DE69521794T2 - Zellen mit mehreren geänderten epitopen auf einem oberflächeantigen zur verwendung in transplantation - Google Patents
Zellen mit mehreren geänderten epitopen auf einem oberflächeantigen zur verwendung in transplantationInfo
- Publication number
- DE69521794T2 DE69521794T2 DE69521794T DE69521794T DE69521794T2 DE 69521794 T2 DE69521794 T2 DE 69521794T2 DE 69521794 T DE69521794 T DE 69521794T DE 69521794 T DE69521794 T DE 69521794T DE 69521794 T2 DE69521794 T2 DE 69521794T2
- Authority
- DE
- Germany
- Prior art keywords
- transplantation
- cells
- antigen
- altered
- epitopes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/407—Liver; Hepatocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22074194A | 1994-03-31 | 1994-03-31 | |
US08/240,150 US5679340A (en) | 1994-03-31 | 1994-05-10 | Cells with multiple altered epitopes on a surface antigen for use in transplantation |
PCT/US1995/004058 WO1995026741A1 (en) | 1994-03-31 | 1995-03-30 | Cells with multiple altered epitopes on a surface antigen for use in transplantation |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69521794D1 DE69521794D1 (de) | 2001-08-23 |
DE69521794T2 true DE69521794T2 (de) | 2002-05-23 |
Family
ID=26915146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69521794T Expired - Fee Related DE69521794T2 (de) | 1994-03-31 | 1995-03-30 | Zellen mit mehreren geänderten epitopen auf einem oberflächeantigen zur verwendung in transplantation |
Country Status (11)
Country | Link |
---|---|
US (2) | US5679340A (de) |
EP (1) | EP0752869B1 (de) |
AT (1) | ATE203163T1 (de) |
AU (1) | AU684932B2 (de) |
CA (1) | CA2186529A1 (de) |
DE (1) | DE69521794T2 (de) |
DK (1) | DK0752869T3 (de) |
ES (1) | ES2161875T3 (de) |
GR (1) | GR3036951T3 (de) |
PT (1) | PT752869E (de) |
WO (1) | WO1995026741A1 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5679340A (en) * | 1994-03-31 | 1997-10-21 | Diacrin, Inc. | Cells with multiple altered epitopes on a surface antigen for use in transplantation |
US5629194A (en) * | 1994-10-21 | 1997-05-13 | Diacrin, Inc. | Isolated porcine pancreatic cells for use in treatment of diseases characterized by insufficient insulin activity |
US6294383B1 (en) * | 1994-11-08 | 2001-09-25 | The Mclean Hospital Corporation | Porcine neural cells and their use in treatment of neurological deficits due to neurodegenerative diseases |
AU736374B2 (en) * | 1994-11-08 | 2001-07-26 | Diacrin, Inc. | Porcine striatal cells and their use in treatment of neurological deficits due to neurodegenerative disease |
US6277372B1 (en) | 1994-11-08 | 2001-08-21 | Diacrin, Inc. | Porcine neural cells and their use in treatment of neurological deficits due to neurodegenerative diseases |
US6204053B1 (en) * | 1994-11-08 | 2001-03-20 | Diacrin, Inc. | Porcine cortical cells and their use in treatment of neurological deficits due to neurodegenerative diseases |
AU6869198A (en) * | 1997-03-25 | 1998-10-20 | Morphogenesis, Inc. | Universal stem cells |
US6368612B1 (en) * | 1997-12-12 | 2002-04-09 | Biohybrid Technologies Llc | Devices for cloaking transplanted cells |
US6284245B1 (en) | 1998-08-25 | 2001-09-04 | Diacrin, Inc. | Neural retinal cells and retinal pigment epithelium cells and their use in treatment of retinal disorders |
US6444205B2 (en) * | 1998-09-30 | 2002-09-03 | Diacrin, Inc. | Transplantation of neural cells for the treatment of chronic pain or spasticity |
AU1623300A (en) * | 1998-11-13 | 2000-06-05 | Sensor Technologies, Inc. | Monodisperse preparations useful with implanted devices |
CA2362592A1 (en) * | 1999-02-12 | 2000-08-17 | Genetics Institute, Inc. | Humanized immunoglobulin reactive with b7 molecules and methods of treatment therewith |
US6972125B2 (en) * | 1999-02-12 | 2005-12-06 | Genetics Institute, Llc | Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith |
US6303355B1 (en) | 1999-03-22 | 2001-10-16 | Duke University | Method of culturing, cryopreserving and encapsulating pancreatic islet cells |
US6365385B1 (en) | 1999-03-22 | 2002-04-02 | Duke University | Methods of culturing and encapsulating pancreatic islet cells |
US7456017B2 (en) * | 1999-10-01 | 2008-11-25 | University Of North Carolina At Chapel Hill | Processes for clonal growth of hepatic progenitor cells |
US20020187133A1 (en) * | 1999-10-01 | 2002-12-12 | Hiroshi Kubota | Methods of isolating bipotent hepatic progenitor cells |
