JP2008508313A5 - - Google Patents
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- JP2008508313A5 JP2008508313A5 JP2007523858A JP2007523858A JP2008508313A5 JP 2008508313 A5 JP2008508313 A5 JP 2008508313A5 JP 2007523858 A JP2007523858 A JP 2007523858A JP 2007523858 A JP2007523858 A JP 2007523858A JP 2008508313 A5 JP2008508313 A5 JP 2008508313A5
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- JP
- Japan
- Prior art keywords
- antigen
- molecular complex
- human
- antibody
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000427 antigen Substances 0.000 claims 49
- 108091007433 antigens Proteins 0.000 claims 49
- 102000036639 antigens Human genes 0.000 claims 49
- 230000003308 immunostimulating effect Effects 0.000 claims 18
- 239000000126 substance Substances 0.000 claims 18
- 210000001744 T-lymphocyte Anatomy 0.000 claims 16
- 239000003795 chemical substances by application Substances 0.000 claims 13
- 230000001404 mediated effect Effects 0.000 claims 13
- 230000004044 response Effects 0.000 claims 11
- 230000002708 enhancing effect Effects 0.000 claims 9
- 230000001939 inductive effect Effects 0.000 claims 9
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 6
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 6
- 102000004127 Cytokines Human genes 0.000 claims 6
- 108090000695 Cytokines Proteins 0.000 claims 6
- 102100022430 Melanocyte protein PMEL Human genes 0.000 claims 6
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 6
- 239000002158 endotoxin Substances 0.000 claims 6
- 230000004048 modification Effects 0.000 claims 6
- 238000012986 modification Methods 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 4
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 4
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 4
- -1 FR3 Proteins 0.000 claims 4
- 101000924577 Homo sapiens Adenomatous polyposis coli protein Proteins 0.000 claims 4
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 4
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 4
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 4
- 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 101800001271 Surface protein Proteins 0.000 claims 4
- 241000223997 Toxoplasma gondii Species 0.000 claims 4
- 210000004602 germ cell Anatomy 0.000 claims 4
- 102000055691 human APC Human genes 0.000 claims 4
- 229940044601 receptor agonist Drugs 0.000 claims 4
- 239000000018 receptor agonist Substances 0.000 claims 4
- 241000304886 Bacilli Species 0.000 claims 3
- 108010029697 CD40 Ligand Proteins 0.000 claims 3
- 102100032937 CD40 ligand Human genes 0.000 claims 3
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 3
- 229920002148 Gellan gum Polymers 0.000 claims 3
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 3
- 108060003951 Immunoglobulin Proteins 0.000 claims 3
- 102000000588 Interleukin-2 Human genes 0.000 claims 3
- 108010002350 Interleukin-2 Proteins 0.000 claims 3
- LAZPBGZRMVRFKY-HNCPQSOCSA-N Levamisole hydrochloride Chemical compound Cl.C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 LAZPBGZRMVRFKY-HNCPQSOCSA-N 0.000 claims 3
- 230000005867 T cell response Effects 0.000 claims 3
- 229940104302 cytosine Drugs 0.000 claims 3
- 102000018358 immunoglobulin Human genes 0.000 claims 3
- 238000001990 intravenous administration Methods 0.000 claims 3
- 230000021633 leukocyte mediated immunity Effects 0.000 claims 3
