JP2007503388A5 - - Google Patents

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Publication number
JP2007503388A5
JP2007503388A5 JP2006523903A JP2006523903A JP2007503388A5 JP 2007503388 A5 JP2007503388 A5 JP 2007503388A5 JP 2006523903 A JP2006523903 A JP 2006523903A JP 2006523903 A JP2006523903 A JP 2006523903A JP 2007503388 A5 JP2007503388 A5 JP 2007503388A5
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JP
Japan
Prior art keywords
substituted
group
alkyl
hydrogen
heterocycle
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006523903A
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English (en)
Japanese (ja)
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JP2007503388A (ja
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Priority claimed from PCT/US2004/025683 external-priority patent/WO2005021546A1/en
Publication of JP2007503388A publication Critical patent/JP2007503388A/ja
Publication of JP2007503388A5 publication Critical patent/JP2007503388A5/ja
Pending legal-status Critical Current

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JP2006523903A 2003-08-22 2004-08-09 マクロファージ遊走阻止因子の阻害剤としての置換ナフチリジン誘導体、およびヒト疾患の治療におけるそれらの使用 Pending JP2007503388A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49744303P 2003-08-22 2003-08-22
PCT/US2004/025683 WO2005021546A1 (en) 2003-08-22 2004-08-09 Substituted naphthyridine derivatives as inhibitors of macrophage migration inhibitory factor and their use in the treatment of human diseases

Publications (2)

Publication Number Publication Date
JP2007503388A JP2007503388A (ja) 2007-02-22
JP2007503388A5 true JP2007503388A5 (enExample) 2007-09-27

Family

ID=34272569

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006523903A Pending JP2007503388A (ja) 2003-08-22 2004-08-09 マクロファージ遊走阻止因子の阻害剤としての置換ナフチリジン誘導体、およびヒト疾患の治療におけるそれらの使用

Country Status (13)

Country Link
US (2) US20050124604A1 (enExample)
EP (1) EP1656376A1 (enExample)
JP (1) JP2007503388A (enExample)
CN (1) CN1839133A (enExample)
AR (1) AR045471A1 (enExample)
AU (1) AU2004268941A1 (enExample)
BR (1) BRPI0413695A (enExample)
CA (1) CA2531506A1 (enExample)
MX (1) MXJL06000006A (enExample)
PE (1) PE20051112A1 (enExample)
TW (1) TW200524928A (enExample)
UY (1) UY28483A1 (enExample)
WO (1) WO2005021546A1 (enExample)

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CN116003405A (zh) 2017-09-08 2023-04-25 美国安进公司 Kras g12c的抑制剂及其使用方法
CN107556309B (zh) * 2017-09-11 2020-12-01 浙江永宁药业股份有限公司 多取代四氢萘啶类化合物的药物用途及其制备方法
ES2995514T3 (en) 2018-05-04 2025-02-10 Amgen Inc Kras g12c inhibitors and methods of using the same
EP3788038B1 (en) 2018-05-04 2023-10-11 Amgen Inc. Kras g12c inhibitors and methods of using the same
MX2020011907A (es) 2018-05-10 2021-01-29 Amgen Inc Inhibidores de kras g12c para el tratamiento de cancer.
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AU2019284472B2 (en) * 2018-06-11 2024-05-30 Amgen Inc. KRAS G12C inhibitors for treating cancer
EP3807276B1 (en) 2018-06-12 2025-12-10 Amgen Inc. Kras g12c inhibitors encompassing a piperazine ring and use thereof in the treatment of cancer
HUE064531T2 (hu) 2018-06-27 2024-04-28 Bristol Myers Squibb Co Szubsztituált naftiridinon vegyületek mint T-sejt aktivátorok
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US11053226B2 (en) 2018-11-19 2021-07-06 Amgen Inc. KRAS G12C inhibitors and methods of using the same
JP7377679B2 (ja) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
CN111471059B (zh) * 2019-01-23 2022-12-02 药捷安康(南京)科技股份有限公司 Pde9抑制剂及其用途
JP7404616B2 (ja) * 2019-03-08 2023-12-26 トランステラ サイエンシーズ （ナンジン）， インコーポレイテッド ホスホジエステラーゼ阻害剤の使用
EP3738593A1 (en) 2019-05-14 2020-11-18 Amgen, Inc Dosing of kras inhibitor for treatment of cancers
KR20220011670A (ko) 2019-05-21 2022-01-28 암젠 인크 고체 상태 형태
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AU2020412698A1 (en) 2019-12-23 2022-08-18 Bristol-Myers Squibb Company Substituted piperazine derivatives useful as T cell activators
CN114846007B (zh) 2019-12-23 2024-11-22 百时美施贵宝公司 可用作t细胞激活剂的经取代的喹唑啉基化合物
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