JP2010518024A5 - - Google Patents
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- JP2010518024A5 JP2010518024A5 JP2009548484A JP2009548484A JP2010518024A5 JP 2010518024 A5 JP2010518024 A5 JP 2010518024A5 JP 2009548484 A JP2009548484 A JP 2009548484A JP 2009548484 A JP2009548484 A JP 2009548484A JP 2010518024 A5 JP2010518024 A5 JP 2010518024A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- immunoglobulin
- antibody
- asgpr
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000427 antigen Substances 0.000 claims 30
- 108091007433 antigens Proteins 0.000 claims 28
- 102000036639 antigens Human genes 0.000 claims 28
- 108060003951 Immunoglobulin Proteins 0.000 claims 16
- 102000018358 immunoglobulin Human genes 0.000 claims 16
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 239000012634 fragment Substances 0.000 claims 8
- 210000004443 dendritic cell Anatomy 0.000 claims 5
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 4
- 108020001507 fusion proteins Proteins 0.000 claims 4
- 102000037865 fusion proteins Human genes 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 230000001580 bacterial effect Effects 0.000 claims 3
- 230000027455 binding Effects 0.000 claims 3
- 108010067331 coherin Proteins 0.000 claims 3
- 230000000295 complement effect Effects 0.000 claims 3
- 230000002538 fungal effect Effects 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 230000003612 virological effect Effects 0.000 claims 3
- -1 CD31 Proteins 0.000 claims 2
- 101150013553 CD40 gene Proteins 0.000 claims 2
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 2
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims 2
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
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- 102100035248 Alpha-(1,3)-fucosyltransferase 4 Human genes 0.000 claims 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
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- 102100028667 C-type lectin domain family 4 member A Human genes 0.000 claims 1
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- 102100028672 C-type lectin domain family 4 member D Human genes 0.000 claims 1
- 102100028681 C-type lectin domain family 4 member K Human genes 0.000 claims 1
- 101710183165 C-type lectin domain family 4 member K Proteins 0.000 claims 1
- 102100040840 C-type lectin domain family 7 member A Human genes 0.000 claims 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 1
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- 101001022185 Homo sapiens Alpha-(1,3)-fucosyltransferase 4 Proteins 0.000 claims 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- 101000766908 Homo sapiens C-type lectin domain family 4 member A Proteins 0.000 claims 1
- 101000766907 Homo sapiens C-type lectin domain family 4 member C Proteins 0.000 claims 1
- 101000766905 Homo sapiens C-type lectin domain family 4 member D Proteins 0.000 claims 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 1
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims 1
- 101000894906 Homo sapiens Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 Proteins 0.000 claims 1
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 1
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- 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 claims 1
- 101000608935 Homo sapiens Leukosialin Proteins 0.000 claims 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 1
- 101001063392 Homo sapiens Lymphocyte function-associated antigen 3 Proteins 0.000 claims 1
- 101001018258 Homo sapiens Macrophage receptor MARCO Proteins 0.000 claims 1
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 1
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims 1
- 101000980827 Homo sapiens T-cell surface glycoprotein CD1a Proteins 0.000 claims 1
- 101000716149 Homo sapiens T-cell surface glycoprotein CD1b Proteins 0.000 claims 1
- 101000716124 Homo sapiens T-cell surface glycoprotein CD1c Proteins 0.000 claims 1
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 1
- 102000009490 IgG Receptors Human genes 0.000 claims 1
- 108010073807 IgG Receptors Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 102100022338 Integrin alpha-M Human genes 0.000 claims 1
- 102100025304 Integrin beta-1 Human genes 0.000 claims 1
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
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- 108010038453 Interleukin-2 Receptors Proteins 0.000 claims 1
- 102100039564 Leukosialin Human genes 0.000 claims 1
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 1
- 102100033486 Lymphocyte antigen 75 Human genes 0.000 claims 1
- 101710157884 Lymphocyte antigen 75 Proteins 0.000 claims 1