- 229960003734 levamisole hydrochloride Drugs 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- LKKMLIBUAXYLOY-UHFFFAOYSA-N 3-Amino-1-methyl-5H-pyrido[4,3-b]indole Chemical compound N1C2=CC=CC=C2C2=C1C=C(N)N=C2C LKKMLIBUAXYLOY-UHFFFAOYSA-N 0.000 claims 2
- 101000768957 Acholeplasma phage L2 Uncharacterized 37.2 kDa protein Proteins 0.000 claims 2
- 101000823746 Acidianus ambivalens Uncharacterized 17.7 kDa protein in bps2 3'region Proteins 0.000 claims 2
- 101000916369 Acidianus ambivalens Uncharacterized protein in sor 5'region Proteins 0.000 claims 2
- 101000769342 Acinetobacter guillouiae Uncharacterized protein in rpoN-murA intergenic region Proteins 0.000 claims 2
- 101000823696 Actinobacillus pleuropneumoniae Uncharacterized glycosyltransferase in aroQ 3'region Proteins 0.000 claims 2
- 101000786513 Agrobacterium tumefaciens (strain 15955) Uncharacterized protein outside the virF region Proteins 0.000 claims 2
- 101000618005 Alkalihalobacillus pseudofirmus (strain ATCC BAA-2126 / JCM 17055 / OF4) Uncharacterized protein BpOF4_00885 Proteins 0.000 claims 2
- 102100020724 Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 Human genes 0.000 claims 2
- 101000967489 Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 / NCIMB 13405 / ORS 571) Uncharacterized protein AZC_3924 Proteins 0.000 claims 2
- 101000977023 Azospirillum brasilense Uncharacterized 17.8 kDa protein in nodG 5'region Proteins 0.000 claims 2
- 241000193738 Bacillus anthracis Species 0.000 claims 2
- 101000823761 Bacillus licheniformis Uncharacterized 9.4 kDa protein in flaL 3'region Proteins 0.000 claims 2
- 101000819719 Bacillus methanolicus Uncharacterized N-acetyltransferase in lysA 3'region Proteins 0.000 claims 2
- 101000789586 Bacillus subtilis (strain 168) UPF0702 transmembrane protein YkjA Proteins 0.000 claims 2
- 101000792624 Bacillus subtilis (strain 168) Uncharacterized protein YbxH Proteins 0.000 claims 2
- 101000790792 Bacillus subtilis (strain 168) Uncharacterized protein YckC Proteins 0.000 claims 2
- 101000819705 Bacillus subtilis (strain 168) Uncharacterized protein YlxR Proteins 0.000 claims 2
- 101000948218 Bacillus subtilis (strain 168) Uncharacterized protein YtxJ Proteins 0.000 claims 2
- 101000961984 Bacillus thuringiensis Uncharacterized 30.3 kDa protein Proteins 0.000 claims 2
- 101000718627 Bacillus thuringiensis subsp. kurstaki Putative RNA polymerase sigma-G factor Proteins 0.000 claims 2
- 101000641200 Bombyx mori densovirus Putative non-structural protein Proteins 0.000 claims 2
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims 2
- 241000606161 Chlamydia Species 0.000 claims 2
- 206010008631 Cholera Diseases 0.000 claims 2
- 101000947633 Claviceps purpurea Uncharacterized 13.8 kDa protein Proteins 0.000 claims 2
- 241000193155 Clostridium botulinum Species 0.000 claims 2
- 208000035473 Communicable disease Diseases 0.000 claims 2
- 101000644901 Drosophila melanogaster Putative 115 kDa protein in type-1 retrotransposable element R1DM Proteins 0.000 claims 2
- 101100012887 Drosophila melanogaster btl gene Proteins 0.000 claims 2
- 101100012878 Drosophila melanogaster htl gene Proteins 0.000 claims 2
- 101000747702 Enterobacteria phage N4 Uncharacterized protein Gp2 Proteins 0.000 claims 2
- 101000948901 Enterobacteria phage T4 Uncharacterized 16.0 kDa protein in segB-ipI intergenic region Proteins 0.000 claims 2
- 101000805958 Equine herpesvirus 4 (strain 1942) Virion protein US10 homolog Proteins 0.000 claims 2
- 101000790442 Escherichia coli Insertion element IS2 uncharacterized 11.1 kDa protein Proteins 0.000 claims 2
