ATE300946T1 - Wasserlösliche wirkstoffvorstufen von azolverbindungen - Google Patents
Wasserlösliche wirkstoffvorstufen von azolverbindungenInfo
- Publication number
- ATE300946T1 ATE300946T1 AT01942553T AT01942553T ATE300946T1 AT E300946 T1 ATE300946 T1 AT E300946T1 AT 01942553 T AT01942553 T AT 01942553T AT 01942553 T AT01942553 T AT 01942553T AT E300946 T1 ATE300946 T1 AT E300946T1
- Authority
- AT
- Austria
- Prior art keywords
- soluble
- water
- procursions
- azole compounds
- triazole antifungal
- Prior art date
Links
- 150000003851 azoles Chemical class 0.000 title 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 3
- 229940121375 antifungal agent Drugs 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 150000003852 triazoles Chemical class 0.000 abstract 3
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
- C07F9/6518—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polymerization Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17716900P | 2000-01-20 | 2000-01-20 | |
| US24996900P | 2000-11-20 | 2000-11-20 | |
| PCT/US2001/001284 WO2001052852A1 (en) | 2000-01-20 | 2001-01-16 | Water soluble prodrugs of azole compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE300946T1 true ATE300946T1 (de) | 2005-08-15 |
Family
ID=26873001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01942553T ATE300946T1 (de) | 2000-01-20 | 2001-01-16 | Wasserlösliche wirkstoffvorstufen von azolverbindungen |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6362172B2 (de) |
| EP (1) | EP1284737B1 (de) |
| JP (1) | JP3766804B2 (de) |
| KR (1) | KR100748299B1 (de) |
| CN (1) | CN1178665C (de) |
| AT (1) | ATE300946T1 (de) |
| AU (1) | AU782177C (de) |
| BR (1) | BR0107618A (de) |
| CA (1) | CA2397734C (de) |
| CZ (1) | CZ20022822A3 (de) |
| DE (1) | DE60112433T2 (de) |
| DK (1) | DK1284737T5 (de) |
| ES (1) | ES2247131T3 (de) |
| HU (1) | HU229226B1 (de) |
| IL (2) | IL150798A0 (de) |
| MX (1) | MXPA02007120A (de) |
| NO (1) | NO330352B1 (de) |
| NZ (1) | NZ519354A (de) |
| PL (1) | PL206024B1 (de) |
| PT (1) | PT1284737E (de) |
| RU (1) | RU2266909C2 (de) |
| WO (1) | WO2001052852A1 (de) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6448401B1 (en) * | 2000-11-20 | 2002-09-10 | Bristol-Myers Squibb Company | Process for water soluble azole compounds |
| HUP0303249A3 (en) | 2001-02-22 | 2007-03-28 | Sankyo Co | Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| MXPA05001096A (es) | 2002-07-29 | 2005-11-23 | Rigel Pharmaceuticals Inc | Metodos para tratamiento o prevencion de enfermedades autoinmunes con compuestos de 2,4-diamino-pirimidina. |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| DE602006010979D1 (de) | 2005-01-19 | 2010-01-21 | Rigel Pharmaceuticals Inc | Prodrugs aus 2,4-pyrimidindiamin-verbindungen und ihre verwendungen |
| JO2691B1 (en) * | 2005-05-03 | 2013-03-03 | ايساي آر آند دي مانجمنت كو.، ليمتد | Monolysine salts for azole compounds |
| DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| EP1964843B1 (de) * | 2005-12-20 | 2013-08-28 | Eisai R&D Management Co., Ltd. | Verfahren zur herstellung einer wasserlöslichen azol-prodrug |
| WO2007092580A2 (en) * | 2006-02-08 | 2007-08-16 | Phibro-Tech Inc. | Biocidal azole emulsion concentrates having high active ingredient content |
| DE602007009489D1 (de) * | 2006-02-22 | 2010-11-11 | Eisai R&D Man Co Ltd | Stabilisierte pharmazeutische zusammensetzung |
