JP2004000208A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004000208A5 JP2004000208A5 JP2003119118A JP2003119118A JP2004000208A5 JP 2004000208 A5 JP2004000208 A5 JP 2004000208A5 JP 2003119118 A JP2003119118 A JP 2003119118A JP 2003119118 A JP2003119118 A JP 2003119118A JP 2004000208 A5 JP2004000208 A5 JP 2004000208A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- cerebral
- spinal cord
- sequence
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1310696P | 1996-03-11 | 1996-03-11 | |
| US1979396P | 1996-06-14 | 1996-06-14 | |
| US72525196A | 1996-10-04 | 1996-10-04 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53280497A Division JP3469584B2 (ja) | 1996-03-11 | 1997-03-10 | ヒト ビクニン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004000208A JP2004000208A (ja) | 2004-01-08 |
| JP2004000208A5 true JP2004000208A5 (https=) | 2005-02-17 |
Family
ID=27359773
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53280497A Expired - Fee Related JP3469584B2 (ja) | 1996-03-11 | 1997-03-10 | ヒト ビクニン |
| JP2003119118A Pending JP2004000208A (ja) | 1996-03-11 | 2003-04-23 | ヒトビクニン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53280497A Expired - Fee Related JP3469584B2 (ja) | 1996-03-11 | 1997-03-10 | ヒト ビクニン |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US6583108B1 (https=) |
| EP (1) | EP0891426B1 (https=) |
| JP (2) | JP3469584B2 (https=) |
| KR (1) | KR100356956B1 (https=) |
| AR (3) | AR006188A1 (https=) |
| AT (1) | ATE328083T1 (https=) |
| AU (1) | AU716923B2 (https=) |
| BR (1) | BR9708021A (https=) |
| CA (1) | CA2247888A1 (https=) |
| CO (1) | CO4600683A1 (https=) |
| DE (1) | DE69735996T2 (https=) |
| DK (1) | DK0891426T3 (https=) |
| ES (1) | ES2263174T3 (https=) |
| HR (1) | HRP970144B1 (https=) |
| HU (1) | HU226419B1 (https=) |
| ID (1) | ID16224A (https=) |
| IL (1) | IL126115A (https=) |
| IN (1) | IN192874B (https=) |
| MY (1) | MY120693A (https=) |
| NZ (1) | NZ331540A (https=) |
| PA (1) | PA8426301A1 (https=) |
| PL (1) | PL188387B1 (https=) |
| PT (1) | PT891426E (https=) |
| SV (1) | SV1997000018A (https=) |
| TR (1) | TR199801794T2 (https=) |
| WO (1) | WO1997033996A2 (https=) |
| YU (1) | YU8997A (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| DE69632435T2 (de) * | 1995-07-24 | 2005-05-12 | Mitsubishi Chemical Corp. | Inhibitor des Hepatozytwachstumsfaktoraktivators |
| JP3469584B2 (ja) | 1996-03-11 | 2003-11-25 | バイエル コーポレイション | ヒト ビクニン |
| JP2001504709A (ja) | 1997-01-31 | 2001-04-10 | ヒューマン ジノーム サイエンシーズ,インコーポレイテッド | 組織因子経路インヒビター3 |
| ES2209542T3 (es) * | 1998-12-22 | 2004-06-16 | Bayer Aktiengesellschaft | Metodo para acelerar la velocidad de eliminacion mucociliar usando un inhibidor de serinproteasa de tipo kunitz. |
| AU3731400A (en) | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Methods and compositions useful in inhibiting apoptosis |
| AU3511500A (en) | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions |
| US20040235715A1 (en) * | 1999-11-12 | 2004-11-25 | Bayer Corporation | Method of producing glycosylated bikunin |
| IL140993A0 (en) | 2000-05-15 | 2002-02-10 | Bayer Ag | Trypsin substrate and diagnostic device, and method of using same |
| IL140994A (en) * | 2000-05-15 | 2005-12-18 | Bayer Ag | Urinary trypsin inhibitor assay containing a chelating agent |