- 101000758599 Escherichia coli Uncharacterized 14.7 kDa protein Proteins 0.000 claims 2
- 101000788354 Escherichia phage P2 Uncharacterized 8.2 kDa protein in gpA 5'region Proteins 0.000 claims 2
- 101710104359 F protein Proteins 0.000 claims 2
- 101000770304 Frankia alni UPF0460 protein in nifX-nifW intergenic region Proteins 0.000 claims 2
- 101000797344 Geobacillus stearothermophilus Putative tRNA (cytidine(34)-2'-O)-methyltransferase Proteins 0.000 claims 2
- 101000748410 Geobacillus stearothermophilus Uncharacterized protein in fumA 3'region Proteins 0.000 claims 2
- 101000772675 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) UPF0438 protein HI_0847 Proteins 0.000 claims 2
- 101000631019 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Uncharacterized protein HI_0350 Proteins 0.000 claims 2
- 101000768938 Haemophilus phage HP1 (strain HP1c1) Uncharacterized 8.9 kDa protein in int-C1 intergenic region Proteins 0.000 claims 2
- 101000785414 Homo sapiens Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 Proteins 0.000 claims 2
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 claims 2
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims 2
- 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 claims 2
- 101000620359 Homo sapiens Melanocyte protein PMEL Proteins 0.000 claims 2
- 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 claims 2
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims 2
- 101001094545 Homo sapiens Retrotransposon-like protein 1 Proteins 0.000 claims 2
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims 2
- 241000701074 Human alphaherpesvirus 2 Species 0.000 claims 2
- 108700020134 Human immunodeficiency virus 1 nef Proteins 0.000 claims 2
- 101000782488 Junonia coenia densovirus (isolate pBRJ/1990) Putative non-structural protein NS2 Proteins 0.000 claims 2
- 101000811523 Klebsiella pneumoniae Uncharacterized 55.8 kDa protein in cps region Proteins 0.000 claims 2
- 102100031413 L-dopachrome tautomerase Human genes 0.000 claims 2
- 101710093778 L-dopachrome tautomerase Proteins 0.000 claims 2
- 101000768930 Lactococcus lactis subsp. cremoris Uncharacterized protein in pepC 5'region Proteins 0.000 claims 2
- 101000818409 Lactococcus lactis subsp. lactis Uncharacterized HTH-type transcriptional regulator in lacX 3'region Proteins 0.000 claims 2
- 101000878851 Leptolyngbya boryana Putative Fe(2+) transport protein A Proteins 0.000 claims 2
- 101000976302 Leptospira interrogans Uncharacterized protein in sph 3'region Proteins 0.000 claims 2
- 101000778886 Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) Uncharacterized protein LA_2151 Proteins 0.000 claims 2
- 208000016604 Lyme disease Diseases 0.000 claims 2
- 108010010995 MART-1 Antigen Proteins 0.000 claims 2
- 101000758828 Methanosarcina barkeri (strain Fusaro / DSM 804) Uncharacterized protein Mbar_A1602 Proteins 0.000 claims 2
- 101000768804 Micromonospora olivasterospora Uncharacterized 10.9 kDa protein in fmrO 5'region Proteins 0.000 claims 2
- 101001122401 Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) Non-structural protein ORF3 Proteins 0.000 claims 2
- 108010008707 Mucin-1 Proteins 0.000 claims 2
- 102100034256 Mucin-1 Human genes 0.000 claims 2
- 101001055788 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) Pentapeptide repeat protein MfpA Proteins 0.000 claims 2
- 101000740670 Orgyia pseudotsugata multicapsid polyhedrosis virus Protein C42 Proteins 0.000 claims 2
