JP2004534825A5 - - Google Patents
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- Publication number
- JP2004534825A5 JP2004534825A5 JP2003507087A JP2003507087A JP2004534825A5 JP 2004534825 A5 JP2004534825 A5 JP 2004534825A5 JP 2003507087 A JP2003507087 A JP 2003507087A JP 2003507087 A JP2003507087 A JP 2003507087A JP 2004534825 A5 JP2004534825 A5 JP 2004534825A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- compound according
- carbons
- acceptable salt
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 34
- 206010003658 Atrial Fibrillation Diseases 0.000 claims description 5
- 206010047249 Venous thrombosis Diseases 0.000 claims description 4
- 208000037260 Atherosclerotic Plaque Diseases 0.000 claims description 3
- 206010051055 Deep vein thrombosis Diseases 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 208000031225 myocardial ischemia Diseases 0.000 claims description 3
- 230000007505 plaque formation Effects 0.000 claims description 3
- 208000031104 Arterial Occlusive disease Diseases 0.000 claims description 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 2
- 206010008132 Cerebral thrombosis Diseases 0.000 claims description 2
- 201000001429 Intracranial Thrombosis Diseases 0.000 claims description 2
- 208000021328 arterial occlusion Diseases 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000002093 peripheral effect Effects 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- 230000009424 thromboembolic effect Effects 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims 19
- 229910052739 hydrogen Inorganic materials 0.000 claims 13
- 239000001257 hydrogen Substances 0.000 claims 12
- 150000004702 methyl esters Chemical group 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 10
- 239000003937 drug carrier Substances 0.000 claims 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 208000007536 Thrombosis Diseases 0.000 claims 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims 4
- 208000027418 Wounds and injury Diseases 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 3
- 230000006378 damage Effects 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000003527 fibrinolytic agent Substances 0.000 claims 3
- 230000003480 fibrinolytic effect Effects 0.000 claims 3
- 208000014674 injury Diseases 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 229920001774 Perfluoroether Polymers 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 2
- BPYFWNGIPZCIAT-UHFFFAOYSA-N 1-benzyl-2-[5-bromo-6-(2h-tetrazol-5-ylmethoxy)naphthalen-2-yl]-3-pentylindole Chemical compound C=1C=CC=CC=1CN1C2=CC=CC=C2C(CCCCC)=C1C(C=C1C=C2)=CC=C1C(Br)=C2OCC1=NN=NN1 BPYFWNGIPZCIAT-UHFFFAOYSA-N 0.000 claims 1
- BDPXZFKVHDEPIQ-UHFFFAOYSA-N 1-benzyl-3-pentyl-2-[6-(2h-tetrazol-5-ylmethoxy)naphthalen-2-yl]indole Chemical compound C=1C=CC=CC=1CN1C2=CC=CC=C2C(CCCCC)=C1C(C=C1C=C2)=CC=C1C=C2OCC=1N=NNN=1 BDPXZFKVHDEPIQ-UHFFFAOYSA-N 0.000 claims 1
- BUMHVJNXFPVEMO-UHFFFAOYSA-N 1-methyl-3-pentyl-2-[6-(2h-tetrazol-5-ylmethoxy)naphthalen-2-yl]indole Chemical compound CN1C2=CC=CC=C2C(CCCCC)=C1C(C=C1C=C2)=CC=C1C=C2OCC1=NN=NN1 BUMHVJNXFPVEMO-UHFFFAOYSA-N 0.000 claims 1
- XVZQHCZCEZTSKR-UHFFFAOYSA-N 2-[1-bromo-6-(1-methyl-3-pentylindol-2-yl)naphthalen-2-yl]oxyacetic acid Chemical compound CN1C2=CC=CC=C2C(CCCCC)=C1C1=CC=C(C(Br)=C(OCC(O)=O)C=C2)C2=C1 XVZQHCZCEZTSKR-UHFFFAOYSA-N 0.000 claims 1
- AAWAZICAXDCTFO-UHFFFAOYSA-N 2-[5-bromo-6-(2h-tetrazol-5-ylmethoxy)naphthalen-2-yl]-1-methyl-3-pentylindole Chemical compound CN1C2=CC=CC=C2C(CCCCC)=C1C(C=C1C=C2)=CC=C1C(Br)=C2OCC1=NN=NN1 AAWAZICAXDCTFO-UHFFFAOYSA-N 0.000 claims 1