| US6955921B2 (en) * | 2001-04-30 | 2005-10-18 | Bayer Corporation | Trypsin substrate and diagnostic device, and method of using same |
| WO2003040330A2 (en) * | 2001-11-05 | 2003-05-15 | Curagen Corporation | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| ES2348230T3 (es) | 2002-06-07 | 2010-12-01 | Dyax Corp. | Prevención y reducción de la isquemia. |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| WO2004060403A2 (en) | 2003-01-06 | 2004-07-22 | Angiochem Inc. | Aprotinin and anglos as carriers across the blood-brain barrier |
| US8460243B2 (en) | 2003-06-10 | 2013-06-11 | Abbott Diabetes Care Inc. | Glucose measuring module and insulin pump combination |
| US7244616B2 (en) | 2003-06-27 | 2007-07-17 | Bayer Pharmaceuticals Corporation | Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells |
| US7722536B2 (en) | 2003-07-15 | 2010-05-25 | Abbott Diabetes Care Inc. | Glucose measuring device integrated into a holster for a personal area network device |
| US7850970B2 (en) | 2003-08-26 | 2010-12-14 | The Regents Of The University Of Colorado | Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections |
| JP2007518426A (ja) * | 2003-10-10 | 2007-07-12 | マルチセル テクノロジーズ、インコーポレイテッド | 不死化肝細胞 |
| WO2005040222A1 (en) * | 2003-10-16 | 2005-05-06 | Bayer Healthcare Llc | Monoclonal antibodies for detection of urinary trypsin inhibitors |
| EP1586587A1 (en) * | 2004-04-16 | 2005-10-19 | Exonhit Therapeutics SA | Compositions and methods for detecting angiogenesis |
| WO2005119524A2 (en) | 2004-06-04 | 2005-12-15 | Therasense, Inc. | Diabetes care host-client architecture and data management system |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| US20090016959A1 (en) * | 2005-02-18 | 2009-01-15 | Richard Beliveau | Delivery of antibodies to the central nervous system |
| RU2408605C2 (ru) * | 2005-02-18 | 2011-01-10 | Анджиокем Инк. | Полипептид, способный преодолевать гематоэнцефалический барьер, и его конъюгат |
| WO2007011693A2 (en) * | 2005-07-14 | 2007-01-25 | Medistem Laboratories, Inc. | Compositions of placentally-derived stem cells for the treatment of cancer |
| ES2744225T3 (es) | 2005-07-15 | 2020-02-24 | Angiochem Inc | Uso de polipéptidos de aprotinina como portadores en conjugados farmacéuticos |
| US8093017B2 (en) * | 2005-12-07 | 2012-01-10 | Siemens Heathcare Diagnostics Inc. | Detection of soluble adiponectin receptor peptides and use in diagnostics and therapeutics |
| PL1981519T3 (pl) * | 2005-12-29 | 2018-07-31 | Dyax Corp. | Hamowanie proteaz |
| CA2663545A1 (en) * | 2006-09-19 | 2008-03-27 | Phylogica Limited | Neuroprotective peptide inhibitors of ap-1 signaling and uses thereof |
| US20100063146A1 (en) * | 2006-11-07 | 2010-03-11 | Medof M Edward | Method for treating disorders related to complement activation |
| WO2008077478A1 (en) * | 2006-12-22 | 2008-07-03 | Bayer Schering Pharma Aktiengesellschaft | Preparation and use of variants of the kunitz domain 2 of the human placental bikunin gene |
| US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| US8822409B2 (en) * | 2007-06-20 | 2014-09-02 | Phylogica Limited | Compositions and uses thereof for the treatment of acute respiratory distress syndrome (ARDS) and clinical disorders associated with therewith |
