ES2161875T3 - Celulas con multiples epitopos alterados en un antigeno superficial para uso en transplantes. - Google Patents
Celulas con multiples epitopos alterados en un antigeno superficial para uso en transplantes.Info
- Publication number
- ES2161875T3 ES2161875T3 ES95914995T ES95914995T ES2161875T3 ES 2161875 T3 ES2161875 T3 ES 2161875T3 ES 95914995 T ES95914995 T ES 95914995T ES 95914995 T ES95914995 T ES 95914995T ES 2161875 T3 ES2161875 T3 ES 2161875T3
- Authority
- ES
- Spain
- Prior art keywords
- altered
- cells
- antigen
- transplantation
- surface antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/407—Liver; Hepatocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
SE MUESTRAN CELULAS PREPARADAS PARA EL TRASPLANTE QUE TIENEN AL MENOS DOS EPITOPES DIFERENTES EN UN ANTIGENO SUPERFICIAL ALTERADOS ANTES DEL TRASPLANTE PARA EVITAR EL RECHAZO QUE SIGUE AL TRASPLANTE EN UN RECEPTOR ALOGENICO O XENOGENICO. ESTAS CELULAS TIENEN UN MAYOR EXITO EN EL TRASPLANTE QUE AQUELLAS QUE TIENEN UN SOLO EPITOPE EN EL ANTIGENO SUPERFICIAL ALTERADO. PREFERIBLEMENTE, EL ANTIGENO EN LA SUPERFICIE CELULAR QUE SE MODIFICA ES UN ANTIGENO MHC CLASE I. SE PUEDEN MODIFICAR DOS EPITOPES DIFERENTES DE UN ANTIGENO MHC CLASE I PONIENDO EN CONTACTO LAS CELULAS CON DOS MOLECULAS, TALES COMO ANTICUERPOS O FRAGMENTOS DE LOS MISMOS (P.E. FRAGMENTOS F(AB`){SUB,2}) QUE SE UNEN A DOS DIFERENTES EPITOPES EN EL ANTIGENO. LOS EPITOPES PREFERIDOS EN LOS ANTIGENOS MHC CLASE I HUMANOS PARA SER MODIFICADOS SON AQUELLOS RECONOCIDOS POR LOS ANTICUERPOS MONOCLONALES W6/32 Y PT85. SE MUESTRAN TAMBIEN METODOS MEJORADOS PARA EL TRASPLANTE UTILIZANDO CELULAS QUE TIENEN AL MENOS DOS EPITOPES DIFERENTES EN UNANTIGENO SUPERFICIAL MODIFICADOS ANTES DEL TRASPLANTE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22074194A | 1994-03-31 | 1994-03-31 | |
US08/240,150 US5679340A (en) | 1994-03-31 | 1994-05-10 | Cells with multiple altered epitopes on a surface antigen for use in transplantation |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2161875T3 true ES2161875T3 (es) | 2001-12-16 |
Family
ID=26915146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95914995T Expired - Lifetime ES2161875T3 (es) | 1994-03-31 | 1995-03-30 | Celulas con multiples epitopos alterados en un antigeno superficial para uso en transplantes. |
Country Status (11)
Country | Link |
---|---|
US (2) | US5679340A (es) |
EP (1) | EP0752869B1 (es) |
AT (1) | ATE203163T1 (es) |
AU (1) | AU684932B2 (es) |
CA (1) | CA2186529A1 (es) |
DE (1) | DE69521794T2 (es) |
DK (1) | DK0752869T3 (es) |
ES (1) | ES2161875T3 (es) |
GR (1) | GR3036951T3 (es) |
PT (1) | PT752869E (es) |
WO (1) | WO1995026741A1 (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5679340A (en) * | 1994-03-31 | 1997-10-21 | Diacrin, Inc. | Cells with multiple altered epitopes on a surface antigen for use in transplantation |
US5629194A (en) * | 1994-10-21 | 1997-05-13 | Diacrin, Inc. | Isolated porcine pancreatic cells for use in treatment of diseases characterized by insufficient insulin activity |
AU736374B2 (en) * | 1994-11-08 | 2001-07-26 | Diacrin, Inc. | Porcine striatal cells and their use in treatment of neurological deficits due to neurodegenerative disease |
