JP2013500304A5 - - Google Patents
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- Publication number
- JP2013500304A5 JP2013500304A5 JP2012522131A JP2012522131A JP2013500304A5 JP 2013500304 A5 JP2013500304 A5 JP 2013500304A5 JP 2012522131 A JP2012522131 A JP 2012522131A JP 2012522131 A JP2012522131 A JP 2012522131A JP 2013500304 A5 JP2013500304 A5 JP 2013500304A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- lower alkyl
- amino
- lower alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC1C(C(C2)C2CC2)*2C1C Chemical compound CC1C(C(C2)C2CC2)*2C1C 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09166469 | 2009-07-27 | ||
| EP09166469.8 | 2009-07-27 | ||
| PCT/EP2010/060803 WO2011012577A1 (en) | 2009-07-27 | 2010-07-26 | Furazanobenzimidazoles as prodrugs to treat neoplastic or autoimmune diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013500304A JP2013500304A (ja) | 2013-01-07 |
| JP2013500304A5 true JP2013500304A5 (enExample) | 2013-05-30 |
| JP5576485B2 JP5576485B2 (ja) | 2014-08-20 |
Family
ID=41226617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012522131A Active JP5576485B2 (ja) | 2009-07-27 | 2010-07-26 | 新生物疾患又は自己免疫疾患を処置するためのプロドラッグとしてのフラザノベンゾイミダゾール |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8802858B2 (enExample) |
| EP (1) | EP2459553B1 (enExample) |
| JP (1) | JP5576485B2 (enExample) |
| KR (1) | KR101758400B1 (enExample) |
| CN (1) | CN102471329B (enExample) |
| AU (1) | AU2010277688B2 (enExample) |
| BR (1) | BR112012001817B8 (enExample) |
| CA (1) | CA2767875C (enExample) |
| CY (1) | CY1115809T1 (enExample) |
| DK (1) | DK2459553T3 (enExample) |
| EA (1) | EA021380B1 (enExample) |
| ES (1) | ES2524119T3 (enExample) |
| HR (1) | HRP20141120T1 (enExample) |
| IL (1) | IL217195A (enExample) |
| MX (1) | MX336240B (enExample) |
| NZ (1) | NZ597376A (enExample) |
| PL (1) | PL2459553T3 (enExample) |
| PT (1) | PT2459553E (enExample) |
| RS (1) | RS53679B1 (enExample) |
| SI (1) | SI2459553T1 (enExample) |
| TW (1) | TWI457337B (enExample) |
| UA (1) | UA106763C2 (enExample) |
| WO (1) | WO2011012577A1 (enExample) |
| ZA (1) | ZA201200228B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3142576A1 (en) | 2011-01-21 | 2012-07-26 | Basilea Pharmaceutica Ag | Use of bubr1 as a biomarker of drug response to furazanobenzimidazoles |
| ES2608315T3 (es) | 2011-01-21 | 2017-04-07 | Basilea Pharmaceutica Ag | Uso de glu-tubulina como un biomarcador de la respuesta de fármacos a furazanobencimidazoles |
| PL2666015T3 (pl) * | 2011-01-21 | 2017-06-30 | Basilea Pharmaceutica Ag | Zastosowanie statminy jako biomarkera odpowiedzi lekowej na furazanobenzoimidazole |
| PT2678679T (pt) * | 2011-02-24 | 2017-04-07 | Basilea Pharmaceutica Ag | Utilização de tubulina acetilada como um biomarcador da resposta farmacológica a furazanobenzimidazolos |
| JP6334393B2 (ja) | 2011-03-29 | 2018-05-30 | バジリア ファルマスーチカ アーゲーＢａｓｉｌｅａ Ｐｈａｒｍａｃｅｕｔｉｃａ ＡＧ | 薬物応答のバイオマーカーとしてのホスホＡｋｔの使用 |
| US9558575B2 (en) | 2012-02-28 | 2017-01-31 | Blackberry Limited | Methods and devices for selecting objects in images |
| ITRM20130248A1 (it) * | 2013-04-24 | 2014-10-25 | Medivis S R L | Formulazioni di riboflavina per il cross-linking transepiteliale. |
| WO2015173341A1 (en) * | 2014-05-13 | 2015-11-19 | Basilea Pharmaceutica Ag | Dosage principle for anti-cancer furazanylbenzimidazoles |
