JP2004534848A5 - - Google Patents
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- Publication number
- JP2004534848A5 JP2004534848A5 JP2003512202A JP2003512202A JP2004534848A5 JP 2004534848 A5 JP2004534848 A5 JP 2004534848A5 JP 2003512202 A JP2003512202 A JP 2003512202A JP 2003512202 A JP2003512202 A JP 2003512202A JP 2004534848 A5 JP2004534848 A5 JP 2004534848A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- methyl
- group
- phenyl
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 72
- 125000000217 alkyl group Chemical group 0.000 claims 40
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 36
- 125000003118 aryl group Chemical group 0.000 claims 30
- -1 2,5-dimethoxyphenyl Chemical group 0.000 claims 18
- 125000001931 aliphatic group Chemical group 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000003107 substituted aryl group Chemical group 0.000 claims 15
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 14
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 9
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 8
- 125000000547 substituted alkyl group Chemical group 0.000 claims 6
- 125000002252 acyl group Chemical group 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000001617 2,3-dimethoxy phenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] 0.000 claims 4
- 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims 4
- 239000003085 diluting agent Substances 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000001544 thienyl group Chemical group 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 229930012538 Paclitaxel Natural products 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 3
- 229960001592 paclitaxel Drugs 0.000 claims 3
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 3
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 2
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 2
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 2
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims 2
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 2
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 claims 2
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 1
- 101150065749 Churc1 gene Proteins 0.000 claims 1
- 102100038239 Protein Churchill Human genes 0.000 claims 1
- 125000004849 alkoxymethyl group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- OKPYIWASQZGASP-UHFFFAOYSA-N n-(2-hydroxypropyl)-2-methylprop-2-enamide Chemical compound CC(O)CNC(=O)C(C)=C OKPYIWASQZGASP-UHFFFAOYSA-N 0.000 claims 1
- VZKBEZDJWDUUFH-UHFFFAOYSA-N n-[2-(2-hydroxypropylamino)-2-oxoethyl]-2-methylprop-2-enamide Chemical compound CC(O)CNC(=O)CNC(=O)C(C)=C VZKBEZDJWDUUFH-UHFFFAOYSA-N 0.000 claims 1
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000004055 thiomethyl group Chemical group [H]SC([H])([H])* 0.000 claims 1
- 125000003944 tolyl group Chemical group 0.000 claims 1
- 0 *C(N(*)N(*)C(*C(N(*)N(*)C(I)=S)=O)=O)=S Chemical compound *C(N(*)N(*)C(*C(N(*)N(*)C(I)=S)=O)=O)=S 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30425201P | 2001-07-10 | 2001-07-10 | |
| US36194602P | 2002-03-06 | 2002-03-06 | |
| PCT/US2002/021717 WO2003006430A1 (en) | 2001-07-10 | 2002-07-10 | Taxol enhancer compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004534848A JP2004534848A (ja) | 2004-11-18 |
| JP2004534848A5 true JP2004534848A5 (enExample) | 2006-01-05 |
| JP4344235B2 JP4344235B2 (ja) | 2009-10-14 |
Family
ID=26973915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003512202A Expired - Fee Related JP4344235B2 (ja) | 2001-07-10 | 2002-07-10 | タキソール増強剤化合物 |
Country Status (23)
| Country | Link |
|---|---|
| US (6) | US6800660B2 (enExample) |
