JP2003530093A5 - - Google Patents

Info

Publication number

JP2003530093A5

JP2003530093A5 JP2001569351A JP2001569351A JP2003530093A5 JP 2003530093 A5 JP2003530093 A5 JP 2003530093A5 JP 2001569351 A JP2001569351 A JP 2001569351A JP 2001569351 A JP2001569351 A JP 2001569351A JP 2003530093 A5 JP2003530093 A5 JP 2003530093A5

Authority

JP

Japan

Prior art keywords

factor viii

viii mutein

mutein

vector

replaced

Prior art date

2001-03-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 108010054218 Factor VIII Proteins 0.000 claims 22
• 102000001690 Factor VIII Human genes 0.000 claims 22
• 229960000301 factor viii Drugs 0.000 claims 22
• 230000035772 mutation Effects 0.000 claims 8
• 238000000034 method Methods 0.000 claims 7
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
• 125000000539 amino acid group Chemical group 0.000 claims 5
• 210000004027 cell Anatomy 0.000 claims 4
• 210000005260 human cell Anatomy 0.000 claims 4
• 108090000623 proteins and genes Proteins 0.000 claims 3
• 208000009292 Hemophilia A Diseases 0.000 claims 2
• 241000700605 Viruses Species 0.000 claims 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims 2
• 239000003114 blood coagulation factor Substances 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• 108010047303 von Willebrand Factor Proteins 0.000 claims 2
• 102100036537 von Willebrand factor Human genes 0.000 claims 2
• 229960001134 von willebrand factor Drugs 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 102000015081 Blood Coagulation Factors Human genes 0.000 claims 1
• 108010039209 Blood Coagulation Factors Proteins 0.000 claims 1
• 102100026735 Coagulation factor VIII Human genes 0.000 claims 1
• 108020004414 DNA Proteins 0.000 claims 1
• 201000003542 Factor VIII deficiency Diseases 0.000 claims 1
• 208000031220 Hemophilia Diseases 0.000 claims 1
• 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims 1
• 230000002378 acidificating effect Effects 0.000 claims 1
• 108091006088 activator proteins Proteins 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 239000000427 antigen Substances 0.000 claims 1
• 102000036639 antigens Human genes 0.000 claims 1
• 108091007433 antigens Proteins 0.000 claims 1
• 229940019700 blood coagulation factors Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 230000002496 gastric effect Effects 0.000 claims 1
• 239000001963 growth medium Substances 0.000 claims 1
• 230000002779 inactivation Effects 0.000 claims 1
• 210000003734 kidney Anatomy 0.000 claims 1
• 210000003292 kidney cell Anatomy 0.000 claims 1
• 210000004185 liver Anatomy 0.000 claims 1
• 210000004072 lung Anatomy 0.000 claims 1
• 239000003550 marker Substances 0.000 claims 1
• 210000004165 myocardium Anatomy 0.000 claims 1
• 230000007935 neutral effect Effects 0.000 claims 1
• 210000001672 ovary Anatomy 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• 210000002460 smooth muscle Anatomy 0.000 claims 1
• 210000003932 urinary bladder Anatomy 0.000 claims 1
• 230000006490 viral transcription Effects 0.000 claims 1