JP2020532565A5 - - Google Patents
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- Publication number
- JP2020532565A5 JP2020532565A5 JP2020513526A JP2020513526A JP2020532565A5 JP 2020532565 A5 JP2020532565 A5 JP 2020532565A5 JP 2020513526 A JP2020513526 A JP 2020513526A JP 2020513526 A JP2020513526 A JP 2020513526A JP 2020532565 A5 JP2020532565 A5 JP 2020532565A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- composition
- alkyl
- protein monomer
- halos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762554067P | 2017-09-05 | 2017-09-05 | |
| US62/554,067 | 2017-09-05 | ||
| US201862616221P | 2018-01-11 | 2018-01-11 | |
| US62/616,221 | 2018-01-11 | ||
| PCT/US2018/049594 WO2019050977A1 (en) | 2017-09-05 | 2018-09-05 | REVERSIBLE LINKS AND THEIR USE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020532565A JP2020532565A (ja) | 2020-11-12 |
| JP2020532565A5 true JP2020532565A5 (enExample) | 2021-10-14 |
Family
ID=65634522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020513526A Pending JP2020532565A (ja) | 2017-09-05 | 2018-09-05 | 可逆性リンカーおよびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11547760B2 (enExample) |
| EP (1) | EP3678704A4 (enExample) |
| JP (1) | JP2020532565A (enExample) |
| KR (1) | KR20210031848A (enExample) |
| CN (1) | CN111432843A (enExample) |
| AU (1) | AU2018328208A1 (enExample) |
| CA (1) | CA3075027A1 (enExample) |
| WO (1) | WO2019050977A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210032924A (ko) | 2017-09-05 | 2021-03-25 | 토크 테라퓨틱스, 인코포레이티드 | 치료용 단백질 조성물 및 그의 제조 및 사용 방법 |
| CN112891556B (zh) * | 2021-02-01 | 2023-03-03 | 浙江大学医学院附属第一医院 | 一种单抗类药物口服纳米凝胶及其制备方法 |
| WO2024086827A2 (en) | 2022-10-20 | 2024-04-25 | Repertoire Immune Medicines, Inc. | Cd8 t cell targeted il2 |
| CN115785490A (zh) * | 2022-11-29 | 2023-03-14 | 广西医科大学 | 一种交联改性的明胶材料及其制备方法 |
| EP4634216A1 (en) | 2022-12-16 | 2025-10-22 | Repertoire Immune Medicines, Inc. | T cell receptors binding hpv-16 epitopes |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1112021A (en) * | 1964-01-02 | 1968-05-01 | Gevaert Photo Prod Nv | Polycarbonates with increased crystallizability |
| DE2633685A1 (de) | 1976-07-27 | 1978-02-02 | Basf Ag | 1,3,5-tris-(2-chloroformyl- oxyaethyl)-isocyanurat |
| US4549010A (en) * | 1984-06-27 | 1985-10-22 | Merck & Co., Inc. | Bioerodible poly(ortho ester) thermoplastic elastomer from diketene diacetal |
| US7011812B1 (en) | 1996-05-03 | 2006-03-14 | Immunomedics, Inc. | Targeted combination immunotherapy of cancer and infectious diseases |
| WO1998012274A1 (en) | 1996-09-23 | 1998-03-26 | Chandrashekar Pathak | Methods and devices for preparing protein concentrates |
| US6258351B1 (en) * | 1996-11-06 | 2001-07-10 | Shearwater Corporation | Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels |
| AU755968B2 (en) | 1998-07-30 | 2003-01-02 | Oakville Hong Kong Co., Limited | Method for preparing water-soluble cross-linked conjugates |
| US6613582B1 (en) | 1999-05-25 | 2003-09-02 | Board Of Regents, The University Of Texas System | Methods for rapid and efficient protein cross-linking |
| US6521431B1 (en) | 1999-06-22 | 2003-02-18 | Access Pharmaceuticals, Inc. | Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments |
| US7538092B2 (en) | 2002-10-08 | 2009-05-26 | Fresenius Kabi Deutschland Gmbh | Pharmaceutically active oligosaccharide conjugates |
