PL352213A1 - Antagonistic compounds of the il-8 receptor - Google Patents

Antagonistic compounds of the il-8 receptor

Info

Publication number
PL352213A1
PL352213A1 PL00352213A PL35221300A PL352213A1 PL 352213 A1 PL352213 A1 PL 352213A1 PL 00352213 A PL00352213 A PL 00352213A PL 35221300 A PL35221300 A PL 35221300A PL 352213 A1 PL352213 A1 PL 352213A1
Authority
PL
Poland
Prior art keywords
receptor
antagonistic compounds
antagonistic
compounds
Prior art date
Application number
PL00352213A
Inventor
Gregory Martin Benson
Melvin Clarence Rutledge
Katherine L Widdowson
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PL352213A1 publication Critical patent/PL352213A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL00352213A 1999-06-16 2000-06-15 Antagonistic compounds of the il-8 receptor PL352213A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14002499P 1999-06-16 1999-06-16
PCT/US2000/016506 WO2000076501A1 (en) 1999-06-16 2000-06-15 Il-8 receptor antagonists

Publications (1)

Publication Number Publication Date
PL352213A1 true PL352213A1 (en) 2003-08-11

Family

ID=22489379

Family Applications (1)

Application Number Title Priority Date Filing Date
PL00352213A PL352213A1 (en) 1999-06-16 2000-06-15 Antagonistic compounds of the il-8 receptor

Country Status (19)

Country Link
EP (1) EP1185265A4 (en)
JP (1) JP2003501463A (en)
KR (1) KR20020015347A (en)
CN (1) CN1356899A (en)
AR (1) AR024350A1 (en)
AU (1) AU766235B2 (en)
BR (1) BR0011122A (en)
CA (1) CA2377386A1 (en)
CO (1) CO5190696A1 (en)
CZ (1) CZ20014472A3 (en)
HU (1) HUP0201582A3 (en)
IL (1) IL145762A0 (en)
MX (1) MXPA01013005A (en)
NO (1) NO20016052L (en)
NZ (1) NZ514696A (en)
PL (1) PL352213A1 (en)
TR (1) TR200103638T2 (en)
WO (1) WO2000076501A1 (en)
ZA (1) ZA200109480B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2501535A1 (en) 2002-10-09 2004-04-22 Schering Corporation Thiadiazoledioxides and thiadiazoleoxides as cxc- and cc-chemokine receptor ligands
US7094794B2 (en) 2003-07-28 2006-08-22 Sanofi-Aventis Deutschland Gmbh Substituted thiazole-benzoisothiazole dioxide derivatives, process for their preparation and their use
DE10334309A1 (en) * 2003-07-28 2005-03-03 Aventis Pharma Deutschland Gmbh Substituted thiazole-Benzoisothiazoldioxidderivate, processes for their preparation and their use
EP1664021A1 (en) 2003-08-21 2006-06-07 OSI Pharmaceuticals, Inc. N-substituted benzimidazolyl c-kit inhibitors
US7442709B2 (en) 2003-08-21 2008-10-28 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine c-Kit inhibitors
RU2006108791A (en) 2003-08-21 2006-07-27 Оси Фармасьютикалз, Инк. (Us) N-SUBSTITUTED PYRAZOLYLAMIDYLBENZIMIDAZOLYLES AS C-KIT INHIBITORS
MY139808A (en) 2003-12-19 2009-10-30 Schering Corp Thiadiazoles as cxc-and cc-chemokine receptor ligands
JP2008517930A (en) 2004-10-21 2008-05-29 トランス テック ファーマ，インコーポレイテッド Bissulfonamide compounds, compositions, and methods of use as agonists of GalR1
JP2008521903A (en) 2004-12-01 2008-06-26 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド N-substituted benzimidazolyl C-kit inhibitor and combinatorial benzimidazole library
AU2010289143A1 (en) 2009-08-24 2012-02-16 Ascepion Pharmaceuticals, Inc. 5,6-bicyclic heteroaryl-containing urea compounds as kinase inhibitors
EP2377850A1 (en) * 2010-03-30 2011-10-19 Pharmeste S.r.l. TRPV1 vanilloid receptor antagonists with a bicyclic portion
CN102060780B (en) 2010-12-27 2014-11-05 雅本化学股份有限公司 Preparation method of 2-(N-substituted).-aminobenzimidazole derivative
CN111116502A (en) * 2018-10-30 2020-05-08 中国石油化工股份有限公司 One-step method for synthesizing benzotriazole

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA921120B (en) * 1991-02-19 1993-01-27 Smithkline Beecham Corp Cytokine inhibitors
TR199901710T2 (en) * 1997-01-23 1999-09-21 Smithkline Beecham Corporation IL-8 receptor antagonists.

Also Published As

Publication number Publication date
BR0011122A (en) 2002-02-26
CN1356899A (en) 2002-07-03
AU5616100A (en) 2001-01-02
EP1185265A4 (en) 2004-02-04
NO20016052D0 (en) 2001-12-11
EP1185265A1 (en) 2002-03-13
HUP0201582A3 (en) 2003-02-28
ZA200109480B (en) 2002-11-18
WO2000076501A1 (en) 2000-12-21
JP2003501463A (en) 2003-01-14
CZ20014472A3 (en) 2002-06-12
KR20020015347A (en) 2002-02-27
NZ514696A (en) 2004-03-26
HUP0201582A2 (en) 2002-12-28
MXPA01013005A (en) 2002-07-02
IL145762A0 (en) 2002-07-25
AU766235B2 (en) 2003-10-09
CA2377386A1 (en) 2000-12-21
AR024350A1 (en) 2002-10-02
NO20016052L (en) 2001-12-11
TR200103638T2 (en) 2002-04-22
CO5190696A1 (en) 2002-08-29

Similar Documents

Publication Publication Date Title
PL351690A1 (en) Pyrimidinone compounds
PL352232A1 (en) Il-8 receptor antagonists
PL352213A1 (en) Antagonistic compounds of the il-8 receptor
IL146046A0 (en) Il-8 receptor antagonists
PL351947A1 (en) Il-8 receptor antagonists
EP1039903A4 (en) Il-8 receptor antagonists
EP1047424A4 (en) Il-8 receptor antagonists
EP1194143A4 (en) Il-8 receptor antagonists
HK1044475A1 (en) Il-8 receptor antagonists
AU5168900A (en) Il-8 receptor antagonists
PL352222A1 (en) Antagonists of the il-8 receptor
PL346178A1 (en) Il-8 receptor antagonists
HUP0202019A3 (en) Il-8 receptor antagonists
AU5622400A (en) Il-8 receptor antagonists
EP1237548A4 (en) Il-8 receptor antagonists
ZA985975B (en) IL-8 receptor antagonists
ZA985813B (en) IL-8 receptor antagonists
EP1121360A4 (en) Il-8 receptor antagonists
EP1087661A4 (en) Il-8 receptor antagonists

Legal Events

Date Code Title Description
REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)