- 101000769182 Photorhabdus luminescens Uncharacterized protein in pnp 3'region Proteins 0.000 claims 2
- 102100022019 Pregnancy-specific beta-1-glycoprotein 2 Human genes 0.000 claims 2
- 101000961392 Pseudescherichia vulneris Uncharacterized 29.9 kDa protein in crtE 3'region Proteins 0.000 claims 2
- 101000731030 Pseudomonas oleovorans Poly(3-hydroxyalkanoate) polymerase 2 Proteins 0.000 claims 2
- 101001065485 Pseudomonas putida Probable fatty acid methyltransferase Proteins 0.000 claims 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 2
- 101000711023 Rhizobium leguminosarum bv. trifolii Uncharacterized protein in tfuA 3'region Proteins 0.000 claims 2
- 101000948156 Rhodococcus erythropolis Uncharacterized 47.3 kDa protein in thcA 5'region Proteins 0.000 claims 2
- 101000917565 Rhodococcus fascians Uncharacterized 33.6 kDa protein in fasciation locus Proteins 0.000 claims 2
- 101001121571 Rice tungro bacilliform virus (isolate Philippines) Protein P2 Proteins 0.000 claims 2
- 101000790284 Saimiriine herpesvirus 2 (strain 488) Uncharacterized 9.5 kDa protein in DHFR 3'region Proteins 0.000 claims 2
- 101710173694 Short transient receptor potential channel 2 Proteins 0.000 claims 2
- 101000818098 Spirochaeta aurantia Uncharacterized protein in trpE 3'region Proteins 0.000 claims 2
- 101000936719 Streptococcus gordonii Accessory Sec system protein Asp3 Proteins 0.000 claims 2
- 101001026590 Streptomyces cinnamonensis Putative polyketide beta-ketoacyl synthase 2 Proteins 0.000 claims 2
- 101000788499 Streptomyces coelicolor Uncharacterized oxidoreductase in mprA 5'region Proteins 0.000 claims 2
- 101001102841 Streptomyces griseus Purine nucleoside phosphorylase ORF3 Proteins 0.000 claims 2
- 101000708557 Streptomyces lincolnensis Uncharacterized 17.2 kDa protein in melC2-rnhH intergenic region Proteins 0.000 claims 2
- 101000750896 Synechococcus elongatus (strain PCC 7942 / FACHB-805) Uncharacterized protein Synpcc7942_2318 Proteins 0.000 claims 2
- 108010017842 Telomerase Proteins 0.000 claims 2
- 206010043376 Tetanus Diseases 0.000 claims 2
- 101000649826 Thermotoga neapolitana Putative anti-sigma factor antagonist TM1081 homolog Proteins 0.000 claims 2
- 241000589884 Treponema pallidum Species 0.000 claims 2
- 102000003425 Tyrosinase Human genes 0.000 claims 2
- 108060008724 Tyrosinase Proteins 0.000 claims 2
- 101000827562 Vibrio alginolyticus Uncharacterized protein in proC 3'region Proteins 0.000 claims 2
- 101000778915 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) Uncharacterized membrane protein VP2115 Proteins 0.000 claims 2
- 101000916321 Xenopus laevis Transposon TX1 uncharacterized 149 kDa protein Proteins 0.000 claims 2
- 101000760088 Zymomonas mobilis subsp. mobilis (strain ATCC 10988 / DSM 424 / LMG 404 / NCIMB 8938 / NRRL B-806 / ZM1) 20.9 kDa protein Proteins 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 229940065181 bacillus anthracis Drugs 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 210000004443 dendritic cell Anatomy 0.000 claims 2
- 206010013023 diphtheria Diseases 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 208000006379 syphilis Diseases 0.000 claims 2
