JP2020532565A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020532565A5 JP2020532565A5 JP2020513526A JP2020513526A JP2020532565A5 JP 2020532565 A5 JP2020532565 A5 JP 2020532565A5 JP 2020513526 A JP2020513526 A JP 2020513526A JP 2020513526 A JP2020513526 A JP 2020513526A JP 2020532565 A5 JP2020532565 A5 JP 2020532565A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- composition
- alkyl
- protein monomer
- halos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762554067P | 2017-09-05 | 2017-09-05 | |
| US62/554,067 | 2017-09-05 | ||
| US201862616221P | 2018-01-11 | 2018-01-11 | |
| US62/616,221 | 2018-01-11 | ||
| PCT/US2018/049594 WO2019050977A1 (en) | 2017-09-05 | 2018-09-05 | REVERSIBLE LINKS AND THEIR USE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020532565A JP2020532565A (ja) | 2020-11-12 |
| JP2020532565A5 true JP2020532565A5 (enExample) | 2021-10-14 |
Family
ID=65634522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020513526A Pending JP2020532565A (ja) | 2017-09-05 | 2018-09-05 | 可逆性リンカーおよびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11547760B2 (enExample) |
| EP (1) | EP3678704A4 (enExample) |
| JP (1) | JP2020532565A (enExample) |
| KR (1) | KR20210031848A (enExample) |
| CN (1) | CN111432843A (enExample) |
| AU (1) | AU2018328208A1 (enExample) |
| CA (1) | CA3075027A1 (enExample) |
| WO (1) | WO2019050977A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3074826A1 (en) | 2017-09-05 | 2019-03-14 | Torque Therapeutics, Inc. | Therapeutic protein compositions and methods of making and using the same |
| CN112891556B (zh) * | 2021-02-01 | 2023-03-03 | 浙江大学医学院附属第一医院 | 一种单抗类药物口服纳米凝胶及其制备方法 |
| US20260234258A1 (en) | 2022-10-20 | 2026-08-13 | Repertoire Immune Medicines, Inc. | Cd8 t cell targeted il2 |
| CN115785490A (zh) * | 2022-11-29 | 2023-03-14 | 广西医科大学 | 一种交联改性的明胶材料及其制备方法 |
| EP4634216A1 (en) | 2022-12-16 | 2025-10-22 | Repertoire Immune Medicines, Inc. | T cell receptors binding hpv-16 epitopes |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1112021A (en) * | 1964-01-02 | 1968-05-01 | Gevaert Photo Prod Nv | Polycarbonates with increased crystallizability |
| DE2633685A1 (de) * | 1976-07-27 | 1978-02-02 | Basf Ag | 1,3,5-tris-(2-chloroformyl- oxyaethyl)-isocyanurat |
| US4549010A (en) * | 1984-06-27 | 1985-10-22 | Merck & Co., Inc. | Bioerodible poly(ortho ester) thermoplastic elastomer from diketene diacetal |
| US7011812B1 (en) * | 1996-05-03 | 2006-03-14 | Immunomedics, Inc. | Targeted combination immunotherapy of cancer and infectious diseases |
| WO1998012274A1 (en) | 1996-09-23 | 1998-03-26 | Chandrashekar Pathak | Methods and devices for preparing protein concentrates |
| US6258351B1 (en) * | 1996-11-06 | 2001-07-10 | Shearwater Corporation | Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels |
| DE69917908T2 (de) | 1998-07-30 | 2005-05-25 | Oakville Trading Hong Kong Ltd. | Verfahren zur Herstellung von wasserlöslichen,vernetzten Konjugaten |
| US6613582B1 (en) | 1999-05-25 | 2003-09-02 | Board Of Regents, The University Of Texas System | Methods for rapid and efficient protein cross-linking |
| US6521431B1 (en) | 1999-06-22 | 2003-02-18 | Access Pharmaceuticals, Inc. | Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments |
| WO2004032971A1 (en) | 2002-10-08 | 2004-04-22 | Fresenius Kabi Deutschland Gmbh | Pharmaceutically active oligosaccharide conjugates |
| SG159387A1 (en) | 2002-11-26 | 2010-03-30 | Biocon Ltd In | Modified natriuretic compounds, conjugates, and uses thereof |
| US7648962B2 (en) | 2002-11-26 | 2010-01-19 | Biocon Limited | Natriuretic compounds, conjugates, and uses thereof |
| US7604804B2 (en) | 2004-02-09 | 2009-10-20 | University Of Maryland Biotechnology Institute | Enhancing anti-HIV efficiency through multivalent inhibitors targeting oligomeric gp120 |
| WO2005108463A2 (en) | 2004-05-03 | 2005-11-17 | Nektar Therapeutics Al, Corporation | Branched polyethylen glycol derivates comprising an acetal or ketal branching point |
| TW200616604A (en) | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
