JP2015071598A5 - - Google Patents
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- Publication number
- JP2015071598A5 JP2015071598A5 JP2014205331A JP2014205331A JP2015071598A5 JP 2015071598 A5 JP2015071598 A5 JP 2015071598A5 JP 2014205331 A JP2014205331 A JP 2014205331A JP 2014205331 A JP2014205331 A JP 2014205331A JP 2015071598 A5 JP2015071598 A5 JP 2015071598A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- antibody
- vaccine
- antigen complex
- gag
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000427 antigen Substances 0.000 claims 20
- 210000004443 dendritic cell Anatomy 0.000 claims 15
- 229960005486 vaccine Drugs 0.000 claims 11
- 101710177291 Gag polyprotein Proteins 0.000 claims 9
- 239000012634 fragment Substances 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- -1 CD31 Proteins 0.000 claims 3
- 230000001461 cytolytic effect Effects 0.000 claims 3
- 230000013595 glycosylation Effects 0.000 claims 3
- 238000006206 glycosylation reaction Methods 0.000 claims 3
- 101150013553 CD40 gene Proteins 0.000 claims 2
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 2
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 2
- 108010045512 cohesins Proteins 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000002797 proteolythic effect Effects 0.000 claims 2
- 102100035248 Alpha-(1,3)-fucosyltransferase 4 Human genes 0.000 claims 1
- 101150075175 Asgr1 gene Proteins 0.000 claims 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- 102100028667 C-type lectin domain family 4 member A Human genes 0.000 claims 1
- 102100028668 C-type lectin domain family 4 member C Human genes 0.000 claims 1
- 102100028672 C-type lectin domain family 4 member D Human genes 0.000 claims 1
- 102100028681 C-type lectin domain family 4 member K Human genes 0.000 claims 1
- 101710183165 C-type lectin domain family 4 member K Proteins 0.000 claims 1
- 102100040840 C-type lectin domain family 7 member A Human genes 0.000 claims 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 1
- 102100032912 CD44 antigen Human genes 0.000 claims 1
- 102100035793 CD83 antigen Human genes 0.000 claims 1
- 102100021260 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 Human genes 0.000 claims 1
- 101001022185 Homo sapiens Alpha-(1,3)-fucosyltransferase 4 Proteins 0.000 claims 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- 101000766908 Homo sapiens C-type lectin domain family 4 member A Proteins 0.000 claims 1
- 101000766907 Homo sapiens C-type lectin domain family 4 member C Proteins 0.000 claims 1
- 101000766905 Homo sapiens C-type lectin domain family 4 member D Proteins 0.000 claims 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 1
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims 1
- 101000894906 Homo sapiens Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 Proteins 0.000 claims 1
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 1
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims 1
- 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 claims 1
- 101000608935 Homo sapiens Leukosialin Proteins 0.000 claims 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 1
- 101001063392 Homo sapiens Lymphocyte function-associated antigen 3 Proteins 0.000 claims 1
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 1
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims 1
- 101000980827 Homo sapiens T-cell surface glycoprotein CD1a Proteins 0.000 claims 1
- 101000716149 Homo sapiens T-cell surface glycoprotein CD1b Proteins 0.000 claims 1
- 101000716124 Homo sapiens T-cell surface glycoprotein CD1c Proteins 0.000 claims 1
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 1
