JP2020511547A5 - - Google Patents
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- Publication number
- JP2020511547A5 JP2020511547A5 JP2020501418A JP2020501418A JP2020511547A5 JP 2020511547 A5 JP2020511547 A5 JP 2020511547A5 JP 2020501418 A JP2020501418 A JP 2020501418A JP 2020501418 A JP2020501418 A JP 2020501418A JP 2020511547 A5 JP2020511547 A5 JP 2020511547A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound according
- optionally substituted
- fluorine atoms
- membered ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762474686P | 2017-03-22 | 2017-03-22 | |
| US62/474,686 | 2017-03-22 | ||
| PCT/US2018/023455 WO2018175512A1 (en) | 2017-03-22 | 2018-03-21 | Bruton's tyrosine kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020511547A JP2020511547A (ja) | 2020-04-16 |
| JP2020511547A5 true JP2020511547A5 (enExample) | 2021-04-30 |
| JP7219902B2 JP7219902B2 (ja) | 2023-02-09 |
Family
ID=63585694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020501418A Active JP7219902B2 (ja) | 2017-03-22 | 2018-03-21 | ブルトン型チロシンキナーゼ阻害剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US11554118B2 (enExample) |
| EP (1) | EP3601264A4 (enExample) |
| JP (1) | JP7219902B2 (enExample) |
| KR (1) | KR102627756B1 (enExample) |
| CN (1) | CN110494433B (enExample) |
| AU (1) | AU2018237123B2 (enExample) |
| CA (1) | CA3055602A1 (enExample) |
| EA (1) | EA201992147A1 (enExample) |
| IL (1) | IL269152B2 (enExample) |
| MX (1) | MX2019011116A (enExample) |
| WO (1) | WO2018175512A1 (enExample) |
| ZA (1) | ZA201906887B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018237123B2 (en) * | 2017-03-22 | 2022-08-04 | Xibin Liao | Bruton's tyrosine kinase inhibitors |
| KR20210136995A (ko) * | 2019-01-18 | 2021-11-17 | 시빈 리아오 | 브루톤 티로신 키나아제 억제제 |
| BR112021018168B1 (pt) | 2019-03-21 | 2023-11-28 | Onxeo | Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer |
| EP3966204B1 (en) * | 2019-05-10 | 2024-11-27 | Henan Zhiwei Biomedicine Co., Ltd. | Substituted 1-amino-1h-imidazole-5-carboxamide as bruton's tyrosine kinase inhibitors |
| US20220401436A1 (en) | 2019-11-08 | 2022-12-22 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN111471048B (zh) * | 2020-04-30 | 2021-06-15 | 成都海博为药业有限公司 | 一种具有含氮桥环、螺环或并环结构的化合物及其用途 |
| CN115073468B (zh) * | 2021-03-15 | 2023-12-22 | 药雅科技(上海)有限公司 | 咪唑并吡嗪类btk抑制剂的制备及用途 |
| CN116348453B (zh) * | 2021-04-25 | 2025-07-04 | 烨辉医药科技(上海)有限公司 | 杂芳族甲酰胺化合物及其用途 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004058755A2 (en) * | 2002-12-24 | 2004-07-15 | Biofocus Plc | Compound libraries of imidazo[1,5-a]pyridin-3-yl derivatives and related heterobicycles for targetting compounds capable of binding to g-protein coupled receptors |
| JP2007504220A (ja) * | 2003-09-03 | 2007-03-01 | ガラパゴス・エヌブイ | イミダゾ［１，５−ａ］ピリジン又はイミダゾ［１，５−ａ］ピペリジン誘導体および５ＨＴ２Ａ受容体関連障害に対する薬剤の製造のためのその使用 |
| WO2008022060A2 (en) * | 2006-08-14 | 2008-02-21 | Novartis Ag | Imidazo-pyridine derivatives for modulating protein kinase activity |
| ES2673973T3 (es) * | 2006-09-22 | 2018-06-26 | Pharmacyclics Llc | Inhibidores de tirosina cinasa de Bruton |
| CA2681756C (en) | 2007-03-28 | 2015-02-24 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
| WO2009143051A1 (en) * | 2008-05-19 | 2009-11-26 | Osi Pharmaceuticals, Inc. | Substituted imidazopyr-and imidazotri-azines |
| US8658794B2 (en) * | 2010-02-08 | 2014-02-25 | Merck Sharp & Dohme B.V. | 8-methyl-1-phenyl-imidazol[1,5-a]pyrazine compounds as Lck inhibitors and uses thereof |
| EP2691392A1 (en) * | 2011-03-31 | 2014-02-05 | EMBLEM Technology Transfer GmbH | Imidazo [1,2-a]pyridine compounds for use in therapy |
| GB2513821A (en) * | 2011-06-28 | 2014-11-12 | Andrew Levine | Speech-to-text conversion |
| EP2548877A1 (en) | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