| EP (3) | EP1406869B1 (enExample) |
| JP (1) | JP4344235B2 (enExample) |
| KR (2) | KR100990581B1 (enExample) |
| CN (1) | CN100348580C (enExample) |
| AT (2) | ATE339402T1 (enExample) |
| AU (1) | AU2002316626B2 (enExample) |
| BR (1) | BR0211227A (enExample) |
| CA (1) | CA2455453C (enExample) |
| CY (1) | CY1105811T1 (enExample) |
| DE (1) | DE60214718T2 (enExample) |
| DK (2) | DK1406869T3 (enExample) |
| ES (2) | ES2395193T3 (enExample) |
| IL (2) | IL159773A0 (enExample) |
| IS (1) | IS2412B (enExample) |
| MX (1) | MXPA04000244A (enExample) |
| NO (1) | NO329457B1 (enExample) |
| NZ (1) | NZ530963A (enExample) |
| PT (1) | PT1406869E (enExample) |
| SI (1) | SI1406869T1 (enExample) |
| TW (1) | TWI332943B (enExample) |
| WO (1) | WO2003006430A1 (enExample) |
| ZA (1) | ZA200401051B (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI252847B (en) * | 2001-07-10 | 2006-04-11 | Synta Pharmaceuticals Corp | Synthesis of taxol enhancers |
| TWI332943B (en) | 2001-07-10 | 2010-11-11 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| US6924312B2 (en) | 2001-07-10 | 2005-08-02 | Synta Pharmaceuticals Corp. | Taxol enhancer compounds |
| TWI297335B (en) | 2001-07-10 | 2008-06-01 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| AU2006228035B2 (en) * | 2003-01-15 | 2010-02-18 | Synta Pharmaceuticals Corp. | Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer |
| TWI330079B (en) * | 2003-01-15 | 2010-09-11 | Synta Pharmaceuticals Corp | Treatment for cancers |
| PL1781604T3 (pl) | 2004-06-23 | 2014-01-31 | Synta Pharmaceuticals Corp | Sole bis(tiohydrazydoamidu) do leczenia nowotworów |
| WO2006033913A2 (en) * | 2004-09-16 | 2006-03-30 | Synta Pharmaceuticals Corp. | Bis (thio-hydrazide amides) for treament of hyperplasia |
| WO2006062732A2 (en) * | 2004-11-19 | 2006-06-15 | Synta Pharmaceuticals Corp. | Compounds acting at the centrosome |
| AU2005306471B2 (en) * | 2004-11-19 | 2009-12-17 | Synta Pharmaceuticals Corp. | Bis(thio-hydrazide amides) for increasing Hsp70 expression |
| MX2007012688A (es) * | 2005-04-15 | 2008-03-14 | Synta Pharmaceuticals Corp | Terapia de combinacion para el cancer con compuestos de bis(tiohidrazida) amida. |
| US20090042991A1 (en) * | 2005-04-15 | 2009-02-12 | James Barsoum | Methods of increasing natural killer cell activity for therapy |
| US7709683B2 (en) | 2005-05-16 | 2010-05-04 | Synta Pharmaceuticals Corp. | Synthesis of bis(thio-hydrazide amide) salts |
| US7678832B2 (en) * | 2005-08-16 | 2010-03-16 | Synta Pharmaceuticals Corp. | Bis(thio-hydrazide amide) formulation |
| TW200804307A (en) * | 2005-10-27 | 2008-01-16 | Synta Pharmaceuticals Corp | Process for preparing mesylate salts of IL-12 inhibitory compounds |
| EP2063878A2 (en) * | 2006-08-21 | 2009-06-03 | Synta Pharmaceuticals Corporation | Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma |
| US8497272B2 (en) | 2006-08-21 | 2013-07-30 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| US8785451B2 (en) * | 2006-08-21 | 2014-07-22 | Synta Pharmaceuticals Corp. | Compounds for the treatment of proliferative disorders |
| RU2475478C2 (ru) | 2006-08-21 | 2013-02-20 | Синта Фармасьютиклз Корп. | Соединения для лечения пролиферативных расстройств |
| AU2007288340A1 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis (thiohydrazide amides) for treating melanoma |
| WO2008024299A2 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Combination with bis(thiohydrazide amides) for treating cancer |
| JP2010502616A (ja) * | 2006-08-31 | 2010-01-28 | シンタ ファーマシューティカルズ コーポレーション | 癌を治療するためのビス（チオヒドラジドアミド）の組み合わせ |
| US20080118562A1 (en) * | 2006-09-11 | 2008-05-22 | Keizo Koya | Bis(thiohydrazide amides) formulation |
