DE69117545T2 - Faktor X-LACI-Hybridprotein - Google Patents

Faktor X-LACI-Hybridprotein

Info

Publication number
DE69117545T2
DE69117545T2 DE69117545T DE69117545T DE69117545T2 DE 69117545 T2 DE69117545 T2 DE 69117545T2 DE 69117545 T DE69117545 T DE 69117545T DE 69117545 T DE69117545 T DE 69117545T DE 69117545 T2 DE69117545 T2 DE 69117545T2
Authority
DE
Germany
Prior art keywords
laci
factor
hybrid protein
amino acid
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69117545T
Other languages
English (en)
Other versions
DE69117545D1 (de
Inventor
Thomas James Girard
George John Broze Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Washington University in St Louis WUSTL
Original Assignee
University of Washington
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Washington University in St Louis WUSTL filed Critical University of Washington
Application granted granted Critical
Publication of DE69117545D1 publication Critical patent/DE69117545D1/de
Publication of DE69117545T2 publication Critical patent/DE69117545T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
DE69117545T 1990-01-25 1991-01-21 Faktor X-LACI-Hybridprotein Expired - Fee Related DE69117545T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47028990A 1990-01-25 1990-01-25

Publications (2)

Publication Number Publication Date
DE69117545D1 DE69117545D1 (de) 1996-04-11
DE69117545T2 true DE69117545T2 (de) 1996-10-31

Family

ID=23866994

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69117545T Expired - Fee Related DE69117545T2 (de) 1990-01-25 1991-01-21 Faktor X-LACI-Hybridprotein

Country Status (8)

Country Link
EP (1) EP0439442B1 (de)
JP (1) JP2560150B2 (de)
AT (1) ATE135044T1 (de)
CA (1) CA2034881C (de)
DE (1) DE69117545T2 (de)
DK (1) DK0439442T3 (de)
ES (1) ES2086521T3 (de)
GR (1) GR3019877T3 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69118056T2 (de) * 1990-08-27 1996-10-24 Monsanto Co Anticoagulatorische Zusammensetzung aus LACI und sulfatierten Polysacchariden
US5276015A (en) * 1992-03-18 1994-01-04 Washington University Method of inhibiting microvascular thrombosis
CA2145517A1 (en) * 1992-09-25 1994-04-14 Ignace Lasters Bovine pancreatic trypsin inhibitor derived inhibitors of factor viia - tissue factor complex
US6090916A (en) * 1994-10-18 2000-07-18 Corvas International, Inc. Nematode-extracted serine protease inhibitors and anticoagulant proteins
US5945275A (en) * 1994-10-18 1999-08-31 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5866542A (en) * 1994-10-18 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5872098A (en) * 1995-06-05 1999-02-16 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5866543A (en) * 1995-06-05 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5863894A (en) * 1995-06-05 1999-01-26 Corvas International, Inc. Nematode-extracted anticoagulant protein
CA2202351A1 (en) * 1994-10-18 1996-04-25 George Phillip Vlasuk Nematode-extracted serine protease inhibitors and anticoagulant proteins
US5772629A (en) * 1995-10-23 1998-06-30 Localmed, Inc. Localized intravascular delivery of TFPI for inhibition of restenosis in recanalized blood vessels
US5910481A (en) * 1995-11-13 1999-06-08 Immuno Ag Hybrid proteins with modified activity
ES2195025T3 (es) * 1995-12-01 2003-12-01 Genentech Inc Proteinas de fusion de un dominio de factor tisular-dominio de kunitz como inhibidores del factor viia.
US5736364A (en) * 1995-12-04 1998-04-07 Genentech, Inc. Factor viia inhibitors
DE69735996T2 (de) 1996-03-11 2007-02-15 Bayer Corp. Menschlicher bikunin
US6159722A (en) * 1997-12-03 2000-12-12 Boehringer Mannheim Gmbh Chimeric serine proteases
EP0927764B1 (de) * 1997-12-03 2004-05-26 Boehringer Mannheim Gmbh Chimäre Serinproteasen
EP1274720A4 (de) * 2000-04-12 2004-08-18 Human Genome Sciences Inc Albumin enthaltende fusionsproteine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL87171A (en) * 1987-11-23 1995-08-31 Monsanto Co ANDC of human tissue factor inhibitor

Also Published As

Publication number Publication date
JP2560150B2 (ja) 1996-12-04
EP0439442A3 (en) 1992-05-27
ATE135044T1 (de) 1996-03-15
EP0439442B1 (de) 1996-03-06
JPH04211000A (ja) 1992-08-03
EP0439442A2 (de) 1991-07-31
CA2034881A1 (en) 1991-07-26
CA2034881C (en) 2001-05-29
DK0439442T3 (da) 1996-07-08
DE69117545D1 (de) 1996-04-11
ES2086521T3 (es) 1996-07-01
GR3019877T3 (en) 1996-08-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee