BR0210504A - Derivados de naftil-indol substituidos, atuantes como inibidores do inibidor tipo 1 (pai-1) do ativador de plasminogênio - Google Patents

Derivados de naftil-indol substituidos, atuantes como inibidores do inibidor tipo 1 (pai-1) do ativador de plasminogênio

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Publication number
BR0210504A
BR0210504A BR0210504-7A BR0210504A BR0210504A BR 0210504 A BR0210504 A BR 0210504A BR 0210504 A BR0210504 A BR 0210504A BR 0210504 A BR0210504 A BR 0210504A
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Prior art keywords
hydrogen
optionally substituted
alkyl
inhibitors
alkanoyl
Prior art date
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BR0210504-7A
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English (en)
Inventor
Scott Christian Mayer
Eric Gould Gundersen
Hassan Mahmoud Elokdah
David Leroy Crandall
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Wyeth Corp
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Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BR0210504A publication Critical patent/BR0210504A/pt

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

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Abstract

"DERIVADOS DE NAFTIL-INDOL SUBSTITUìDOS, ATUANTES COMO INIBIDORES DO INIBIDOR TIPO 1 (PAI-1) DO ATIVADOR DE PLASMINOGêNIO". A presente invenção refere-se a compostos inibidores de PAI-1 de Fórmula (I): em que: R~ 1~, R~ 2~, R~ 3~ e R~ 4~ são cada um hidrogênio, alquila, alcanoíla, halogênio, OH, e arila opcionalmente substituída por R~ 8~, perfluoroalquila, alcóxi, amino, alquilamino, dialquilamino, perfluoroalcóxi; R~ 5~ é hidrogênio, alquila, perfluoroalquila, arila opcionalmente substituída por R~ 8~, alcanoíla, aroíla opcionalmente substituída por R~ 8~; R~ 6~ é hidrogênio, alquila, alquilarila, benzila opcionalmente substituída. por R~ 8~, alcanoíla, aroíla opcionalmente substituída por R~ 8~; R~ 7~ é hidrogênio, alquila, alquilarila, arila opcionalmente substituída por R~ 8~; n é um número inteiro de 0-6; A é COOH ou um ácido mímico, tal como tetrazol, SO~ 3~H, PO~ 3~H~ 2~, ácido tetrónico, etc. R~ 8~ é hidrogênio, alquila, cicloalquila, alcanoíla, halogênio, OH, perfluoroalquila, alcóxi, amino, alquilamino, dialquilamino, perfluoroalcóxi; ou um sal farmaceuticamente aceitável dos mesmos; assim como composições farmacêuticas e métodos de tratamento usando esses compostos.
BR0210504-7A 2001-06-20 2002-06-18 Derivados de naftil-indol substituidos, atuantes como inibidores do inibidor tipo 1 (pai-1) do ativador de plasminogênio BR0210504A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29965101P 2001-06-20 2001-06-20
PCT/US2002/021113 WO2003000684A1 (en) 2001-06-20 2002-06-18 Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (pai-1)

Publications (1)

Publication Number Publication Date
BR0210504A true BR0210504A (pt) 2004-05-18

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BR0210504-7A BR0210504A (pt) 2001-06-20 2002-06-18 Derivados de naftil-indol substituidos, atuantes como inibidores do inibidor tipo 1 (pai-1) do ativador de plasminogênio

Country Status (25)

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US (4) US6800654B2 (pt)
EP (1) EP1397356B1 (pt)
JP (1) JP4520144B2 (pt)
KR (1) KR20040007744A (pt)
CN (1) CN1280288C (pt)
AR (1) AR036101A1 (pt)
AT (1) ATE431346T1 (pt)
AU (1) AU2002316533B2 (pt)
BR (1) BR0210504A (pt)
CA (1) CA2448798C (pt)
CO (1) CO5540286A2 (pt)
DE (1) DE60232328D1 (pt)
EA (1) EA009696B1 (pt)
EC (1) ECSP034904A (pt)
ES (1) ES2325733T3 (pt)
HU (1) HUP0400233A3 (pt)
IL (1) IL159449A0 (pt)
MX (1) MXPA03011522A (pt)
NO (2) NO326316B1 (pt)
NZ (1) NZ530312A (pt)
PL (1) PL367525A1 (pt)
TW (1) TWI224101B (pt)
UA (1) UA78708C2 (pt)
WO (1) WO2003000684A1 (pt)
ZA (1) ZA200400380B (pt)

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US20080182883A1 (en) 2008-07-31
CA2448798A1 (en) 2003-01-03
WO2003000684A1 (en) 2003-01-03
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CA2448798C (en) 2010-07-20
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