US6204053B1 (en) * | 1994-11-08 | 2001-03-20 | Diacrin, Inc. | Porcine cortical cells and their use in treatment of neurological deficits due to neurodegenerative diseases |
US6294383B1 (en) * | 1994-11-08 | 2001-09-25 | The Mclean Hospital Corporation | Porcine neural cells and their use in treatment of neurological deficits due to neurodegenerative diseases |
US6277372B1 (en) | 1994-11-08 | 2001-08-21 | Diacrin, Inc. | Porcine neural cells and their use in treatment of neurological deficits due to neurodegenerative diseases |
AU6869198A (en) | 1997-03-25 | 1998-10-20 | Morphogenesis, Inc. | Universal stem cells |
US6368612B1 (en) * | 1997-12-12 | 2002-04-09 | Biohybrid Technologies Llc | Devices for cloaking transplanted cells |
US6284245B1 (en) * | 1998-08-25 | 2001-09-04 | Diacrin, Inc. | Neural retinal cells and retinal pigment epithelium cells and their use in treatment of retinal disorders |
US6444205B2 (en) * | 1998-09-30 | 2002-09-03 | Diacrin, Inc. | Transplantation of neural cells for the treatment of chronic pain or spasticity |
WO2000029206A1 (en) * | 1998-11-13 | 2000-05-25 | Sensor Technologies Inc. | Monodisperse preparations useful with implanted devices |
CA2362592A1 (en) * | 1999-02-12 | 2000-08-17 | Genetics Institute, Inc. | Humanized immunoglobulin reactive with b7 molecules and methods of treatment therewith |
US6972125B2 (en) * | 1999-02-12 | 2005-12-06 | Genetics Institute, Llc | Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith |
US6303355B1 (en) | 1999-03-22 | 2001-10-16 | Duke University | Method of culturing, cryopreserving and encapsulating pancreatic islet cells |
US6365385B1 (en) | 1999-03-22 | 2002-04-02 | Duke University | Methods of culturing and encapsulating pancreatic islet cells |
US7456017B2 (en) * | 1999-10-01 | 2008-11-25 | University Of North Carolina At Chapel Hill | Processes for clonal growth of hepatic progenitor cells |
AU7740600A (en) * | 1999-10-01 | 2001-05-10 | Biotransplant Incorporated | Process for inducing functional tolerance to gene transfer products |
US20020187133A1 (en) * | 1999-10-01 | 2002-12-12 | Hiroshi Kubota | Methods of isolating bipotent hepatic progenitor cells |
US7199216B1 (en) * | 1999-10-27 | 2007-04-03 | Cel-Sci Corporation | Peptide constructs for treating autoimmune and related diseases |
US20040072350A1 (en) * | 2000-09-14 | 2004-04-15 | Atsushi Yuki | Process for producing normal parenchymal cells tissue or organ by bioincubator |
US20030175255A1 (en) * | 2000-10-03 | 2003-09-18 | Hiroshi Kubota | Methods of isolating bipotent hepatic progenitor cells |
EP2625263B1 (en) | 2010-10-08 | 2020-03-11 | Terumo BCT, Inc. | Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
WO2012162564A1 (en) | 2011-05-25 | 2012-11-29 | Cel-Sci Corporation | Method for inducing an immune response and formulations thereof |
PL3003473T3 (pl) | 2013-05-30 | 2019-05-31 | Neurostim Solutions LLC | Miejscowa stymulacja neurologiczna |
US11229789B2 (en) | 2013-05-30 | 2022-01-25 | Neurostim Oab, Inc. | Neuro activator with controller |
JP6633522B2 (ja) | 2013-11-16 | 2020-01-22 | テルモ ビーシーティー、インコーポレーテッド | バイオリアクターにおける細胞増殖 |
US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
JP6830059B2 (ja) | 2014-09-26 | 2021-02-17 | テルモ ビーシーティー、インコーポレーテッド | スケジュール化された細胞フィーディング |