| DE60331584D1 (de) | 2002-11-26 | 2010-04-15 | Biocon Ltd | Modifizierte natriuretic verbindungen, konjugate und ihre verwendungen |
| US7648962B2 (en) | 2002-11-26 | 2010-01-19 | Biocon Limited | Natriuretic compounds, conjugates, and uses thereof |
| US7604804B2 (en) | 2004-02-09 | 2009-10-20 | University Of Maryland Biotechnology Institute | Enhancing anti-HIV efficiency through multivalent inhibitors targeting oligomeric gp120 |
| US8562965B2 (en) | 2004-05-03 | 2013-10-22 | Nektar Therapeutics | Polymer derivatives comprising an acetal or ketal branching point |
| TW200616604A (en) | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
| WO2006052790A2 (en) | 2004-11-05 | 2006-05-18 | The Children's Hospital Of Philadelphia | Biodegradable linkers for molecular therapies |
| WO2006076471A2 (en) | 2005-01-12 | 2006-07-20 | Nobex Corporation | Bnp conjugates and methods of use |
| TW200820963A (en) | 2006-07-28 | 2008-05-16 | Xenoport Inc | Acyloxyalkyl carbamate prodrugs of α-amino acids, methods of synthesis and use |
| CA2742043C (en) | 2008-10-24 | 2014-11-25 | Irm Llc | Biosynthetically generated pyrroline-carboxy-lysine and site specific protein modifications via chemical derivatization of pyrroline-carboxy-lysine and pyrrolysine residues |
| RU2012145811A (ru) | 2010-03-29 | 2014-05-10 | Евоник Корпорейшн | Композиции и способы улучшенного удержания фармацевтической композиции на участке местного введения |
| US8440309B2 (en) | 2011-01-31 | 2013-05-14 | Confluent Surgical, Inc. | Crosslinked polymers with the crosslinker as therapeutic for sustained release |
| WO2012112689A1 (en) | 2011-02-15 | 2012-08-23 | The University Of North Carolina At Chapel Hill | Nanoparticle, liposomes, polymers, agents and proteins modified with reversible linkers |
| US9511150B2 (en) | 2011-07-19 | 2016-12-06 | CellMosaic, Inc. | Crosslinking reagents, macromolecules, therapeutic bioconjugates, and synthetic methods thereof |
| EP2734238B1 (en) | 2011-07-19 | 2020-02-19 | CellMosaic, Inc. | Sugar alcohol-based crosslinking reagents, macromolecules, therapeutic bioconjugates, and synthetic methods thereof |
| US9695189B2 (en) * | 2013-03-01 | 2017-07-04 | Mark Quang Nguyen | Chemical crosslinkers and compositions thereof |
| CN104232576B (zh) * | 2013-06-14 | 2018-07-17 | 加思葆（北京）医药科技有限公司 | 蛋白-细胞偶联物、其制备方法和用途 |
| JP7097667B2 (ja) | 2013-09-27 | 2022-07-08 | マサチューセッツ インスティテュート オブ テクノロジー | 無担体生物活性タンパク質ナノ構造体 |
| CN108990413A (zh) | 2015-08-12 | 2018-12-11 | 麻省理工学院 | 纳米颗粒的细胞表面偶联 |
| KR20210032924A (ko) | 2017-09-05 | 2021-03-25 | 토크 테라퓨틱스, 인코포레이티드 | 치료용 단백질 조성물 및 그의 제조 및 사용 방법 |
-
2018
- 2018-09-05 JP JP2020513526A patent/JP2020532565A/ja active Pending
- 2018-09-05 CN CN201880067030.0A patent/CN111432843A/zh active Pending
- 2018-09-05 EP EP18853003.4A patent/EP3678704A4/en not_active Withdrawn
- 2018-09-05 US US16/644,675 patent/US11547760B2/en active Active
- 2018-09-05 KR KR1020207009619A patent/KR20210031848A/ko not_active Abandoned
- 2018-09-05 CA CA3075027A patent/CA3075027A1/en active Pending
- 2018-09-05 AU AU2018328208A patent/AU2018328208A1/en not_active Abandoned
- 2018-09-05 WO PCT/US2018/049594 patent/WO2019050977A1/en not_active Ceased
-
2022
- 2022-11-11 US US17/985,401 patent/US20230248841A1/en not_active Abandoned
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