| US9498528B2 (en) * | 2006-09-13 | 2016-11-22 | Genzyme Corporation | Treatment of multiple sclerosis (MS) |
| WO2008033494A2 (en) * | 2006-09-15 | 2008-03-20 | Synta Pharmaceuticals Corp. | Purification of bis(thiohydrazide amides) |
| US20090093538A1 (en) * | 2007-01-03 | 2009-04-09 | Synta Pharmaceuticals Corp | Method for treating cancer |
| US8093425B2 (en) * | 2007-04-30 | 2012-01-10 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| US8729111B2 (en) | 2007-08-07 | 2014-05-20 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| WO2009064374A2 (en) * | 2007-11-09 | 2009-05-22 | Synta Pharmaceuticals Corp. | Oral formulations of bis(thiohydrazide amides) |
| TW200940050A (en) * | 2007-11-28 | 2009-10-01 | Synta Pharmaceuticals Corp | Polymorphs of N-malonyl-bis(N'-methyl-N'-thiobenzoylhydrazide) |
| US8637704B2 (en) | 2007-11-28 | 2014-01-28 | Synta Pharmaceuticals Corp. | Polymorphs of N-malonyl-bis(N′-methyl-N′-thiobenzoylhydrazide) |
| US8581004B2 (en) | 2008-02-21 | 2013-11-12 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| US8633323B2 (en) * | 2008-03-31 | 2014-01-21 | Synta Pharmaceuticals Corp. | Process for preparing bis(thiohydrazide amides) |
| MX2011004114A (es) * | 2008-10-22 | 2011-08-15 | Synta Pharmaceuticals Corp | Complejos de metales de transicion de un compuesto bis (tiohidrazida amida). |
| NZ592400A (en) | 2008-10-22 | 2013-09-27 | Synta Pharmaceuticals Corp | Transition metal complexes of bis[thiohydrazide amide] compounds |
| US8525776B2 (en) * | 2008-10-27 | 2013-09-03 | Lenovo (Singapore) Pte. Ltd | Techniques for controlling operation of a device with a virtual touchscreen |
| EP2370402A2 (en) | 2008-12-01 | 2011-10-05 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| WO2011069159A2 (en) | 2009-12-04 | 2011-06-09 | Synta Pharmaceuticals Corp. | Bis[thiohydrazide amide] compounds for treating leukemia |
| US8815945B2 (en) | 2010-04-20 | 2014-08-26 | Masazumi Nagai | Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers |
| JP2014534238A (ja) | 2011-11-10 | 2014-12-18 | シンタ ファーマシューティカルズ コーポレーション | 癌を治療するためのビス（チオヒドラジドアミド）化合物の投与 |
| US20130149392A1 (en) * | 2011-12-12 | 2013-06-13 | Synta Pharmaceuticals Corp. | Method of treating non-small cell lung cancer with bis-(thiohydrazide)amide compounds |
| WO2013103795A1 (en) | 2012-01-05 | 2013-07-11 | The Board Of Trustees Of The Leland Stanford Junior University | Bis (thiohydrazide amide) compounds for treating cancers |
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| WO2006062732A2 (en) | 2004-11-19 | 2006-06-15 | Synta Pharmaceuticals Corp. | Compounds acting at the centrosome |
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| US20090042991A1 (en) * | 2005-04-15 | 2009-02-12 | James Barsoum | Methods of increasing natural killer cell activity for therapy |
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| RU2475478C2 (ru) | 2006-08-21 | 2013-02-20 | Синта Фармасьютиклз Корп. | Соединения для лечения пролиферативных расстройств |
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- 2002-07-10 ES ES02746947T patent/ES2271292T3/es not_active Expired - Lifetime
- 2002-07-10 PT PT02746947T patent/PT1406869E/pt unknown
- 2002-07-10 US US10/193,075 patent/US6800660B2/en not_active Expired - Fee Related
- 2002-07-10 DK DK02746947T patent/DK1406869T3/da active
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- 2002-07-10 DK DK06019066.7T patent/DK1731148T3/da active
- 2002-07-10 EP EP10075453A patent/EP2289876A1/en not_active Withdrawn
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- 2002-07-10 WO PCT/US2002/021717 patent/WO2003006430A1/en not_active Ceased
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