JP2003520235A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003520235A5 JP2003520235A5 JP2001552899A JP2001552899A JP2003520235A5 JP 2003520235 A5 JP2003520235 A5 JP 2003520235A5 JP 2001552899 A JP2001552899 A JP 2001552899A JP 2001552899 A JP2001552899 A JP 2001552899A JP 2003520235 A5 JP2003520235 A5 JP 2003520235A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- compound
- acceptable salt
- embedded image
- triazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*C(C[n]1ncnc1)([C@@](C)C1=NC(c(cc2)ccc2N)=C*1)c(ccc(F)c1)c1F Chemical compound C*C(C[n]1ncnc1)([C@@](C)C1=NC(c(cc2)ccc2N)=C*1)c(ccc(F)c1)c1F 0.000 description 5
- UDCZFHQUDWLOAN-AQWWGDNPSA-N CCC(C)CC(C/C=C1/N=CN=C1)(C[n]1nc(/C=C/c(cc2)ccc2OCC(C)(C)C(F)F)nc1)c1ccc(C)cc1F Chemical compound CCC(C)CC(C/C=C1/N=CN=C1)(C[n]1nc(/C=C/c(cc2)ccc2OCC(C)(C)C(F)F)nc1)c1ccc(C)cc1F UDCZFHQUDWLOAN-AQWWGDNPSA-N 0.000 description 1
- ONLCIIGTBQVTDO-CMJOXMDJSA-N C[C@H]([C@](C)(CN1O[CH]N=C1)c(ccc(F)c1)c1F)N(C1=O)N=CN1c(cc1)ccc1OCC(C(F)F)(F)F Chemical compound C[C@H]([C@](C)(CN1O[CH]N=C1)c(ccc(F)c1)c1F)N(C1=O)N=CN1c(cc1)ccc1OCC(C(F)F)(F)F ONLCIIGTBQVTDO-CMJOXMDJSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17716900P | 2000-01-20 | 2000-01-20 | |
| US60/177,169 | 2000-01-20 | ||
| US24996900P | 2000-11-20 | 2000-11-20 | |
| US60/249,969 | 2000-11-20 | ||
| PCT/US2001/001284 WO2001052852A1 (en) | 2000-01-20 | 2001-01-16 | Water soluble prodrugs of azole compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003520235A JP2003520235A (ja) | 2003-07-02 |
| JP2003520235A5 true JP2003520235A5 (https=) | 2006-02-02 |
| JP3766804B2 JP3766804B2 (ja) | 2006-04-19 |
Family
ID=26873001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001552899A Expired - Lifetime JP3766804B2 (ja) | 2000-01-20 | 2001-01-16 | アゾール化合物の水溶性プロドラッグ |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6362172B2 (https=) |
| EP (1) | EP1284737B1 (https=) |
| JP (1) | JP3766804B2 (https=) |
| KR (1) | KR100748299B1 (https=) |
| CN (1) | CN1178665C (https=) |
| AT (1) | ATE300946T1 (https=) |
| AU (1) | AU782177C (https=) |
| BR (1) | BR0107618A (https=) |
| CA (1) | CA2397734C (https=) |
| CZ (1) | CZ20022822A3 (https=) |
| DE (1) | DE60112433T2 (https=) |
| DK (1) | DK1284737T5 (https=) |
| ES (1) | ES2247131T3 (https=) |
| HU (1) | HU229226B1 (https=) |
| IL (2) | IL150798A0 (https=) |
| MX (1) | MXPA02007120A (https=) |
| NO (1) | NO330352B1 (https=) |
| NZ (1) | NZ519354A (https=) |
| PL (1) | PL206024B1 (https=) |
| PT (1) | PT1284737E (https=) |
| RU (1) | RU2266909C2 (https=) |
| WO (1) | WO2001052852A1 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6448401B1 (en) * | 2000-11-20 | 2002-09-10 | Bristol-Myers Squibb Company | Process for water soluble azole compounds |
| HUP0303249A3 (en) | 2001-02-22 | 2007-03-28 | Sankyo Co | Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| HRP20050089B1 (hr) | 2002-07-29 | 2015-06-19 | Rigel Pharmaceuticals | Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| WO2005012294A1 (en) | 2003-07-30 | 2005-02-10 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| AU2006206458B2 (en) | 2005-01-19 | 2012-10-25 | Rigel Pharmaceuticals, Inc. | Prodrugs of 2,4-pyrimidinediamine compounds and their uses |