- 102100030984 Lymphocyte function-associated antigen 3 Human genes 0.000 claims 1
- 208000030289 Lymphoproliferative disease Diseases 0.000 claims 1
- 102000043129 MHC class I family Human genes 0.000 claims 1
- 108091054437 MHC class I family Proteins 0.000 claims 1
- 102000043131 MHC class II family Human genes 0.000 claims 1
- 108091054438 MHC class II family Proteins 0.000 claims 1
- 102100033272 Macrophage receptor MARCO Human genes 0.000 claims 1
- 108010031099 Mannose Receptor Proteins 0.000 claims 1
- 108010052285 Membrane Proteins Proteins 0.000 claims 1
- 102000018697 Membrane Proteins Human genes 0.000 claims 1
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 1
- 231100000678 Mycotoxin Toxicity 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 108010039491 Ricin Proteins 0.000 claims 1
- 108010079723 Shiga Toxin Proteins 0.000 claims 1
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims 1
- 102100024219 T-cell surface glycoprotein CD1a Human genes 0.000 claims 1
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 1
- 206010043376 Tetanus Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000005409 aflatoxin Substances 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 229940053031 botulinum toxin Drugs 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- 108010045512 cohesins Proteins 0.000 claims 1
- 108010025838 dectin 1 Proteins 0.000 claims 1
- 206010013023 diphtheria Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 231100000655 enterotoxin Toxicity 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
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- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- RPQXVSUAYFXFJA-HGRQIUPRSA-N saxitoxin Chemical compound NC(=O)OC[C@@H]1N=C(N)N2CCC(O)(O)[C@@]22N=C(N)N[C@@H]12 RPQXVSUAYFXFJA-HGRQIUPRSA-N 0.000 claims 1
- RPQXVSUAYFXFJA-UHFFFAOYSA-N saxitoxin hydrate Natural products NC(=O)OCC1N=C(N)N2CCC(O)(O)C22NC(N)=NC12 RPQXVSUAYFXFJA-UHFFFAOYSA-N 0.000 claims 1
- 239000003998 snake venom Substances 0.000 claims 1
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- 239000002708 spider venom Substances 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
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- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 238000002255 vaccination Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88803607P | 2007-02-02 | 2007-02-02 | |
| PCT/US2008/052865 WO2008097870A2 (en) | 2007-02-02 | 2008-02-02 | Agents that engage antigen - presenting cells through dendritic cell asialoglycoprotein receptor (dc- asgpr) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010518024A JP2010518024A (ja) | 2010-05-27 |
| JP2010518024A5 true JP2010518024A5 (enExample) | 2011-03-17 |
Family
ID=39682353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009548484A Pending JP2010518024A (ja) | 2007-02-02 | 2008-02-02 | 樹状細胞アシアロ糖タンパク質受容体（ｄｃ−ａｓｇｐｒ）を介して抗原提示細胞に結合する作用物質 |
Country Status (14)
| Country | Link |
|---|---|
| US (7) | US8236934B2 (enExample) |
| EP (1) | EP2115129B1 (enExample) |
| JP (1) | JP2010518024A (enExample) |
| KR (1) | KR20090114432A (enExample) |
| CN (1) | CN101952414A (enExample) |
| AU (1) | AU2008214036B2 (enExample) |
| BR (1) | BRPI0807152A2 (enExample) |
| CA (1) | CA2715045C (enExample) |
| IL (2) | IL200093A0 (enExample) |
| MX (1) | MX2009008211A (enExample) |
| NZ (2) | NZ593639A (enExample) |
| TW (1) | TWI422594B (enExample) |
| WO (1) | WO2008097870A2 (enExample) |
| ZA (1) | ZA200905274B (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7786267B2 (en) * | 2007-02-02 | 2010-08-31 | Baylor Research Institute | Multivariable antigens complexed with targeting humanized monoclonal antibody |
| TWI422594B (zh) | 2007-02-02 | 2014-01-11 | Baylor Res Inst | 經由樹狀細胞去唾液酸糖蛋白受體（ｄｃ-ａｓｇｐｒ）接合抗原呈現細胞之藥劑 |
| CN105884903B (zh) * | 2009-03-10 | 2019-12-06 | 贝勒研究院 | 靶向抗原呈递细胞的疫苗 |
| ES2584956T3 (es) | 2009-03-10 | 2016-09-30 | Baylor Research Institute | Anticuerpos anti-CD40 y usos de los mismos |
| CN103415534A (zh) * | 2009-03-10 | 2013-11-27 | 贝勒研究院 | 靶向抗原呈递细胞的癌症疫苗 |
| FR2955773B1 (fr) * | 2010-02-01 | 2017-05-26 | Commissariat Energie Atomique | Complexe moleculaire de ciblage des antigenes vers les cellules presentatrices d'antigene et ses applications pour la vaccination |
| MX2012012833A (es) | 2010-05-07 | 2012-11-30 | Baylor Res Inst | Cebado cruzado de celulas t cd8 positivas humanos moderada por inmunoreceptores de celulas dendriticas (dcir). |
| CN108117586A (zh) | 2010-08-10 | 2018-06-05 | 洛桑聚合联合学院 | 红细胞结合性治疗剂 |
| US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US20120121592A1 (en) * | 2010-10-13 | 2012-05-17 | Baylor Research Institute | Targeting Antigens to Human Dendritic Cells Via DC-Asialoglycoprotein Receptor to Produce IL-10 Regulatory T-Cells |
