JP2004528021A5 - - Google Patents
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- JP2004528021A5 JP2004528021A5 JP2002565070A JP2002565070A JP2004528021A5 JP 2004528021 A5 JP2004528021 A5 JP 2004528021A5 JP 2002565070 A JP2002565070 A JP 2002565070A JP 2002565070 A JP2002565070 A JP 2002565070A JP 2004528021 A5 JP2004528021 A5 JP 2004528021A5
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- Prior art keywords
- placenta
- isolated
- perfused
- stem cells
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000002826 Placenta Anatomy 0.000 claims 66
- 210000000130 stem cell Anatomy 0.000 claims 24
- 210000004027 cells Anatomy 0.000 claims 13
- 230000003169 placental Effects 0.000 claims 13
- 239000003102 growth factor Substances 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 102100016492 CD34 Human genes 0.000 claims 3
- 108060001251 CD34 Proteins 0.000 claims 3
- 210000004700 Fetal Blood Anatomy 0.000 claims 3
- 210000004291 Uterus Anatomy 0.000 claims 3
- 230000002429 anti-coagulation Effects 0.000 claims 3
- 239000003146 anticoagulant agent Substances 0.000 claims 3
- 239000004599 antimicrobial Substances 0.000 claims 3
- 102100003279 CD38 Human genes 0.000 claims 2
- 101700044948 CD38 Proteins 0.000 claims 2
- 210000003958 Hematopoietic Stem Cells Anatomy 0.000 claims 2
- 230000000845 anti-microbial Effects 0.000 claims 2
- 238000010322 bone marrow transplantation Methods 0.000 claims 2
- 230000001605 fetal Effects 0.000 claims 2
- 210000004369 Blood Anatomy 0.000 claims 1
- 102100003735 CD44 Human genes 0.000 claims 1
- 101700078950 CD44 Proteins 0.000 claims 1
- 210000001671 Embryonic Stem Cells Anatomy 0.000 claims 1
- 102100004115 ICAM1 Human genes 0.000 claims 1
- 101700051176 ICAM1 Proteins 0.000 claims 1
- 102100001478 ITGB1 Human genes 0.000 claims 1
- 101710006661 ITGB1 Proteins 0.000 claims 1
- 108090000028 MMP12 Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 102000003729 Neprilysin Human genes 0.000 claims 1
- 102100008333 THY1 Human genes 0.000 claims 1
- 101700026084 THY1 Proteins 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 230000001747 exhibiting Effects 0.000 claims 1
- 230000012953 feeding on blood of other organism Effects 0.000 claims 1
- 210000004962 mammalian cells Anatomy 0.000 claims 1