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 1
- 102000009490 IgG Receptors Human genes 0.000 claims 1
- 108010073807 IgG Receptors Proteins 0.000 claims 1
- 102100022338 Integrin alpha-M Human genes 0.000 claims 1
- 102100025304 Integrin beta-1 Human genes 0.000 claims 1
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 102000010789 Interleukin-2 Receptors Human genes 0.000 claims 1
- 108010038453 Interleukin-2 Receptors Proteins 0.000 claims 1
- 102100039564 Leukosialin Human genes 0.000 claims 1
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 1
- 102100033486 Lymphocyte antigen 75 Human genes 0.000 claims 1
- 101710157884 Lymphocyte antigen 75 Proteins 0.000 claims 1
- 102100030984 Lymphocyte function-associated antigen 3 Human genes 0.000 claims 1
- 102000043129 MHC class I family Human genes 0.000 claims 1
- 108091054437 MHC class I family Proteins 0.000 claims 1
- 102000043131 MHC class II family Human genes 0.000 claims 1
- 108091054438 MHC class II family Proteins 0.000 claims 1
- 108010031099 Mannose Receptor Proteins 0.000 claims 1
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 1
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 1
- 102100025386 Oxidized low-density lipoprotein receptor 1 Human genes 0.000 claims 1
- 101710199789 Oxidized low-density lipoprotein receptor 1 Proteins 0.000 claims 1
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims 1
- 102100024219 T-cell surface glycoprotein CD1a Human genes 0.000 claims 1
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 1
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000030741 antigen processing and presentation Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 108010025838 dectin 1 Proteins 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8123408P | 2008-07-16 | 2008-07-16 | |
| US61/081,234 | 2008-07-16 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011518925A Division JP5984388B2 (ja) | 2008-07-16 | 2009-07-16 | 最大限のｇａｇ及びｎｅｆを樹状細胞に対して標的化することに基づくｈｉｖワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015071598A JP2015071598A (ja) | 2015-04-16 |
| JP2015071598A5 true JP2015071598A5 (enExample) | 2015-05-28 |
| JP6109800B2 JP6109800B2 (ja) | 2017-04-05 |
Family
ID=41551022
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011518925A Expired - Fee Related JP5984388B2 (ja) | 2008-07-16 | 2009-07-16 | 最大限のｇａｇ及びｎｅｆを樹状細胞に対して標的化することに基づくｈｉｖワクチン |
| JP2014205331A Expired - Fee Related JP6109800B2 (ja) | 2008-07-16 | 2014-10-06 | 最大限のｇａｇ及びｎｅｆを樹状細胞に対して標的化することに基づくｈｉｖワクチン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011518925A Expired - Fee Related JP5984388B2 (ja) | 2008-07-16 | 2009-07-16 | 最大限のｇａｇ及びｎｅｆを樹状細胞に対して標的化することに基づくｈｉｖワクチン |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9109011B2 (enExample) |
| EP (3) | EP2307048A4 (enExample) |
| JP (2) | JP5984388B2 (enExample) |
| KR (2) | KR20110036618A (enExample) |
| CN (1) | CN102625714B (enExample) |
| AP (1) | AP2011005541A0 (enExample) |
| AU (1) | AU2009270771B2 (enExample) |
| BR (1) | BRPI0915915A2 (enExample) |
| CA (1) | CA2730742C (enExample) |
| DK (1) | DK2966091T3 (enExample) |
| ES (2) | ES2685823T3 (enExample) |
| IL (1) | IL210646A0 (enExample) |
| MX (1) | MX2011000507A (enExample) |
| MY (1) | MY155377A (enExample) |
| NZ (3) | NZ596171A (enExample) |
| PT (1) | PT2966091T (enExample) |
| RU (2) | RU2539765C2 (enExample) |
| WO (1) | WO2010009346A2 (enExample) |
| ZA (1) | ZA201100398B (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2685823T3 (es) | 2008-07-16 | 2018-10-11 | Baylor Research Institute | Anticuerpos antagonistas anti-CD40 |
| AU2009286247A1 (en) * | 2008-08-29 | 2010-03-04 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Delivery of a CD40 agonist to a tumor draining lymph node of a subject |
| JP2012520073A (ja) | 2009-03-10 | 2012-09-06 | ベイラー リサーチ インスティテュート | 抗原提示細胞ターゲティングワクチン |
| EP2406286B1 (en) | 2009-03-10 | 2016-05-18 | Baylor Research Institute | Anti-cd40 antibodies and uses thereof |
| CN105837691B (zh) * | 2009-03-10 | 2021-06-29 | 贝勒研究院 | 靶向抗原呈递细胞的癌症疫苗 |
| EP2477655A4 (en) | 2009-09-14 | 2014-02-12 | Baylor Res Inst | VACCINES TREATED ON LANGERHANS CELLS |
| JP5628544B2 (ja) * | 2010-04-07 | 2014-11-19 | 株式会社豊田中央研究所 | クロストリジウム・サーモセラム由来のタンパク質複合体を構築するためのタンパク質及びその利用 |
| US20110274653A1 (en) | 2010-05-07 | 2011-11-10 | Baylor Research Institute | Dendritic cell immunoreceptors (dcir)-mediated crosspriming of human cd8+ t cells |
| TWI506035B (zh) * | 2010-08-13 | 2015-11-01 | Baylor Res Inst | 以直接針對抗原呈現細胞之抗體的標靶佐劑為主之新穎疫苗佐劑 |
| US20120128710A1 (en) * | 2010-11-02 | 2012-05-24 | Baylor Research Institute | Enhancement of Pathogen-Specific Memory Th17 Cell Responses |
| TW201247706A (en) * | 2011-03-08 | 2012-12-01 | Baylor Res Inst | Novel vaccine adjuvants based on targeting adjuvants to antibodies directly to antigen-presenting cells |
| CA2831294A1 (en) * | 2011-03-25 | 2012-10-04 | Baylor Research Institute | Compositions and methods to immunize against hepatitis c virus |
| CN103635488B (zh) * | 2011-04-29 | 2016-12-14 | 埃派斯进有限公司 | 抗-cd40抗体及其使用方法 |
| EP2620446A1 (en) | 2012-01-27 | 2013-07-31 | Laboratorios Del Dr. Esteve, S.A. | Immunogens for HIV vaccination |
| WO2014031984A1 (en) * | 2012-08-24 | 2014-02-27 | Baylor Research Institute | Immunological detection methods and compositions |
| WO2014039840A1 (en) * | 2012-09-07 | 2014-03-13 | Baylor Research Institute | Hiv vaccine compositions and methods |
| EP2914627B1 (en) | 2012-10-30 | 2021-04-07 | Apexigen, Inc. | Anti-cd40 antibodies and methods of use |
| EP3013362B1 (en) | 2013-06-28 | 2021-08-04 | Baylor Research Institute | Dendritic cell asgpr targeting immunotherapeutics for multiple sclerosis |
| AU2015204503B2 (en) | 2014-01-13 | 2020-07-09 | Baylor Research Institute | Novel vaccines against HPV and HPV-related diseases |
| EA201790024A1 (ru) | 2014-07-11 | 2017-07-31 | Джилид Сайэнс, Инк. | Модуляторы toll-подобных рецепторов для лечения вич |
| CN105821029A (zh) * | 2015-01-04 | 2016-08-03 | 彭霞 | 异源融合基因修饰的癌细胞/树突状细胞融合肿瘤疫苗及其制备方法 |
| CN105821030A (zh) * | 2015-01-04 | 2016-08-03 | 彭霞 | 表达α1，3半乳糖转移酶的癌细胞/树突状细胞融合肿瘤疫苗及其制备方法 |
| US20180356398A1 (en) | 2017-06-09 | 2018-12-13 | Fujifilm Corporation | Living tissue model device, vascular wall model, vascular wall model device and method of evaluating test substance |
| WO2019031939A2 (ko) | 2017-08-10 | 2019-02-14 | 주식회사 굳티셀 | 암 치료를 위한 t 세포의 활성화 방법 |
| US10610585B2 (en) | 2017-09-26 | 2020-04-07 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and compositions for treating and preventing HIV |
| KR20210035805A (ko) | 2018-06-15 | 2021-04-01 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 세포후 신호전달 인자의 조절을 통한 면역 활성의 증가 |
| JP2022519378A (ja) | 2019-02-08 | 2022-03-23 | グッド ティー セルズ、 インコーポレイテッド | がん治療のためのｔ細胞の活性化方法 |
| WO2020193718A1 (en) | 2019-03-27 | 2020-10-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Recombinant proteins with cd40 activating properties |
| MA55805A (fr) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V Inc | Métodes de modulation de l'activité immunitaire |
| EP4058058A1 (en) | 2019-11-14 | 2022-09-21 | Aelix Therapeutics S.L. | Dosage regimens for vaccines |
| CN114787181A (zh) * | 2019-11-21 | 2022-07-22 | Inserm(法国国家健康医学研究院) | 用抗pd-1/il-15免疫细胞因子靶向pd-1的新型免疫疗法 |
| US20230114107A1 (en) | 2019-12-17 | 2023-04-13 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
