JP2010500962A5 - - Google Patents
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- Publication number
- JP2010500962A5 JP2010500962A5 JP2009515635A JP2009515635A JP2010500962A5 JP 2010500962 A5 JP2010500962 A5 JP 2010500962A5 JP 2009515635 A JP2009515635 A JP 2009515635A JP 2009515635 A JP2009515635 A JP 2009515635A JP 2010500962 A5 JP2010500962 A5 JP 2010500962A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aralkyl
- group
- heterocyclyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 aralkenyl Chemical group 0.000 claims 45
- 150000001875 compounds Chemical class 0.000 claims 31
- 125000000217 alkyl group Chemical group 0.000 claims 28
- 125000003710 aryl alkyl group Chemical group 0.000 claims 20
- 125000003118 aryl group Chemical group 0.000 claims 20
- 125000000623 heterocyclic group Chemical group 0.000 claims 20
- 229940124530 sulfonamide Drugs 0.000 claims 20
- 125000000753 cycloalkyl group Chemical group 0.000 claims 15
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 15
- 125000001072 heteroaryl group Chemical group 0.000 claims 15
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 15
- 125000004432 carbon atom Chemical group C* 0.000 claims 12
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 10
- 229930194542 Keto Chemical group 0.000 claims 10
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 10
- 125000002252 acyl group Chemical group 0.000 claims 10
- 125000005236 alkanoylamino group Chemical group 0.000 claims 10
- 125000003342 alkenyl group Chemical group 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 125000000304 alkynyl group Chemical group 0.000 claims 10
- 125000005239 aroylamino group Chemical group 0.000 claims 10
- 125000004104 aryloxy group Chemical group 0.000 claims 10
- 239000004202 carbamide Substances 0.000 claims 10
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 10
- 125000004093 cyano group Chemical group *C#N 0.000 claims 10
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 10
- ZFTFAPZRGNKQPU-UHFFFAOYSA-N dicarbonic acid Chemical compound OC(=O)OC(O)=O ZFTFAPZRGNKQPU-UHFFFAOYSA-N 0.000 claims 10
- 125000005843 halogen group Chemical group 0.000 claims 10
- 125000005842 heteroatom Chemical group 0.000 claims 10
- 125000004449 heterocyclylalkenyl group Chemical group 0.000 claims 10
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 10
- 125000000468 ketone group Chemical group 0.000 claims 10
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims 10
- 150000003456 sulfonamides Chemical class 0.000 claims 10
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 125000001424 substituent group Chemical group 0.000 claims 9
- 125000003282 alkyl amino group Chemical group 0.000 claims 5
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 239000000651 prodrug Substances 0.000 claims 5
- 229940002612 prodrug Drugs 0.000 claims 5
- 125000000732 arylene group Chemical group 0.000 claims 4
- 125000002993 cycloalkylene group Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000005549 heteroarylene group Chemical group 0.000 claims 4
- 125000006588 heterocycloalkylene group Chemical group 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 102000005927 Cysteine Proteases Human genes 0.000 claims 3
