JP2004535402A5 - - Google Patents
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- JP2004535402A5 JP2004535402A5 JP2002590923A JP2002590923A JP2004535402A5 JP 2004535402 A5 JP2004535402 A5 JP 2004535402A5 JP 2002590923 A JP2002590923 A JP 2002590923A JP 2002590923 A JP2002590923 A JP 2002590923A JP 2004535402 A5 JP2004535402 A5 JP 2004535402A5
- Authority
- JP
- Japan
- Prior art keywords
- soluble
- atcc
- antibody
- reacts
- antibodies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102100032937 CD40 ligand Human genes 0.000 description 5
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 description 5
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 description 5
- 101000868215 Homo sapiens CD40 ligand Proteins 0.000 description 3
- 108010029697 CD40 Ligand Proteins 0.000 description 2
- 101150013553 CD40 gene Proteins 0.000 description 2
- 102100032912 CD44 antigen Human genes 0.000 description 2
- 108010024212 E-Selectin Proteins 0.000 description 2
- 102100023471 E-selectin Human genes 0.000 description 2
- 101000759376 Escherichia phage Mu Tail sheath protein Proteins 0.000 description 2
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 2
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 description 2
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 description 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 2
- 108010008212 Integrin alpha4beta1 Proteins 0.000 description 2
- 102100025304 Integrin beta-1 Human genes 0.000 description 2
- 108010092694 L-Selectin Proteins 0.000 description 2
- 102000016551 L-selectin Human genes 0.000 description 2
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 description 2
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 2
- 101150052863 THY1 gene Proteins 0.000 description 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 2
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 description 2
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 description 2
- 229940046781 other immunosuppressants in atc Drugs 0.000 description 2
- 102100036008 CD48 antigen Human genes 0.000 description 1
- 101000716130 Homo sapiens CD48 antigen Proteins 0.000 description 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 102100025390 Integrin beta-2 Human genes 0.000 description 1
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 description 1
- 102000015271 Intercellular Adhesion Molecule-1 Human genes 0.000 description 1
- 108010064600 Intercellular Adhesion Molecule-3 Proteins 0.000 description 1
- 102100037872 Intercellular adhesion molecule 2 Human genes 0.000 description 1
- 101710148794 Intercellular adhesion molecule 2 Proteins 0.000 description 1
- 102100037871 Intercellular adhesion molecule 3 Human genes 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 description 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29340201P | 2001-05-23 | 2001-05-23 | |
| US60/293,402 | 2001-05-23 | ||
| PCT/US2002/016708 WO2002094202A2 (en) | 2001-05-23 | 2002-05-23 | Methods for protecting allogeneic islet transplant using soluble ctla4 mutant molecules |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004535402A JP2004535402A (ja) | 2004-11-25 |
| JP2004535402A5 true JP2004535402A5 (enExample) | 2009-02-05 |
| JP4837880B2 JP4837880B2 (ja) | 2011-12-14 |
Family
ID=23128937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002590923A Expired - Fee Related JP4837880B2 (ja) | 2001-05-23 | 2002-05-23 | 可溶性ｃｔｌａ４突然変異体分子を使って同種異系島移植片を保護する方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7304033B2 (enExample) |
| EP (1) | EP1397153B1 (enExample) |
| JP (1) | JP4837880B2 (enExample) |
| AT (1) | ATE390931T1 (enExample) |
| AU (1) | AU2002305716B2 (enExample) |
| CA (1) | CA2447921C (enExample) |
| CY (1) | CY1108127T1 (enExample) |
| CZ (1) | CZ305380B6 (enExample) |
| DE (1) | DE60225914T2 (enExample) |
| DK (1) | DK1397153T3 (enExample) |
| ES (1) | ES2302811T3 (enExample) |
| HU (1) | HU229680B1 (enExample) |
| MX (1) | MXPA03010568A (enExample) |
| NO (1) | NO332465B1 (enExample) |
| PL (1) | PL204899B1 (enExample) |
| PT (1) | PT1397153E (enExample) |
| WO (1) | WO2002094202A2 (enExample) |
Families Citing this family (79)
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|---|---|---|---|---|
| US5637481A (en) | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
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| ZA98533B (en) * | 1997-01-31 | 1999-07-22 | Bristol Myers Squibb Co | Soluble CTLA4 mutant molecules and uses thereof. |
| US20030219863A1 (en) * | 1997-01-31 | 2003-11-27 | Bristol-Myers Squibb Company | Soluble CTLA4 mutant molecules and uses thereof |
| US7094874B2 (en) * | 2000-05-26 | 2006-08-22 | Bristol-Myers Squibb Co. | Soluble CTLA4 mutant molecules |
