SI1399430T1 - Oksazolni/tiazolni derivati kot aktivatorji hPPAR-alfa receptorja - Google Patents

Oksazolni/tiazolni derivati kot aktivatorji hPPAR-alfa receptorja

Info

Publication number
SI1399430T1
SI1399430T1 SI200230654T SI200230654T SI1399430T1 SI 1399430 T1 SI1399430 T1 SI 1399430T1 SI 200230654 T SI200230654 T SI 200230654T SI 200230654 T SI200230654 T SI 200230654T SI 1399430 T1 SI1399430 T1 SI 1399430T1
Authority
SI
Slovenia
Prior art keywords
hppar
oxazol
thiazol
alpha receptor
activators
Prior art date
Application number
SI200230654T
Other languages
English (en)
Slovenian (sl)
Inventor
Francoise Jeanne Gla Gellibert
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of SI1399430T1 publication Critical patent/SI1399430T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
SI200230654T 2001-05-31 2002-05-29 Oksazolni/tiazolni derivati kot aktivatorji hPPAR-alfa receptorja SI1399430T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0113231.5A GB0113231D0 (en) 2001-05-31 2001-05-31 Chemical compounds
EP02747331A EP1399430B1 (en) 2001-05-31 2002-05-29 Oxazol/ thiazol-derivatives activators of the hppar-alpha receptor
PCT/EP2002/005886 WO2002096895A1 (en) 2001-05-31 2002-05-29 Oxazol/ thiazol-derivatives activators of the hppar-alpha receptor

Publications (1)

Publication Number Publication Date
SI1399430T1 true SI1399430T1 (sl) 2008-04-30

Family

ID=9915636

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200230654T SI1399430T1 (sl) 2001-05-31 2002-05-29 Oksazolni/tiazolni derivati kot aktivatorji hPPAR-alfa receptorja

Country Status (28)

Country Link
US (1) US7157479B2 (enExample)
EP (1) EP1399430B1 (enExample)
JP (1) JP2004532267A (enExample)
KR (1) KR100859591B1 (enExample)
CN (1) CN1307166C (enExample)
AR (1) AR034051A1 (enExample)
AU (1) AU2002317765B2 (enExample)
BR (1) BR0209785A (enExample)
CA (1) CA2448205A1 (enExample)
CO (1) CO5540297A2 (enExample)
CY (1) CY1107206T1 (enExample)
CZ (1) CZ20033252A3 (enExample)
DE (1) DE60223805T2 (enExample)
DK (1) DK1399430T3 (enExample)
ES (1) ES2296965T3 (enExample)
GB (1) GB0113231D0 (enExample)
HU (1) HUP0400043A3 (enExample)
IL (1) IL158929A0 (enExample)
MX (1) MXPA03011032A (enExample)
MY (1) MY132656A (enExample)
NO (1) NO20035209L (enExample)
NZ (1) NZ529754A (enExample)
PL (1) PL367248A1 (enExample)
PT (1) PT1399430E (enExample)
SI (1) SI1399430T1 (enExample)
TW (1) TWI245760B (enExample)
WO (1) WO2002096895A1 (enExample)
ZA (1) ZA200309095B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2326411T3 (es) * 2001-10-12 2009-10-09 Nippon Chemiphar Co., Ltd. Activador del receptor delta activado por proliferadores de peroxisomas.
US7553867B2 (en) 2002-09-06 2009-06-30 Takeda Pharmaceutical Company Limited Furan or thiophene derivative and medicinal use thereof
GB0314370D0 (en) * 2003-06-19 2003-07-23 Glaxo Group Ltd Chemical compounds
GB0323702D0 (en) * 2003-10-09 2003-11-12 Smithkline Beecham Corp Chemical compound
EP1682508A1 (en) 2003-11-05 2006-07-26 F. Hoffmann-La Roche Ag Phenyl derivatives as ppar agonists
FR2882359A1 (fr) * 2005-02-24 2006-08-25 Negma Lerads Soc Par Actions S Derives activateurs de ppar, procede de preparation et application en therapeutique
CN101007790B (zh) * 2006-01-27 2011-03-30 北京摩力克科技有限公司 草氨酸衍生物、其制备方法和医药用途
FR2901792A1 (fr) * 2006-06-06 2007-12-07 Negma Lerads Soc Par Actions S DERIVES ACTIVATEURS DE PPARs, PROCEDE DE PREPARATION ET APPLICATION EN THERAPEUTIQUE
KR101290868B1 (ko) * 2008-12-01 2013-07-29 미쓰비시 타나베 파마 코퍼레이션 티아졸환을 포함하는 카르복실산 유도체 및 그의 의약 용도
CN110803996B (zh) * 2019-11-13 2022-01-11 台州市创源工业技术有限公司 一种羟基苄胺的合成方法
CN116511225B (zh) * 2023-03-30 2025-09-23 江南大学 一种油酸基des液体及其制备方法和它在厌氧发酵液高效浓缩中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ53699A3 (cs) * 1996-08-19 1999-07-14 Japan Tobacco Inc. Deriváty propionové kyseliny a jejich použití
KR100620337B1 (ko) * 1998-03-10 2006-09-13 오노 야꾸힝 고교 가부시키가이샤 카르복실산 유도체와 그 유도체를 유효 성분으로서함유하는 약제
IL145923A0 (en) * 1999-04-28 2002-07-25 Aventis Pharma Gmbh Tri-aryl acid derivatives as ppar receptor ligands
GB9914977D0 (en) * 1999-06-25 1999-08-25 Glaxo Group Ltd Chemical compounds
AU7073400A (en) * 1999-08-27 2001-03-26 Eli Lilly And Company Biaryl-oxa(thia)zole derivatives and their use as ppars modulators
PE20011010A1 (es) * 1999-12-02 2001-10-18 Glaxo Group Ltd Oxazoles y tiazoles sustituidos como agonista del receptor activado por el proliferador de peroxisomas humano
GB0113233D0 (en) * 2001-05-31 2001-07-25 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
PL367248A1 (en) 2005-02-21
NZ529754A (en) 2005-12-23
NO20035209L (no) 2004-01-27
WO2002096895A1 (en) 2002-12-05
CA2448205A1 (en) 2002-12-05
ES2296965T3 (es) 2008-05-01
KR20040007632A (ko) 2004-01-24
HK1064367A1 (en) 2005-01-28
HUP0400043A2 (hu) 2004-04-28
AR034051A1 (es) 2004-01-21
US7157479B2 (en) 2007-01-02
KR100859591B1 (ko) 2008-09-23
NO20035209D0 (no) 2003-11-24
PT1399430E (pt) 2008-02-19
DK1399430T3 (da) 2008-03-25
EP1399430A1 (en) 2004-03-24
CZ20033252A3 (en) 2004-03-17
JP2004532267A (ja) 2004-10-21
MY132656A (en) 2007-10-31
IL158929A0 (en) 2004-05-12
GB0113231D0 (en) 2001-07-25
DE60223805D1 (de) 2008-01-10
EP1399430B1 (en) 2007-11-28
MXPA03011032A (es) 2004-03-19
CN1633421A (zh) 2005-06-29
AU2002317765B2 (en) 2005-02-03
CY1107206T1 (el) 2012-11-21
BR0209785A (pt) 2004-06-01
ZA200309095B (en) 2005-02-21
TWI245760B (en) 2005-12-21
DE60223805T2 (de) 2008-10-30
CN1307166C (zh) 2007-03-28
HUP0400043A3 (en) 2008-03-28
CO5540297A2 (es) 2005-07-29
US20050070517A1 (en) 2005-03-31

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