- NJGPFBJGXYWQGI-UHFFFAOYSA-N 2-[5-bromo-6-(2h-tetrazol-5-ylmethoxy)naphthalen-2-yl]-3-pentyl-1-[[2-(trifluoromethyl)phenyl]methyl]indole Chemical compound C=1C=CC=C(C(F)(F)F)C=1CN1C2=CC=CC=C2C(CCCCC)=C1C(C=C1C=C2)=CC=C1C(Br)=C2OCC1=NN=NN1 NJGPFBJGXYWQGI-UHFFFAOYSA-N 0.000 claims 1
- SJDRBMZDCCSQEB-UHFFFAOYSA-N 3-pentyl-2-[6-(2h-tetrazol-5-ylmethoxy)naphthalen-2-yl]-1-[[2-(trifluoromethyl)phenyl]methyl]indole Chemical compound C=1C=CC=C(C(F)(F)F)C=1CN1C2=CC=CC=C2C(CCCCC)=C1C(C=C1C=C2)=CC=C1C=C2OCC1=NN=NN1 SJDRBMZDCCSQEB-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 210000001367 artery Anatomy 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 230000015271 coagulation Effects 0.000 claims 1
- 238000005345 coagulation Methods 0.000 claims 1
- PGRHXDWITVMQBC-UHFFFAOYSA-N dehydroacetic acid Natural products CC(=O)C1C(=O)OC(C)=CC1=O PGRHXDWITVMQBC-UHFFFAOYSA-N 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- PEQJBOMPGWYIRO-UHFFFAOYSA-N n-ethyl-3,4-dimethoxyaniline Chemical compound CCNC1=CC=C(OC)C(OC)=C1 PEQJBOMPGWYIRO-UHFFFAOYSA-N 0.000 claims 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 150000003536 tetrazoles Chemical class 0.000 claims 1
- 210000003462 vein Anatomy 0.000 claims 1
- 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 description 2
- 102100039418 Plasminogen activator inhibitor 1 Human genes 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000001732 thrombotic effect Effects 0.000 description 2
- 206010003178 Arterial thrombosis Diseases 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 102100027378 Prothrombin Human genes 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- 206010037340 Pulmonary artery thrombosis Diseases 0.000 description 1
- 229940122055 Serine protease inhibitor Drugs 0.000 description 1
- 101710102218 Serine protease inhibitor Proteins 0.000 description 1
- 208000015294 blood coagulation disease Diseases 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000009852 coagulant defect Effects 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- 239000003001 serine protease inhibitor Substances 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29965101P | 2001-06-20 | 2001-06-20 | |
| PCT/US2002/021113 WO2003000684A1 (en) | 2001-06-20 | 2002-06-18 | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (pai-1) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004534825A JP2004534825A (ja) | 2004-11-18 |
| JP2004534825A5 true JP2004534825A5 (enExample) | 2010-03-11 |
| JP4520144B2 JP4520144B2 (ja) | 2010-08-04 |
Family
ID=23155676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003507087A Expired - Fee Related JP4520144B2 (ja) | 2001-06-20 | 2002-06-18 | プラスミノゲンアクチベーターインヒビタータイプ−１（ｐａｉ−１）のインヒビターとしての置換ナフチルインドール誘導体 |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US6800654B2 (enExample) |
| EP (1) | EP1397356B1 (enExample) |
| JP (1) | JP4520144B2 (enExample) |
| KR (1) | KR20040007744A (enExample) |
| CN (1) | CN1280288C (enExample) |
| AR (1) | AR036101A1 (enExample) |
| AT (1) | ATE431346T1 (enExample) |
| AU (1) | AU2002316533B2 (enExample) |
| BR (1) | BR0210504A (enExample) |
| CA (1) | CA2448798C (enExample) |
| CO (1) | CO5540286A2 (enExample) |
| DE (1) | DE60232328D1 (enExample) |
| EA (1) | EA009696B1 (enExample) |
| EC (1) | ECSP034904A (enExample) |
| ES (1) | ES2325733T3 (enExample) |
| HU (1) | HUP0400233A3 (enExample) |
| IL (1) | IL159449A0 (enExample) |
| MX (1) | MXPA03011522A (enExample) |
| NO (2) | NO326316B1 (enExample) |
| NZ (1) | NZ530312A (enExample) |
| PL (1) | PL367525A1 (enExample) |
| TW (1) | TWI224101B (enExample) |
| UA (1) | UA78708C2 (enExample) |
| WO (1) | WO2003000684A1 (enExample) |
| ZA (1) | ZA200400380B (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7291639B2 (en) * | 2001-06-20 | 2007-11-06 | Wyeth | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| WO2003000253A1 (en) * | 2001-06-20 | 2003-01-03 | Wyeth | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| TWI224101B (en) * | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| CN1726191A (zh) * | 2002-12-10 | 2006-01-25 | 惠氏公司 | 用作纤溶酶原激活物抑制剂－1(pai－1)的抑制剂的取代的吲哚氧代－乙酰氨基乙酸衍生物 |
| US7078429B2 (en) | 2002-12-10 | 2006-07-18 | Wyeth | Substituted 3-carbonyl-1H-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| ATE411288T1 (de) * | 2002-12-10 | 2008-10-15 | Wyeth Corp | Aryl-, aryloxy- und alkyloxysubstituierte 1h- indol-3-yl-glyoxylsäurederivateals inhibitoren des plasminogenaktivatorinhibitors-1 (pai-1) |
| UA80453C2 (en) * | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
| US7348351B2 (en) * | 2002-12-10 | 2008-03-25 | Wyeth | Substituted 3-alkyl and 3-arylalkyl 1H-indol-1yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| JP4390460B2 (ja) * | 2003-02-21 | 2009-12-24 | 株式会社静岡カフェイン工業所 | オキサゾール誘導体 |
| US7442805B2 (en) * | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| US7268159B2 (en) * | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| US7265148B2 (en) * | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7351726B2 (en) * | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7411083B2 (en) * | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
| US7332521B2 (en) * | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7141592B2 (en) * | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| US7446201B2 (en) * | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
| US7420083B2 (en) * | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
| US7582773B2 (en) * | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| US7342039B2 (en) * | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
| US7163954B2 (en) * | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
| US7534894B2 (en) * | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
| US7115815B2 (en) * | 2003-10-31 | 2006-10-03 | Adc Telecommunications, Inc. | Cable utilizing varying lay length mechanisms to minimize alien crosstalk |
| MX2007002177A (es) * | 2004-08-23 | 2007-04-02 | Wyeth Corp | Acidos de pirrolo-naftilo como inhibidores de pai-1. |
| CN101044127A (zh) | 2004-08-23 | 2007-09-26 | 惠氏公司 | 用作纤溶酶原激活剂抑制剂－1的噻唑基－萘基酸 |
| KR20070055563A (ko) * | 2004-08-23 | 2007-05-30 | 와이어쓰 | 혈전증 및 심혈관 질병의 치료에 유용한 플라스미노겐활성화제 억제제 타입-1(ｐａｉ-1)의 조절제로서의옥사졸로-나프틸 산 |
| EP1856104A1 (en) * | 2005-01-27 | 2007-11-21 | Wyeth a Corporation of the State of Delaware | Processes and compounds for the preparation of substituted naphthylindole derivatives |
| BRPI0614340A2 (pt) * | 2005-08-17 | 2011-04-12 | Wyeth Corp | indóis substituìdos e métodos de seu uso |
| AU2007217363A1 (en) * | 2006-02-27 | 2007-08-30 | Wyeth | Inhibitors of PAI-1 for treatment of muscular conditions |
| US7884234B2 (en) * | 2006-10-12 | 2011-02-08 | Institute Of Medicinal Molecular Design, Inc. | N-phenyloxamide derivatives |
| EP2080751A4 (en) | 2006-10-12 | 2011-06-22 | Inst Med Molecular Design Inc | CARBON ACID DERIVATIVE |
| US9120744B2 (en) * | 2007-04-16 | 2015-09-01 | The Regents Of The University Of Michigan | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism |
| WO2008131047A2 (en) | 2007-04-16 | 2008-10-30 | The Regents Of The University Of Michigan | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism |
| JP5213855B2 (ja) | 2007-06-27 | 2013-06-19 | 興和株式会社 | ピラゾロン誘導体 |
| EP2201946A4 (en) | 2007-10-23 | 2012-01-25 | Inst Med Molecular Design Inc | HAMMER OF PAI-1 PRODUCTION |
| US8633245B2 (en) * | 2008-04-11 | 2014-01-21 | Institute Of Medicinal Molecular Design, Inc. | PAI-1 inhibitor |
| JPWO2009125606A1 (ja) | 2008-04-11 | 2011-08-04 | 株式会社医薬分子設計研究所 | Ｐａｉ−１阻害剤 |
| US9718760B2 (en) | 2012-10-31 | 2017-08-01 | The Regents Of The University Of Michigan | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof |
| DK3395354T3 (da) | 2015-12-18 | 2024-06-03 | Talengen Int Ltd | Plasminogen til anvendelse i behandling af diabetisk nefropati |
| CN106890324A (zh) * | 2015-12-18 | 2017-06-27 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗糖尿病肾病的方法 |
| CA3047176C (en) | 2016-12-15 | 2021-11-30 | Talengen International Limited | Use of plasminogen for promoting secretion of insulin in treatment of diabetes |
| WO2019023526A1 (en) | 2017-07-27 | 2019-01-31 | The Regents Of The University Of Michigan | PLASMINOGEN-1 ACTIVATOR INHIBITOR (PAI-1) AND METHOD OF USE |
| CN114057623B (zh) * | 2021-12-07 | 2023-07-21 | 湖南第一师范学院 | 一种n-萘基吲哚衍生物及其合成方法 |
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-
2002
- 2002-06-10 TW TW091112530A patent/TWI224101B/zh not_active IP Right Cessation
- 2002-06-13 US US10/171,041 patent/US6800654B2/en not_active Expired - Fee Related
- 2002-06-18 CN CNB028123913A patent/CN1280288C/zh not_active Expired - Fee Related
- 2002-06-18 NZ NZ530312A patent/NZ530312A/en unknown
- 2002-06-18 HU HU0400233A patent/HUP0400233A3/hu unknown
- 2002-06-18 CA CA2448798A patent/CA2448798C/en not_active Expired - Fee Related
- 2002-06-18 KR KR10-2003-7016636A patent/KR20040007744A/ko not_active Abandoned
- 2002-06-18 DE DE60232328T patent/DE60232328D1/de not_active Expired - Lifetime
- 2002-06-18 IL IL15944902A patent/IL159449A0/xx unknown
- 2002-06-18 JP JP2003507087A patent/JP4520144B2/ja not_active Expired - Fee Related
- 2002-06-18 EA EA200400054A patent/EA009696B1/ru not_active IP Right Cessation
- 2002-06-18 BR BR0210504-7A patent/BR0210504A/pt not_active IP Right Cessation
- 2002-06-18 PL PL02367525A patent/PL367525A1/xx not_active Application Discontinuation
- 2002-06-18 AT AT02746846T patent/ATE431346T1/de not_active IP Right Cessation
- 2002-06-18 AU AU2002316533A patent/AU2002316533B2/en not_active Ceased
- 2002-06-18 WO PCT/US2002/021113 patent/WO2003000684A1/en not_active Ceased
- 2002-06-18 UA UA2004010350A patent/UA78708C2/uk unknown
- 2002-06-18 ES ES02746846T patent/ES2325733T3/es not_active Expired - Lifetime
- 2002-06-18 MX MXPA03011522A patent/MXPA03011522A/es active IP Right Grant
- 2002-06-18 EP EP02746846A patent/EP1397356B1/en not_active Expired - Lifetime
- 2002-06-20 AR ARP020102315A patent/AR036101A1/es unknown
-
2003
- 2003-12-17 EC EC2003004904A patent/ECSP034904A/es unknown
- 2003-12-17 NO NO20035635A patent/NO326316B1/no unknown
- 2003-12-19 CO CO03111217A patent/CO5540286A2/es not_active Application Discontinuation
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2004
- 2004-01-19 ZA ZA200400380A patent/ZA200400380B/en unknown
- 2004-07-20 US US10/894,618 patent/US6939886B2/en not_active Expired - Fee Related
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2005
- 2005-06-22 US US11/158,881 patent/US7351730B2/en not_active Expired - Fee Related
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2008
- 2008-02-05 US US12/026,272 patent/US7629377B2/en not_active Expired - Fee Related
- 2008-10-20 NO NO20084390A patent/NO20084390L/no not_active Application Discontinuation
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