-11-03 | 2003-05-20 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| UA73530C2 (uk) | 1999-11-10 | 2005-08-15 | Ново Нордіск А/С | Сполука з властивостями вивільнювати гормон росту |
| ES2333097T3 (es) * | 2000-05-31 | 2010-02-17 | Raqualia Pharma Inc | Uso de secretagogos de la hormona de crecimiento para estimular la motilidad gastrointestinal. |
| AU8180001A (en) * | 2000-06-07 | 2001-12-17 | Applied Research Systems | Human growth hormone to stimulate mobilization of pluripotent hematopoietic stemcells |
| JP2005511475A (ja) * | 2001-03-02 | 2005-04-28 | ブリストル−マイヤーズ スクイブ カンパニー | メラノコルチン受容体のモジュレーターとして有用な化合物及びそれを含む製薬組成物 |
| EP1312363A1 (en) * | 2001-09-28 | 2003-05-21 | Pfizer Products Inc. | Methods of treatment and kits comprising a growth hormone secretagogue |
| US7491695B2 (en) * | 2003-06-18 | 2009-02-17 | Tranzyme Pharma Inc. | Methods of using macrocyclic modulators of the ghrelin receptor |
| EP1735055A1 (en) | 2004-03-30 | 2006-12-27 | Sapphire Therapeutics, Inc. | Method of reducing c-reactive protein using growth hormone secretagogues |
| EA200901077A1 (ru) * | 2007-02-09 | 2010-04-30 | Транзим Фарма, Инк. | Макроциклические модуляторы грелинового рецептора и их применение |
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2008
- 2008-02-08 MX MX2009008561A patent/MX2009008561A/es not_active Application Discontinuation
- 2008-02-08 CA CA002677813A patent/CA2677813A1/en not_active Abandoned
- 2008-02-08 JP JP2009549593A patent/JP2010518158A/ja active Pending
- 2008-02-08 EA EA200970764A patent/EA200970764A1/ru unknown
- 2008-02-08 KR KR1020097017491A patent/KR20090112720A/ko not_active Ceased
- 2008-02-08 WO PCT/US2008/001748 patent/WO2008100448A2/en not_active Ceased
- 2008-02-08 CN CN200880011801A patent/CN101686966A/zh active Pending
- 2008-02-08 EP EP08725389.4A patent/EP2134341B1/en not_active Not-in-force
- 2008-02-08 AU AU2008216789A patent/AU2008216789A1/en not_active Abandoned
- 2008-02-11 US US12/069,533 patent/US20080207640A1/en not_active Abandoned
- 2008-02-13 TW TW097104956A patent/TWI450719B/zh active
-
2009
- 2009-08-12 IL IL200367A patent/IL200367A0/en unknown