| US20090075887A1 (en) * | 2007-08-21 | 2009-03-19 | Genzyme Corporation | Treatment with Kallikrein Inhibitors |
| DE102007056231A1 (de) | 2007-09-08 | 2009-03-12 | Bayer Healthcare Ag | Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI) |
| MX355683B (es) * | 2008-04-18 | 2018-04-26 | Angiochem Inc | Composiciones farmacéuticas de paclitaxel, análogos de paclitaxel o conjugados de paclitaxel, y métodos relacionados de preparación y uso. |
| WO2010043049A1 (en) | 2008-10-15 | 2010-04-22 | Angiochem Inc. | Etoposide and doxorubicin conjugates for drug delivery |
| CA2740316A1 (en) | 2008-10-15 | 2010-04-22 | Angiochem Inc. | Conjugates of glp-1 agonists and uses thereof |
| CA2745524C (en) | 2008-12-05 | 2020-06-09 | Angiochem Inc. | Conjugates of neurotensin or neurotensin analogs and uses thereof |
| US8853353B2 (en) | 2008-12-17 | 2014-10-07 | Angiochem, Inc. | Membrane type-1 matrix metalloprotein inhibitors and uses thereof |
| US8637454B2 (en) | 2009-01-06 | 2014-01-28 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
| MX2011011023A (es) | 2009-04-20 | 2012-01-20 | Angiochem Inc | Tratamiento de cancer de ovarios usando un agente anti-cancer conjugado con un analogo de angiopep-2. |
| RU2012103240A (ru) | 2009-07-02 | 2013-08-10 | Ангиокем Инк. | Мультимерные пептидные конъюгаты и их применение |
| SMT201800552T1 (it) | 2010-01-06 | 2018-11-09 | Dyax Corp | Proteine che legano la callicreina plasmatica |
| EP2371857A1 (en) * | 2010-04-01 | 2011-10-05 | CSL Behring GmbH | Factor XII inhibitors for treating interstitial lung disease |
| KR102320178B1 (ko) | 2011-01-06 | 2021-11-02 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 결합 단백질 |
| US10136845B2 (en) | 2011-02-28 | 2018-11-27 | Abbott Diabetes Care Inc. | Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same |
| WO2012178102A2 (en) | 2011-06-24 | 2012-12-27 | The Regents Of The Unversity Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| CA2896951A1 (en) | 2012-01-10 | 2013-07-18 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| JP2015526434A (ja) | 2012-08-14 | 2015-09-10 | アンジオケム インコーポレーテッド | ペプチド−デンドリマーコンジュゲート及びその使用 |
| PL3110434T3 (pl) | 2014-02-24 | 2019-01-31 | Takeda Gmbh | Białka fuzyjne uti |
| US10428158B2 (en) | 2014-03-27 | 2019-10-01 | Dyax Corp. | Compositions and methods for treatment of diabetic macular edema |
| EP3307326B9 (en) | 2015-06-15 | 2021-02-24 | Angiochem Inc. | Methods for the treatment of leptomeningeal carcinomatosis |
| EP3387018A1 (en) | 2015-12-11 | 2018-10-17 | Dyax Corp. | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
| EP4090427A1 (en) | 2020-01-13 | 2022-11-23 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack |
| US11725043B2 (en) | 2020-03-05 | 2023-08-15 | DiaMedica USA Inc. | Ulinastatin polypeptides |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223482A (en) | 1986-11-17 | 1993-06-29 | Scios Nova Inc. | Recombinant Alzheimer's protease inhibitory amyloid protein and method of use |
| US5106833A (en) | 1987-07-23 | 1992-04-21 | Washington University | Coagulation inhibitors |
| US5663143A (en) | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| DK0401508T3 (da) * | 1989-05-13 | 1995-05-15 | Bayer Ag | Proteaseinhibitorer, fremgangsmåde til deres fremstilling samt lægemidler med indhold deraf |