| CA2810839A1 (en) | 2006-05-04 | 2007-11-15 | Boehringer Ingelheim International Gmbh | A polymorphic form of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(r)-amino-piperidin-1-yl)-xanthine |
| EP1852108A1 (de) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | Zusammensetzungen von DPP-IV-Inhibitoren |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| JP5757864B2 (ja) | 2008-05-20 | 2015-08-05 | ニューロジェシックス， インコーポレイテッド | 水溶性アセトアミノフェン類似体 |
| EP2291084A4 (de) | 2008-05-20 | 2012-04-25 | Neurogesx Inc | Carbonat-prodrugs und verfahren zu ihrer verwendung |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| BRPI0916997A2 (pt) | 2008-08-06 | 2020-12-15 | Boehringer Ingelheim International Gmbh | Inibidor de dpp-4 e seu uso |
| CN102149407A (zh) | 2008-09-10 | 2011-08-10 | 贝林格尔.英格海姆国际有限公司 | 治疗糖尿病和相关病症的组合疗法 |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| BRPI0923121A2 (pt) | 2008-12-23 | 2015-08-11 | Boehringer Ingelheim Int | Formas salinas de compostos orgânico |
| AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
| CN107115530A (zh) | 2009-11-27 | 2017-09-01 | 勃林格殷格翰国际有限公司 | 基因型糖尿病患者利用dpp‑iv抑制剂例如利拉利汀的治疗 |
| KR101927068B1 (ko) | 2010-05-05 | 2018-12-10 | 베링거 인겔하임 인터내셔날 게엠베하 | 체중 감소 치료에 후속하는 dpp-4 억제제에 의한 순차적 병용 요법 |
| CN102971005A (zh) | 2010-06-24 | 2013-03-13 | 贝林格尔.英格海姆国际有限公司 | 糖尿病治疗 |
| US20130288956A1 (en) | 2010-11-05 | 2013-10-31 | Eisai R&D Management Co., Ltd. | Combined pharmaceutical composition as antifungal agent |
| US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
| RU2734128C2 (ru) * | 2010-12-16 | 2020-10-13 | Плэтформ Брайтворкс Ту,Лтд | Фармацевтические препараты азолов для парентерального введения и способы их получения и применения для лечения заболеваний, чувствительных к азольным соединениям |
| EA032840B8 (ru) | 2011-06-22 | 2020-06-18 | Вайоми Терапеутикс Лимитед | Пролекарства на основе конъюгатов противогрибковых агентов и их применение |
| EP3517539B1 (de) | 2011-07-15 | 2022-12-14 | Boehringer Ingelheim International GmbH | Substituiertes dimeres chinazolinderivat, dessen herstellung und dessen verwendung in pharmazeutischen zusammensetzungen zur behandlung von diabetes typ i und ii |
| US8426450B1 (en) * | 2011-11-29 | 2013-04-23 | Helsinn Healthcare Sa | Substituted 4-phenyl pyridines having anti-emetic effect |
| IN2014DN06792A (de) | 2012-01-20 | 2015-05-22 | Viamet Pharmaceuticals Inc | |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| TWI574705B (zh) | 2012-04-20 | 2017-03-21 | 衛材Ｒ＆Ｄ企管股份有限公司 | Capsules |
| US20130303462A1 (en) | 2012-05-14 | 2013-11-14 | Boehringer Ingelheim International Gmbh | Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| KR101814895B1 (ko) | 2013-06-04 | 2018-01-04 | 바이옴 바이오사이언스 피브이티. 엘티디. | 코팅된 입자 및 이를 포함하는 조성물 |
| MX2016009898A (es) | 2014-01-29 | 2017-01-23 | Vyome Biosciences Pvt Ltd | Tratamientos para acne resistente. |
| JP6615109B2 (ja) | 2014-02-28 | 2019-12-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｄｐｐ−４阻害薬の医学的使用 |
| CN104926870B (zh) * | 2014-03-21 | 2017-02-08 | 合肥久诺医药科技有限公司 | 一种福司氟康唑的精制方法 |
| AU2016298280A1 (en) * | 2015-07-28 | 2018-02-22 | Beta Cat Pharmaceuticals, Inc. | Anthracene-9, 10-dione dioxime compounds prodrugs and their uses |
| CA3022202A1 (en) | 2016-06-10 | 2017-12-14 | Boehringer Ingelheim International Gmbh | Combinations of linagliptin and metformin |
| CN107501255B (zh) * | 2017-09-12 | 2019-08-23 | 成都施贝康生物医药科技有限公司 | 一种艾沙康唑衍生物及其用途 |
| CN108676031A (zh) * | 2018-05-29 | 2018-10-19 | 重庆威鹏药业有限公司 | 水溶性三唑类抗真菌膦酸化合物及其制备方法和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2111527C (en) | 1992-12-24 | 2000-07-18 | Jerzy Golik | Phosphonooxymethyl ethers of taxane derivatives |
