JP2006507313A5 - - Google Patents
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- Publication number
- JP2006507313A5 JP2006507313A5 JP2004550845A JP2004550845A JP2006507313A5 JP 2006507313 A5 JP2006507313 A5 JP 2006507313A5 JP 2004550845 A JP2004550845 A JP 2004550845A JP 2004550845 A JP2004550845 A JP 2004550845A JP 2006507313 A5 JP2006507313 A5 JP 2006507313A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound according
- optionally substituted
- groups
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 239000000178 monomer Substances 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
- 125000001544 thienyl group Chemical group 0.000 claims 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 239000000539 dimer Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Chemical group COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0226593.2A GB0226593D0 (en) | 2002-11-14 | 2002-11-14 | Compounds |
| GB0226593.2 | 2002-11-14 | ||
| PCT/GB2003/004963 WO2004043963A1 (en) | 2002-11-14 | 2003-11-14 | Pyrrolobenzodiazepines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006507313A JP2006507313A (ja) | 2006-03-02 |
| JP2006507313A5 true JP2006507313A5 (enExample) | 2006-12-28 |
| JP4750418B2 JP4750418B2 (ja) | 2011-08-17 |
Family
ID=9947829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004550845A Expired - Fee Related JP4750418B2 (ja) | 2002-11-14 | 2003-11-14 | ピロロベンゾジアゼピン |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7407951B2 (enExample) |
| EP (1) | EP1575955B1 (enExample) |
| JP (1) | JP4750418B2 (enExample) |
| KR (1) | KR101059183B1 (enExample) |
| CN (1) | CN100396683C (enExample) |
| AT (1) | ATE497963T1 (enExample) |
| AU (1) | AU2003282251B2 (enExample) |
| BR (1) | BR0316241A (enExample) |
| CA (1) | CA2505489C (enExample) |
| DE (1) | DE60336014D1 (enExample) |
| GB (1) | GB0226593D0 (enExample) |
| MX (1) | MXPA05005179A (enExample) |
| NZ (1) | NZ540050A (enExample) |
| WO (1) | WO2004043963A1 (enExample) |
| ZA (1) | ZA200504432B (enExample) |
Families Citing this family (102)
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|---|---|---|---|---|
| GB9818730D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collections of compounds |
| CA2341471C (en) | 1998-08-27 | 2009-04-07 | Spirogen Limited | Pyrrolbenzodiazepines |
| GB0226593D0 (en) | 2002-11-14 | 2002-12-24 | Consultants Ltd | Compounds |
| GB0321295D0 (en) | 2003-09-11 | 2003-10-15 | Spirogen Ltd | Synthesis of protected pyrrolobenzodiazepines |
| CA2558195C (en) | 2004-03-01 | 2012-11-06 | Spirogen Limited | 11-hydroxy-5h-pyrrolo[2,1-c][1,4]benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines |
| GB0404574D0 (en) * | 2004-03-01 | 2004-04-07 | Spirogen Ltd | Amino acids |
| GB0404577D0 (en) | 2004-03-01 | 2004-04-07 | Spirogen Ltd | Pyrrolobenzodiazepines |
| US7528126B2 (en) * | 2004-03-09 | 2009-05-05 | Spirogen Limited | Pyrrolobenzodiazepines |
| GB0410725D0 (en) * | 2004-05-13 | 2004-06-16 | Spirogen Ltd | Pyrrolobenzodiazepine therapeutic agents |
| NZ563136A (en) * | 2005-04-21 | 2009-11-27 | Spirogen Ltd | Pyrrolobenzodiazepines |
| US8637664B2 (en) * | 2005-10-05 | 2014-01-28 | Spirogen Sarl | Alkyl 4- [4- (5-oxo-2,3,5, 11a-tetrahydo-5H-pyrrolo [2, 1-c] [1,4] benzodiazepine-8-yloxy)-butyrylamino]-1H-pyrrole-2-carboxylate derivatives and related compounds for the treatment of a proliferative disease |
| GB0813432D0 (en) | 2008-07-22 | 2008-08-27 | Spirogen Ltd | Pyrrolobenzodiazepines |
| GB0819097D0 (en) | 2008-10-17 | 2008-11-26 | Spirogen Ltd | Pyrrolobenzodiazepines |