| CA2841887A1 (en) * | 2011-07-19 | 2013-01-24 | Merck Sharp & Dohme B.V. | 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides as btk - inhibitors |
| HRP20190135T1 (hr) | 2011-07-19 | 2019-03-22 | Merck Sharp & Dohme B.V. | 4-imidazopiridazin-1-yl-benzamidi i 4-imidazotriazin-1-yl-benzamidi kao inhibitori btk |
| FR2985185B1 (fr) * | 2012-01-04 | 2013-12-27 | Sanofi Sa | Utilisation en therapeutique de derives d'imidazopyridine |
| WO2013113097A1 (en) | 2012-01-31 | 2013-08-08 | Beta Pharma Canada Inc. | Cyclic molecules as bruton's tyrosine kinase inhibitors |
| WO2014114185A1 (en) | 2013-01-23 | 2014-07-31 | Merck Sharp & Dohme Corp. | Btk inhibitors |
| WO2014113942A1 (en) * | 2013-01-23 | 2014-07-31 | Merck Sharp & Dohme Corp. | Btk inhibitors |
| CA2921880A1 (en) * | 2013-08-22 | 2015-02-26 | F. Hoffmann-La Roche Ag | Alkynyl alcohols and methods of use |
| WO2015057992A1 (en) * | 2013-10-16 | 2015-04-23 | Izumi Raquel | Btk inhibitors for hematopoietic mobilization |
| WO2015157955A1 (en) * | 2014-04-17 | 2015-10-22 | Abbvie Inc. | Heterocyclic btk inhibit ors |
| CN105017256A (zh) | 2014-04-29 | 2015-11-04 | 浙江导明医药科技有限公司 | 多氟化合物作为布鲁顿酪氨酸激酶抑制剂 |
| WO2016106623A1 (en) * | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Benzamide imidazopyrazine btk inhibitors |
| WO2016106626A1 (en) | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Imidazopyrazine analogs with 3-tertiary carbon substitutions as btk inhibitors |
| WO2016106652A1 (en) * | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Biarylether imidazopyrazine btk inhibitors |
| MA41614A (fr) * | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
| US20180305350A1 (en) | 2015-06-24 | 2018-10-25 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| WO2017033113A1 (en) | 2015-08-21 | 2017-03-02 | Acerta Pharma B.V. | Therapeutic combinations of a mek inhibitor and a btk inhibitor |
| CN106478633A (zh) * | 2015-08-27 | 2017-03-08 | 正大天晴药业集团股份有限公司 | 一类布鲁顿酪氨酸激酶抑制剂 |
| US20170071962A1 (en) * | 2015-09-11 | 2017-03-16 | Acerta Pharma B.V. | Therapeutic Combinations of a Proteasome Inhibitor and a BTK Inhibitor |
| US20170035881A1 (en) * | 2015-10-19 | 2017-02-09 | Acerta Pharma B.V. | Therapeutic Combinations of an IRAK4 Inhibitor and a BTK Inhibitor |
| CN108602827B (zh) * | 2015-11-06 | 2021-08-20 | 安塞塔制药公司 | Bruton酪氨酸激酶的咪唑并吡嗪抑制剂 |
| JP6972002B2 (ja) | 2016-03-11 | 2021-11-24 | エンジェル・ファーマシューティカル・カンパニー・リミテッド | ブルトン型チロシンキナーゼを調節する化合物及び方法 |
| CA3032795C (en) * | 2016-06-30 | 2021-06-22 | Yubin LV | Imidazopyridinamine phenyl derivative and use thereof |
| WO2018033091A1 (zh) * | 2016-08-17 | 2018-02-22 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制酪氨酸激酶活性的稠合双环类化合物 |
| AU2018237123B2 (en) * | 2017-03-22 | 2022-08-04 | Xibin Liao | Bruton's tyrosine kinase inhibitors |
-
2018
- 2018-03-21 AU AU2018237123A patent/AU2018237123B2/en active Active
- 2018-03-21 EP EP18770944.9A patent/EP3601264A4/en not_active Withdrawn
- 2018-03-21 CA CA3055602A patent/CA3055602A1/en active Pending
- 2018-03-21 MX MX2019011116A patent/MX2019011116A/es unknown
- 2018-03-21 JP JP2020501418A patent/JP7219902B2/ja active Active
- 2018-03-21 EA EA201992147A patent/EA201992147A1/ru unknown
- 2018-03-21 WO PCT/US2018/023455 patent/WO2018175512A1/en not_active Ceased
- 2018-03-21 IL IL269152A patent/IL269152B2/en unknown
- 2018-03-21 US US16/496,426 patent/US11554118B2/en active Active
- 2018-03-21 KR KR1020197031084A patent/KR102627756B1/ko active Active
- 2018-03-21 CN CN201880020300.2A patent/CN110494433B/zh active Active
-
2019
- 2019-05-22 US US16/420,148 patent/US10933063B2/en active Active
- 2019-10-18 ZA ZA2019/06887A patent/ZA201906887B/en unknown
-
2021
- 2021-01-01 US US17/140,025 patent/US11974999B2/en active Active
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