| CA2129288C (en) | 1993-08-17 | 2000-05-16 | Jerzy Golik | Phosphonooxymethyl esters of taxane derivatives |
| US5714490A (en) * | 1993-12-21 | 1998-02-03 | Schering Corporation | Tetrahydrofuran antifungals |
| DK0736030T3 (da) | 1993-12-21 | 2001-10-29 | Schering Corp | Fungicide tetrahydrofuraner |
| PL181947B1 (en) | 1994-01-24 | 2001-10-31 | Janssen Pharmaceutica Nv | Water-soluble azole-type antimycotic agents |
| NZ270418A (en) | 1994-02-07 | 1997-09-22 | Eisai Co Ltd | Polycyclic triazole & imidazole derivatives, antifungal compositions |
| WO1996038443A1 (en) | 1995-06-02 | 1996-12-05 | Schering Corporation | Tetrahydrofuran antifungals |
| TW354293B (en) * | 1995-06-06 | 1999-03-11 | Bristol Myers Squibb Co | Prodrugs of paclitaxel derivatives |
| GB9602080D0 (en) | 1996-02-02 | 1996-04-03 | Pfizer Ltd | Pharmaceutical compounds |
| EP0829478A3 (de) | 1996-09-09 | 1998-03-25 | F. Hoffmann-La Roche Ag | N-Benzylimidazolium und N-Benzyltriazolium Derivate, deren Herstellung und deren Verwendung als fungizides und anti-mykotisches Mittel |
| DE69912250T2 (de) | 1998-01-29 | 2004-07-29 | Bristol-Myers Squibb Co., Wallingford | Phosphorylierte derivate des diaryl 1,3,4 oxadiazolon |
| US5883097A (en) | 1998-04-16 | 1999-03-16 | Schering Corporation | Soluble azole antifungal salt |
| US6204257B1 (en) * | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
| WO2000030655A1 (en) * | 1998-11-20 | 2000-06-02 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
| US6448401B1 (en) * | 2000-11-20 | 2002-09-10 | Bristol-Myers Squibb Company | Process for water soluble azole compounds |
-
2001
- 2001-01-10 US US09/757,438 patent/US6362172B2/en not_active Expired - Lifetime
- 2001-01-16 PT PT01942553T patent/PT1284737E/pt unknown
- 2001-01-16 CZ CZ20022822A patent/CZ20022822A3/cs unknown
- 2001-01-16 KR KR1020027009320A patent/KR100748299B1/ko active IP Right Grant
- 2001-01-16 HU HU0204405A patent/HU229226B1/hu not_active IP Right Cessation
- 2001-01-16 BR BR0107618-3A patent/BR0107618A/pt active Search and Examination
- 2001-01-16 WO PCT/US2001/001284 patent/WO2001052852A1/en active IP Right Grant
- 2001-01-16 JP JP2001552899A patent/JP3766804B2/ja not_active Expired - Lifetime
- 2001-01-16 NZ NZ519354A patent/NZ519354A/en not_active IP Right Cessation
- 2001-01-16 PL PL356164A patent/PL206024B1/pl not_active IP Right Cessation
- 2001-01-16 CA CA2397734A patent/CA2397734C/en not_active Expired - Lifetime
- 2001-01-16 DE DE60112433T patent/DE60112433T2/de not_active Expired - Lifetime
- 2001-01-16 EP EP01942553A patent/EP1284737B1/de not_active Expired - Lifetime
- 2001-01-16 ES ES01942553T patent/ES2247131T3/es not_active Expired - Lifetime
- 2001-01-16 DK DK01942553T patent/DK1284737T5/da active
- 2001-01-16 CN CNB018038581A patent/CN1178665C/zh not_active Expired - Lifetime
- 2001-01-16 RU RU2002118606/04A patent/RU2266909C2/ru active
- 2001-01-16 AT AT01942553T patent/ATE300946T1/de active
- 2001-01-16 IL IL15079801A patent/IL150798A0/xx active IP Right Grant
- 2001-01-16 AU AU29485/01A patent/AU782177C/en not_active Expired
- 2001-01-16 MX MXPA02007120A patent/MXPA02007120A/es active IP Right Grant
-
2002
- 2002-07-17 IL IL150798A patent/IL150798A/en unknown
- 2002-07-19 NO NO20023468A patent/NO330352B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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