| EP1807092B1 (en) | 2004-11-05 | 2016-09-07 | The Children's Hospital of Philadelphia | Biodegradable linkers for molecular therapies |
| WO2006076471A2 (en) | 2005-01-12 | 2006-07-20 | Nobex Corporation | Bnp conjugates and methods of use |
| TW200820963A (en) | 2006-07-28 | 2008-05-16 | Xenoport Inc | Acyloxyalkyl carbamate prodrugs of α-amino acids, methods of synthesis and use |
| JP5542832B2 (ja) | 2008-10-24 | 2014-07-09 | アイアールエム・リミテッド・ライアビリティ・カンパニー | 生合成的に製造したピロリン−カルボキシ−リシンならびにピロリン−カルボキシ−リシンおよびピロリシン基の化学誘導体化を介する部位特異的タンパク質修飾 |
| JP2013523752A (ja) | 2010-03-29 | 2013-06-17 | エボニック デグサ コーポレイション | 局所投与部位における医薬組成物の保持改善のための組成物および方法 |
| US8440309B2 (en) | 2011-01-31 | 2013-05-14 | Confluent Surgical, Inc. | Crosslinked polymers with the crosslinker as therapeutic for sustained release |
| US20140081012A1 (en) | 2011-02-15 | 2014-03-20 | The University Of North Carolina At Chapel Hill | Nanoparticle, liposomes, polymers, agents and proteins modified with reversible linkers |
| US9511150B2 (en) | 2011-07-19 | 2016-12-06 | CellMosaic, Inc. | Crosslinking reagents, macromolecules, therapeutic bioconjugates, and synthetic methods thereof |
| CN107043339B (zh) | 2011-07-19 | 2019-09-06 | 希默赛生物技术有限责任公司 | 新交联试剂、大分子、治疗用偶联物及其合成方法 |
| US9695189B2 (en) * | 2013-03-01 | 2017-07-04 | Mark Quang Nguyen | Chemical crosslinkers and compositions thereof |
| CN108939059B (zh) * | 2013-06-14 | 2022-05-10 | 康思葆（北京）生物技术有限公司 | 蛋白-细胞偶联物、其制备方法和用途 |
| CA3191031A1 (en) * | 2013-09-27 | 2015-04-02 | Massachusetts Institute Of Technology | Carrier-free biologically-active protein nanostructures |
| AU2016305087B2 (en) | 2015-08-12 | 2022-01-20 | Massachusetts Institute Of Technology | Cell surface coupling of nanoparticles |
| CA3074826A1 (en) | 2017-09-05 | 2019-03-14 | Torque Therapeutics, Inc. | Therapeutic protein compositions and methods of making and using the same |
-
2018
- 2018-09-05 EP EP18853003.4A patent/EP3678704A4/en not_active Withdrawn
- 2018-09-05 AU AU2018328208A patent/AU2018328208A1/en not_active Abandoned
- 2018-09-05 JP JP2020513526A patent/JP2020532565A/ja active Pending
- 2018-09-05 KR KR1020207009619A patent/KR20210031848A/ko not_active Abandoned
- 2018-09-05 WO PCT/US2018/049594 patent/WO2019050977A1/en not_active Ceased
- 2018-09-05 CA CA3075027A patent/CA3075027A1/en active Pending
- 2018-09-05 US US16/644,675 patent/US11547760B2/en active Active
- 2018-09-05 CN CN201880067030.0A patent/CN111432843A/zh active Pending
-
2022
- 2022-11-11 US US17/985,401 patent/US20230248841A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10472420B2 (en) | Immune response modifier conjugates | |
| DK174053B1 (da) | Stjerneesksplosionskonjugater, fremgangsmåder til fremstilling deraf, fremgangsmåde til fremstilling af en stjerneeksplosionspolyethylenimin og fremgangsmåde til rensning af en stjerneeksplosionsdendrimer | |
| CN107921144B (zh) | 澳瑞他汀类似物及其与细胞结合分子的共轭偶联物 | |
| TWI825007B (zh) | 用於cd137＋細胞耗盡（depletion）之組合物及方法 | |
| RU2218337C2 (ru) | Производные тиазола, способ их получения и фармацевтическая композиция на их основе | |
| TW401404B (en) | Imidazole derivatives | |
| CN114072178A (zh) | 可编程的聚合药物 | |
| CN112876471A (zh) | 吡啶并嘧啶类kras g12c突变蛋白抑制剂 | |
| CN114430738A (zh) | 可编程的聚合药物 | |
| JP2020188789A (ja) | 免疫療法のためのナノ粒子組成物及び方法 | |
| JP2006507265A5 (enExample) | ||
| US20200179531A1 (en) | Methods for assembling scavenging particles | |
| JP2013525080A5 (enExample) | ||
| JP2018523639A (ja) | 細胞結合分子の特異的共役体 | |
| AU2020366257B2 (en) | Conjugate molecules | |
| CN105555302B (zh) | 用于免疫疗法的组合物和方法 | |
| CN1671412A (zh) | 免疫刺激组合物及刺激免疫反应的方法 | |
| JP2002542365A (ja) | シアニン色素及びその合成法 | |
| JP2005500266A5 (enExample) | ||
| BR122019000248B1 (pt) | reagente de ligador de pró-fármaco de cascata polimérico | |
| CA2882492A1 (en) | Antibodies to aripiprazole haptens and use thereof | |
| CN113260382A (zh) | 含整合素配体的细胞抑制性缀合物 | |
| JP2023552448A5 (enExample) | ||
| CA2882449A1 (en) | Haptens of aripiprazole and their use in immunoassays | |
| CN106470980B (zh) | 靛红酸酐衍生物及其应用 |