- 108010005843 Cysteine Proteases Proteins 0.000 claims 3
- 102000005600 Cathepsins Human genes 0.000 claims 2
- 108010084457 Cathepsins Proteins 0.000 claims 2
- 150000001336 alkenes Chemical class 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 230000007838 tissue remodeling Effects 0.000 claims 1
- 0 **C(C1OC1C(N(*)*C(N(*)*)=O)=O)=O Chemical compound **C(C1OC1C(N(*)*C(N(*)*)=O)=O)=O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81363906P | 2006-06-13 | 2006-06-13 | |
| PCT/US2007/071145 WO2008042480A2 (en) | 2006-06-13 | 2007-06-13 | Epoxide inhibitors of cysteine proteases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010500962A JP2010500962A (ja) | 2010-01-14 |
| JP2010500962A5 true JP2010500962A5 (enExample) | 2010-07-29 |
Family
ID=39269056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009515635A Pending JP2010500962A (ja) | 2006-06-13 | 2007-06-13 | システインプロテアーゼ類のエポキシド阻害剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8673904B2 (enExample) |
| EP (1) | EP2029135A4 (enExample) |
| JP (1) | JP2010500962A (enExample) |
| KR (1) | KR20090029725A (enExample) |
| CN (1) | CN101808634A (enExample) |
| AU (1) | AU2007305138A1 (enExample) |
| BR (1) | BRPI0712868A2 (enExample) |
| CA (1) | CA2655139A1 (enExample) |
| IL (1) | IL195782A0 (enExample) |
| RU (1) | RU2009100878A (enExample) |
| WO (1) | WO2008042480A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2921486B1 (en) | 2009-08-07 | 2017-09-27 | American Life Science Pharmaceuticals, Inc. | Compositions and methods for treating beta-amyloid related diseases |
| WO2011075678A1 (en) | 2009-12-18 | 2011-06-23 | The Board Of Trustees Of The Leland Stanford Junior University | Specific inhibitors and active site probes for legumain |
| WO2012142003A2 (en) | 2011-04-15 | 2012-10-18 | Life Technologies Corporation | Chemical ligation |
| EP2811999B1 (en) | 2012-02-01 | 2021-10-27 | The Trustees of Columbia University in the City of New York | Novel cysteine protease inhibitors and uses thereof |
| CN104211666B (zh) * | 2013-05-31 | 2017-11-14 | 中国人民解放军军事医学科学院毒物药物研究所 | 2,3‑环氧丁二酰胺类化合物、其制备方法和用途 |
| CN107151236B (zh) * | 2016-03-03 | 2021-04-30 | 中国人民解放军军事医学科学院毒物药物研究所 | 一种2,3-环氧丁二酰衍生物及其制备方法和用途 |
| JP2020534283A (ja) * | 2017-09-15 | 2020-11-26 | アンパサンド バイオファーマシューティカルズ インコーポレイテッドＡｍｐｅｒｓａｎｄ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | システインプロテアーゼのタンパク質阻害剤を介した自然転移の阻害 |
| JP2020534285A (ja) | 2017-09-15 | 2020-11-26 | アンパサンド バイオファーマシューティカルズ インコーポレイテッドＡｍｐｅｒｓａｎｄ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | 投与および処置の方法 |
| CN110241438A (zh) * | 2018-03-08 | 2019-09-17 | 天津大学 | 泡沫铜担载钯铜合金纳米笼催化剂及其制备方法 |
| US11905249B2 (en) | 2021-01-25 | 2024-02-20 | Jackson State University | Covalent inhibitors of equine encephalitis virus |
| KR20230165715A (ko) | 2022-05-27 | 2023-12-05 | 서울대학교산학협력단 | 기생충 감염증의 예방 또는 치료용 약학 조성물 |
| CN120813388A (zh) * | 2023-03-02 | 2025-10-17 | 日本医事物理股份有限公司 | 放射性金属标记抗体、放射性药物及化合物 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1469797A (en) | 1974-11-07 | 1977-04-06 | Pfizer Ltd | Antibacterial cephalosporin derivatives |
| US4172896A (en) | 1978-06-05 | 1979-10-30 | Dainippon Pharmaceutical Co., Ltd. | Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same |
| JPS55115878A (en) * | 1979-02-27 | 1980-09-06 | Taisho Pharmaceut Co Ltd | Epoxysuccinic acid derivative |