| GB0819095D0 (en) | 2008-10-17 | 2008-11-26 | Spirogen Ltd | Pyrrolobenzodiazepines |
| ES2623057T3 (es) | 2010-04-15 | 2017-07-10 | Medimmune Limited | Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas |
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| KR101772354B1 (ko) | 2010-04-15 | 2017-08-28 | 시애틀 지네틱스, 인크. | 표적화된 피롤로벤조디아제핀 접합체 |
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| US20130058947A1 (en) | 2011-09-02 | 2013-03-07 | Stem Centrx, Inc | Novel Modulators and Methods of Use |
| WO2013041606A1 (en) | 2011-09-20 | 2013-03-28 | Spirogen Sàrl | Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates |
| WO2013055987A1 (en) | 2011-10-14 | 2013-04-18 | Spirogen Sàrl | Pyrrolobenzodiazepines and conjugates thereof |
| EP2751076B1 (en) * | 2011-10-14 | 2018-04-25 | MedImmune Limited | Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines |
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| MX358757B (es) | 2011-10-14 | 2018-09-03 | Seattle Genetics Inc | Pirrolobenzodiazepinas y conjugados dirigidos. |
| BR112014008888A2 (pt) | 2011-10-14 | 2017-04-18 | Seattle Genetics Inc | pirrolobenzodiazepinas |
| US9526798B2 (en) | 2011-10-14 | 2016-12-27 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines and targeted conjugates |
| KR102099073B1 (ko) | 2012-02-24 | 2020-04-10 | 애브비 스템센트알엑스 엘엘씨 | 항 ｓｅｚ6 항체들 및 사용 방법 |
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| NZ701290A (en) | 2012-04-30 | 2016-08-26 | Medimmune Ltd | Pyrrolobenzodiazepines |
| KR101960130B1 (ko) | 2012-04-30 | 2019-03-19 | 메디뮨 리미티드 | 피롤로벤조디아제핀 |
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| CA2891280C (en) | 2012-11-24 | 2018-03-20 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
| CN105246894A (zh) | 2012-12-21 | 2016-01-13 | 斯皮罗根有限公司 | 用于治疗增殖性和自身免疫疾病的非对称吡咯并苯并二氮杂卓二聚物 |
| AU2013366493B2 (en) * | 2012-12-21 | 2017-08-24 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| RU2019109456A (ru) | 2013-02-22 | 2019-04-10 | ЭББВИ СТЕМСЕНТРКС ЭлЭлСи | Новые конъюгаты антител и их применения |
| JP6445519B2 (ja) | 2013-03-13 | 2018-12-26 | メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ | ピロロベンゾジアゼピン及びそのコンジュゲート |
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| WO2014140862A2 (en) | 2013-03-13 | 2014-09-18 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| JP2016538318A (ja) | 2013-08-28 | 2016-12-08 | ステムセントリックス， インコーポレイテッド | 新規ｓｅｚ６モジュレーターおよび使用方法 |
| WO2015031698A1 (en) | 2013-08-28 | 2015-03-05 | Stem Centrx, Inc. | Site-specific antibody conjugation methods and compositions |
| GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| US10010624B2 (en) | 2013-10-11 | 2018-07-03 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| US9950078B2 (en) | 2013-10-11 | 2018-04-24 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| GB201317981D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| EP3054986B1 (en) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| PE20160870A1 (es) | 2013-11-06 | 2016-09-09 | Abbvie Stemcentrx Llc | Anticuerpos anti-claudina novedosos y metodos de uso |
| KR20160097336A (ko) | 2013-12-12 | 2016-08-17 | 스템센트알엑스 인코포레이티드 | 신규 항-ｄｐｅｐ3 항체 및 이의 사용 방법 |
| KR20170008202A (ko) | 2014-02-21 | 2017-01-23 | 애브비 스템센트알엑스 엘엘씨 | 흑색종에 사용하기 위한 항-ｄｌｌ3 항체 및 약물 접합체 |
| CN106414465B (zh) | 2014-02-28 | 2021-11-16 | 杭州多禧生物科技有限公司 | 带电荷链接体及其在共轭反应上的应用 |
| GB201407816D0 (en) | 2014-05-02 | 2014-06-18 | King S College London | Pyrrolobenzodiazepine Compounds |
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| CN116143678A (zh) | 2016-11-14 | 2023-05-23 | 杭州多禧生物科技有限公司 | 偶联连接体，含有此连接体的细胞结合分子-药物偶联物及其制备和应用 |
