BR0307266A - Compostos que inibem a atividade do fator xa - Google Patents

Compostos que inibem a atividade do fator xa

Info

Publication number
BR0307266A
BR0307266A BR0307266-5A BR0307266A BR0307266A BR 0307266 A BR0307266 A BR 0307266A BR 0307266 A BR0307266 A BR 0307266A BR 0307266 A BR0307266 A BR 0307266A
Authority
BR
Brazil
Prior art keywords
compounds
activity
inhibit factor
factor
pharmaceutically acceptable
Prior art date
Application number
BR0307266-5A
Other languages
English (en)
Inventor
Robert Eckl
Silke Schabbert
Thilo Fuchs
Lutz Weber
Christian Oefner
Original Assignee
Morphochem Ag Komb Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10204072A external-priority patent/DE10204072A1/de
Priority claimed from DE10300049A external-priority patent/DE10300049A1/de
Application filed by Morphochem Ag Komb Chemie filed Critical Morphochem Ag Komb Chemie
Publication of BR0307266A publication Critical patent/BR0307266A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"COMPOSTOS QUE INIBEM A ATIVIDADE DO FATOR XA". A presente invenção refere-se a compostos da fórmula (I) ou a sais, solvatos, hidratos farmaceuticamente aceitáveis ou formulações farmaceuticamente aceitáveis dos mesmos. Esses compostos podem ser empregados para a inibição do fator Xa e para a prevenção e/ou tratamento de doenças trombolíticas.
BR0307266-5A 2002-01-31 2003-01-31 Compostos que inibem a atividade do fator xa BR0307266A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10204072A DE10204072A1 (de) 2002-01-31 2002-01-31 Neue Verbindungen, die Faktor Xa-Aktivität inhibieren
DE10300049A DE10300049A1 (de) 2003-01-03 2003-01-03 Neue Verbindungen, die Faktor VIIa inhibieren
PCT/EP2003/001011 WO2003064440A1 (de) 2002-01-31 2003-01-31 Verbindungen, die faktor xa-aktivät inhibieren

Publications (1)

Publication Number Publication Date
BR0307266A true BR0307266A (pt) 2004-12-07

Family

ID=27664555

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0307266-5A BR0307266A (pt) 2002-01-31 2003-01-31 Compostos que inibem a atividade do fator xa

Country Status (13)

Country Link
US (1) US20050049283A1 (pt)
EP (1) EP1470143B1 (pt)
JP (1) JP2005525325A (pt)
KR (1) KR20040096541A (pt)
CN (1) CN1322001C (pt)
AT (1) ATE377017T1 (pt)
BR (1) BR0307266A (pt)
CA (1) CA2473169A1 (pt)
DE (1) DE50308492D1 (pt)
MX (1) MXPA04007461A (pt)
NZ (1) NZ534238A (pt)
PL (1) PL369772A1 (pt)
WO (1) WO2003064440A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1732531A2 (en) * 2004-02-25 2006-12-20 La Jolla Pharmaceutical Company Amines and amides for the treatment of diseases
EA014245B1 (ru) 2005-12-14 2010-10-29 Бристол-Маерс Сквибб Компани Аналоги арилпропионамида, арилакриламида, арилпропинамида или арилметилмочевины в качестве ингибиторов фактора xia
CN101341129B (zh) * 2005-12-14 2011-12-14 布里斯托尔-迈尔斯斯奎布公司 作为因子xia抑制剂的芳基丙酰胺，芳基丙烯酰胺，芳基丙炔酰胺，或芳基甲基脲类似物
US10590084B2 (en) 2016-03-09 2020-03-17 Blade Therapeutics, Inc. Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof
WO2018009417A1 (en) 2016-07-05 2018-01-11 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
KR20190063473A (ko) 2016-09-28 2019-06-07 블레이드 테라퓨틱스, 인크. 칼페인 조정자 및 그 치료학적 용도

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2614893B1 (fr) * 1987-05-04 1989-12-22 Fournier Innovation Synergie Nouveaux b-d-phenyl-thioxylosides, leur procede de preparation et leur application en therapeutique
EP0560568A3 (en) * 1992-03-13 1994-06-29 Takeda Chemical Industries Ltd Hydroquinone derivatives and intermediates for production thereof
DK0921116T3 (da) * 1997-12-04 2003-10-06 Hoffmann La Roche N-(4-carbamimido-phenyl)-glycinamidderivater
EP1078917A4 (en) * 1998-02-17 2002-11-06 Ono Pharmaceutical Co AMIDINO DERIVATIVES FOR USE AS ACTIVE INGREDIENTS AND MEDICINES CONTAINING THEM
RU2225869C2 (ru) * 1998-06-17 2004-03-20 Акцо Нобель Н.В. Антитромботические соединения
DE10041402A1 (de) * 2000-08-23 2002-03-14 Morphochem Ag Neue Verbindungen, die Faktor Xa-Aktivität inhibieren
MXPA03003572A (es) * 2000-11-22 2003-07-14 Yamanouchi Pharma Co Ltd Derivados de benceno sustituidos o sales de los mismos.

Also Published As

Publication number Publication date
DE50308492D1 (de) 2007-12-13
US20050049283A1 (en) 2005-03-03
JP2005525325A (ja) 2005-08-25
CN1322001C (zh) 2007-06-20
NZ534238A (en) 2006-09-29
KR20040096541A (ko) 2004-11-16
CN1625559A (zh) 2005-06-08
ATE377017T1 (de) 2007-11-15
CA2473169A1 (en) 2003-08-07
WO2003064440A1 (de) 2003-08-07
EP1470143B1 (de) 2007-10-31
EP1470143A1 (de) 2004-10-27
MXPA04007461A (es) 2005-07-13
PL369772A1 (en) 2005-05-02

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6O E 7O ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2047 DE 30/03/2010.