| JPS55153778A (en) | 1979-05-17 | 1980-11-29 | Taisho Pharmaceut Co Ltd | Epoxysuccinylamino acid derivative |
| JPS57169478A (en) | 1981-04-10 | 1982-10-19 | Nippon Chemiphar Co Ltd | Piperazine derivative |
| JPS6276A (ja) | 1985-03-26 | 1987-01-06 | Toyo Jozo Co Ltd | 酵素阻害性新規物質 |
| JP2808877B2 (ja) | 1990-09-29 | 1998-10-08 | 大正製薬株式会社 | エポキシスクシナム酸誘導体およびその中間体 |
| GB9217295D0 (en) | 1992-08-14 | 1992-09-30 | Wellcome Found | Controlled released tablets |
| US5358970A (en) | 1993-08-12 | 1994-10-25 | Burroughs Wellcome Co. | Pharmaceutical composition containing bupropion hydrochloride and a stabilizer |
| US5541231A (en) | 1993-07-30 | 1996-07-30 | Glaxo Wellcome Inc. | Stabilized Pharmaceutical |
| GB9315856D0 (en) | 1993-07-30 | 1993-09-15 | Wellcome Found | Stabilized pharmaceutical |
| US5556853A (en) | 1993-10-29 | 1996-09-17 | Takeda Chemical Industries, Ltd. | Epoxysuccinic acid derivatives |
| JPH08104683A (ja) | 1993-10-29 | 1996-04-23 | Takeda Chem Ind Ltd | エポキシコハク酸誘導体 |
| JPH08104684A (ja) | 1994-05-31 | 1996-04-23 | Takeda Chem Ind Ltd | エポキシコハク酸関連化合物 |
| US5679708A (en) * | 1994-05-31 | 1997-10-21 | Takeda Chemical Industries, Ltd. | Epoxysuccinic acid derivatives, their production and use |
| AU697565B2 (en) | 1995-12-12 | 1998-10-08 | Taiho Pharmaceutical Co., Ltd. | Epoxysuccinamide derivative or salt thereof and medicine comprising the same |
| DE69814800T2 (de) * | 1997-04-18 | 2003-12-18 | Taiho Pharmaceutical Co. Ltd., Tokio/Tokyo | Epoxysuccinamid-derivate oder ihre salze |
| JPH11263783A (ja) | 1998-01-09 | 1999-09-28 | Taisho Pharmaceut Co Ltd | エポキシスクシナム酸誘導体 |
| JP2002501892A (ja) | 1998-01-29 | 2002-01-22 | セプラコア インコーポレーテッド | 光学的に純粋な（−）−ビュープロピオンの薬学的使用 |
| US20020150961A1 (en) | 2000-11-10 | 2002-10-17 | The Regents Of The University Of California Office Of Technology Management | Activity-dependent cysteine protease profiling reagent |
| DE60203189T2 (de) | 2001-09-12 | 2005-07-28 | Dow Global Technologies, Inc., Midland | Netzwerkpolymere mit epoxidgruppenterminierten estern |
| US20030212003A1 (en) | 2002-02-14 | 2003-11-13 | Hermann Lubbert | Cathepsin Y for the development of a medicament for the treatment of pain |
| US20060154325A1 (en) | 2005-01-10 | 2006-07-13 | Matthew Bogyo | Synthesis of epoxide based inhibitors of cysteine proteases |
-
2007
- 2007-06-13 JP JP2009515635A patent/JP2010500962A/ja active Pending
- 2007-06-13 BR BRPI0712868-1A patent/BRPI0712868A2/pt not_active IP Right Cessation
- 2007-06-13 US US11/762,735 patent/US8673904B2/en not_active Expired - Fee Related
- 2007-06-13 WO PCT/US2007/071145 patent/WO2008042480A2/en not_active Ceased
- 2007-06-13 CA CA002655139A patent/CA2655139A1/en not_active Abandoned
- 2007-06-13 AU AU2007305138A patent/AU2007305138A1/en not_active Abandoned
- 2007-06-13 RU RU2009100878/21A patent/RU2009100878A/ru not_active Application Discontinuation
- 2007-06-13 EP EP07863360A patent/EP2029135A4/en not_active Withdrawn
- 2007-06-13 KR KR1020087030795A patent/KR20090029725A/ko not_active Withdrawn
- 2007-06-13 CN CN200780029699A patent/CN101808634A/zh active Pending
-
2008
- 2008-12-08 IL IL195782A patent/IL195782A0/en unknown
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