JP2013500304A5 - - Google Patents
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- Publication number
- JP2013500304A5 JP2013500304A5 JP2012522131A JP2012522131A JP2013500304A5 JP 2013500304 A5 JP2013500304 A5 JP 2013500304A5 JP 2012522131 A JP2012522131 A JP 2012522131A JP 2012522131 A JP2012522131 A JP 2012522131A JP 2013500304 A5 JP2013500304 A5 JP 2013500304A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- lower alkyl
- amino
- lower alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC1C(C(C2)C2CC2)*2C1C Chemical compound CC1C(C(C2)C2CC2)*2C1C 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09166469 | 2009-07-27 | ||
| EP09166469.8 | 2009-07-27 | ||
| PCT/EP2010/060803 WO2011012577A1 (en) | 2009-07-27 | 2010-07-26 | Furazanobenzimidazoles as prodrugs to treat neoplastic or autoimmune diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013500304A JP2013500304A (ja) | 2013-01-07 |
| JP2013500304A5 true JP2013500304A5 (enExample) | 2013-05-30 |
| JP5576485B2 JP5576485B2 (ja) | 2014-08-20 |
Family
ID=41226617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012522131A Expired - Fee Related JP5576485B2 (ja) | 2009-07-27 | 2010-07-26 | 新生物疾患又は自己免疫疾患を処置するためのプロドラッグとしてのフラザノベンゾイミダゾール |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8802858B2 (enExample) |
| EP (1) | EP2459553B1 (enExample) |
| JP (1) | JP5576485B2 (enExample) |
| KR (1) | KR101758400B1 (enExample) |
| CN (1) | CN102471329B (enExample) |
| AU (1) | AU2010277688B2 (enExample) |
| BR (1) | BR112012001817B8 (enExample) |
| CA (1) | CA2767875C (enExample) |
| CY (1) | CY1115809T1 (enExample) |
| DK (1) | DK2459553T3 (enExample) |
| EA (1) | EA021380B1 (enExample) |
| ES (1) | ES2524119T3 (enExample) |
| HR (1) | HRP20141120T1 (enExample) |
| IL (1) | IL217195A (enExample) |
| MX (1) | MX336240B (enExample) |
| NZ (1) | NZ597376A (enExample) |
| PL (1) | PL2459553T3 (enExample) |
| PT (1) | PT2459553E (enExample) |
| RS (1) | RS53679B1 (enExample) |
| SI (1) | SI2459553T1 (enExample) |
| TW (1) | TWI457337B (enExample) |
| UA (1) | UA106763C2 (enExample) |
| WO (1) | WO2011012577A1 (enExample) |
| ZA (1) | ZA201200228B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012098203A1 (en) | 2011-01-21 | 2012-07-26 | Basilea Pharmaceutica Ag | Use of glu-tubulin as a biomarker of drug response to furazanobenzimidazoles |
| JP6302674B2 (ja) * | 2011-01-21 | 2018-03-28 | バジリア ファルマスーチカ アーゲーＢａｓｉｌｅａ Ｐｈａｒｍａｃｅｕｔｉｃａ ＡＧ | フラザノベンゾイミダゾールに対する薬物応答のバイオマーカーとしてのスタスミンの使用 |
| US10222377B2 (en) | 2011-01-21 | 2019-03-05 | Basilea Pharmaceutica Ag | Use of BUBR1 as a biomarker of drug response to furazanobenzimidazoles |
| JP6295081B2 (ja) * | 2011-02-24 | 2018-03-14 | バジリア ファルマスーチカ アーゲーＢａｓｉｌｅａ Ｐｈａｒｍａｃｅｕｔｉｃａ ＡＧ | フラザノベンゾイミダゾールに対する薬物応答のバイオマーカーとしてのアセチル化チューブリンの使用 |
| JP6334393B2 (ja) | 2011-03-29 | 2018-05-30 | バジリア ファルマスーチカ アーゲーＢａｓｉｌｅａ Ｐｈａｒｍａｃｅｕｔｉｃａ ＡＧ | 薬物応答のバイオマーカーとしてのホスホＡｋｔの使用 |
| US9558575B2 (en) | 2012-02-28 | 2017-01-31 | Blackberry Limited | Methods and devices for selecting objects in images |
| ITRM20130248A1 (it) * | 2013-04-24 | 2014-10-25 | Medivis S R L | Formulazioni di riboflavina per il cross-linking transepiteliale. |
| WO2015173341A1 (en) * | 2014-05-13 | 2015-11-19 | Basilea Pharmaceutica Ag | Dosage principle for anti-cancer furazanylbenzimidazoles |
| HK1257768A1 (zh) * | 2015-10-22 | 2019-10-25 | Basilea Pharmaceutica International AG | Eb1作为药物应答的生物标记物的用途 |