JP2003531816A (ja) * | 1999-10-01 | 2003-10-28 | バイオトランスプラント,インコーポレイテッド | 遺伝子導入産物に機能的寛容を誘導する方法 |
US7199216B1 (en) * | 1999-10-27 | 2007-04-03 | Cel-Sci Corporation | Peptide constructs for treating autoimmune and related diseases |
US20040072350A1 (en) * | 2000-09-14 | 2004-04-15 | Atsushi Yuki | Process for producing normal parenchymal cells tissue or organ by bioincubator |
US20030175255A1 (en) * | 2000-10-03 | 2003-09-18 | Hiroshi Kubota | Methods of isolating bipotent hepatic progenitor cells |
WO2012048275A2 (en) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
WO2012162564A1 (en) | 2011-05-25 | 2012-11-29 | Cel-Sci Corporation | Method for inducing an immune response and formulations thereof |
US11229789B2 (en) | 2013-05-30 | 2022-01-25 | Neurostim Oab, Inc. | Neuro activator with controller |
PL3003473T3 (pl) | 2013-05-30 | 2019-05-31 | Neurostim Solutions LLC | Miejscowa stymulacja neurologiczna |
JP6633522B2 (ja) | 2013-11-16 | 2020-01-22 | テルモ ビーシーティー、インコーポレーテッド | バイオリアクターにおける細胞増殖 |
WO2015148704A1 (en) | 2014-03-25 | 2015-10-01 | Terumo Bct, Inc. | Passive replacement of media |
JP6830059B2 (ja) | 2014-09-26 | 2021-02-17 | テルモ ビーシーティー、インコーポレーテッド | スケジュール化された細胞フィーディング |
US11077301B2 (en) | 2015-02-21 | 2021-08-03 | NeurostimOAB, Inc. | Topical nerve stimulator and sensor for bladder control |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
WO2017205667A1 (en) | 2016-05-25 | 2017-11-30 | Terumo Bct, Inc. | Cell expansion |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
US11629332B2 (en) | 2017-03-31 | 2023-04-18 | Terumo Bct, Inc. | Cell expansion |
EP3706856A4 (de) | 2017-11-07 | 2021-08-18 | Neurostim Oab, Inc. | Nicht-invasiver nervenaktivator mit adaptiver schaltung |
EP3990100A4 (de) | 2019-06-26 | 2023-07-19 | Neurostim Technologies LLC | Nicht-invasiver nervenaktivator mit adaptiver schaltung |
JP2023506713A (ja) | 2019-12-16 | 2023-02-20 | ニューロスティム テクノロジーズ エルエルシー | 昇圧電荷送達を用いた非侵襲性神経アクティベータ |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1355961A (en) * | 1970-02-27 | 1974-06-12 | Wellcome Found | Preparation of immunosuppressive antilymphocytic serum |
US4399123A (en) * | 1980-04-01 | 1983-08-16 | Oliver Roy F | Fibrous tissue dressing or implant |
ES2064327T3 (es) * | 1987-11-02 | 1995-02-01 | Baylor College Medicine | Uso de icam-1 o de sus derivados funcionales para el tratamiento de una inflamacion no especifica. |
US5283058A (en) * | 1990-08-30 | 1994-02-01 | The General Hospital Corporation | Methods for inhibiting rejection of transplanted tissue |
WO1992009688A1 (en) * | 1990-11-21 | 1992-06-11 | Massachusetts Institute Of Technology | MICE HAVING β2 MICROGLOBULIN GENE DISRUPTION |
DE4110337A1 (de) * | 1991-03-28 | 1992-10-01 | Siemens Ag | Verfahren und einrichtung zur regeneration verbrauchter deno(pfeil abwaerts)x(pfeil abwaerts)-katalysatoren |
US5679340A (en) * | 1994-03-31 | 1997-10-21 | Diacrin, Inc. | Cells with multiple altered epitopes on a surface antigen for use in transplantation |
-
1994
- 1994-05-10 US US08/240,150 patent/US5679340A/en not_active Expired - Fee Related
-
1995
- 1995-03-30 ES ES95914995T patent/ES2161875T3/es not_active Expired - Lifetime
- 1995-03-30 WO PCT/US1995/004058 patent/WO1995026741A1/en active IP Right Grant
- 1995-03-30 DE DE69521794T patent/DE69521794T2/de not_active Expired - Fee Related
- 1995-03-30 AU AU22039/95A patent/AU684932B2/en not_active Ceased
- 1995-03-30 EP EP95914995A patent/EP0752869B1/de not_active Expired - Lifetime
- 1995-03-30 PT PT95914995T patent/PT752869E/pt unknown
- 1995-03-30 DK DK95914995T patent/DK0752869T3/da active
- 1995-03-30 CA CA002186529A patent/CA2186529A1/en not_active Abandoned
- 1995-03-30 AT AT95914995T patent/ATE203163T1/de not_active IP Right Cessation
-
1997
- 1997-10-07 US US08/946,637 patent/US6096537A/en not_active Expired - Fee Related
-
2001
- 2001-10-18 GR GR20010401816T patent/GR3036951T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
GR3036951T3 (en) | 2002-01-31 |
DE69521794D1 (de) | 2001-08-23 |
CA2186529A1 (en) | 1995-10-12 |
PT752869E (pt) | 2002-01-30 |
ATE203163T1 (de) | 2001-08-15 |
US5679340A (en) | 1997-10-21 |
DK0752869T3 (da) | 2001-11-05 |
EP0752869A1 (de) | 1997-01-15 |
EP0752869B1 (de) | 2001-07-18 |
US6096537A (en) | 2000-08-01 |
AU684932B2 (en) | 1998-01-08 |
AU2203995A (en) | 1995-10-23 |
WO1995026741A1 (en) | 1995-10-12 |
ES2161875T3 (es) | 2001-12-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |