JP2004532267A5 - - Google Patents
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- Publication number
- JP2004532267A5 JP2004532267A5 JP2003500074A JP2003500074A JP2004532267A5 JP 2004532267 A5 JP2004532267 A5 JP 2004532267A5 JP 2003500074 A JP2003500074 A JP 2003500074A JP 2003500074 A JP2003500074 A JP 2003500074A JP 2004532267 A5 JP2004532267 A5 JP 2004532267A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- compound according
- compound
- ylcarbonyl
- methylphenoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 17
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- VZXBQRCIGBRUII-UHFFFAOYSA-N 2-[4-[[[5-(4-ethylphenyl)-4-methyl-1,3-thiazole-2-carbonyl]amino]methyl]phenoxy]-2-methylpropanoic acid Chemical compound C1=CC(CC)=CC=C1C1=C(C)N=C(C(=O)NCC=2C=CC(OC(C)(C)C(O)=O)=CC=2)S1 VZXBQRCIGBRUII-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- RGGCLVJOVNTTNL-UHFFFAOYSA-N 2-[4-[[[5-(4-fluorophenyl)-4-methyl-1,3-thiazole-2-carbonyl]amino]methyl]phenoxy]-2-methylpropanoic acid Chemical compound CC=1N=C(C(=O)NCC=2C=CC(OC(C)(C)C(O)=O)=CC=2)SC=1C1=CC=C(F)C=C1 RGGCLVJOVNTTNL-UHFFFAOYSA-N 0.000 claims 1
- 208000032841 Bulimia Diseases 0.000 claims 1
- 206010006550 Bulimia nervosa Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 208000022531 anorexia Diseases 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 206010061428 decreased appetite Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- DPKNPTTVXZMOOJ-UHFFFAOYSA-N ethyl 2-[4-[[[5-(4-ethylphenyl)-4-methyl-1,3-thiazole-2-carbonyl]amino]methyl]phenoxy]-2-methylpropanoate Chemical compound C1=CC(OC(C)(C)C(=O)OCC)=CC=C1CNC(=O)C1=NC(C)=C(C=2C=CC(CC)=CC=2)S1 DPKNPTTVXZMOOJ-UHFFFAOYSA-N 0.000 claims 1
- KJNVGNGOLMZKJP-UHFFFAOYSA-N ethyl 2-[4-[[[5-(4-fluorophenyl)-4-methyl-1,3-thiazole-2-carbonyl]amino]methyl]phenoxy]-2-methylpropanoate Chemical compound C1=CC(OC(C)(C)C(=O)OCC)=CC=C1CNC(=O)C1=NC(C)=C(C=2C=CC(F)=CC=2)S1 KJNVGNGOLMZKJP-UHFFFAOYSA-N 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 230000037356 lipid metabolism Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0113231.5A GB0113231D0 (en) | 2001-05-31 | 2001-05-31 | Chemical compounds |
| PCT/EP2002/005886 WO2002096895A1 (en) | 2001-05-31 | 2002-05-29 | Oxazol/ thiazol-derivatives activators of the hppar-alpha receptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004532267A JP2004532267A (ja) | 2004-10-21 |
| JP2004532267A5 true JP2004532267A5 (enExample) | 2005-12-22 |
Family
ID=9915636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003500074A Pending JP2004532267A (ja) | 2001-05-31 | 2002-05-29 | ｈＰＰＡＲα受容体のオキサゾール／チアゾール誘導体アクチベーター |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7157479B2 (enExample) |
| EP (1) | EP1399430B1 (enExample) |
| JP (1) | JP2004532267A (enExample) |
| KR (1) | KR100859591B1 (enExample) |
| CN (1) | CN1307166C (enExample) |
| AR (1) | AR034051A1 (enExample) |
| AU (1) | AU2002317765B2 (enExample) |
| BR (1) | BR0209785A (enExample) |
| CA (1) | CA2448205A1 (enExample) |
| CO (1) | CO5540297A2 (enExample) |
| CY (1) | CY1107206T1 (enExample) |
| CZ (1) | CZ20033252A3 (enExample) |
| DE (1) | DE60223805T2 (enExample) |
| DK (1) | DK1399430T3 (enExample) |
| ES (1) | ES2296965T3 (enExample) |
| GB (1) | GB0113231D0 (enExample) |
| HU (1) | HUP0400043A3 (enExample) |
| IL (1) | IL158929A0 (enExample) |
| MX (1) | MXPA03011032A (enExample) |
| MY (1) | MY132656A (enExample) |
| NO (1) | NO20035209L (enExample) |
| NZ (1) | NZ529754A (enExample) |
| PL (1) | PL367248A1 (enExample) |
| PT (1) | PT1399430E (enExample) |
| SI (1) | SI1399430T1 (enExample) |
| TW (1) | TWI245760B (enExample) |
| WO (1) | WO2002096895A1 (enExample) |
| ZA (1) | ZA200309095B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2326411T3 (es) * | 2001-10-12 | 2009-10-09 | Nippon Chemiphar Co., Ltd. | Activador del receptor delta activado por proliferadores de peroxisomas. |
| US7553867B2 (en) | 2002-09-06 | 2009-06-30 | Takeda Pharmaceutical Company Limited | Furan or thiophene derivative and medicinal use thereof |
| GB0314370D0 (en) * | 2003-06-19 | 2003-07-23 | Glaxo Group Ltd | Chemical compounds |
| GB0323702D0 (en) * | 2003-10-09 | 2003-11-12 | Smithkline Beecham Corp | Chemical compound |
| EP1682508A1 (en) | 2003-11-05 | 2006-07-26 | F. Hoffmann-La Roche Ag | Phenyl derivatives as ppar agonists |
| FR2882359A1 (fr) * | 2005-02-24 | 2006-08-25 | Negma Lerads Soc Par Actions S | Derives activateurs de ppar, procede de preparation et application en therapeutique |
| CN101007790B (zh) * | 2006-01-27 | 2011-03-30 | 北京摩力克科技有限公司 | 草氨酸衍生物、其制备方法和医药用途 |
| FR2901792A1 (fr) * | 2006-06-06 | 2007-12-07 | Negma Lerads Soc Par Actions S | DERIVES ACTIVATEURS DE PPARs, PROCEDE DE PREPARATION ET APPLICATION EN THERAPEUTIQUE |
| KR101290868B1 (ko) * | 2008-12-01 | 2013-07-29 | 미쓰비시 타나베 파마 코퍼레이션 | 티아졸환을 포함하는 카르복실산 유도체 및 그의 의약 용도 |
| CN110803996B (zh) * | 2019-11-13 | 2022-01-11 | 台州市创源工业技术有限公司 | 一种羟基苄胺的合成方法 |
| CN116511225B (zh) * | 2023-03-30 | 2025-09-23 | 江南大学 | 一种油酸基des液体及其制备方法和它在厌氧发酵液高效浓缩中的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ53699A3 (cs) * | 1996-08-19 | 1999-07-14 | Japan Tobacco Inc. | Deriváty propionové kyseliny a jejich použití |
| KR100620337B1 (ko) * | 1998-03-10 | 2006-09-13 | 오노 야꾸힝 고교 가부시키가이샤 | 카르복실산 유도체와 그 유도체를 유효 성분으로서함유하는 약제 |
| IL145923A0 (en) * | 1999-04-28 | 2002-07-25 | Aventis Pharma Gmbh | Tri-aryl acid derivatives as ppar receptor ligands |
| GB9914977D0 (en) * | 1999-06-25 | 1999-08-25 | Glaxo Group Ltd | Chemical compounds |
| AU7073400A (en) * | 1999-08-27 | 2001-03-26 | Eli Lilly And Company | Biaryl-oxa(thia)zole derivatives and their use as ppars modulators |
| PE20011010A1 (es) * | 1999-12-02 | 2001-10-18 | Glaxo Group Ltd | Oxazoles y tiazoles sustituidos como agonista del receptor activado por el proliferador de peroxisomas humano |
| GB0113233D0 (en) * | 2001-05-31 | 2001-07-25 | Glaxo Group Ltd | Chemical compounds |
-
2001
- 2001-05-31 GB GBGB0113231.5A patent/GB0113231D0/en not_active Ceased
-
2002
- 2002-05-29 CA CA002448205A patent/CA2448205A1/en not_active Abandoned
- 2002-05-29 CN CNB028149424A patent/CN1307166C/zh not_active Expired - Fee Related
- 2002-05-29 PT PT02747331T patent/PT1399430E/pt unknown
- 2002-05-29 WO PCT/EP2002/005886 patent/WO2002096895A1/en not_active Ceased
- 2002-05-29 AR ARP020101999A patent/AR034051A1/es unknown
- 2002-05-29 CZ CZ20033252A patent/CZ20033252A3/cs unknown
- 2002-05-29 HU HU0400043A patent/HUP0400043A3/hu unknown
- 2002-05-29 BR BR0209785-0A patent/BR0209785A/pt not_active IP Right Cessation
- 2002-05-29 ES ES02747331T patent/ES2296965T3/es not_active Expired - Lifetime
- 2002-05-29 SI SI200230654T patent/SI1399430T1/sl unknown
- 2002-05-29 IL IL15892902A patent/IL158929A0/xx unknown
- 2002-05-29 AU AU2002317765A patent/AU2002317765B2/en not_active Ceased
- 2002-05-29 MY MYPI20021973A patent/MY132656A/en unknown
- 2002-05-29 MX MXPA03011032A patent/MXPA03011032A/es active IP Right Grant
- 2002-05-29 EP EP02747331A patent/EP1399430B1/en not_active Expired - Lifetime
- 2002-05-29 NZ NZ529754A patent/NZ529754A/en unknown
- 2002-05-29 KR KR1020037015678A patent/KR100859591B1/ko not_active Expired - Fee Related
- 2002-05-29 DE DE60223805T patent/DE60223805T2/de not_active Expired - Fee Related
- 2002-05-29 PL PL02367248A patent/PL367248A1/xx not_active Application Discontinuation
- 2002-05-29 TW TW091111392A patent/TWI245760B/zh not_active IP Right Cessation
- 2002-05-29 JP JP2003500074A patent/JP2004532267A/ja active Pending
- 2002-05-29 US US10/478,936 patent/US7157479B2/en not_active Expired - Fee Related
- 2002-05-29 DK DK02747331T patent/DK1399430T3/da active
-
2003
- 2003-11-21 ZA ZA200309095A patent/ZA200309095B/en unknown
- 2003-11-24 NO NO20035209A patent/NO20035209L/no not_active Application Discontinuation
- 2003-12-03 CO CO03106490A patent/CO5540297A2/es not_active Application Discontinuation
-
2008
- 2008-02-19 CY CY20081100202T patent/CY1107206T1/el unknown
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