JP2010518158A - 成長ホルモン分泌促進物質を用いた細胞増殖性障害の治療方法 - Google Patents

成長ホルモン分泌促進物質を用いた細胞増殖性障害の治療方法 Download PDF

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JP2010518158A
JP2010518158A JP2009549593A JP2009549593A JP2010518158A JP 2010518158 A JP2010518158 A JP 2010518158A JP 2009549593 A JP2009549593 A JP 2009549593A JP 2009549593 A JP2009549593 A JP 2009549593A JP 2010518158 A JP2010518158 A JP 2010518158A
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alkyl
aryl
hetaryl
growth hormone
independently
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JP2010518158A5 (enExample
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ジェイ． ポルビーノ，ウィリアムズ
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ヘルシン セラピューティクス（ユー．エス．），インコーポレイティド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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  • Life Sciences & Earth Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2009549593A 2007-02-13 2008-02-08 成長ホルモン分泌促進物質を用いた細胞増殖性障害の治療方法 Pending JP2010518158A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90160907P 2007-02-13 2007-02-13
PCT/US2008/001748 WO2008100448A2 (en) 2007-02-13 2008-02-08 Method of treating cell proliferative disorders using growth hormone secretagogues

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JP2010518158A true JP2010518158A (ja) 2010-05-27
JP2010518158A5 JP2010518158A5 (enExample) 2011-03-31

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US (1) US20080207640A1 (enExample)
EP (1) EP2134341B1 (enExample)
JP (1) JP2010518158A (enExample)
KR (1) KR20090112720A (enExample)
CN (1) CN101686966A (enExample)
AU (1) AU2008216789A1 (enExample)
CA (1) CA2677813A1 (enExample)
EA (1) EA200970764A1 (enExample)
IL (1) IL200367A0 (enExample)
MX (1) MX2009008561A (enExample)
TW (1) TWI450719B (enExample)
WO (1) WO2008100448A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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JP2017526695A (ja) * 2014-09-04 2017-09-14 ヘルシン ヘルスケア ソシエテ アノニム アナモレリンに基づく医療

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2011105611A1 (ja) * 2010-02-26 2013-06-20 ラクオリア創薬株式会社 悪液質を治療するためのグレリン受容体作動物質
JO3353B1 (ar) 2012-04-20 2019-03-13 Ono Pharmaceutical Co شكل صلب معزول من أحادي هيدروكلوريد أناموريلين بنسبة مولارية منخفضة من الكلوريد: أناموريلين ومحتوى منخفض من مذيب عضوي متبقي
CN108902893B (zh) 2013-02-08 2022-02-25 通用磨坊公司 低钠食品
TWI773657B (zh) 2015-12-18 2022-08-11 美商亞德利克斯公司 作爲非全身ｔｇｒ５促效劑之經取代之4-苯基吡啶化合物
US12084472B2 (en) 2015-12-18 2024-09-10 Ardelyx, Inc. Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists
JP7854809B2 (ja) 2019-08-30 2026-05-07 ヘルシン ヘルスケア ソシエテ アノニム 安定性が改善されたアナモレリン錠剤の製造方法
US12195458B2 (en) 2019-12-02 2025-01-14 Storm Therapeutics Limited Polyheterocyclic compounds as METTL3 inhibitors
WO2025104491A1 (en) 2023-11-14 2025-05-22 Mindset Pharma Inc. Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto

