DK0439442T3 - Faktor X-LACI-hybridprotein - Google Patents

Faktor X-LACI-hybridprotein

Info

Publication number
DK0439442T3
DK0439442T3 DK91870008.9T DK91870008T DK0439442T3 DK 0439442 T3 DK0439442 T3 DK 0439442T3 DK 91870008 T DK91870008 T DK 91870008T DK 0439442 T3 DK0439442 T3 DK 0439442T3
Authority
DK
Denmark
Prior art keywords
laci
factor
hybrid protein
amino acid
acid sequence
Prior art date
Application number
DK91870008.9T
Other languages
Danish (da)
English (en)
Inventor
Thomas James Girard
George John Broze Jr
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Application granted granted Critical
Publication of DK0439442T3 publication Critical patent/DK0439442T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK91870008.9T 1990-01-25 1991-01-21 Faktor X-LACI-hybridprotein DK0439442T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47028990A 1990-01-25 1990-01-25

Publications (1)

Publication Number Publication Date
DK0439442T3 true DK0439442T3 (da) 1996-07-08

Family

ID=23866994

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91870008.9T DK0439442T3 (da) 1990-01-25 1991-01-21 Faktor X-LACI-hybridprotein

Country Status (8)

Country Link
EP (1) EP0439442B1 (de)
JP (1) JP2560150B2 (de)
AT (1) ATE135044T1 (de)
CA (1) CA2034881C (de)
DE (1) DE69117545T2 (de)
DK (1) DK0439442T3 (de)
ES (1) ES2086521T3 (de)
GR (1) GR3019877T3 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT98779B (pt) * 1990-08-27 1999-06-30 Monsanto Co Processo para a preparacao de uma composicao anticoagulante contendo inibidor sulfatados e metodos para a sua utilizacao
US5276015A (en) * 1992-03-18 1994-01-04 Washington University Method of inhibiting microvascular thrombosis
WO1994007528A1 (en) * 1992-09-25 1994-04-14 Corvas International, Inc. Bovine pancreatic trypsin inhibitor derived inhibitors of factor viia-tissue factor complex
CA2202351A1 (en) * 1994-10-18 1996-04-25 George Phillip Vlasuk Nematode-extracted serine protease inhibitors and anticoagulant proteins
US5872098A (en) * 1995-06-05 1999-02-16 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5866542A (en) * 1994-10-18 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
AU711405B2 (en) * 1994-10-18 1999-10-14 Dendreon Corporation Nematode-extracted serine protease inhibitors and anticoagulant proteins
US5866543A (en) * 1995-06-05 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5863894A (en) * 1995-06-05 1999-01-26 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5945275A (en) * 1994-10-18 1999-08-31 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5772629A (en) * 1995-10-23 1998-06-30 Localmed, Inc. Localized intravascular delivery of TFPI for inhibition of restenosis in recanalized blood vessels
US5910481A (en) * 1995-11-13 1999-06-08 Immuno Ag Hybrid proteins with modified activity
US5736364A (en) * 1995-12-04 1998-04-07 Genentech, Inc. Factor viia inhibitors
ES2195025T3 (es) * 1995-12-01 2003-12-01 Genentech Inc Proteinas de fusion de un dominio de factor tisular-dominio de kunitz como inhibidores del factor viia.
BR9708021A (pt) 1996-03-11 1999-07-27 Bayer Ag Proteína substancialmente purificada composição farmacêutica sequência de ácido nucleico isolada vetor de express o de protéina auto-replicante e processos para inibir a atividade de protéinas de serina tratar uma condição e preparar um medicamento de uma proteína
EP0927764B1 (de) * 1997-12-03 2004-05-26 Boehringer Mannheim Gmbh Chimäre Serinproteasen
US6159722A (en) 1997-12-03 2000-12-12 Boehringer Mannheim Gmbh Chimeric serine proteases
CA2405557C (en) * 2000-04-12 2013-09-24 Human Genome Sciences, Inc. Albumin fusion proteins

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL87171A (en) * 1987-11-23 1995-08-31 Monsanto Co ANDC of human tissue factor inhibitor

Also Published As

Publication number Publication date
EP0439442B1 (de) 1996-03-06
ES2086521T3 (es) 1996-07-01
CA2034881C (en) 2001-05-29
JP2560150B2 (ja) 1996-12-04
JPH04211000A (ja) 1992-08-03
DE69117545T2 (de) 1996-10-31
DE69117545D1 (de) 1996-04-11
CA2034881A1 (en) 1991-07-26
EP0439442A3 (en) 1992-05-27
EP0439442A2 (de) 1991-07-31
GR3019877T3 (en) 1996-08-31
ATE135044T1 (de) 1996-03-15

Similar Documents

Publication Publication Date Title
ATE135044T1 (de) Faktor x-laci-hybridprotein
DE122004000045I1 (de) Neuartige Peptidderivate.
ES2031806T3 (es) Factor de permeabilidad vascular humano.
ATE81503T1 (de) N-(mercaptoalkyl)-omega-hydroxyalkylamide und ihre verwendung als reduktionsmittel in einem verfahren zur bleibenden gestaltung von haaren.
DK0625912T3 (da) Behandling af inflammatorisk tarmsygdom
FI883487A (fi) Ihmisen kudostekijäinhibiittorin DNA-klooni
ES551820A0 (es) Un procedimiento para la fabricacion de derivados peptidicos inhibidores de la renina y de las proteasas acidas
ATE84716T1 (de) 4-chinolincarbonsaeure-derivate, brauchbar zur behandlung von haut- und muco-epithelialgewebekrankheiten.
SE8901552D0 (sv) Acid addition salts of amidated or glycine, their preparation and use
DK627687A (da) Hirudinvariant
PT88383A (pt) Verfahren fuer die herstellung von 2-[4-<2-(4-chlorbenzamido)-ethyl-phenoxy]-2-methylpropionsaeure enthaltenden pharmazeutischen zusammensetzungen zur behandlung von diabetes geeignet
BG97123A (bg) Производни на човешка, стимулирана от жлъчните соли, липаза и фармацевтични състави на тяхна основа
FI925696A0 (fi) Pao hirudinets aminosyrasekvens baserade trombininhibitorer
DE3769910D1 (de) Verwendung von n, n'-bis-l-aminosaeure-l-cystinpeptiden in aminosaeure-praeparaten fuer orale und parenterale ernaehrung.
ATE151996T1 (de) Kit zur einführung eines fremdkörpers, der geeignet zur identifikation eines tieres ist
ATE80388T1 (de) Verfahren zur herstellung von 5-gliedrigen, stickstoffhaltigen heteroaromaten.
DK0490383T3 (da) Peptider af HIV-gag-proteinet, fremstilling og anvendelse deraf
MX9205978A (es) Nuevas proteinas inhibidoras de trombina de garrapatas.
DK366380A (da) Anvendelsen af grp og salte deraf
DK53290A (da) Syntetiske gaer-leader-peptider
DK288581A (da) Anvendelse af peptider som diagnost ikum