| EP3365680A1 (en) * | 2015-10-22 | 2018-08-29 | Basilea Pharmaceutica International AG | Use of eb1 as a biomarker of drug response |
| MX2019012468A (es) * | 2017-04-20 | 2019-12-11 | Pi Industries Ltd | Nuevos compuestos de fenilamina. |
| MX388196B (es) * | 2017-04-26 | 2025-03-19 | Basilea Pharm Int Ag | Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos. |
| US11633383B2 (en) * | 2017-05-16 | 2023-04-25 | Basilea Pharmaceutica International AG | Dosage principle for drugs useful for treating neoplastic diseases |
| WO2019097073A1 (en) | 2017-11-20 | 2019-05-23 | Basilea Pharmaceutica International AG | Pharmaceutical combinations for use in the treatment of neoplastic diseases |
| EP3853224A1 (en) | 2018-09-20 | 2021-07-28 | Basilea Pharmaceutica International AG | Pharmaceutical combinations for use in the treatment of neoplastic diseases |
| EP4027998A1 (en) | 2019-09-09 | 2022-07-20 | Basilea Pharmaceutica International AG | Pharmaceutical combinations comprising a furazanobenzimidazoles and a cd40 agonist for use in the treatment of neoplastic diseases |
| CN111454254B (zh) | 2020-04-26 | 2023-06-02 | 云白药征武科技(上海)有限公司 | 一种具有含氟取代基的苯并咪唑衍生物的制备及其应用 |
| CN111423429A (zh) * | 2020-05-19 | 2020-07-17 | 江西科技师范大学 | 苯并咪唑联呋咱类系列化合物及其合成方法 |
| WO2022053549A1 (en) | 2020-09-10 | 2022-03-17 | Basilea Pharmaceutica International AG | Use of c-myc as a biomarker of drug response |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6897208B2 (en) * | 2001-10-26 | 2005-05-24 | Aventis Pharmaceuticals Inc. | Benzimidazoles |
| KR20040084896A (ko) * | 2002-02-06 | 2004-10-06 | 버텍스 파마슈티칼스 인코포레이티드 | Ｇｓｋ-3의 억제제로서 유용한 헤테로아릴 화합물 |
| EP1636215B1 (en) * | 2003-05-23 | 2008-01-23 | Basilea Pharmaceutica AG | Furazanobenzimidazoles |
| CA2553704C (en) * | 2004-02-11 | 2011-04-19 | Basilea Pharmaceutica Ag | Substituted benzimidazoles and their use for inducing apoptosis |
-
2010
- 2010-07-26 MX MX2012000611A patent/MX336240B/es unknown
- 2010-07-26 NZ NZ597376A patent/NZ597376A/en not_active IP Right Cessation
- 2010-07-26 ES ES10740196.0T patent/ES2524119T3/es active Active
- 2010-07-26 BR BR112012001817A patent/BR112012001817B8/pt active IP Right Grant
- 2010-07-26 DK DK10740196.0T patent/DK2459553T3/da active
- 2010-07-26 US US13/384,467 patent/US8802858B2/en active Active
- 2010-07-26 JP JP2012522131A patent/JP5576485B2/ja active Active
- 2010-07-26 KR KR1020127005138A patent/KR101758400B1/ko active Active
- 2010-07-26 CA CA2767875A patent/CA2767875C/en active Active
- 2010-07-26 EP EP10740196.0A patent/EP2459553B1/en active Active
- 2010-07-26 WO PCT/EP2010/060803 patent/WO2011012577A1/en not_active Ceased
- 2010-07-26 RS RS20140669A patent/RS53679B1/sr unknown
- 2010-07-26 AU AU2010277688A patent/AU2010277688B2/en not_active Ceased
- 2010-07-26 SI SI201030829T patent/SI2459553T1/sl unknown
- 2010-07-26 HR HRP20141120AT patent/HRP20141120T1/hr unknown
- 2010-07-26 PL PL10740196T patent/PL2459553T3/pl unknown
- 2010-07-26 CN CN201080033104.2A patent/CN102471329B/zh active Active
- 2010-07-26 PT PT107401960T patent/PT2459553E/pt unknown
- 2010-07-26 UA UAA201201704A patent/UA106763C2/uk unknown
- 2010-07-26 EA EA201200189A patent/EA021380B1/ru unknown
- 2010-07-27 TW TW099124742A patent/TWI457337B/zh active
-
2011
- 2011-12-25 IL IL217195A patent/IL217195A/en active IP Right Grant
-
2012
- 2012-01-11 ZA ZA2012/00228A patent/ZA201200228B/en unknown
-
2014
- 2014-12-03 CY CY20141101010T patent/CY1115809T1/el unknown