- 201000008827 tuberculosis Diseases 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- DMWMUMWKGKGSNW-OPMCLZTFSA-N (2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-4-amino-2-[[2-[[(2R)-2-amino-3-[(2R)-2,3-di(hexadecanoyloxy)propyl]sulfanylpropanoyl]amino]acetyl]amino]-4-oxobutanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]hexanoyl]amino]-4-carboxybutanoyl]amino]hexanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](CSC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(O)=O)OC(=O)CCCCCCCCCCCCCCC DMWMUMWKGKGSNW-OPMCLZTFSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108090000342 C-Type Lectins Proteins 0.000 claims 1
- 102000003930 C-Type Lectins Human genes 0.000 claims 1
- 108010040721 Flagellin Proteins 0.000 claims 1
- 101000576894 Homo sapiens Macrophage mannose receptor 1 Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102100026720 Interferon beta Human genes 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108090000467 Interferon-beta Proteins 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 102000043129 MHC class I family Human genes 0.000 claims 1
- 108091054437 MHC class I family Proteins 0.000 claims 1
- 102000043131 MHC class II family Human genes 0.000 claims 1
- 108091054438 MHC class II family Proteins 0.000 claims 1
- 102100025354 Macrophage mannose receptor 1 Human genes 0.000 claims 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 108010051618 macrophage stimulatory lipopeptide 2 Proteins 0.000 claims 1
- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 230000006798 recombination Effects 0.000 claims 1
- 238000005215 recombination Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/903,191 | 2004-07-30 | ||
| US10/903,191 US9259459B2 (en) | 2003-01-31 | 2004-07-30 | Antibody vaccine conjugates and uses therefor |
| PCT/US2005/027044 WO2006073493A2 (en) | 2004-07-30 | 2005-07-28 | Vaccine conjugates comprising a monoclonal antibody binding to human dentritic cells and beta human chronic gonadotropin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008508313A JP2008508313A (ja) | 2008-03-21 |
| JP2008508313A5 true JP2008508313A5 (enExample) | 2008-09-18 |
| JP4846718B2 JP4846718B2 (ja) | 2011-12-28 |
Family
ID=36647929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007523858A Expired - Fee Related JP4846718B2 (ja) | 2004-07-30 | 2005-07-28 | ヒト樹状細胞に結合するモノクローナル抗体とβヒト絨毛性性腺刺激ホルモンを含むワクチン結合体 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9259459B2 (enExample) |
| EP (1) | EP1789093B1 (enExample) |
| JP (1) | JP4846718B2 (enExample) |
| CN (1) | CN101039700B (enExample) |
| AU (1) | AU2005323472B2 (enExample) |
| CA (1) | CA2575248A1 (enExample) |
| WO (1) | WO2006073493A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007103048A2 (en) * | 2006-03-01 | 2007-09-13 | Regents Of The University Of Colorado | Tlr agonist (flagellin)/cd40 agonist/antigen protein and dna conjugates and use thereof for inducing synergistic enhancement in immunity |
| WO2007130493A2 (en) * | 2006-05-03 | 2007-11-15 | Regents Of The University Of Colorado | Cd40 agonist antibody/type1 interferon synergistic adjuvant combination, conjugates containing and use thereof as a therapeutic to enhance cellular immunity |
| EP2047863B1 (en) * | 2006-06-08 | 2013-07-31 | Chugai Seiyaku Kabushiki Kaisha | Preventive or remedy for inflammatory disease |
| CA2663851A1 (en) * | 2006-09-26 | 2008-04-03 | Alexion Pharmaceuticals, Inc. | Compositions and methods for enhancing an adjuvant |
| EP2066351B1 (en) | 2006-10-02 | 2015-09-09 | E. R. Squibb & Sons, L.L.C. | Human antibodies that bind cxcr4 and uses thereof |
| CA2697448C (en) * | 2007-08-30 | 2019-06-11 | The Burnet Institute | Dendritic cell marker and uses thereof |