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| UA125198C2 (uk) | 2017-02-08 | 2022-01-26 | Ейдісі Терапьютікс Са | Кон'югати піролобензодіазепін-антитіло |
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| GB9205051D0 (en) | 1992-03-09 | 1992-04-22 | Cancer Res Campaign Tech | Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them |
| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| US5502068A (en) | 1995-01-31 | 1996-03-26 | Synphar Laboratories, Inc. | Cyclopropylpyrroloindole-oligopeptide anticancer agents |
| WO1997001560A1 (en) | 1995-06-29 | 1997-01-16 | Pharmacopeia, Inc. | Combinatorial 1,4-benzodiazepin-2,5-dione library |
| GB9516943D0 (en) | 1995-08-18 | 1995-10-18 | Cancer Soc Auckland Div Nz Inc | Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs |
| AU721037B2 (en) | 1996-09-12 | 2000-06-22 | Auckland Uniservices Limited | Condensed N-acylindoles as antitumor agents |
| JPH1087666A (ja) | 1996-09-18 | 1998-04-07 | Kyorin Pharmaceut Co Ltd | デュオカルマイシンｓａ及びその誘導体の製造中間体と製造方法 |
| NZ504884A (en) | 1997-12-08 | 2002-10-25 | Scripps Research Inst | Synthesis of the dihydroindole C-ring of CC-1065/duocarmycin analogs and certain intermediates |
| WO1999046244A1 (en) | 1998-03-12 | 1999-09-16 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (ptpases) |
| CA2341471C (en) * | 1998-08-27 | 2009-04-07 | Spirogen Limited | Pyrrolbenzodiazepines |
| GB9818731D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Compounds |
| GB9818730D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collections of compounds |
| GB9818732D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collection of compounds |
| GB9909612D0 (en) | 1999-04-26 | 1999-06-23 | Cancer Res Campaign Tech | N-protected amines and their use as prodrugs |
| US6660856B2 (en) | 2002-03-08 | 2003-12-09 | Kaohsiung Medical University | Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine analogues |
| GB0226593D0 (en) | 2002-11-14 | 2002-12-24 | Consultants Ltd | Compounds |
| GB0321295D0 (en) | 2003-09-11 | 2003-10-15 | Spirogen Ltd | Synthesis of protected pyrrolobenzodiazepines |
| WO2005040170A2 (en) | 2003-10-22 | 2005-05-06 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto |
| CA2558195C (en) | 2004-03-01 | 2012-11-06 | Spirogen Limited | 11-hydroxy-5h-pyrrolo[2,1-c][1,4]benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines |
-
2002
- 2002-11-14 GB GBGB0226593.2A patent/GB0226593D0/en not_active Ceased
-
2003
- 2003-11-14 AT AT03773870T patent/ATE497963T1/de not_active IP Right Cessation
- 2003-11-14 AU AU2003282251A patent/AU2003282251B2/en not_active Ceased
- 2003-11-14 CA CA2505489A patent/CA2505489C/en not_active Expired - Fee Related
- 2003-11-14 EP EP03773870A patent/EP1575955B1/en not_active Expired - Lifetime
- 2003-11-14 KR KR1020057008663A patent/KR101059183B1/ko not_active Expired - Fee Related
- 2003-11-14 WO PCT/GB2003/004963 patent/WO2004043963A1/en not_active Ceased
- 2003-11-14 BR BR0316241-9A patent/BR0316241A/pt not_active IP Right Cessation
- 2003-11-14 DE DE60336014T patent/DE60336014D1/de not_active Expired - Lifetime
- 2003-11-14 NZ NZ540050A patent/NZ540050A/en not_active IP Right Cessation
- 2003-11-14 JP JP2004550845A patent/JP4750418B2/ja not_active Expired - Fee Related
- 2003-11-14 US US10/534,825 patent/US7407951B2/en not_active Expired - Lifetime
- 2003-11-14 CN CNB2003801083730A patent/CN100396683C/zh not_active Expired - Fee Related
- 2003-11-14 MX MXPA05005179A patent/MXPA05005179A/es unknown
-
2005
- 2005-05-31 ZA ZA200504432A patent/ZA200504432B/en unknown
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