| US20020039577A1 (en) * | 2000-06-09 | 2002-04-04 | Townsend Robert M. | Methods for regulating a lymphocyte-mediated immune response by blocking costimulatory signals and blocking LFA-1 mediated adhesion in lymphocytes |
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| RU2287340C2 (ru) * | 2000-07-03 | 2006-11-20 | Бристол-Маерс Сквибб Компани | Способы лечения ревматических заболеваний с применением растворимого ctla4 |
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| HU229680B1 (hu) * | 2001-05-23 | 2014-04-28 | Bristol Myers Squibb Co | Eljárások allogén sziget átültetés védelmére oldható CTLA4 mutáns molekulák alkalmazásával |
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| WO2005018668A1 (en) * | 2003-08-25 | 2005-03-03 | Pangenetics B.V. | Method of inducing immune tolerance |
| PT1868635T (pt) * | 2005-04-06 | 2017-07-27 | Bristol Myers Squibb Co | Métodos para tratar distúrbios imunes associados a transplantação de enxerto com moléculas mutantes solúveis de ctla4 |
| US9457070B2 (en) | 2005-06-07 | 2016-10-04 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses of alpha 1-antitrypsin for early intervention in bone marrow transplantation and treatment of graft versus host disease |
| ES2516690T5 (es) * | 2005-06-07 | 2017-11-21 | The Regents Of The University Of Colorado, A Body Corporate | Inhibidores de la actividad de serina proteasa y su uso en métodos y composiciones para el tratamiento de rechazo de injertos y promoción de supervivencia de injertos |
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| CN115089718B (zh) * | 2021-11-30 | 2024-05-28 | 杭州瑞普晨创科技有限公司 | 用于异种移植的免疫抑制剂组合和免疫抑制方法 |
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| WO2001090122A2 (en) | 2000-05-23 | 2001-11-29 | Genaissance Pharmaceuticals, Inc. | Haplotypes of the ctla4 gene |
| EG24459A (en) | 2000-05-26 | 2009-07-16 | Bristol Myers Squibb Co | Soluble CTLA4 mutant molecules and uses thereof |
| AU2006203199B2 (en) * | 2000-05-26 | 2009-02-12 | Bristol-Myers Squibb Company | Soluble CTLA4 mutant molecules and uses thereof |
| US7094874B2 (en) * | 2000-05-26 | 2006-08-22 | Bristol-Myers Squibb Co. | Soluble CTLA4 mutant molecules |
| US20020039577A1 (en) | 2000-06-09 | 2002-04-04 | Townsend Robert M. | Methods for regulating a lymphocyte-mediated immune response by blocking costimulatory signals and blocking LFA-1 mediated adhesion in lymphocytes |
| RU2287340C2 (ru) | 2000-07-03 | 2006-11-20 | Бристол-Маерс Сквибб Компани | Способы лечения ревматических заболеваний с применением растворимого ctla4 |
| US20040022787A1 (en) | 2000-07-03 | 2004-02-05 | Robert Cohen | Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID |
| PL375139A1 (en) | 2001-01-26 | 2005-11-28 | Emory University | Methods of inducing organ transplant tolerance and correcting hemoglobinopathies |
| US20030031652A1 (en) | 2001-04-16 | 2003-02-13 | Bernhard Hering | Systems and methods for inducing mixed chimerism |
| HU229680B1 (hu) * | 2001-05-23 | 2014-04-28 | Bristol Myers Squibb Co | Eljárások allogén sziget átültetés védelmére oldható CTLA4 mutáns molekulák alkalmazásával |
| TWI328614B (en) | 2002-12-23 | 2010-08-11 | Bristol Myers Squibb Co | Product quality enhancement in mammalian cell culture processes for protein production |
| CA2511520A1 (en) | 2002-12-23 | 2004-07-15 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
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-
2002
- 2002-05-23 HU HU0401590A patent/HU229680B1/hu not_active IP Right Cessation
- 2002-05-23 PT PT02734556T patent/PT1397153E/pt unknown
- 2002-05-23 AU AU2002305716A patent/AU2002305716B2/en not_active Ceased
- 2002-05-23 US US10/155,514 patent/US7304033B2/en not_active Expired - Lifetime
- 2002-05-23 EP EP02734556A patent/EP1397153B1/en not_active Expired - Lifetime
- 2002-05-23 JP JP2002590923A patent/JP4837880B2/ja not_active Expired - Fee Related
- 2002-05-23 DE DE60225914T patent/DE60225914T2/de not_active Expired - Lifetime
- 2002-05-23 AT AT02734556T patent/ATE390931T1/de active
- 2002-05-23 CZ CZ2003-3188A patent/CZ305380B6/cs not_active IP Right Cessation
- 2002-05-23 CA CA2447921A patent/CA2447921C/en not_active Expired - Fee Related
- 2002-05-23 ES ES02734556T patent/ES2302811T3/es not_active Expired - Lifetime
- 2002-05-23 DK DK02734556T patent/DK1397153T3/da active
- 2002-05-23 WO PCT/US2002/016708 patent/WO2002094202A2/en not_active Ceased
- 2002-05-23 PL PL364578A patent/PL204899B1/pl unknown
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- 2003-11-21 NO NO20035176A patent/NO332465B1/no not_active IP Right Cessation
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- 2008-06-09 CY CY20081100608T patent/CY1108127T1/el unknown
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