| US9102734B2 (en) * | 2009-03-10 | 2015-08-11 | Baylor Research Institute | Fusion proteins comprising antibody and HPV E6 and E7 antigens |
| CA2798616A1 (en) * | 2010-05-07 | 2011-11-10 | Baylor Research Institute | Dendritic cell immunoreceptors (dcir)-mediated crosspriming of human cd8+ t cells |
| AR082686A1 (es) * | 2010-08-13 | 2012-12-26 | Baylor Res Inst | Adyuvantes de vacuna que direccionan a los adyuvantes de anticuerpos directamente hacia las celulas presentadoras de antigenos |
| BR112013007593A2 (pt) * | 2010-09-30 | 2016-08-09 | Franvax S R L | partícula de virossoma produzida sinteticamente, vacina, método para produzir uma partícula de virossoma, uso de uma partícula de virossoma e de uma vacina |
| CN112587671A (zh) | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| CA2936375A1 (en) | 2014-01-10 | 2015-07-16 | Shanghai Birdie Biotech, Inc. | Compounds and compositions for treating her2 positive tumors |
| FI4001311T3 (fi) | 2014-07-09 | 2026-01-27 | Birdie Biopharmaceuticals Inc | Pd-l1/pd-1-vasta-aineiden yhdistelmiä kasvaimien hoitoon |
| CN105440135A (zh) | 2014-09-01 | 2016-03-30 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-pd-l1结合物 |
| MA44334A (fr) | 2015-10-29 | 2018-09-05 | Novartis Ag | Conjugués d'anticorps comprenant un agoniste du récepteur de type toll |
| CN106943598A (zh) | 2016-01-07 | 2017-07-14 | 博笛生物科技（北京）有限公司 | 用于治疗肿瘤的抗-her2组合 |
| CN106943596A (zh) | 2016-01-07 | 2017-07-14 | 博笛生物科技（北京）有限公司 | 用于治疗肿瘤的抗-cd20组合 |
| CN115252792A (zh) | 2016-01-07 | 2022-11-01 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-egfr组合 |
| PL3426680T3 (pl) * | 2016-03-10 | 2025-03-31 | Acceleron Pharma Inc. | Białka wiążące receptor aktywiny typu 2 i ich zastosowania |
| CN108794467A (zh) | 2017-04-27 | 2018-11-13 | 博笛生物科技有限公司 | 2-氨基-喹啉衍生物 |
| CN110769827A (zh) | 2017-06-23 | 2020-02-07 | 博笛生物科技有限公司 | 药物组合物 |
| CN109517066A (zh) * | 2018-11-08 | 2019-03-26 | 深圳容金科技有限公司 | 一种抗hCGβ-CTP单克隆抗体及其制备方法 |
| CN114836389B (zh) * | 2022-07-05 | 2022-09-30 | 山东硕景生物科技有限公司 | 分泌抗hcg单克隆抗体的杂交瘤细胞株、抗hcg单克隆抗体及应用 |
| WO2025250964A1 (en) * | 2024-05-31 | 2025-12-04 | Aro Biotherapeutics Company | Cd206 binding human fibronectin type iii protein scaffolds |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4474893A (en) * | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US4954617A (en) | 1986-07-07 | 1990-09-04 | Trustees Of Dartmouth College | Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes |
| US5260203A (en) * | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| ATE243754T1 (de) * | 1987-05-21 | 2003-07-15 | Micromet Ag | Multifunktionelle proteine mit vorbestimmter zielsetzung |
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-
2004
- 2004-07-30 US US10/903,191 patent/US9259459B2/en not_active Expired - Fee Related
-
2005
- 2005-07-28 CA CA002575248A patent/CA2575248A1/en not_active Abandoned
- 2005-07-28 WO PCT/US2005/027044 patent/WO2006073493A2/en not_active Ceased
- 2005-07-28 JP JP2007523858A patent/JP4846718B2/ja not_active Expired - Fee Related
- 2005-07-28 CN CN2005800324279A patent/CN101039700B/zh not_active Expired - Fee Related
- 2005-07-28 EP EP05856893.2A patent/EP1789093B1/en not_active Expired - Lifetime
- 2005-07-28 AU AU2005323472A patent/AU2005323472B2/en not_active Ceased
-
2009
- 2009-07-02 US US12/496,719 patent/US20090324622A1/en not_active Abandoned
-
2016
- 2016-01-12 US US14/993,265 patent/US20160355593A1/en not_active Abandoned
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