KR100356956B1 - 사람비쿠닌 - Google Patents

사람비쿠닌 Download PDF

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Publication number
KR100356956B1
KR100356956B1 KR10-1998-0707163A KR19980707163A KR100356956B1 KR 100356956 B1 KR100356956 B1 KR 100356956B1 KR 19980707163 A KR19980707163 A KR 19980707163A KR 100356956 B1 KR100356956 B1 KR 100356956B1
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KR
South Korea
Prior art keywords
bikunin
placenta
protein
sequence
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR10-1998-0707163A
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English (en)
Korean (ko)
Other versions
KR19990087697A (ko
Inventor
폴 피. 탬버리니
게리 데이비스
캐더린 에이. 델라리아
크리스토퍼 더블유. 말로어
다니엘 케이. 멀러
Original Assignee
베이어 코오포레이숀
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Publication of KR19990087697A publication Critical patent/KR19990087697A/ko
Application granted granted Critical
Publication of KR100356956B1 publication Critical patent/KR100356956B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
KR10-1998-0707163A 1996-03-11 1997-03-10 사람비쿠닌 Expired - Fee Related KR100356956B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US1310696P 1996-03-11 1996-03-11
US60/013,106 1996-03-11
US1979396P 1996-06-14 1996-06-14
US60/019,793 1996-06-14
US72525196A 1996-10-04 1996-10-04
US08/725,251 1996-10-04
US8/725,251 1996-10-04

Publications (2)

Publication Number Publication Date
KR19990087697A KR19990087697A (ko) 1999-12-27
KR100356956B1 true KR100356956B1 (ko) 2003-03-15

Family

ID=27359773

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-1998-0707163A Expired - Fee Related KR100356956B1 (ko) 1996-03-11 1997-03-10 사람비쿠닌

Country Status (27)

Country Link
US (3) US6583108B1 (https=)
EP (1) EP0891426B1 (https=)
JP (2) JP3469584B2 (https=)
KR (1) KR100356956B1 (https=)
AR (3) AR006188A1 (https=)
AT (1) ATE328083T1 (https=)
AU (1) AU716923B2 (https=)
BR (1) BR9708021A (https=)
CA (1) CA2247888A1 (https=)
CO (1) CO4600683A1 (https=)
DE (1) DE69735996T2 (https=)
DK (1) DK0891426T3 (https=)
ES (1) ES2263174T3 (https=)
HR (1) HRP970144B1 (https=)
HU (1) HU226419B1 (https=)
ID (1) ID16224A (https=)
IL (1) IL126115A (https=)
IN (1) IN192874B (https=)
MY (1) MY120693A (https=)
NZ (1) NZ331540A (https=)
PA (1) PA8426301A1 (https=)
PL (1) PL188387B1 (https=)
PT (1) PT891426E (https=)
SV (1) SV1997000018A (https=)
TR (1) TR199801794T2 (https=)
WO (1) WO1997033996A2 (https=)
YU (1) YU8997A (https=)

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Also Published As

Publication number Publication date
US7452859B2 (en) 2008-11-18
NZ331540A (en) 1999-10-28
AU716923B2 (en) 2000-03-09
PL188387B1 (pl) 2005-01-31
HUP9902698A2 (hu) 1999-11-29
IL126115A0 (en) 1999-05-09
CO4600683A1 (es) 1998-05-08
HRP970144B1 (en) 2004-10-31
DK0891426T3 (da) 2006-10-02
JP2001521367A (ja) 2001-11-06
US20060172946A1 (en) 2006-08-03
TR199801794T2 (xx) 2000-07-21
AU2207797A (en) 1997-10-01
IL126115A (en) 2007-03-08
US7019123B2 (en) 2006-03-28
JP3469584B2 (ja) 2003-11-25
JP2004000208A (ja) 2004-01-08
US20030194398A1 (en) 2003-10-16
IN192874B (https=) 2004-05-29
ATE328083T1 (de) 2006-06-15
BR9708021A (pt) 1999-07-27
KR19990087697A (ko) 1999-12-27
HUP9902698A3 (en) 2001-06-28
ID16224A (id) 1997-09-11
YU8997A (sh) 1999-09-27
PL328822A1 (en) 1999-02-15
CA2247888A1 (en) 1997-09-18
AR053063A2 (es) 2007-04-18
EP0891426A2 (en) 1999-01-20
AR006188A1 (es) 1999-08-11
EP0891426B1 (en) 2006-05-31
DE69735996D1 (de) 2006-07-06
ES2263174T3 (es) 2006-12-01
PA8426301A1 (es) 2000-05-24
DE69735996T2 (de) 2007-02-15
PT891426E (pt) 2006-10-31
HRP970144A2 (en) 1998-04-30
WO1997033996A3 (en) 1997-11-13
US6583108B1 (en) 2003-06-24
MY120693A (en) 2005-11-30
HU226419B1 (en) 2008-12-29
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AR058982A1 (es) 2008-03-05
SV1997000018A (es) 1999-01-14

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