| DK408089D0 (da) | 1989-08-18 | 1989-08-18 | Novo Nordisk As | Proteiner |
| DE69117545T2 (de) | 1990-01-25 | 1996-10-31 | Univ Washington | Faktor X-LACI-Hybridprotein |
| AU1581692A (en) | 1991-03-01 | 1992-10-06 | Protein Engineering Corporation | Inhibitors of human neutrophil elastase and human cathepsin g |
| RU2054180C1 (ru) | 1991-08-21 | 1996-02-10 | Жирнов Олег Петрович (н/п) | Способ лечения вирусных респираторных инфекций |
| IL104325A (en) | 1992-01-07 | 2000-10-31 | Novo Nordisk As | Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above |
| IL104326A0 (en) | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Variant of human kunitz-type protease inhibitor |
| JPH07509229A (ja) | 1992-07-13 | 1995-10-12 | コルバス・インターナショナル、インコーポレイテッド | ウシ膵トリプシン阻害因子から誘導される因子Xaの阻害因子 |
| US5436153A (en) | 1992-12-02 | 1995-07-25 | Sprecher; Cindy A. | Human amyloid protein precursor homolog and Kunitz-type inhibitor |
| WO1994012637A2 (en) | 1992-12-02 | 1994-06-09 | Zymogenetics, Inc. | Novel human amyloid protein precursor homologue and kunitz-type inhibitors |
| JP2769083B2 (ja) | 1993-02-22 | 1998-06-25 | 日清食品株式会社 | エラスターゼ阻害活性を有する新規ペプチドおよびその製造方法 |
| US5455338A (en) | 1993-11-05 | 1995-10-03 | Zymogenetics, Inc. | DNA encoding novel human kunitz-type inhibitors and methods relating thereto |
| WO1995021601A2 (en) | 1994-01-11 | 1995-08-17 | Protein Engineering Corporation | Kallikrein-inhibiting 'kunitz domain' proteins and analogues thereof |
| ATE277081T1 (de) | 1994-01-11 | 2004-10-15 | Dyax Corp | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
| US5795954A (en) | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
| WO1996003503A1 (en) | 1994-07-21 | 1996-02-08 | The Green Cross Corporation | Process for producing urinary trypsin inhibitor and domains thereof, novel polypeptide related to the both, and process for producing the polypeptide |
| US5541228A (en) * | 1994-10-14 | 1996-07-30 | Bristol-Myers Squibb Co. | Melatonergic agents |
| KR19990008458A (ko) | 1995-05-08 | 1999-01-25 | 쉬어러 피터 알. | 쿠니츠(kunitz) 타입 프로테아제 억제 물질 |
| US5786328A (en) | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
| DE69632435T2 (de) | 1995-07-24 | 2005-05-12 | Mitsubishi Chemical Corp. | Inhibitor des Hepatozytwachstumsfaktoraktivators |
| US5736364A (en) | 1995-12-04 | 1998-04-07 | Genentech, Inc. | Factor viia inhibitors |
| JP3469584B2 (ja) | 1996-03-11 | 2003-11-25 | バイエル コーポレイション | ヒト ビクニン |
| JP2001504709A (ja) | 1997-01-31 | 2001-04-10 | ヒューマン ジノーム サイエンシーズ,インコーポレイテッド | 組織因子経路インヒビター3 |
| US6294648B1 (en) * | 1999-07-20 | 2001-09-25 | Bayer Corporation | Protein having proteinase inhibitor activity |
-
1997
- 1997-03-10 JP JP53280497A patent/JP3469584B2/ja not_active Expired - Fee Related
- 1997-03-10 HU HU9902698A patent/HU226419B1/hu not_active IP Right Cessation
- 1997-03-10 BR BR9708021A patent/BR9708021A/pt not_active Application Discontinuation
- 1997-03-10 EP EP97915029A patent/EP0891426B1/en not_active Expired - Lifetime
- 1997-03-10 IL IL126115A patent/IL126115A/en not_active IP Right Cessation
- 1997-03-10 TR TR1998/01794T patent/TR199801794T2/xx unknown
- 1997-03-10 AU AU22077/97A patent/AU716923B2/en not_active Ceased
- 1997-03-10 AT AT97915029T patent/ATE328083T1/de not_active IP Right Cessation