US11077301B2 (en) | 2015-02-21 | 2021-08-03 | NeurostimOAB, Inc. | Topical nerve stimulator and sensor for bladder control |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
EP3464565A4 (en) | 2016-05-25 | 2020-01-01 | Terumo BCT, Inc. | CELL EXPANSION |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
CN117247899A (zh) | 2017-03-31 | 2023-12-19 | 泰尔茂比司特公司 | 细胞扩增 |
KR102562469B1 (ko) | 2017-11-07 | 2023-08-01 | 뉴로스팀 오에이비, 인크. | 적응형 회로를 구비한 비침습성 신경 활성화기 |
JP2022538419A (ja) | 2019-06-26 | 2022-09-02 | ニューロスティム テクノロジーズ エルエルシー | 適応回路を備えた非侵襲性神経活性化装置 |
CN114728161A (zh) | 2019-12-16 | 2022-07-08 | 神经科学技术有限责任公司 | 具有升压电荷输送的非侵入性神经激活器 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1355961A (en) * | 1970-02-27 | 1974-06-12 | Wellcome Found | Preparation of immunosuppressive antilymphocytic serum |
US4399123A (en) * | 1980-04-01 | 1983-08-16 | Oliver Roy F | Fibrous tissue dressing or implant |
DE3852374T2 (de) * | 1987-11-02 | 1995-05-04 | Baylor College Medicine | Verwendung von ICAM-1 oder ihre funktionelle Derivate zur Behandlung unspezifischer Entzündungen. |
US5283058A (en) * | 1990-08-30 | 1994-02-01 | The General Hospital Corporation | Methods for inhibiting rejection of transplanted tissue |
AU9076191A (en) * | 1990-11-21 | 1992-06-25 | Massachusetts Institute Of Technology | Mice having beta 2 microglobulin gene disruption |
DE4110337A1 (de) * | 1991-03-28 | 1992-10-01 | Siemens Ag | Verfahren und einrichtung zur regeneration verbrauchter deno(pfeil abwaerts)x(pfeil abwaerts)-katalysatoren |
US5679340A (en) * | 1994-03-31 | 1997-10-21 | Diacrin, Inc. | Cells with multiple altered epitopes on a surface antigen for use in transplantation |
-
1994
- 1994-05-10 US US08/240,150 patent/US5679340A/en not_active Expired - Fee Related
-
1995
- 1995-03-30 AU AU22039/95A patent/AU684932B2/en not_active Ceased
- 1995-03-30 CA CA002186529A patent/CA2186529A1/en not_active Abandoned
- 1995-03-30 EP EP95914995A patent/EP0752869B1/en not_active Expired - Lifetime
- 1995-03-30 AT AT95914995T patent/ATE203163T1/de not_active IP Right Cessation
- 1995-03-30 DK DK95914995T patent/DK0752869T3/da active
- 1995-03-30 WO PCT/US1995/004058 patent/WO1995026741A1/en active IP Right Grant
- 1995-03-30 ES ES95914995T patent/ES2161875T3/es not_active Expired - Lifetime
- 1995-03-30 DE DE69521794T patent/DE69521794T2/de not_active Expired - Fee Related
- 1995-03-30 PT PT95914995T patent/PT752869E/pt unknown
-
1997
- 1997-10-07 US US08/946,637 patent/US6096537A/en not_active Expired - Fee Related
-
2001
- 2001-10-18 GR GR20010401816T patent/GR3036951T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US5679340A (en) | 1997-10-21 |
PT752869E (pt) | 2002-01-30 |
EP0752869A1 (en) | 1997-01-15 |
DE69521794T2 (de) | 2002-05-23 |
DK0752869T3 (da) | 2001-11-05 |
CA2186529A1 (en) | 1995-10-12 |
GR3036951T3 (en) | 2002-01-31 |
WO1995026741A1 (en) | 1995-10-12 |
US6096537A (en) | 2000-08-01 |
EP0752869B1 (en) | 2001-07-18 |
ATE203163T1 (de) | 2001-08-15 |
AU2203995A (en) | 1995-10-23 |
AU684932B2 (en) | 1998-01-08 |
DE69521794D1 (de) | 2001-08-23 |
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Legal Events
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FG2A | Definitive protection |
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