| JO2691B1 (en) * | 2005-05-03 | 2013-03-03 | ايساي آر آند دي مانجمنت كو.، ليمتد | Monolysine salts for azole compounds |
| DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| US7803949B2 (en) * | 2005-12-20 | 2010-09-28 | Eisai R&D Management Co., Ltd. | Process for preparation of water-soluble azole prodrugs |
| WO2007092580A2 (en) * | 2006-02-08 | 2007-08-16 | Phibro-Tech Inc. | Biocidal azole emulsion concentrates having high active ingredient content |
| JP5058150B2 (ja) | 2006-02-22 | 2012-10-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 安定化医薬組成物 |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| EP2540725A1 (de) | 2006-05-04 | 2013-01-02 | Boehringer Ingelheim International GmbH | Polymorphe von 1-((4-Methyl-chinazolin-2-yl)methyl)-3-methyl-7-(2-butin-1-yl)-8-(3-(R)-amino-piperidin-1-yl)xanthin |
| PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| EP2291084A4 (en) | 2008-05-20 | 2012-04-25 | Neurogesx Inc | CARBONATE PRODRUGS AND METHOD FOR THEIR USE |
| JP5757864B2 (ja) | 2008-05-20 | 2015-08-05 | ニューロジェシックス， インコーポレイテッド | 水溶性アセトアミノフェン類似体 |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| BRPI0916997A2 (pt) | 2008-08-06 | 2020-12-15 | Boehringer Ingelheim International Gmbh | Inibidor de dpp-4 e seu uso |
| CN102149407A (zh) | 2008-09-10 | 2011-08-10 | 贝林格尔.英格海姆国际有限公司 | 治疗糖尿病和相关病症的组合疗法 |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| CN102256976A (zh) | 2008-12-23 | 2011-11-23 | 贝林格尔.英格海姆国际有限公司 | 有机化合物的盐形式 |
| AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
| KR20240090632A (ko) | 2009-11-27 | 2024-06-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료 |
| CN102946875A (zh) | 2010-05-05 | 2013-02-27 | 贝林格尔.英格海姆国际有限公司 | 组合疗法 |
| WO2011161161A1 (en) | 2010-06-24 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Diabetes therapy |
| EP2636409A1 (en) | 2010-11-05 | 2013-09-11 | Eisai R&D Management Co., Ltd. | Combined pharmaceutical composition as antifungal agent |
| AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
| ES2565353T3 (es) * | 2010-12-16 | 2016-04-04 | Borje S. Andersson | Formulaciones farmacéuticas de azol para administración parenteral y métodos para la preparación y el uso de las mismas como tratamiento de enfermedades sensibles a los compuestos de azol |
| CN103857440B (zh) | 2011-06-22 | 2018-09-25 | 维奥姆生物科学有限公司 | 基于缀合物的抗真菌和抗细菌前药 |
| US8883800B2 (en) | 2011-07-15 | 2014-11-11 | Boehringer Ingelheim International Gmbh | Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions |
| US8426450B1 (en) * | 2011-11-29 | 2013-04-23 | Helsinn Healthcare Sa | Substituted 4-phenyl pyridines having anti-emetic effect |
| WO2013109998A1 (en) | 2012-01-20 | 2013-07-25 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| EP2839835B1 (en) * | 2012-04-20 | 2016-12-21 | Eisai R&D Management Co., Ltd. | Encapsulated formulation |
| JP6218811B2 (ja) | 2012-05-14 | 2017-10-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｓｉｒｓ及び／又は敗血症の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体 |