| JP2023528017A (ja) | 2020-05-26 | 2023-07-03 | アンセルム（アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル） | 重症急性呼吸器症候群コロナウイルス２（ｓａｒｓ－ｃｏｖ－２）ポリペプチドおよびワクチン目的でのその使用 |
| US20230355804A1 (en) | 2020-06-29 | 2023-11-09 | Flagship Pioneering Innovations V, Inc. | Viruses engineered to promote thanotransmission and their use in treating cancer |
| KR20230107260A (ko) | 2020-11-12 | 2023-07-14 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | Sars-cov-2 스파이크 단백질의 수용체-결합 도메인에 접합되거나 융합된 항체, 및 백신 목적을 위한 이의 용도 |
| GB202019879D0 (en) * | 2020-12-16 | 2021-01-27 | Ucl Business Ltd | Polypeptide |
| CA3205280A1 (en) | 2020-12-23 | 2022-06-30 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Chlamydia vaccine based on targeting momp vs4 antigen to antigen presenting cells |
| MX2023008986A (es) | 2021-01-29 | 2023-08-15 | Inst Nat Sante Rech Med | Polipeptidos antigenicos de chlamydia trachomatis y usos de los mismos con fines de vacuna. |
| CA3214085A1 (en) | 2021-03-31 | 2022-10-06 | Darby Rye Schmidt | Thanotransmission polypeptides and their use in treating cancer |
| KR20240026507A (ko) | 2021-06-29 | 2024-02-28 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 타노트랜스미션을 촉진시키도록 엔지니어링된 면역 세포 및 이의 용도 |
| KR20240103030A (ko) | 2021-11-17 | 2024-07-03 | 인스티튜트 내셔날 드 라 싼테 에 드 라 리셰르셰 메디칼르 | 범용 사르베코바이러스 백신 |
| WO2024074571A1 (en) | 2022-10-05 | 2024-04-11 | Institut National de la Santé et de la Recherche Médicale | Dc-targeting vaccine against nipah virus infection |
| WO2024077191A1 (en) | 2022-10-05 | 2024-04-11 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer |
| WO2024151687A1 (en) | 2023-01-09 | 2024-07-18 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
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| ES2685823T3 (es) * | 2008-07-16 | 2018-10-11 | Baylor Research Institute | Anticuerpos antagonistas anti-CD40 |
-
2009
- 2009-07-16 ES ES15182056.0T patent/ES2685823T3/es active Active
- 2009-07-16 JP JP2011518925A patent/JP5984388B2/ja not_active Expired - Fee Related
- 2009-07-16 CN CN200980136014.3A patent/CN102625714B/zh not_active Expired - Fee Related
- 2009-07-16 US US12/504,463 patent/US9109011B2/en active Active
- 2009-07-16 CA CA2730742A patent/CA2730742C/en active Active
- 2009-07-16 NZ NZ596171A patent/NZ596171A/xx not_active IP Right Cessation
- 2009-07-16 KR KR1020117003562A patent/KR20110036618A/ko not_active Ceased
- 2009-07-16 MY MYPI2011000174A patent/MY155377A/en unknown
- 2009-07-16 PT PT151820560T patent/PT2966091T/pt unknown
- 2009-07-16 RU RU2011105119/10A patent/RU2539765C2/ru not_active IP Right Cessation
- 2009-07-16 ES ES18173658T patent/ES2890230T3/es active Active
- 2009-07-16 KR KR1020137016705A patent/KR101548143B1/ko not_active Expired - Fee Related
- 2009-07-16 BR BRPI0915915A patent/BRPI0915915A2/pt not_active IP Right Cessation
- 2009-07-16 AU AU2009270771A patent/AU2009270771B2/en not_active Ceased
- 2009-07-16 EP EP09798772A patent/EP2307048A4/en not_active Withdrawn
- 2009-07-16 MX MX2011000507A patent/MX2011000507A/es active IP Right Grant
- 2009-07-16 DK DK15182056.0T patent/DK2966091T3/en active
- 2009-07-16 WO PCT/US2009/050903 patent/WO2010009346A2/en not_active Ceased
- 2009-07-16 NZ NZ594540A patent/NZ594540A/en not_active IP Right Cessation
- 2009-07-16 AP AP2011005541A patent/AP2011005541A0/xx unknown
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- 2009-07-16 EP EP18173658.8A patent/EP3388450B1/en active Active
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2011
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2012
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2014
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