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JPN6012066450; Ｂａｘｔｅｒ　ＲＣ．: 'Ｓｉｇｎａｌｌｉｎｇ　ｐａｔｈｗａｙｓ　ｉｎｖｏｌｖｅｄ　ｉｎ　ａｎｔｉｐｒｏｌｉｆｅｒａｔｉｖｅ　ｅｆｆｅｃｔｓ　ｏｆ　ＩＧＦＢＰ-３：　ａ　ｒｅｖｉｅｗ．' Ｍｏｌ　Ｐａｔｈｏｌ． Ｖｏｌ．５４　Ｎｏ．３, 200106, ｐｐ．１４５-１４８ *
JPN6012066452; Ｎｅａｒｙ　ＮＭ　ｅｔ　ａｌ．: 'Ｇｈｒｅｌｉｎ　ｉｎｃｒｅａｓｅｓ　ｅｎｅｒｇｙ　ｉｎｔａｋｅ　ｉｎ　ｃａｎｃｅｒ　ｐａｔｉｅｎｔｓ　ｗｉｔｈ　ｉｍｐａｉｒｅｄ　ａｐｐｅｔｉｔｅ：　ａｃｕｔｅ，　ｒａｎｄｏｍｉｚｅｄ，　ｐｌａｃｅｂ' Ｊ　Ｃｌｉｎ　Ｅｎｄｏｃｒｉｎｏｌ　Ｍｅｔａｂ． Ｖｏｌ．８９　Ｎｏ．６, 200406, ｐｐ．２８３２-２８３６ *
JPN6012066455; Ｐｉｎｅｓ　ＳＨ: 'Ａ　Ｐｒａｃｔｉｃａｌ　Ｓｙｎｔｈｅｓｉｓ　ｏｆ　ｔｈｅ　Ｐｓｅｕｄｏｔｒｉｐｅｐｔｉｄｅ　ＲＣ-１２９１' Ｏｒｇ．　Ｐｒｏｃｅｓｓ　Ｒｅｓ．　Ｄｅｖ．， Ｖｏｌ．１０　Ｎｏ．２, 2006, ｐｐ．３３９-３４５ *
JPN6014002496; Ｋｕｍｏｒ　Ｋ　ａｎｄ　Ｐｏｌｖｉｎｏ　Ｗ: 'Ｂｉｏｌｏｇｉｃ　ａｃｔｉｖｉｔｙ　ｏｆ　ＲＣ-１２９１，　ａ　ｎｏｖｅｌ　ｏｒａｌ　ｇｈｒｅｌｉｎ　ｍｉｍｅｔｉｃ　ｆｏｒ　ｔｈｅ　ｔｒｅａｔｍｅｎｔ　ｏｆ　ｃａｎｃｅｒ　ａｎｏｒｅｘｉａ／ｃａｃｈ' Ｓｕｐｐｏｒｔ　Ｃａｒｅ　Ｃａｎｃｅｒ Ｖｏｌ．１４, 2006, ｐ．５９３ *
JPN6014002500; Ｈａｎａｄａ　Ｔ　ｅｔ　ａｌ．: 'Ａｎｔｉ-ｃａｃｈｅｃｔｉｃ　ｅｆｆｅｃｔ　ｏｆ　ｇｈｒｅｌｉｎ　ｉｎ　ｎｕｄｅ　ｍｉｃｅ　ｂｅａｒｉｎｇ　ｈｕｍａｎ　ｍｅｌａｎｏｍａ　ｃｅｌｌｓ．' Ｂｉｏｃｈｅｍ　Ｂｉｏｐｈｙｓ　Ｒｅｓ　Ｃｏｍｍｕｎ． Ｖｏｌ．３０１　Ｎｏ．２, 20030207, ｐｐ．２７５-２７９ *
JPN6014002501; 塚田　俊彦: '増殖因子、サイトカインによるがん病態の修飾に関する研究' 厚生労働省がん研究助成金による研究報告集 平成１３年度, 200209, ｐｐ．１３８-１４３ *
JPN6014002504; Ａｋａｍｉｚｕ　Ｔ　ａｎｄ　Ｋａｎｇａｗａ　Ｋ: 'Ｔｒａｎｓｌａｔｉｏｎａｌ　ｒｅｓｅａｒｃｈ　ｏｎ　ｔｈｅ　ｃｌｉｎｉｃａｌ　ａｐｐｌｉｃａｔｉｏｎｓ　ｏｆ　ｇｈｒｅｌｉｎ．' Ｅｎｄｏｃｒ　Ｊ． Ｖｏｌ．５３　Ｎｏ．５, 20060728, ｐｐ．５８５-５９１ *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017526695A (ja) * 2014-09-04 2017-09-14 ヘルシン ヘルスケア ソシエテ アノニム アナモレリンに基づく医療
JP2018154655A (ja) * 2014-09-04 2018-10-04 ヘルシン ヘルスケア ソシエテ アノニム アナモレリンに基づく医療
JP2021080281A (ja) * 2014-09-04 2021-05-27 ヘルシン ヘルスケア ソシエテ アノニム アナモレリンに基づく医療
JP7044918B2 (ja) 2014-09-04 2022-03-30 ヘルシン ヘルスケア ソシエテ アノニム アナモレリンに基づく医療

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KR20090112720A (ko) 2009-10-28
US20080207640A1 (en) 2008-08-28
WO2008100448A2 (en) 2008-08-21
AU2008216789A1 (en) 2008-08-21
TW200914019A (en) 2009-04-01
WO2008100448A3 (en) 2008-10-23
EP2134341A2 (en) 2009-12-23
MX2009008561A (es) 2010-01-15
EP2134341B1 (en) 2015-06-17
TWI450719B (zh) 2014-09-01
EP2134341A4 (en) 2011-08-17
IL200367A0 (en) 2010-04-29
EA200970764A1 (ru) 2010-04-30
CA2677813A1 (en) 2008-08-21

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