CN101808634A - 半胱氨酸蛋白酶的环氧化物抑制剂 - Google Patents

半胱氨酸蛋白酶的环氧化物抑制剂 Download PDF

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Publication number
CN101808634A
CN101808634A CN200780029699A CN200780029699A CN101808634A CN 101808634 A CN101808634 A CN 101808634A CN 200780029699 A CN200780029699 A CN 200780029699A CN 200780029699 A CN200780029699 A CN 200780029699A CN 101808634 A CN101808634 A CN 101808634A
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group
alkyl
chemical compound
heterocyclic radical
infection
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M·S·博尤
A·M·萨达希亚尼
S·费尔赫尔斯特
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D303/02—Compounds containing oxirane rings
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  • Heart & Thoracic Surgery (AREA)
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CN200780029699A 2006-06-13 2007-06-13 半胱氨酸蛋白酶的环氧化物抑制剂 Pending CN101808634A (zh)

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US81363906P 2006-06-13 2006-06-13
US60/813,639 2006-06-13
PCT/US2007/071145 WO2008042480A2 (en) 2006-06-13 2007-06-13 Epoxide inhibitors of cysteine proteases

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CN101808634A true CN101808634A (zh) 2010-08-18

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US (1) US8673904B2 (enExample)
EP (1) EP2029135A4 (enExample)
JP (1) JP2010500962A (enExample)
KR (1) KR20090029725A (enExample)
CN (1) CN101808634A (enExample)
AU (1) AU2007305138A1 (enExample)
BR (1) BRPI0712868A2 (enExample)
CA (1) CA2655139A1 (enExample)
IL (1) IL195782A0 (enExample)
RU (1) RU2009100878A (enExample)
WO (1) WO2008042480A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017148417A1 (zh) * 2016-03-03 2017-09-08 中国人民解放军军事医学科学院毒物药物研究所 一种2,3-环氧丁二酰衍生物及其制备方法和用途
CN110241438A (zh) * 2018-03-08 2019-09-17 天津大学 泡沫铜担载钯铜合金纳米笼催化剂及其制备方法

Families Citing this family (10)

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WO2011017600A2 (en) 2009-08-07 2011-02-10 American Life Science Pharmaceuticals, Inc. (Alsp Inc.) Compositions and methods for treating beta-amyloid related diseases
WO2011075678A1 (en) 2009-12-18 2011-06-23 The Board Of Trustees Of The Leland Stanford Junior University Specific inhibitors and active site probes for legumain
US20140170653A1 (en) 2011-04-15 2014-06-19 Life Technologies Corporation Chemical ligation
WO2013116663A1 (en) 2012-02-01 2013-08-08 The Trustees Of Columbia University In The City Of New York Novel cysteine protease inhibitors and uses thereof
CN104211666B (zh) * 2013-05-31 2017-11-14 中国人民解放军军事医学科学院毒物药物研究所 2,3‑环氧丁二酰胺类化合物、其制备方法和用途
US20190134219A1 (en) * 2017-09-15 2019-05-09 Ampersand Biopharmaceuticals, Inc. Inhibition of spontaneous metastasis via protein inhibitors of cysteine proteases
JP2020534285A (ja) 2017-09-15 2020-11-26 アンパサンド バイオファーマシューティカルズ インコーポレイテッドＡｍｐｅｒｓａｎｄ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． 投与および処置の方法
US11905249B2 (en) 2021-01-25 2024-02-20 Jackson State University Covalent inhibitors of equine encephalitis virus
KR20230165715A (ko) 2022-05-27 2023-12-05 서울대학교산학협력단 기생충 감염증의 예방 또는 치료용 약학 조성물
CN120813388A (zh) * 2023-03-02 2025-10-17 日本医事物理股份有限公司 放射性金属标记抗体、放射性药物及化合物

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017148417A1 (zh) * 2016-03-03 2017-09-08 中国人民解放军军事医学科学院毒物药物研究所 一种2,3-环氧丁二酰衍生物及其制备方法和用途
US10647690B2 (en) 2016-03-03 2020-05-12 Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China 2,3-epoxy succinyl derivative, preparation method and use thereof
CN110241438A (zh) * 2018-03-08 2019-09-17 天津大学 泡沫铜担载钯铜合金纳米笼催化剂及其制备方法

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KR20090029725A (ko) 2009-03-23
EP2029135A2 (en) 2009-03-04
AU2007305138A1 (en) 2008-04-10
IL195782A0 (en) 2009-09-01
EP2029135A4 (en) 2011-08-17
JP2010500962A (ja) 2010-01-14
US20080176841A1 (en) 2008-07-24
CA2655139A1 (en) 2008-04-10
RU2009100878A (ru) 2010-07-20
WO2008042480A2 (en) 2008-04-10
US8673904B2 (en) 2014-03-18
WO2008042480A3 (en) 2008-08-14
BRPI0712868A2 (pt) 2013-05-07

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Application publication date: 20100818