JP2004534846A5 - - Google Patents
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- Publication number
- JP2004534846A5 JP2004534846A5 JP2003512200A JP2003512200A JP2004534846A5 JP 2004534846 A5 JP2004534846 A5 JP 2004534846A5 JP 2003512200 A JP2003512200 A JP 2003512200A JP 2003512200 A JP2003512200 A JP 2003512200A JP 2004534846 A5 JP2004534846 A5 JP 2004534846A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- substituted
- group
- lower alkyl
- methylcyclopropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 86
- 125000000217 alkyl group Chemical group 0.000 claims 42
- 125000001931 aliphatic group Chemical group 0.000 claims 30
- 125000006432 1-methyl cyclopropyl group Chemical group [H]C([H])([H])C1(*)C([H])([H])C1([H])[H] 0.000 claims 25
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 21
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 18
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 15
- 125000003118 aryl group Chemical group 0.000 claims 14
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 9
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 9
- -1 2-methylcyclopropyl Chemical group 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 7
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 7
- 125000003107 substituted aryl group Chemical group 0.000 claims 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 6
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 6
- 125000002252 acyl group Chemical group 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000001544 thienyl group Chemical group 0.000 claims 5
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 4
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000001847 2-phenylcyclopropyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 229930012538 Paclitaxel Natural products 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229960001592 paclitaxel Drugs 0.000 claims 3
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000000066 S-methyl group Chemical group [H]C([H])([H])S* 0.000 claims 1
- 125000004849 alkoxymethyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 125000006165 cyclic alkyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- OKPYIWASQZGASP-UHFFFAOYSA-N n-(2-hydroxypropyl)-2-methylprop-2-enamide Chemical compound CC(O)CNC(=O)C(C)=C OKPYIWASQZGASP-UHFFFAOYSA-N 0.000 claims 1
- VZKBEZDJWDUUFH-UHFFFAOYSA-N n-[2-(2-hydroxypropylamino)-2-oxoethyl]-2-methylprop-2-enamide Chemical compound CC(O)CNC(=O)CNC(=O)C(C)=C VZKBEZDJWDUUFH-UHFFFAOYSA-N 0.000 claims 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 claims 1
- 0 *C(N(*)NC(*C(NN(*)C(*)=S)=O)=O)=S Chemical compound *C(N(*)NC(*C(NN(*)C(*)=S)=O)=O)=S 0.000 description 7
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30425201P | 2001-07-10 | 2001-07-10 | |
| US36193602P | 2002-03-06 | 2002-03-06 | |
| PCT/US2002/021714 WO2003006428A1 (en) | 2001-07-10 | 2002-07-10 | Taxol enhancer compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004534846A JP2004534846A (ja) | 2004-11-18 |
| JP2004534846A5 true JP2004534846A5 (enExample) | 2006-01-05 |
| JP4344234B2 JP4344234B2 (ja) | 2009-10-14 |
Family
ID=26973914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003512200A Expired - Fee Related JP4344234B2 (ja) | 2001-07-10 | 2002-07-10 | タキソール増強剤化合物 |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US6762204B2 (enExample) |
| EP (2) | EP2100605B9 (enExample) |
| JP (1) | JP4344234B2 (enExample) |
| KR (2) | KR101092139B1 (enExample) |
| CN (1) | CN1308302C (enExample) |
| AT (2) | ATE523194T1 (enExample) |
| AU (1) | AU2002354641B2 (enExample) |
| BR (1) | BR0211228A (enExample) |
| CA (1) | CA2454120C (enExample) |
| DE (1) | DE60234345D1 (enExample) |
| ES (1) | ES2395141T3 (enExample) |
| IL (2) | IL159772A0 (enExample) |
| IS (1) | IS2718B (enExample) |
| MX (1) | MXPA04000243A (enExample) |
| NO (1) | NO333230B1 (enExample) |
| NZ (1) | NZ530964A (enExample) |
| TW (1) | TWI297335B (enExample) |
| WO (1) | WO2003006428A1 (enExample) |
| ZA (1) | ZA200401054B (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI252847B (en) * | 2001-07-10 | 2006-04-11 | Synta Pharmaceuticals Corp | Synthesis of taxol enhancers |
| US6924312B2 (en) | 2001-07-10 | 2005-08-02 | Synta Pharmaceuticals Corp. | Taxol enhancer compounds |
| TWI297335B (en) | 2001-07-10 | 2008-06-01 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| TWI332943B (en) | 2001-07-10 | 2010-11-11 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| EP1465618A2 (en) * | 2001-12-20 | 2004-10-13 | Bristol-Myers Squibb Company | Pharmaceutical compositions of orally active taxane derivatives having enhanced bioavailability |
| AU2006228035B2 (en) * | 2003-01-15 | 2010-02-18 | Synta Pharmaceuticals Corp. | Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer |
| TWI330079B (en) * | 2003-01-15 | 2010-09-11 | Synta Pharmaceuticals Corp | Treatment for cancers |
| US7385084B2 (en) * | 2004-06-23 | 2008-06-10 | Synta Pharmaceutical Corp. | Bis(thio-hydrazide amide) salts for treatment of cancers |
| US20060167106A1 (en) * | 2004-11-19 | 2006-07-27 | Mei Zhang | Compounds acting at the centrosome |
| AU2005306471B2 (en) * | 2004-11-19 | 2009-12-17 | Synta Pharmaceuticals Corp. | Bis(thio-hydrazide amides) for increasing Hsp70 expression |
| AU2005232302B2 (en) | 2005-02-14 | 2011-08-18 | Konami Australia Pty Ltd | Gaming Machine with runs of symbols |
| WO2006113572A1 (en) * | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of increasing natural killer cell activity for therapy |
| WO2006113493A2 (en) * | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of determining cancer prognosis via natural killer cell activity |
| EP1877048A1 (en) * | 2005-04-15 | 2008-01-16 | Synta Pharmaceuticals Corporation | Combination cancer therapy with bis(thiohydrazide) amide compounds |
| MX2007014314A (es) | 2005-05-16 | 2008-02-11 | Synta Pharmaceuticals Corp | Sintesis de sales de bis(tio-hidrazida amida). |
| MX2008002152A (es) | 2005-08-16 | 2008-04-19 | Synta Pharmaceuticals Corp | Formulacion de bis(tio-hidrazida amida. |
| US20100068174A1 (en) * | 2006-08-21 | 2010-03-18 | Synta Pharmaceuticals Corp. | Combination with bis (thiohydrazide amides) for treating cancer |
| AU2007288336B2 (en) * | 2006-08-21 | 2011-04-21 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma |
| KR20090045354A (ko) | 2006-08-21 | 2009-05-07 | 신타 파마슈티칼스 코프. | 증식성 장애를 치료하기 위한 화합물 |
| CA2660531A1 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceutical Corp. | Compounds for treatment of proliferative disorders |
| CA2661440A1 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| AU2007288340A1 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis (thiohydrazide amides) for treating melanoma |
| WO2008027445A2 (en) * | 2006-08-31 | 2008-03-06 | Synta Pharmaceuticals Corp. | Combination with bis(thiohydrazide amides) for treating cancer |
| US9498528B2 (en) * | 2006-09-13 | 2016-11-22 | Genzyme Corporation | Treatment of multiple sclerosis (MS) |
| WO2008033494A2 (en) * | 2006-09-15 | 2008-03-20 | Synta Pharmaceuticals Corp. | Purification of bis(thiohydrazide amides) |
| US8729111B2 (en) | 2007-08-07 | 2014-05-20 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| US8618170B2 (en) * | 2007-11-09 | 2013-12-31 | Synta Pharmaceuticals Corp. | Oral formulations of bis(thiohydrazide amides) |
| WO2009105257A1 (en) * | 2008-02-21 | 2009-08-27 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| US8633323B2 (en) * | 2008-03-31 | 2014-01-21 | Synta Pharmaceuticals Corp. | Process for preparing bis(thiohydrazide amides) |
| BRPI0919720A2 (pt) | 2008-10-22 | 2015-12-08 | Synta Pharmaceuticals Corp | complexos de metal de transição de compostos bis-[tio hidrazida amida |
| CN102256949B (zh) | 2008-10-22 | 2014-09-24 | 辛塔医药品有限公司 | 双[硫代酰肼酰胺]化合物的过渡金属络合物 |
| US8525776B2 (en) * | 2008-10-27 | 2013-09-03 | Lenovo (Singapore) Pte. Ltd | Techniques for controlling operation of a device with a virtual touchscreen |
| US8680100B2 (en) | 2008-12-01 | 2014-03-25 | Synta Pharmaceuticals Corp. | Sulfonylhydrazide compounds for treating proliferative disorders |
| WO2011069159A2 (en) | 2009-12-04 | 2011-06-09 | Synta Pharmaceuticals Corp. | Bis[thiohydrazide amide] compounds for treating leukemia |
| WO2011133673A1 (en) | 2010-04-20 | 2011-10-27 | Synta Pharmaceuticals Corp. | Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers |
| EP2776021A1 (en) | 2011-11-10 | 2014-09-17 | Synta Pharmaceuticals Corp. | Administration of a bis(thiohydrazide amide) compound for treating cancers |
| US20130149392A1 (en) | 2011-12-12 | 2013-06-13 | Synta Pharmaceuticals Corp. | Method of treating non-small cell lung cancer with bis-(thiohydrazide)amide compounds |
| WO2013103795A1 (en) | 2012-01-05 | 2013-07-11 | The Board Of Trustees Of The Leland Stanford Junior University | Bis (thiohydrazide amide) compounds for treating cancers |
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