| JP2020517608A (ja) * | 2017-04-20 | 2020-06-18 | ピーアイ インダストリーズ リミテッドＰｉ Ｉｎｄｕｓｔｒｉｅｓ Ｌｔｄ | 新規フェニルアミン化合物 |
| CA3058695A1 (en) * | 2017-04-26 | 2018-11-01 | Basilea Pharmaceutica International AG | Processes for the preparation of furazanobenzimidazoles and crystalline forms thereof |
| EP3624790A1 (en) | 2017-05-16 | 2020-03-25 | Basilea Pharmaceutica International AG | Novel dosage principle for drugs useful for treating neoplastic diseases |
| EP3713565A1 (en) | 2017-11-20 | 2020-09-30 | Basilea Pharmaceutica International AG | Pharmaceutical combinations for use in the treatment of neoplastic diseases |
| US20220031670A1 (en) | 2018-09-20 | 2022-02-03 | Basilea Pharmaceutica International AG | Pharmaceutical combinations for use in the treatment of neoplastic diseases |
| EP4027998A1 (en) | 2019-09-09 | 2022-07-20 | Basilea Pharmaceutica International AG | Pharmaceutical combinations comprising a furazanobenzimidazoles and a cd40 agonist for use in the treatment of neoplastic diseases |
| CN111454254B (zh) | 2020-04-26 | 2023-06-02 | 云白药征武科技(上海)有限公司 | 一种具有含氟取代基的苯并咪唑衍生物的制备及其应用 |
| CN111423429A (zh) * | 2020-05-19 | 2020-07-17 | 江西科技师范大学 | 苯并咪唑联呋咱类系列化合物及其合成方法 |
| WO2022053549A1 (en) | 2020-09-10 | 2022-03-17 | Basilea Pharmaceutica International AG | Use of c-myc as a biomarker of drug response |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6897208B2 (en) * | 2001-10-26 | 2005-05-24 | Aventis Pharmaceuticals Inc. | Benzimidazoles |
| KR20040084896A (ko) * | 2002-02-06 | 2004-10-06 | 버텍스 파마슈티칼스 인코포레이티드 | Ｇｓｋ-3의 억제제로서 유용한 헤테로아릴 화합물 |
| PT1636215E (pt) * | 2003-05-23 | 2008-04-29 | Basilea Pharmaceutica Ag | Furazanobenzimidazoles |
| EP1723138B1 (en) * | 2004-02-11 | 2010-07-14 | Basilea Pharmaceutica AG | Substituted benzimidazoles and their use for inducing apoptosis |
-
2010
- 2010-07-26 KR KR1020127005138A patent/KR101758400B1/ko not_active Expired - Fee Related
- 2010-07-26 CA CA2767875A patent/CA2767875C/en active Active
- 2010-07-26 RS RS20140669A patent/RS53679B1/sr unknown
- 2010-07-26 JP JP2012522131A patent/JP5576485B2/ja not_active Expired - Fee Related
- 2010-07-26 SI SI201030829T patent/SI2459553T1/sl unknown
- 2010-07-26 ES ES10740196.0T patent/ES2524119T3/es active Active
- 2010-07-26 EA EA201200189A patent/EA021380B1/ru unknown
- 2010-07-26 US US13/384,467 patent/US8802858B2/en active Active
- 2010-07-26 CN CN201080033104.2A patent/CN102471329B/zh not_active Expired - Fee Related
- 2010-07-26 MX MX2012000611A patent/MX336240B/es unknown
- 2010-07-26 AU AU2010277688A patent/AU2010277688B2/en not_active Ceased
- 2010-07-26 EP EP10740196.0A patent/EP2459553B1/en active Active
- 2010-07-26 WO PCT/EP2010/060803 patent/WO2011012577A1/en not_active Ceased
- 2010-07-26 PT PT107401960T patent/PT2459553E/pt unknown
- 2010-07-26 PL PL10740196T patent/PL2459553T3/pl unknown
- 2010-07-26 NZ NZ597376A patent/NZ597376A/en not_active IP Right Cessation
- 2010-07-26 DK DK10740196.0T patent/DK2459553T3/da active
- 2010-07-26 UA UAA201201704A patent/UA106763C2/uk unknown
- 2010-07-26 BR BR112012001817A patent/BR112012001817B8/pt active IP Right Grant
- 2010-07-26 HR HRP20141120AT patent/HRP20141120T1/hr unknown
- 2010-07-27 TW TW099124742A patent/TWI457337B/zh active
-
2011
- 2011-12-25 IL IL217195A patent/IL217195A/en active IP Right Grant
-
2012
- 2012-01-11 ZA ZA2012/00228A patent/ZA201200228B/en unknown
-
2014
- 2014-12-03 CY CY20141101010T patent/CY1115809T1/el unknown
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