| CA2830987A1 (en) * | 2011-03-22 | 2012-09-27 | Baylor Research Institute | Dendritic cells (dcs) targeting for tuberculosis (tb) vaccine |
| AR085573A1 (es) * | 2011-03-25 | 2013-10-09 | Baylor Res Inst | Composiciones y metodos de inmunizacion contra el virus de la hepatitis c |
| WO2013009841A1 (en) * | 2011-07-11 | 2013-01-17 | Baylor Research Institute | Subsets of antigen-presenting cells (apc's) in the human vagina and their distinct functions |
| CN112587658A (zh) | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| WO2014031984A1 (en) * | 2012-08-24 | 2014-02-27 | Baylor Research Institute | Immunological detection methods and compositions |
| WO2014085580A1 (en) * | 2012-11-28 | 2014-06-05 | Baylor Research Institute | Methods and compositions involving a flu vaccine |
| CN103409451A (zh) * | 2013-06-28 | 2013-11-27 | 扬州维克斯生物科技有限公司 | 一种向树突状细胞dc靶向加载肿瘤抗原肽的方法 |
| US20160296609A1 (en) * | 2013-06-28 | 2016-10-13 | Baylor Research Institute | Dendritic cell asgpr targeting immunotherapeutics for multiple sclerosis |
| MX2016008520A (es) * | 2013-12-24 | 2016-11-30 | Astellas Pharma Inc | Anticuerpo bdca-2 antihumano novedoso. |
| AU2015205753A1 (en) | 2014-01-10 | 2016-07-21 | Birdie Biopharmaceuticals Inc. | Compounds and compositions for treating HER2 positive tumors |
| CN106103483A (zh) | 2014-01-13 | 2016-11-09 | 贝勒研究院 | 抗hpv和hpv相关的疾病的新疫苗 |
| US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
| US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| SG11201606761RA (en) | 2014-02-21 | 2016-09-29 | Ecole Polytecnique Federale De Lausanne Epfl Epfl Tto | Glycotargeting therapeutics |
| CA2942101A1 (en) | 2014-03-21 | 2015-09-24 | Abbvie Inc. | Anti-egfr antibodies and antibody drug conjugates |
| EP3142691A4 (en) * | 2014-05-16 | 2018-04-11 | Baylor Research Institute | Methods and compositions for treating autoimmune and inflammatory conditions |
| AU2015286043B2 (en) | 2014-07-09 | 2020-08-20 | Birdie Biopharmaceuticals Inc. | Anti-PD-L1 combinations for treating tumors |
| CN112587672A (zh) | 2014-09-01 | 2021-04-02 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-pd-l1结合物 |
| WO2016118787A1 (en) * | 2015-01-21 | 2016-07-28 | University Of Florida Research Foundation, Inc. | Engineered receptor/ligand system for delivery of therapeutic agents |
| CN115350279A (zh) | 2016-01-07 | 2022-11-18 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-her2组合 |
| CN115252792A (zh) | 2016-01-07 | 2022-11-01 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-egfr组合 |
| CN115554406A (zh) | 2016-01-07 | 2023-01-03 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-cd20组合 |
| TWI762487B (zh) | 2016-06-08 | 2022-05-01 | 美商艾伯維有限公司 | 抗-b7-h3抗體及抗體藥物結合物 |
| EP3468993A1 (en) | 2016-06-08 | 2019-04-17 | AbbVie Inc. | Anti-b7-h3 antibodies and antibody drug conjugates |
| MX2018015285A (es) | 2016-06-08 | 2019-09-18 | Abbvie Inc | Anticuerpos anti-b7-h3 y conjugados de anticuerpo y farmaco. |
| MX2018015274A (es) | 2016-06-08 | 2019-10-07 | Abbvie Inc | Anticuerpos anti-cd98 y conjugados de anticuerpo y farmaco. |
| US11702481B2 (en) | 2016-12-16 | 2023-07-18 | Bluefin Biomedicine, Inc. | Anti-cub domain-containing protein 1 (CDCP1) antibodies, antibody drug conjugates, and methods of use thereof |
| EP3585883A4 (en) | 2017-02-21 | 2021-04-14 | University of Florida Research Foundation, Incorporated | MODIFIED AAV CAPSID PROTEINS AND USES THEREOF |
| EP3612567B1 (en) | 2017-04-19 | 2024-09-11 | Bluefin Biomedicine, Inc. | Anti-vtcn1 antibodies and antibody drug conjugates |
| CN108794467A (zh) | 2017-04-27 | 2018-11-13 | 博笛生物科技有限公司 | 2-氨基-喹啉衍生物 |
| CN118994394A (zh) | 2017-06-12 | 2024-11-22 | 蓝鳍生物医药公司 | 抗-il1rap抗体和抗体药物缀合物 |
| WO2018232176A1 (en) | 2017-06-16 | 2018-12-20 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
| CN110769827A (zh) | 2017-06-23 | 2020-02-07 | 博笛生物科技有限公司 | 药物组合物 |
| US10610585B2 (en) | 2017-09-26 | 2020-04-07 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and compositions for treating and preventing HIV |
| IL278538B2 (en) | 2018-05-09 | 2024-01-01 | Univ Chicago | Compositions and methods concerning immune tolerance |
| UY39610A (es) | 2021-01-20 | 2022-08-31 | Abbvie Inc | Conjugados anticuerpo-fármaco anti-egfr |
| WO2025027529A1 (en) | 2023-07-31 | 2025-02-06 | Advesya | Anti-il-1rap antibody drug conjugates and methods of use thereof |
| WO2025126157A1 (en) | 2023-12-15 | 2025-06-19 | Advesya | Anti-il-1rap binding domains and antibody-drug conjugates thereof |
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