MXPA05005179A - Pirrolobenzodiazepinas. - Google Patents

Pirrolobenzodiazepinas.

Info

Publication number
MXPA05005179A
MXPA05005179A MXPA05005179A MXPA05005179A MXPA05005179A MX PA05005179 A MXPA05005179 A MX PA05005179A MX PA05005179 A MXPA05005179 A MX PA05005179A MX PA05005179 A MXPA05005179 A MX PA05005179A MX PA05005179 A MXPA05005179 A MX PA05005179A
Authority
MX
Mexico
Prior art keywords
group
optionally substituted
methyl
groups
pyrrolobenzodiazepines
Prior art date
Application number
MXPA05005179A
Other languages
English (en)
Inventor
Wilson Howard Philip
Original Assignee
Spirogen Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spirogen Ltd filed Critical Spirogen Ltd
Publication of MXPA05005179A publication Critical patent/MXPA05005179A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se describen compuestos de la formula (I) (ver formula (I)): y sales, solvatos, formas quimicamente protegidas y profarmacos de los mismos, en donde R2 se selecciona de: un grupo naftilo sustituido opcionalmente; un grupo tiofenol o furanilo sustituido opcionalmente y un grupo fenilo sustituido por: uno o mas grupos cloro o fluoro; un grupo etilo o propilo; un grupo 4-t-butilo; un grupo 2-metilo o dos grupos metilo en las posiciones 2 y 6.
MXPA05005179A 2002-11-14 2003-11-14 Pirrolobenzodiazepinas. MXPA05005179A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0226593.2A GB0226593D0 (en) 2002-11-14 2002-11-14 Compounds
PCT/GB2003/004963 WO2004043963A1 (en) 2002-11-14 2003-11-14 Pyrrolobenzodiazepines

Publications (1)

Publication Number Publication Date
MXPA05005179A true MXPA05005179A (es) 2005-11-17

Family

ID=9947829

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05005179A MXPA05005179A (es) 2002-11-14 2003-11-14 Pirrolobenzodiazepinas.

Country Status (15)

Country Link
US (1) US7407951B2 (es)
EP (1) EP1575955B1 (es)
JP (1) JP4750418B2 (es)
KR (1) KR101059183B1 (es)
CN (1) CN100396683C (es)
AT (1) ATE497963T1 (es)
AU (1) AU2003282251B2 (es)
BR (1) BR0316241A (es)
CA (1) CA2505489C (es)
DE (1) DE60336014D1 (es)
GB (1) GB0226593D0 (es)
MX (1) MXPA05005179A (es)
NZ (1) NZ540050A (es)
WO (1) WO2004043963A1 (es)
ZA (1) ZA200504432B (es)

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DE60336014D1 (de) 2011-03-24
NZ540050A (en) 2007-02-23
EP1575955B1 (en) 2011-02-09
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CA2505489A1 (en) 2004-05-27
ATE497963T1 (de) 2011-02-15
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CN1735616A (zh) 2006-02-15
CA2505489C (en) 2011-11-15
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BR0316241A (pt) 2005-10-04
EP1575955A1 (en) 2005-09-21
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ZA200504432B (en) 2006-02-22

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