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (69)
- 無菌条件下で瀉血および灌流した、単離された哺乳動物胎盤。
- 胎盤を灌流するのに用いる溶液が抗凝固剤溶液を含む、請求項1に記載の単離された哺乳動物胎盤。
- 胎盤を灌流するのに用いる溶液が抗菌剤溶液を含む、請求項1に記載の単離された哺乳動物胎盤。
- 胎盤を灌流するのに用いる溶液が増殖因子を含む、請求項1に記載の単離された哺乳動物胎盤。
- 胎盤がヒト由来である、請求項1に記載の単離された哺乳動物胎盤。
- 子宮からの胎盤の娩出後約2〜24時間保存した、請求項1に記載の単離された哺乳動物胎盤。
- 胎盤からの胚様幹細胞および他の多能性幹細胞の生産を可能にする条件下で瀉血、灌流およびインキュベーションした、単離された哺乳動物胎盤。
- 約2〜24時間にわたってインキュベーションした、請求項7に記載の単離された哺乳動物胎盤。
- 約24〜48時間以上にわたって灌流またはインキュベーションした、請求項7に記載の単離された哺乳動物胎盤。
- 生存可能な胚様幹細胞を含む、単離され灌流された哺乳動物胎盤。
- 前記幹細胞がOCT-4-およびABC-p+である、請求項10に記載の単離された胎盤。
- 少なくとも2時間灌流した、請求項1に記載の単離された哺乳動物胎盤。
- 少なくとも11時間灌流した、請求項12に記載の単離された哺乳動物胎盤。
- 分娩後に回収された、請求項10に記載の哺乳動物胎盤。
- 少なくとも24時間灌流した、請求項13に記載の単離された哺乳動物胎盤。
- 増殖因子を含む溶液で胎盤を灌流した、請求項10に記載の単離された哺乳動物胎盤。
- 増殖因子を含む溶液で灌流した、請求項7に記載の単離された哺乳動物胎盤。
- ヒト由来である、請求項7に記載の単離された哺乳動物胎盤。
- 子宮からの娩出後に胎盤を取得し、この胎盤を瀉血した後、無菌条件下で灌流することを含んでなる、哺乳動物胎盤の培養方法。
- 抗凝固剤溶液を含む溶液で胎盤を灌流する、請求項19に記載の方法。
- 抗菌剤を含む溶液で胎盤を灌流する、請求項19に記載の方法。
- 前記胎盤がヒト由来である、請求項19に記載の方法。
- 子宮からの娩出後約2〜24時間胎盤を保存する、請求項19に記載の方法。
- 前記娩出が分娩時である、請求項19に記載の方法。
- 胎盤を室温で保存する、請求項23に記載の方法。
- 前記胎盤を冷蔵または冷凍条件下で保存する、請求項23に記載の方法。
- 胎盤からの胚様幹細胞の生産を可能にする条件下で、この胎盤を培養することを含んでなる、瀉血および灌流した、単離された哺乳動物胎盤の培養方法。
- 胎盤を培養することがこの胎盤を灌流することを含む、請求項27に記載の方法。
- 約24〜48時間にわたって前記胎盤をインキュベートする、請求項27または28に記載の方法。
- 前記胎盤を少なくとも2時間灌流する、請求項27に記載の方法。
- 前記胎盤を少なくとも11時間灌流する、請求項30に記載の方法。
- 前記胎盤を少なくとも24時間灌流する、請求項31に記載の方法。
- 前記胎盤を48時間以上灌流する、請求項32に記載の方法。
- 前記胎盤を、増殖因子を含む溶液で灌流する、請求項28に記載の方法。
- 前記胎盤がヒト由来である、請求項27に記載の方法。
- OCT-4+およびABC-p+である、単離されたヒト胎盤幹細胞。
- ヒト細胞である、請求項36に記載の単離されたヒト胎盤幹細胞。
- 少なくとも次の特徴:CD10+、CD29+、CD34-、CD44+、CD45-、CD54+、CD90+、SH2+、SH3+、SH4+、SSEA3-、SSEA4-、OCT-4+およびABC-p+を有する、単離された哺乳動物胎盤幹細胞。
- 前記細胞がSSEA3-およびSSEA4-である、請求項36に記載の単離された胎盤幹細胞。
- 分娩後のヒト胎盤を少なくとも11時間瀉血および灌流した後、この胎盤から単離したヒト胎盤幹細胞。
- (a)瀉血および灌流しておいた分娩後の哺乳動物胎盤;
(b)上記胎盤をインキュベートまたは培養する手段;および
(c)幹細胞を検出する手段;
を含んでなる幹細胞生産装置。 - 幹細胞を収集するための収集装置をさらに含む、請求項41に記載の装置。
- 培養条件をモニタリングおよび調節する手段をさらに含む、請求項41に記載の装置。
- 前記モニタリングおよび調節がコンピュータ化されている、請求項41に記載の装置。
- 細胞分離装置をさらに含む、請求項41に記載の装置。
- 請求項36、37または38に記載のヒト胎盤幹細胞を含む、ヒトにおける疾患を治療するための医薬組成物。
- 請求項36、37または38に記載のヒト胎盤幹細胞を含む、幹細胞を移植するための医薬組成物。
- 請求項36、37または38に記載のヒト胎盤幹細胞を含んでなる、医薬組成物。
- 臍帯血または胎盤血をさらに含む、請求項46に記載の医薬組成物。
- 請求項36、37または38に記載のヒト胎盤幹細胞から分化した前駆細胞。
- すべての細胞型に分化することができる、単離された均一集団のヒト胎盤幹細胞。
- 少なくとも次の細胞表面マーカーOCT-4+およびABC-p+を示す、均一集団の生存可能なヒト胎盤幹細胞。