| JP6224084B2 (ja) | 2012-05-14 | 2017-11-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糸球体上皮細胞関連障害及び／又はネフローゼ症候群の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体 |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| US20160128944A1 (en) | 2013-06-04 | 2016-05-12 | Vyome Biosciences Pvt. Ltd. | Coated particles and compositions comprising same |
| EA201691534A1 (ru) | 2014-01-29 | 2016-12-30 | Вайоми Байосайенсиз Пвт. Лтд. | Лечение устойчивых угрей |
| EP3110449B1 (en) | 2014-02-28 | 2023-06-28 | Boehringer Ingelheim International GmbH | Medical use of a dpp-4 inhibitor |
| CN104926870B (zh) * | 2014-03-21 | 2017-02-08 | 合肥久诺医药科技有限公司 | 一种福司氟康唑的精制方法 |
| EP3328819B1 (en) * | 2015-07-28 | 2020-04-01 | Beta Cat Pharmaceuticals, Inc. | Anthracene-9, 10-dione dioxime compounds prodrugs and their uses |
| CN109310697A (zh) | 2016-06-10 | 2019-02-05 | 勃林格殷格翰国际有限公司 | 利格列汀和二甲双胍的组合 |
| CN107501255B (zh) * | 2017-09-12 | 2019-08-23 | 成都施贝康生物医药科技有限公司 | 一种艾沙康唑衍生物及其用途 |
| CN108676031A (zh) * | 2018-05-29 | 2018-10-19 | 重庆威鹏药业有限公司 | 水溶性三唑类抗真菌膦酸化合物及其制备方法和应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8819308D0 (en) * | 1988-08-13 | 1988-09-14 | Pfizer Ltd | Triazole antifungal agents |
| GB9002375D0 (en) * | 1990-02-02 | 1990-04-04 | Pfizer Ltd | Triazole antifungal agents |
| MX9308012A (es) | 1992-12-24 | 1994-08-31 | Bristol Myers Squibb Co | Eteres fosfonooximetilicos de derivados de taxano, solubles en agua y composiciones farmaceuticas que los incluyen. |
| CA2129288C (en) | 1993-08-17 | 2000-05-16 | Jerzy Golik | Phosphonooxymethyl esters of taxane derivatives |
| IL112081A (en) | 1993-12-21 | 2001-08-26 | Schering Plough Corp | Tetrahydrofuran derivatives, their preparation and antifungal pharmaceutical compositions containing them |
| US5714490A (en) * | 1993-12-21 | 1998-02-03 | Schering Corporation | Tetrahydrofuran antifungals |
| ES2141329T3 (es) | 1994-01-24 | 2000-03-16 | Janssen Pharmaceutica Nv | Antifungicos azolicos solubles en agua. |
| NZ270418A (en) | 1994-02-07 | 1997-09-22 | Eisai Co Ltd | Polycyclic triazole & imidazole derivatives, antifungal compositions |
| IL118464A (en) | 1995-06-02 | 2000-08-13 | Schering Corp | (2R-cis)-4-¬4-¬4-¬4¬¬-5-(2',4 dihalophenyl)-tetrahydro-5-(1-H-1,2,4,triazol-1-yl-methyl)furan-3-yl(methoxy¾phenyl¾-1-piperazinyl¬phenyl2,4,dihydro2¬(5)-1-ethyl-2-(5)hydroxy propyl¾-3H-1,2,4-triazol-3-one and pharmaceutical compositions comprising them |
| TW354293B (en) * | 1995-06-06 | 1999-03-11 | Bristol Myers Squibb Co | Prodrugs of paclitaxel derivatives |
| GB9602080D0 (en) | 1996-02-02 | 1996-04-03 | Pfizer Ltd | Pharmaceutical compounds |
| EP0829478A3 (en) | 1996-09-09 | 1998-03-25 | F. Hoffmann-La Roche Ag | N-Benzylimidazolium and N-benzyltriazolium derivatives, their preparation and their use as antifungal and antimycotic agents |
| DE69912250T2 (de) | 1998-01-29 | 2004-07-29 | Bristol-Myers Squibb Co., Wallingford | Phosphorylierte derivate des diaryl 1,3,4 oxadiazolon |
| US5883097A (en) | 1998-04-16 | 1999-03-16 | Schering Corporation | Soluble azole antifungal salt |
