JP2019525764A5 - - Google Patents
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- Publication number
- JP2019525764A5 JP2019525764A5 JP2019504782A JP2019504782A JP2019525764A5 JP 2019525764 A5 JP2019525764 A5 JP 2019525764A5 JP 2019504782 A JP2019504782 A JP 2019504782A JP 2019504782 A JP2019504782 A JP 2019504782A JP 2019525764 A5 JP2019525764 A5 JP 2019525764A5
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- JP
- Japan
- Prior art keywords
- substitution
- factor
- replaced
- nucleic acid
- acid molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000006467 substitution reaction Methods 0.000 claims 22
- 102100022641 Coagulation factor IX Human genes 0.000 claims 19
- 108010076282 Factor IX Proteins 0.000 claims 17
- 229960004222 factor ix Drugs 0.000 claims 17
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 150000007523 nucleic acids Chemical class 0.000 claims 11
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 239000013598 vector Substances 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 208000009429 hemophilia B Diseases 0.000 claims 2
- 230000023597 hemostasis Effects 0.000 claims 2
- 230000003834 intracellular effect Effects 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 241000701161 unidentified adenovirus Species 0.000 claims 2
- 108090000317 Chymotrypsin Proteins 0.000 claims 1
- 108010048049 Factor IXa Proteins 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 229960002376 chymotrypsin Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002439 hemostatic effect Effects 0.000 claims 1
- 229960000027 human factor ix Drugs 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000001177 retroviral effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662367321P | 2016-07-27 | 2016-07-27 | |
| US62/367,321 | 2016-07-27 | ||
| PCT/US2017/044104 WO2018022844A2 (en) | 2016-07-27 | 2017-07-27 | Compositions and methods for modulating factor ix function |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019525764A JP2019525764A (ja) | 2019-09-12 |
| JP2019525764A5 true JP2019525764A5 (https=) | 2020-09-03 |
| JP7181855B2 JP7181855B2 (ja) | 2022-12-01 |
Family
ID=61016739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019504782A Active JP7181855B2 (ja) | 2016-07-27 | 2017-07-27 | 第ｉｘ因子の機能を調節するための組成物及び方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11708570B2 (https=) |
| EP (2) | EP3490586B1 (https=) |
| JP (1) | JP7181855B2 (https=) |
| CN (1) | CN109789181A (https=) |
| CA (1) | CA3034566A1 (https=) |
| WO (1) | WO2018022844A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201813528D0 (en) | 2018-08-20 | 2018-10-03 | Ucl Business Plc | Factor IX encoding nucleotides |
| US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
| AU2020242945B2 (en) * | 2019-03-19 | 2025-06-26 | CSL Innovation Pty Ltd | Factor IX variants and uses thereof in therapy |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2008006313A (es) | 2005-11-15 | 2008-11-06 | Philadelphia Children Hospital | Metodos y composiciones para modular la hemostasia. |
| KR20090013816A (ko) | 2006-05-24 | 2009-02-05 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 연장된 생체내 반감기를 갖는 인자 ⅸ 유사체 |
| EP2423307A1 (en) * | 2006-06-19 | 2012-02-29 | Catalyst Biosciences, Inc. | Modified coagulation factor IV polypeptides and use thereof for treatment |
| US7968683B1 (en) * | 2008-05-07 | 2011-06-28 | Schering Corporation | Factor IXa crystals, related complexes and methods |
| JP2013500726A (ja) | 2009-07-31 | 2013-01-10 | バイエル・ヘルスケア・エルエルシー | 改変第ｉｘ因子ポリペプチドおよびその使用 |
| TWI557135B (zh) | 2010-11-03 | 2016-11-11 | 介控生化科技公司 | 經修飾之第九因子多胜肽及其用途 |
| US9371522B2 (en) | 2011-09-30 | 2016-06-21 | The Children's Hospital Of Philadelphia | Compositions and methods for modulating hemostasis |
| US10676731B2 (en) * | 2014-08-19 | 2020-06-09 | The Children's Hospital Of Philadelphia | Compositions and methods for modulating factor IX function |
-
2017
- 2017-07-27 CN CN201780059441.0A patent/CN109789181A/zh active Pending
- 2017-07-27 EP EP17835248.0A patent/EP3490586B1/en active Active
- 2017-07-27 JP JP2019504782A patent/JP7181855B2/ja active Active
- 2017-07-27 WO PCT/US2017/044104 patent/WO2018022844A2/en not_active Ceased
- 2017-07-27 US US16/320,137 patent/US11708570B2/en active Active
- 2017-07-27 EP EP25157940.5A patent/EP4566666A3/en active Pending
- 2017-07-27 CA CA3034566A patent/CA3034566A1/en active Pending
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