- 多能性である、単離された均一集団のヒト胎盤幹細胞。
- 胎児由来でも母親由来でもない細胞を含んでなる、単離された胎盤。
- 幹細胞が胎盤に由来する、請求項51または52に記載の幹細胞。
- CD34+およびCD38-である細胞が富化された造血幹細胞の集団を含んでなる、骨髄移植用の組成物。
- CD34+およびCD38+である細胞を有する臍帯血をさらに含む、請求項56に記載の組成物。
- CD34-およびCD38-である細胞が富化された造血幹細胞の集団を含む、骨髄移植用の組成物。
- CD34+およびCD38+である細胞を有する臍帯血をさらに含む、請求項58に記載の組成物。
- 胎児由来でも母親由来でもない細胞を含む、単離され血を除去した灌流された胎盤。
- 48時間を超えて灌流またはインキュベーションした、請求項60に記載の単離された胎盤。
- 少なくとも約24時間にわたり灌流またはインキュベーションした、請求項60に記載の単離された胎盤。
- 胎盤を灌流するのに用いる溶液が抗凝固剤溶液を含む、請求項60に記載の単離された胎盤。
- 胎盤を灌流するのに用いる溶液が抗菌剤溶液を含む、請求項60に記載の単離された胎盤。
- 胎盤を灌流するのに用いる溶液が増殖因子を含む、請求項60に記載の単離された胎盤。
- 胎盤を灌流するのに用いる溶液が本質的に0.9N生理食塩水からなる、請求項60に記載の単離された胎盤。
- 前記細胞が幹細胞である、請求項60に記載の単離された胎盤。
- 前記幹細胞がOCT-4+およびABC-p+の幹細胞である、請求項67に記載の胎盤。
- 前記細胞が哺乳動物細胞である、請求項60に記載の単離された胎盤。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26856001P | 2001-02-14 | 2001-02-14 | |
US10/004,942 US7045148B2 (en) | 2000-12-06 | 2001-12-05 | Method of collecting placental stem cells |
PCT/US2002/004282 WO2002064755A2 (en) | 2001-02-14 | 2002-02-13 | Post-partum mammalian placenta, its use and placental stem cells therefrom |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009188480A Division JP2010000085A (ja) | 2001-02-14 | 2009-08-17 | 分娩後の哺乳動物の胎盤、その使用およびそれに由来する胎盤幹細胞 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2004528021A JP2004528021A (ja) | 2004-09-16 |
JP2004528021A5 true JP2004528021A5 (ja) | 2005-12-22 |
Family
ID=26673686
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002565070A Pending JP2004528021A (ja) | 2001-02-14 | 2002-02-13 | 分娩後の哺乳動物の胎盤、その使用およびそれに由来する胎盤幹細胞 |
Country Status (9)
Country | Link |
---|---|
US (3) | US20030032179A1 (ja) |
EP (7) | EP2316919B1 (ja) |
JP (1) | JP2004528021A (ja) |
AU (1) | AU2002251935B2 (ja) |
CA (3) | CA2438153C (ja) |
IL (1) | IL157350A0 (ja) |
MX (1) | MXPA03007175A (ja) |
NZ (2) | NZ527849A (ja) |
WO (1) | WO2002064755A2 (ja) |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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US9216200B2 (en) | 2007-09-28 | 2015-12-22 | Anthrogenesis Corporation | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
US8969315B2 (en) | 2010-12-31 | 2015-03-03 | Anthrogenesis Corporation | Enhancement of placental stem cell potency using modulatory RNA molecules |
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