| US6204257B1 (en) * | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
| AU1915500A (en) * | 1998-11-20 | 2000-06-13 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
| US6448401B1 (en) * | 2000-11-20 | 2002-09-10 | Bristol-Myers Squibb Company | Process for water soluble azole compounds |
-
2001
- 2001-01-10 US US09/757,438 patent/US6362172B2/en not_active Expired - Lifetime
- 2001-01-16 PT PT01942553T patent/PT1284737E/pt unknown
- 2001-01-16 PL PL356164A patent/PL206024B1/pl not_active IP Right Cessation
- 2001-01-16 HU HU0204405A patent/HU229226B1/hu not_active IP Right Cessation
- 2001-01-16 AT AT01942553T patent/ATE300946T1/de active
- 2001-01-16 WO PCT/US2001/001284 patent/WO2001052852A1/en not_active Ceased
- 2001-01-16 CA CA2397734A patent/CA2397734C/en not_active Expired - Lifetime
- 2001-01-16 DK DK01942553T patent/DK1284737T5/da active
- 2001-01-16 RU RU2002118606/04A patent/RU2266909C2/ru active
- 2001-01-16 AU AU29485/01A patent/AU782177C/en not_active Expired
- 2001-01-16 ES ES01942553T patent/ES2247131T3/es not_active Expired - Lifetime
- 2001-01-16 EP EP01942553A patent/EP1284737B1/en not_active Expired - Lifetime
- 2001-01-16 NZ NZ519354A patent/NZ519354A/en not_active IP Right Cessation
- 2001-01-16 BR BR0107618-3A patent/BR0107618A/pt active Search and Examination
- 2001-01-16 JP JP2001552899A patent/JP3766804B2/ja not_active Expired - Lifetime
- 2001-01-16 IL IL15079801A patent/IL150798A0/xx active IP Right Grant
- 2001-01-16 CZ CZ20022822A patent/CZ20022822A3/cs unknown
- 2001-01-16 MX MXPA02007120A patent/MXPA02007120A/es active IP Right Grant
- 2001-01-16 CN CNB018038581A patent/CN1178665C/zh not_active Expired - Lifetime
- 2001-01-16 KR KR1020027009320A patent/KR100748299B1/ko not_active Expired - Lifetime
- 2001-01-16 DE DE60112433T patent/DE60112433T2/de not_active Expired - Lifetime
-
2002
- 2002-07-17 IL IL150798A patent/IL150798A/en unknown
- 2002-07-19 NO NO20023468A patent/NO330352B1/no not_active IP Right Cessation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2003520235A5 (https=) | ||
| RU2002118606A (ru) | Водорастворимые азольные пролекарства | |
| CA2397734A1 (en) | Water soluble prodrugs of azole compounds | |
| JP3210017B2 (ja) | 三置換テトラヒドロフラン抗真菌化合物 | |
| CN1040504C (zh) | 含三唑类的药用组合物的制备方法 | |
| CA2485926A1 (en) | (imidazol-1-yl-methyl)-pyridazine as nmda receptor blocker | |
| RU98116435A (ru) | Производные триазола, используемые в терапии | |
| JP2001516732A5 (https=) | ||
| CN1210540A (zh) | 用于治疗的三唑衍生物 | |
| US6300353B1 (en) | Azoles for treatment of fungal infections | |
| JP2004506736A5 (https=) | ||
| JP2005526836A5 (https=) | ||
| JP2002513793A5 (https=) | ||
| JP2005536519A5 (https=) | ||
| JP2020122016A5 (https=) | ||
| JP2002505286A5 (https=) | ||
| JP2008540557A5 (https=) | ||
| JP2020506192A5 (https=) | ||
| JP2004525184A5 (https=) | ||
| JP2003507380A5 (https=) | ||
| JP2005526773A5 (https=) | ||
| JP2004509121A5 (https=) | ||
| JP2003513075A5 (https=) | ||
| JP2002530378A5 (https=) | ||
| EP0829478A2 (en) | N-Benzylimidazolium and N-benzyltriazolium derivatives, their preparation and their use as antifungal and antimycotic agents |