- 1997-03-10 PT PT97915029T patent/PT891426E/pt unknown
- 1997-03-10 DE DE69735996T patent/DE69735996T2/de not_active Expired - Fee Related
- 1997-03-10 YU YU8997A patent/YU8997A/sh unknown
- 1997-03-10 CA CA002247888A patent/CA2247888A1/en not_active Abandoned
- 1997-03-10 KR KR10-1998-0707163A patent/KR100356956B1/ko not_active Expired - Fee Related
- 1997-03-10 PL PL97328822A patent/PL188387B1/pl not_active IP Right Cessation
- 1997-03-10 NZ NZ331540A patent/NZ331540A/en unknown
- 1997-03-10 ES ES97915029T patent/ES2263174T3/es not_active Expired - Lifetime
- 1997-03-10 DK DK97915029T patent/DK0891426T3/da active
- 1997-03-10 WO PCT/US1997/003894 patent/WO1997033996A2/en not_active Ceased
- 1997-03-11 MY MYPI97001015A patent/MY120693A/en unknown
- 1997-03-11 PA PA19978426301A patent/PA8426301A1/es unknown
- 1997-03-11 IN IN601DE1997 patent/IN192874B/en unknown
- 1997-03-11 SV SV1997000018A patent/SV1997000018A/es not_active Application Discontinuation
- 1997-03-11 HR HR970144A patent/HRP970144B1/xx not_active IP Right Cessation
- 1997-03-11 CO CO97013175A patent/CO4600683A1/es unknown
- 1997-03-11 ID IDP970779A patent/ID16224A/id unknown
- 1997-03-11 AR ARP970100967A patent/AR006188A1/es active IP Right Grant
-
1998
- 1998-08-31 US US09/144,428 patent/US6583108B1/en not_active Expired - Fee Related
-
2001
- 2001-10-10 US US09/974,026 patent/US7019123B2/en not_active Expired - Fee Related
-
2003
- 2003-04-23 JP JP2003119118A patent/JP2004000208A/ja active Pending
-
2006
- 2006-03-27 US US11/390,775 patent/US7452859B2/en not_active Expired - Fee Related
- 2006-04-20 AR ARP060101562A patent/AR053063A2/es unknown
-
2007
- 2007-01-11 AR ARP070100116A patent/AR058982A1/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004000208A5 (https=) | ||
| JP3469584B2 (ja) | ヒト ビクニン | |
| DK171824B1 (da) | Blodkoagulationsinhiberende hirudinderivater, fremgangsmåde til deres udvinding, deres anvendelse samt middel indeholdende dem | |
| JP2004525097A5 (https=) | ||
| KR20170123640A (ko) | 면역조절제로서의 1,2,4-옥사다이아졸 및 티아다이아졸 화합물 | |
| KR20170123680A (ko) | 면역조절제로서의 1,3,4-옥사다이아졸 및 티아다이아졸 화합물 | |
| JPH08509735A (ja) | トロンビン阻害剤 | |
| JP2001519358A (ja) | ジペプチドのアポトーシスインヒビターおよびそれらの使用 | |
| JP2004143182A (ja) | インターロイキン−1β変換酵素のインヒビター | |
| HU230773B1 (hu) | Benzamidok és rokon Xa faktor inhibitorok | |
| MXPA01010114A (es) | Inhibidores de peso molecular bajo de las proteasas complemento. | |
| US10351594B2 (en) | Process for preparing compounds having triple activities of thrombolysis, antithrombosis, and radical scavenging | |
| JP2018520707A (ja) | 新規なトリプシンアイソフォームおよびそれらの使用 | |
| JP7606966B2 (ja) | ミトコンドリア病を標的とするアナログ | |
| JP7018075B2 (ja) | メトトレキサートとペプチドの結合体 | |
| JP6860877B2 (ja) | 骨芽細胞の分化促進剤および骨形成促進剤 | |
| KR20090009796A (ko) | 키메라 쿠니츠 도메인 및 그의 용도 | |
| BG108587A (bg) | Пептиди притежаващи анти -ангиогенна активност | |
| CA2310677C (en) | In vitro and in vivo growth-promoting proteins and peptides for kidney epithelial cells | |
| JPH0625288A (ja) | ペプチドまたはその塩 | |
| JP3893579B2 (ja) | 新規なテトラペプチドおよびアンジオテンシン変換酵素阻害剤 | |
| CN103370331B (zh) | 用于治疗关节病的氨基他汀衍生物 | |
| US11492390B2 (en) | Mutant alpha-1-antitrypsin compositions and use thereof | |
| JPH06220088A (ja) | アンジオテンシンi変換酵素を阻害するトリペプチドおよびその製造法ならびにそれを含む食品 | |
| RU98118678A (ru) | Бикунин человека |